5WFZ
Crystal structure of the influenza virus PA endonuclease (E119D mutant) in complex with inhibitor 8e (SRI-30049)
Summary for 5WFZ
| Entry DOI | 10.2210/pdb5wfz/pdb |
| Related | 5W3I 5W44 5W73 5W7U 5W92 5W9G 5WA6 5WA7 5WAP 5WB3 5WCS 5WCT 5WDC 5WDN 5WDW 5WE7 5WE9 5WEB 5WEF 5WEI 5WF3 5WFM 5WFW |
| Descriptor | Polymerase acidic protein, MANGANESE (II) ION, SULFATE ION, ... (6 entities in total) |
| Functional Keywords | virus, nuclease, transcription, cap-snatching, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
| Biological source | Influenza A virus More |
| Total number of polymer chains | 1 |
| Total formula weight | 24094.83 |
| Authors | Kumar, G.,White, S.W. (deposition date: 2017-07-13, release date: 2017-12-27, Last modification date: 2024-03-13) |
| Primary citation | Beylkin, D.,Kumar, G.,Zhou, W.,Park, J.,Jeevan, T.,Lagisetti, C.,Harfoot, R.,Webby, R.J.,White, S.W.,Webb, T.R. Protein-Structure Assisted Optimization of 4,5-Dihydroxypyrimidine-6-Carboxamide Inhibitors of Influenza Virus Endonuclease. Sci Rep, 7:17139-17139, 2017 Cited by PubMed: 29215062DOI: 10.1038/s41598-017-17419-6 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.35 Å) |
Structure validation
Download full validation report
