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4C70
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BU of 4c70 by Molmil
Crystal structure of M. tuberculosis C171Q KasA in complex with TLM4
Descriptor: (2R)-2-(hexadecanoyloxy)-3-{[(10R)-10-methyloctadecanoyl]oxy}propyl phosphate, (5R)-4-hydroxy-5-methyl-5-[(1E)-2-methylbuta-1,3-dien-1-yl]-3-propylthiophen-2(5H)-one, 3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE 1, ...
Authors:Schiebel, J, Kapilashrami, K, Fekete, A, Bommineni, G.R, Schaefer, C.M, Mueller, M.J, Tonge, P.J, Kisker, C.
Deposit date:2013-09-19
Release date:2013-10-09
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structural Basis for the Recognition of Mycolic Acid Precursors by Kasa, a Condensing Enzyme and Drug Target from Mycobacterium Tuberculosis
J.Biol.Chem., 288, 2013
4C73
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BU of 4c73 by Molmil
Crystal structure of M. tuberculosis C171Q KasA in complex with TLM6
Descriptor: (2R)-2-(hexadecanoyloxy)-3-{[(10R)-10-methyloctadecanoyl]oxy}propyl phosphate, (5R)-5-methyl-5-[(1E)-2-methylbuta-1,3-dienyl]-4-oxidanyl-3-[2,2,2-tris(fluoranyl)ethanoyl]thiophen-2-one, 1,2-ETHANEDIOL, ...
Authors:Schiebel, J, Kapilashrami, K, Fekete, A, Bommineni, G.R, Schaefer, C.M, Mueller, M.J, Tonge, P.J, Kisker, C.
Deposit date:2013-09-19
Release date:2013-10-09
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural Basis for the Recognition of Mycolic Acid Precursors by Kasa, a Condensing Enzyme and Drug Target from Mycobacterium Tuberculosis
J.Biol.Chem., 288, 2013
3R44
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BU of 3r44 by Molmil
Mycobacterium tuberculosis fatty acyl CoA synthetase
Descriptor: HISTIDINE, MALONATE ION, fatty acyl CoA synthetase FADD13 (FATTY-ACYL-CoA SYNTHETASE)
Authors:Andersson, C.S, Martinez Molina, D, Hogbom, M.
Deposit date:2011-03-17
Release date:2012-02-08
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The Mycobacterium tuberculosis Very-Long-Chain Fatty Acyl-CoA Synthetase: Structural Basis for Housing Lipid Substrates Longer than the Enzyme.
Structure, 20, 2012
5DZ6
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BU of 5dz6 by Molmil
Acyl transferase from Bacillaene PKS
Descriptor: 1,2-ETHANEDIOL, BROMIDE ION, CHLORIDE ION, ...
Authors:Till, M, Race, P.R.
Deposit date:2015-09-25
Release date:2016-10-05
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.44 Å)
Cite:Architectural hierarchy of trans-acting enoyl reductases from polyunsaturated fatty acid and trans-acyltransferase polyketide synthases
To Be Published
5I0K
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BU of 5i0k by Molmil
Insights into Substrate Modification by Dehydratases from Type I Polyketide Synthases
Descriptor: CROTONYL COENZYME A, Phthiocerol synthesis polyketide synthase type I PpsC
Authors:Faille, A, Mourey, L, Pedelacq, J.D.
Deposit date:2016-02-04
Release date:2017-08-09
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (3.197 Å)
Cite:Insights into Substrate Modification by Dehydratases from Type I Polyketide Synthases.
J. Mol. Biol., 429, 2017
2GFY
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BU of 2gfy by Molmil
Structure of E. coli FabF(K335A) mutant with covalently linked dodecanoic acid
Descriptor: 3-oxoacyl-[acyl-carrier-protein] synthase 2, LAURIC ACID
Authors:Soisson, S.M, Parthasarathy, G.
Deposit date:2006-03-23
Release date:2006-05-23
Last modified:2021-10-20
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Platensimycin is a selective FabF inhibitor with potent antibiotic properties.
Nature, 441, 2006
7D41
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BU of 7d41 by Molmil
Crystal structure of type III polyketide synthase from Mycobacterium marinum - P 21 21 21 Space group
Descriptor: Chalcone synthase-like protein, Chalcone/stilbene synthase, OCTANOIC ACID (CAPRYLIC ACID)
Authors:Pratap, S, Kant, A, Saxena, P, Krishnan, V.
Deposit date:2020-09-21
Release date:2022-03-23
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.419 Å)
Cite:crystal structure of type III polyketide synthase from Mycobacterium marinum
To Be Published
7WVZ
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BU of 7wvz by Molmil
CalA3_modular PKS_KS-AT-DH-KR
Descriptor: Beta-ketoacyl-acyl-carrier-protein synthase I
Authors:Wang, J, Wang, Z.
