9CRE
 
 | | Cryo-EM structure of SARS-CoV-2 Spike Proteins on intact virions: Alpha (B.1.1.7) variant 3 closed RBDs | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Ke, Z, Croll, T.I, Briggs, J.A.G. | | Deposit date: | 2024-07-22 | | Release date: | 2024-11-27 | | Last modified: | 2024-12-25 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Virion morphology and on-virus spike protein structures of diverse SARS-CoV-2 variants.
Embo J., 43, 2024
|
|
9CRG
 | | Cryo-EM structure of SARS-CoV-2 Spike Proteins on intact virions: Gamma (P.1) variant 3 closed RBDs | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Ke, Z, Kotecha, A, Briggs, J.A.G. | | Deposit date: | 2024-07-22 | | Release date: | 2024-11-27 | | Last modified: | 2024-12-25 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Virion morphology and on-virus spike protein structures of diverse SARS-CoV-2 variants.
Embo J., 43, 2024
|
|
4UYG
 | | C-Terminal bromodomain of Human BRD2 with I-BET726 (GSK1324726A) | | Descriptor: | 4-[(2S,4R)-1-acetyl-4-[(4-chlorophenyl)amino]-2-methyl-1,2,3,4-tetrahydroquinolin-6-yl]benzoic acid, BROMODOMAIN-CONTAINING PROTEIN 2, SULFATE ION | | Authors: | Chung, C, Bamborough, P, Gosmini, R. | | Deposit date: | 2014-08-31 | | Release date: | 2014-10-08 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | The Discovery of I-Bet726 (Gsk1324726A), a Potent Tetrahydroquinoline Apoa1 Up-Regulator and Selective Bet Bromodomain Inhibitor.
J.Med.Chem., 57, 2014
|
|
9CO6
 | | BA.5 spike/Nanosota-9 complex | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Nanosota-9, ... | | Authors: | Ye, G, Bu, F, Liu, B, Li, F. | | Deposit date: | 2024-07-16 | | Release date: | 2024-11-20 | | Last modified: | 2024-12-11 | | Method: | ELECTRON MICROSCOPY (3.01 Å) | | Cite: | Discovery of Nanosota-9 as anti-Omicron nanobody therapeutic candidate.
Plos Pathog., 20, 2024
|
|
4UV2
 | | Structure of the curli transport lipoprotein CsgG in a non-lipidated, pre-pore conformation | | Descriptor: | CURLI PRODUCTION TRANSPORT COMPONENT CSGG | | Authors: | Goyal, P, Krasteva, P.V, Gerven, N.V, Gubellini, F, Broeck, I.V.D, Troupiotis-Tsailaki, A, Jonckheere, W, Pehau-Arnaudet, G, Pinkner, J.S, Chapman, M.R, Hultgren, S.J, Howorka, S, Fronzes, R, Remaut, H. | | Deposit date: | 2014-08-04 | | Release date: | 2014-09-24 | | Last modified: | 2024-11-13 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Structural and Mechanistic Insights Into the Bacterial Amyloid Secretion Channel Csgg.
Nature, 516, 2014
|
|
4V2T
 | | Membrane embedded pleurotolysin pore with 13 fold symmetry | | Descriptor: | PLEUROTOLYSIN A, PLEUROTOLYSIN B | | Authors: | Lukoyanova, N, Kondos, S.C, Farabella, I, Law, R.H.P, Reboul, C.F, Caradoc-Davies, T.T, Spicer, B.A, Kleifeld, O, Perugini, M, Ekkel, S, Hatfaludi, T, Oliver, K, Hotze, E.M, Tweten, R.K, Whisstock, J.C, Topf, M, Dunstone, M.A, Saibil, H.R. | | Deposit date: | 2014-10-15 | | Release date: | 2015-02-18 | | Last modified: | 2024-05-08 | | Method: | ELECTRON MICROSCOPY (11 Å) | | Cite: | Conformational Changes During Pore Formation by the Perforin-Related Protein Pleurotolysin.
Plos Biol., 13, 2015
|
|
6CK5
 | | PRPP riboswitch from T. mathranii bound to PRPP | | Descriptor: | 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, BARIUM ION, MAGNESIUM ION, ... | | Authors: | Knappenberger, A.J, Reiss, C.W, Strobel, S.A. | | Deposit date: | 2018-02-27 | | Release date: | 2018-06-20 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.49 Å) | | Cite: | Structures of two aptamers with differing ligand specificity reveal ruggedness in the functional landscape of RNA.
