2HEO

General Structure-Based Approach to the Design of Protein Ligands: Application to the Design of Kv1.2 Potassium Channel Blockers.

Summary for 2HEO

• Entry DOI: 10.2210/pdb2heo/pdb
• Related: 1J75
• Descriptor: 5'-D(*TP*CP*GP*CP*GP*CP*G)-3', Z-DNA binding protein 1 (3 entities in total)
• Functional Keywords: protein dlm1-z-dna complex, immune system-dna complex, immune system/dna
• Biological source: Mus musculus (house mouse)
• Total number of polymer chains: 4
• Total formula weight: 19106.01

Authors

Magis, C.,Gasparini, S.,Charbonnier, J.B.,Stura, E.,Le Du, M.H.,Menez, A.,Cuniasse, P. (deposition date: 2006-06-21, release date: 2006-11-21, Last modification date: 2023-08-30)

• Primary citation: Magis, C.,Gasparini, D.,Lecoq, A.,Le Du, M.H.,Stura, E.,Charbonnier, J.B.,Mourier, G.,Boulain, J.C.,Pardo, L.,Caruana, A.,Joly, A.,Lefranc, M.,Masella, M.,Menez, A.,Cuniasse, P.; Structure-based secondary structure-independent approach to design protein ligands: Application to the design of Kv1.2 potassium channel blockers.; J.Am.Chem.Soc., 128:16190-16205, 2006; PubMed: 17165772; DOI: 10.1021/ja0646491

Experimental method

X-RAY DIFFRACTION (1.7 Å)