8FJ2
 
 | | Crystal Structure of the Tick Evasin EVA-AAM1001(C8) Complexed to Human Chemokine CCL17 | | Descriptor: | C-C motif chemokine 17, Evasin P1243 | | Authors: | Devkota, S.R, Bhusal, R.P, Aryal, P, Wilce, M.C.J, Stone, M.J. | | Deposit date: | 2022-12-19 | | Release date: | 2023-03-29 | | Last modified: | 2023-07-26 | | Method: | X-RAY DIFFRACTION (2.07 Å) | | Cite: | Engineering broad-spectrum inhibitors of inflammatory chemokines from subclass A3 tick evasins.
Nat Commun, 14, 2023
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8F8X
 | | Crystal structure of Nb.X0 bound to the afucosylated human IgG1 fragment crystal form II | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Nb.X0, Uncharacterized protein DKFZp686C11235 | | Authors: | Goldgur, Y, Ravetch, J, Gupta, A, Kao, K, Oren, D. | | Deposit date: | 2022-11-22 | | Release date: | 2023-03-29 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Mechanism of glycoform specificity and in vivo protection by an anti-afucosylated IgG nanobody.
Nat Commun, 14, 2023
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8FDS
 | | Ankyrin domain of SKD3 isoform 2 | | Descriptor: | Caseinolytic peptidase B protein homolog, FORMIC ACID | | Authors: | Lee, S, Tsai, F.T.F, Chang, C. | | Deposit date: | 2022-12-04 | | Release date: | 2023-04-19 | | Last modified: | 2024-05-01 | | Method: | X-RAY DIFFRACTION (1.65 Å) | | Cite: | Structural basis of impaired disaggregase function in the oxidation-sensitive SKD3 mutant causing 3-methylglutaconic aciduria.
Nat Commun, 14, 2023
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8FCK
 | | Structure of the vertebrate augmin complex | | Descriptor: | HAUS augmin like complex subunit 2 L homeolog, Green fluorescent protein chimera, HAUS augmin like complex subunit 4 L homeolog, ... | | Authors: | Travis, S.M, Huang, W, Zhang, R, Petry, S. | | Deposit date: | 2022-12-01 | | Release date: | 2023-04-19 | | Last modified: | 2024-06-19 | | Method: | ELECTRON MICROSCOPY (6.88 Å) | | Cite: | Integrated model of the vertebrate augmin complex.
Nat Commun, 14, 2023
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8FZR
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8FOJ
 | | Cryo-EM structure of S. cerevisiae DNA polymerase alpha-primase complex in the post RNA handoff state | | Descriptor: | DNA polymerase, DNA polymerase alpha subunit B, DNA primase, ... | | Authors: | Yuan, Z, Georgescu, R, Li, H, O'Donnell, M. | | Deposit date: | 2022-12-30 | | Release date: | 2023-05-31 | | Last modified: | 2024-03-13 | | Method: | ELECTRON MICROSCOPY (4.8 Å) | | Cite: | Molecular choreography of primer synthesis by the eukaryotic Pol alpha-primase.
Nat Commun, 14, 2023
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8FOH
 | | Cryo-EM structure of S. cerevisiae DNA polymerase alpha-primase complex in the RNA synthesis state | | Descriptor: | DNA polymerase, DNA polymerase alpha subunit B, DNA primase, ... | | Authors: | Yuan, Z, Georgescu, R, Li, H, O'Donnell, M. | | Deposit date: | 2022-12-30 | | Release date: | 2023-05-31 | | Last modified: | 2024-03-13 | | Method: | ELECTRON MICROSCOPY (4.6 Å) | | Cite: | Molecular choreography of primer synthesis by the eukaryotic Pol alpha-primase.
Nat Commun, 14, 2023
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8FOC
 | | Cryo-EM structure of S. cerevisiae DNA polymerase alpha-primase in Apo state conformation I | | Descriptor: | DNA polymerase, DNA polymerase alpha subunit B, DNA primase, ... | | Authors: | Yuan, Z, Georgescu, R, Li, H, O'Donnell, M. | | Deposit date: | 2022-12-30 | | Release date: | 2023-05-31 | | Last modified: | 2024-03-13 | | Method: | ELECTRON MICROSCOPY (3.7 Å) | | Cite: | Molecular choreography of primer synthesis by the eukaryotic Pol alpha-primase.
Nat Commun, 14, 2023
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8FOW
 | | Ternary complex of CDK2 with small molecule ligands TW8672 and Dinaciclib | | Descriptor: | 1,2-ETHANEDIOL, 2-{[2-(1H-indol-3-yl)ethyl]amino}-5-nitrobenzoic acid, 3-[({3-ethyl-5-[(2S)-2-(2-hydroxyethyl)piperidin-1-yl]pyrazolo[1,5-a]pyrimidin-7-yl}amino)methyl]-1-hydroxypyridinium, ... | | Authors: | Schonbrunn, E, Sun, L. | | Deposit date: | 2023-01-03 | | Release date: | 2023-05-31 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Development of allosteric and selective CDK2 inhibitors for contraception with negative cooperativity to cyclin binding.
