2HEO
General Structure-Based Approach to the Design of Protein Ligands: Application to the Design of Kv1.2 Potassium Channel Blockers.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (B, E) | 5'-D(*TP*CP*GP*CP*GP*CP*G)-3' | polymer | 7 | 2114.4 | 2 | |||
| 2 | C, D (A, D) | Z-DNA binding protein 1 | polymer | 67 | 7438.6 | 2 | UniProt (Q9QY24) Pfam (PF02295) | Mus musculus (house mouse) | Tumor stroma and activated macrophage protein DLM-1 |
| 3 | E, F, G, H (B, E, A, D) | water | water | 18.0 | 228 | Chemie (HOH) |
Sequence modifications
A, D: 108 - 170 (UniProt: Q9QY24)
| PDB | External Database | Details |
|---|---|---|
| Gly 104 | - | cloning artifact |
| Ser 105 | - | cloning artifact |
| His 106 | - | cloning artifact |
| Met 107 | - | cloning artifact |
| Ala 130 | Lys 30 | engineered mutation |
| Phe 132 | Gly 32 | engineered mutation |
| Ser 162 | Glu 62 | engineered mutation |
| Lys 164 | Ala 64 | engineered mutation |
| Tyr 165 | Thr 65 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 19106.0 | |
| All* | Total formula weight | 19106.0 |