Elife, 7, 2018
|
|
6CTY
 | | Crystal structure of dihydroorotase pyrC from Yersinia pestis in complex with zinc and malate at 2.4 A resolution | | Descriptor: | D-MALATE, Dihydroorotase, ZINC ION | | Authors: | Lipowska, J, Shabalin, I.G, Winsor, J, Woinska, M, Cooper, D.R, Kwon, K, Shuvalova, L, Anderson, W.F, Minor, W, Center for Structural Genomics of Infectious Diseases (CSGID) | | Deposit date: | 2018-03-23 | | Release date: | 2018-04-04 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (2.41 Å) | | Cite: | Pyrimidine biosynthesis in pathogens - Structures and analysis of dihydroorotases from Yersinia pestis and Vibrio cholerae.
Int.J.Biol.Macromol., 136, 2019
|
|
9CBN
 | | HAstV1 spike in complex with neutralizing Fabs 3H4 and 3B4 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, HAstV1 neutralizing Fab 3B4 heavy chain, HAstV1 neutralizing Fab 3B4 kappa chain, ... | | Authors: | Lanning, S, DuBois, R.M, Balasco Serrao, V.H. | | Deposit date: | 2024-06-19 | | Release date: | 2024-12-25 | | Last modified: | 2025-03-05 | | Method: | ELECTRON MICROSCOPY (3.33 Å) | | Cite: | Discovery of three novel neutralizing antibody epitopes on the human astrovirus capsid spike and mechanistic insights into virus neutralization.
J.Virol., 99, 2025
|
|
2BS2
 | | QUINOL:FUMARATE REDUCTASE FROM WOLINELLA SUCCINOGENES | | Descriptor: | DODECYL-BETA-D-MALTOSIDE, FE2/S2 (INORGANIC) CLUSTER, FE3-S4 CLUSTER, ... | | Authors: | Lancaster, C.R.D. | | Deposit date: | 2005-05-14 | | Release date: | 2006-10-25 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (1.78 Å) | | Cite: | Evidence for Transmembrane Proton Transfer in a Dihaem-Containing Membrane Protein Complex.
Embo J., 25, 2006
|
|
7AQB
 | | Crystal structure of human mitogen activated protein kinase 6 (MAPK6) | | Descriptor: | 1,2-ETHANEDIOL, MAGNESIUM ION, Mitogen-activated protein kinase 6 | | Authors: | Filippakopoulos, P, Schroeder, M, Chaikuad, A, Knapp, S, Structural Genomics Consortium (SGC) | | Deposit date: | 2020-10-20 | | Release date: | 2020-11-11 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (2.25 Å) | | Cite: | Crystal Structure and Inhibitor Identifications Reveal Targeting Opportunity for the Atypical MAPK Kinase ERK3.
Int J Mol Sci, 21, 2020
|
|
9D1W
 | | Cryo-EM structure of PGDM1400 Fab bound to HIV-1 BG505 DS-SOSIP.664 Env trimer | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, HIV-1 BG505 DS-SOSIP glycoprotein gp41, ... | | Authors: | Kanai, T, Morano, N.C, Shapiro, L, Kwong, P.D, Gorman, J. | | Deposit date: | 2024-08-08 | | Release date: | 2024-12-25 | | Last modified: | 2025-02-05 | | Method: | ELECTRON MICROSCOPY (3.44 Å) | | Cite: | Structural development of the HIV-1 apex-directed PGT145-PGDM1400 antibody lineage.
Cell Rep, 44, 2025
|
|
9D3D
 | | Cryo-EM structure of PGT145 R100aS Fab bound to HIV-1 BG505 DS-SOSIP.664 Env trimer | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, BG505 DS-SOSIP glycoprotein gp41, ... | | Authors: | Hodges, S, Morano, N.C, Shapiro, L, Kwong, P.D, Gorman, J. | | Deposit date: | 2024-08-09 | | Release date: | 2024-12-25 | | Last modified: | 2025-02-05 | | Method: | ELECTRON MICROSCOPY (3.41 Å) | | Cite: | Structural development of the HIV-1 apex-directed PGT145-PGDM1400 antibody lineage.
Cell Rep, 44, 2025
|
|
9CU4
 | | KSHV glycoprotein B ectodomain, postfusion form | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ORF8, ... | | Authors: | Ito, F, Zhen, J, Xie, G, Huang, H, Silva, J.C, Wu, T, Zhou, Z.H. | | Deposit date: | 2024-07-25 | | Release date: | 2025-01-08 | | Last modified: | 2025-06-04 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Structure of the Kaposi's sarcoma-associated herpesvirus gB in post-fusion conformation.
J.Virol., 99, 2025
|
|
9CQ8
 | | Dimeric 9C2 gamma delta TCR extracellular domain bound by Fab 2 | | Descriptor: | 9C2 TCR delta chain, 9C2 TCR gamma chain, anti TCR variable delta 1 Fab heavy chain, ... | | Authors: | Hoque, M, Saotome, K, Franklin, M.C. | | Deposit date: | 2024-07-19 | | Release date: | 2025-01-15 | | Method: | ELECTRON MICROSCOPY (3.45 Å) | | Cite: | Structural characterization of two gamma delta TCR/CD3 complexes.