Nat Commun, 14, 2023
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8FYO
 | | MicroED structure of Proteinase K from lamellae milled from multiple plasma sources | | Descriptor: | CALCIUM ION, NITRATE ION, Proteinase K | | Authors: | Martynowycz, M.W, Shiriaeva, A, Clabbers, M.T.B, Nicolas, W.J, Weaver, S.J, Hattne, J, Gonen, T. | | Deposit date: | 2023-01-26 | | Release date: | 2023-05-24 | | Method: | ELECTRON CRYSTALLOGRAPHY (1.39 Å) | | Cite: | A robust approach for MicroED sample preparation of lipidic cubic phase embedded membrane protein crystals.
Nat Commun, 14, 2023
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8FOA
 | | Cryo-EM structure of human TRPV6 in complex with the natural phytoestrogen genistein | | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, CALCIUM ION, CHOLESTEROL HEMISUCCINATE, ... | | Authors: | Neuberger, A, Yelshanskaya, M.V, Nadezhdin, K.D, Sobolevsky, A.I. | | Deposit date: | 2022-12-30 | | Release date: | 2023-05-24 | | Last modified: | 2024-06-19 | | Method: | ELECTRON MICROSCOPY (2.66 Å) | | Cite: | Structural mechanism of human oncochannel TRPV6 inhibition by the natural phytoestrogen genistein.
Nat Commun, 14, 2023
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8FOB
 | | Cryo-EM structure of human TRPV6 in the open state | | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, CALCIUM ION, ... | | Authors: | Neuberger, A, Yelshanskaya, M.V, Nadezhdin, K.D, Sobolevsky, A.I. | | Deposit date: | 2022-12-30 | | Release date: | 2023-05-24 | | Last modified: | 2024-06-19 | | Method: | ELECTRON MICROSCOPY (2.71 Å) | | Cite: | Structural mechanism of human oncochannel TRPV6 inhibition by the natural phytoestrogen genistein.
Nat Commun, 14, 2023
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8FP5
 | | CDK2 liganded with ATP and Mg2+ | | Descriptor: | 1,2-ETHANEDIOL, ADENOSINE-5'-TRIPHOSPHATE, Cyclin-dependent kinase 2, ... | | Authors: | Schonbrunn, E, Sun, L. | | Deposit date: | 2023-01-04 | | Release date: | 2023-05-31 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Development of allosteric and selective CDK2 inhibitors for contraception with negative cooperativity to cyclin binding.
Nat Commun, 14, 2023
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8FOE
 | | Cryo-EM structure of S. cerevisiae DNA polymerase alpha-primase complex bound to a template DNA | | Descriptor: | DNA polymerase, DNA polymerase alpha subunit B, DNA primase, ... | | Authors: | Yuan, Z, Georgescu, R, Li, H, O'Donnell, M. | | Deposit date: | 2022-12-30 | | Release date: | 2023-05-31 | | Last modified: | 2024-03-13 | | Method: | ELECTRON MICROSCOPY (5.6 Å) | | Cite: | Molecular choreography of primer synthesis by the eukaryotic Pol alpha-primase.
Nat Commun, 14, 2023
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8FOK
 | | Cryo-EM structure of S. cerevisiae DNA polymerase alpha-primase complex in the DNA elongation state | | Descriptor: | DNA polymerase, DNA polymerase alpha subunit B, DNA primase, ... | | Authors: | Yuan, Z, Georgescu, R, Li, H, O'Donnell, M. | | Deposit date: | 2022-12-30 | | Release date: | 2023-05-31 | | Last modified: | 2024-03-13 | | Method: | ELECTRON MICROSCOPY (3.56 Å) | | Cite: | Molecular choreography of primer synthesis by the eukaryotic Pol alpha-primase.
Nat Commun, 14, 2023
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8FOD
 | | Cryo-EM structure of S. cerevisiae DNA polymerase alpha-primase complex in Apo state conformation II | | Descriptor: | DNA polymerase, DNA polymerase alpha subunit B, DNA primase, ... | | Authors: | Yuan, Z, Georgescu, R, Li, H, O'Donnell, M. | | Deposit date: | 2022-12-30 | | Release date: | 2023-05-31 | | Last modified: | 2024-03-13 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | Molecular choreography of primer synthesis by the eukaryotic Pol alpha-primase.
Nat Commun, 14, 2023
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8FP0
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8DHN
 | | The N-terminal domain of PA endonuclease from the influenza H1N1 viral polymerase in complex with 6-Bromo-3-hydroxy-2-(5-methyl-1,2,4-oxadiazol-3-yl)pyridin-4(1H)-one | | Descriptor: | (2P)-6-bromo-3-hydroxy-2-(5-methyl-1,2,4-oxadiazol-3-yl)pyridin-4(1H)-one, MANGANESE (II) ION, PA endonuclease | | Authors: | Kohlbrand, A.J, Stokes, R.W, Karges, J, Seo, H, Sankaran, B, Cohen, S.M. | | Deposit date: | 2022-06-27 | | Release date: | 2022-12-21 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Carboxylic Acid Isostere Derivatives of Hydroxypyridinones as Core Scaffolds for Influenza Endonuclease Inhibitors.
Acs Med.Chem.Lett., 14, 2023
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8FAK
 | | DNA replication fork binding triggers structural changes in the PriA DNA helicase that regulate the PriA-PriB replication restart pathway in E. coli | | Descriptor: | DNA (5'-D(P*CP*AP*GP*AP*CP*TP*CP*AP*TP*TP*TP*AP*GP*CP*CP*CP*TP*TP*AP*TP*CP*CP*G)-3'), DNA (5'-D(P*CP*GP*GP*AP*TP*AP*AP*GP*GP*GP*CP*TP*GP*AP*GP*CP*AP*CP*GP*CP*CP*GP*A)-3'), DNA (5'-D(P*TP*CP*GP*GP*CP*GP*TP*GP*CP*TP*C)-3'), ... | | Authors: | Duckworth, A.T, Ducos, P.L, McMillan, S.D, Satyshur, K.A, Blumenthal, K.H, Deorio, H.R, Larson, J.A, Sandler, S.J, Grant, T, Keck, J.L. | | Deposit date: | 2022-11-28 | | Release date: | 2023-05-10 | | Last modified: | 2023-05-24 | | Method: | ELECTRON MICROSCOPY (3.22 Å) | | Cite: | Replication fork binding triggers structural changes in the PriA helicase that govern DNA replication restart in E. coli.
Nat Commun, 14, 2023
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8CTF
 | | The N-terminal domain of PA endonuclease from the influenza H1N1 viral polymerase in complex with 3-hydroxy-4-oxo-1,4-dihydropyridine-2-carboxylic acid | | Descriptor: | 3-hydroxy-4-oxo-1,4-dihydropyridine-2-carboxylic acid, ACETATE ION, MANGANESE (II) ION, ... | | Authors: | Kohlbrand, A.J, Stokes, R.W, Karges, J, Seo, H, Sankaran, B, Cohen, S.M. | | Deposit date: | 2022-05-14 | | Release date: | 2022-12-21 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.14 Å) | | Cite: | Carboxylic Acid Isostere Derivatives of Hydroxypyridinones as Core Scaffolds for Influenza Endonuclease Inhibitors.
Acs Med.Chem.Lett., 14, 2023
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8DJV
 | | The N-terminal domain of PA endonuclease from the influenza H1N1 viral polymerase in complex with 6-Bromo-3-hydroxy-N-methoxy-4-oxo-1,4-dihydropyridine-2-carboxamide | | Descriptor: | 6-bromo-3-hydroxy-N-methoxy-4-oxo-1,4-dihydropyridine-2-carboxamide, MANGANESE (II) ION, Polymerase acidic protein | | Authors: | Kohlbrand, A.J, Stokes, R.W, Karges, J, Seo, H, Sankaran, B, Cohen, S.M. | | Deposit date: | 2022-07-01 | | Release date: | 2022-12-21 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.08 Å) | | Cite: | Carboxylic Acid Isostere Derivatives of Hydroxypyridinones as Core Scaffolds for Influenza Endonuclease Inhibitors.
Acs Med.Chem.Lett., 14, 2023
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8FZY
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8FVI
 | | Human APOBEC3H bound to HIV-1 Vif in complex with CBF-beta, ELOB, ELOC, and CUL5 | | Descriptor: | Core-binding factor subunit beta, Cullin 5, DNA dC->dU-editing enzyme APOBEC-3H, ... | | Authors: | Ito, F, Alvarez-Cabrera, A.L, Zhou, Z.H, Chen, X.S. | | Deposit date: | 2023-01-19 | | Release date: | 2023-09-06 | | Last modified: | 2024-05-01 | | Method: | ELECTRON MICROSCOPY (3.24 Å) | | Cite: | Structural basis of HIV-1 Vif-mediated E3 ligase targeting of host APOBEC3H.
Nat Commun, 14, 2023
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8FR3
 | | E. coli EF-Tu in complex with KKL-55 | | Descriptor: | 3-chloro-N-(1-propyl-1H-tetrazol-5-yl)benzamide, Elongation factor Tu, GUANOSINE-5'-DIPHOSPHATE, ... | | Authors: | Nguyen, H.A, Kuzmishin Nagy, A.B, Dunham, C.M. | | Deposit date: | 2023-01-06 | | Release date: | 2023-09-20 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.23 Å) | | Cite: | Antibiotic that inhibits trans -translation blocks binding of EF-Tu to tmRNA but not to tRNA.
Mbio, 14, 2023
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8DH4
 | | T7 RNA polymerase elongation complex with unnatural base dPa-DsTP pair | | Descriptor: | (7P)-3-{5-O-[(R)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]oxy}phosphoryl]-beta-D-ribofuranosyl}-7-(thiophen-2-yl)-3H-imidazo[4,5-b]pyridine, MAGNESIUM ION, Non-template strand DNA, ... | | Authors: | Oh, J, Wang, D. | | Deposit date: | 2022-06-24 | | Release date: | 2023-02-01 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Structural basis of transcription recognition of a hydrophobic unnatural base pair by T7 RNA polymerase.
Nat Commun, 14, 2023
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