Nat Commun, 16, 2025
|
|
9CQ4
 | | G115 gamma delta TCR/CD3 complex bound by OKT3 Fab | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL, ... | | Authors: | Hoque, M, Saotome, K, Franklin, M.C. | | Deposit date: | 2024-07-19 | | Release date: | 2025-01-15 | | Method: | ELECTRON MICROSCOPY (3.27 Å) | | Cite: | Structural characterization of two gamma delta TCR/CD3 complexes.
Nat Commun, 16, 2025
|
|
9CQ7
 | | G115 TCR extracellular domain bound to Fab 1 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, G115 TCR delta chain, ... | | Authors: | Hoque, M, Saotome, K, Franklin, M.C. | | Deposit date: | 2024-07-19 | | Release date: | 2025-01-15 | | Method: | ELECTRON MICROSCOPY (3.21 Å) | | Cite: | Structural characterization of two gamma delta TCR/CD3 complexes.
Nat Commun, 16, 2025
|
|
9CQL
 | | Dimeric 9C2 gamma delta TCR bound by Fab 3 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 9C2 TCR delta chain, ... | | Authors: | Hoque, M, Saotome, K, Franklin, M.C. | | Deposit date: | 2024-07-19 | | Release date: | 2025-01-15 | | Method: | ELECTRON MICROSCOPY (3.46 Å) | | Cite: | Structural characterization of two gamma delta TCR/CD3 complexes.
Nat Commun, 16, 2025
|
|
9CXA
 | | Native human GABAA receptor of beta2-alpha1-beta3-alpha1-gamma2 assembly | | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Zhou, J, Hibbs, R.E, Noviello, C.M. | | Deposit date: | 2024-07-31 | | Release date: | 2025-01-22 | | Last modified: | 2025-05-14 | | Method: | ELECTRON MICROSCOPY (3.04 Å) | | Cite: | Resolving native GABA A receptor structures from the human brain.
Nature, 638, 2025
|
|
9CRV
 | | Native human GABAA receptor of beta2-alpha1-gamma2-beta2-alpha2 assembly | | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Zhou, J, Hibbs, R.E, Noviello, C.M. | | Deposit date: | 2024-07-22 | | Release date: | 2025-01-22 | | Last modified: | 2025-05-21 | | Method: | ELECTRON MICROSCOPY (3.18 Å) | | Cite: | Resolving native GABA A receptor structures from the human brain.
Nature, 638, 2025
|
|
9CSB
 | | Native human GABAA receptor of beta3-alpha1-beta2-alpha2-gamma2 assembly | | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Zhou, J, Hibbs, R.E, Noviello, C.M. | | Deposit date: | 2024-07-23 | | Release date: | 2025-01-22 | | Last modified: | 2025-05-14 | | Method: | ELECTRON MICROSCOPY (3.34 Å) | | Cite: | Resolving native GABA A receptor structures from the human brain.
Nature, 638, 2025
|
|
9CX7
 | | Native human GABAA receptor of beta3-alpha1-gamma2-beta3-alpha2 assembly | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GAMMA-AMINO-BUTANOIC ACID, ... | | Authors: | Zhou, J, Hibbs, R.E, Noviello, C.M. | | Deposit date: | 2024-07-30 | | Release date: | 2025-01-22 | | Last modified: | 2025-05-14 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Resolving native GABA A receptor structures from the human brain.
Nature, 638, 2025
|
|
9CT0
 | | Native human GABAA receptor of beta2-alpha1-beta2-alpha2-gamma2 assembly | | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Zhou, J, Hibbs, R.E, Noviello, C.M. | | Deposit date: | 2024-07-24 | | Release date: | 2025-01-22 | | Last modified: | 2025-05-28 | | Method: | ELECTRON MICROSCOPY (3.19 Å) | | Cite: | Resolving native GABA A receptor structures from the human brain.
Nature, 638, 2025
|
|
9CXC
 | | Native human GABAA receptor of beta3-alpha1-gamma2-beta2-alpha2 assembly | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GAMMA-AMINO-BUTANOIC ACID, ... | | Authors: | Zhou, J, Hibbs, R.E, Noviello, C.M. | | Deposit date: | 2024-07-31 | | Release date: | 2025-01-22 | | Last modified: | 2025-06-04 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Resolving native GABA A receptor structures from the human brain.
Nature, 638, 2025
|
|
9CRS
 | | Native human GABAA receptor of beta2-alpha1-beta2-alpha1-gamma2 assembly | | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Zhou, J, Hibbs, R.E, Noviello, C.M. | | Deposit date: | 2024-07-22 | | Release date: | 2025-01-22 | | Last modified: | 2025-05-21 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Resolving native GABA A receptor structures from the human brain.
Nature, 638, 2025
|
|