Deposit date:2022-02-12
Release date:2023-02-22
Last modified:2023-10-11
Method:ELECTRON MICROSCOPY (3.38 Å)
Cite:C-N bond formation by a polyketide synthase.
Nat Commun, 14, 2023
6DGN
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BU of 6dgn by Molmil
Cronobacter turicensis BDSF synthase RpfF in complex with the RpfR quorum-sensing receptor FI domain
Descriptor: GLYCEROL, PHOSPHATE ION, RpfF, ...
Authors:Waldron, E.J, Neiditch, M.B.
Deposit date:2018-05-17
Release date:2019-01-02
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.999 Å)
Cite:Structural basis of DSF recognition by its receptor RpfR and its regulatory interaction with the DSF synthase RpfF.
PLoS Biol., 17, 2019
3QH0
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BU of 3qh0 by Molmil
X-ray crystal structure of palmitic acid bound to the cyclooxygenase channel of cyclooxygenase-2
Descriptor: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Vecchio, A.J, Malkowski, M.G.
Deposit date:2011-01-25
Release date:2011-04-13
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Human cyclooxygenase-2 is a sequence homodimer that functions as a conformational heterodimer.
J.Biol.Chem., 286, 2011
4JAR
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BU of 4jar by Molmil
Crystal structure of mycobacterium tuberculosis pks11 in complex with polyketide intermediates and evidence that it synthesize ALKYLPYRONES
Descriptor: Alpha-pyrone synthesis polyketide synthase-like Pks11
Authors:Gokulan, K, Sacchettini, J.C, Mycobacterium Tuberculosis Structural Proteomics Project (XMTB)
Deposit date:2013-02-19
Release date:2013-04-24
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Crystal structure of Mycobacterium tuberculosis polyketide synthase 11 (PKS11) reveals intermediates in the synthesis of methyl-branched alkylpyrones.
J.Biol.Chem., 288, 2013
3HEM
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BU of 3hem by Molmil
Structure of Mycobacterium tuberculosis Mycolic Acid Cyclopropane Synthase CmaA2 in Complex with Dioctylamine
Descriptor: CARBONATE ION, Cyclopropane-fatty-acyl-phospholipid synthase 2, N-octyloctan-1-amine
Authors:Liu, Z, Sacchettini, J.C.
Deposit date:2009-05-09
Release date:2009-06-16
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.39 Å)
Cite:Structure of Mycobacterium tuberculosis Mycolic Acid Cyclopropane Synthase CmaA2 in Complex with Dioctylamine
TO BE PUBLISHED
8EE0
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BU of 8ee0 by Molmil
KS-AT didomain from module 2 of the 6-deoxyerythronolide B synthase in complex with antibody fragment 1B2
Descriptor: 1B2 antibody heavy chain, 1B2 antibody light chain, 6-deoxyerythronolide B synthase
Authors:Cogan, D.P, Brodsky, K.L, Guzman, K.M, Mathews, I.I, Khosla, C.
Deposit date:2022-09-06
Release date:2023-05-31
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Discovery and Characterization of Antibody Probes of Module 2 of the 6-Deoxyerythronolide B Synthase.
Biochemistry, 62, 2023
2X2B
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BU of 2x2b by Molmil
Crystal structure of malonyl-ACP (acyl carrier protein) from Bacillus subtilis
Descriptor: 3-{[2-({N-[(2S)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl]sulfanyl}-3-oxopropanoic acid, ACYL CARRIER PROTEIN, PLATINUM (II) ION
Authors:Bellinzoni, M, Martinez, M.A, DeMendoza, D, Alzari, P.M.
Deposit date:2010-01-12
Release date:2010-03-16
Last modified:2011-10-12
Method:X-RAY DIFFRACTION (2.69 Å)
Cite:A Novel Role of Malonyl-Acp in Lipid Homeostasis.
Biochemistry, 49, 2010
2WYA
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BU of 2wya by Molmil
CRYSTAL STRUCTURE OF HUMAN MITOCHONDRIAL 3-HYDROXY-3-METHYLGLUTARYL- COENZYME A SYNTHASE 2 (HMGCS2)
Descriptor: 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A, GLYCEROL, HYDROXYMETHYLGLUTARYL-COA SYNTHASE, ...
Authors:Yue, W.W, Shafqat, N, Savitsky, P, Roos, A.K, Cooper, C, Murray, J.W, von Delft, F, Arrowsmith, C, Wikstrom, M, Edwards, A, Bountra, C, Oppermann, U.
Deposit date:2009-11-13
Release date:2009-11-24
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal Structures of Human Hmg-Coa Synthase Isoforms Provide Insights Into Inherited Ketogenesis Disorders and Inhibitor Design.
J.Mol.Biol., 398, 2010
3O8J
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BU of 3o8j by Molmil
Crystal structure of 2-methylcitrate synthase (PrpC) from Salmonella typhimurium
Descriptor: 2-methylcitrate synthase, GLYCEROL
Authors:Chittori, S, Savithri, H.S, Murthy, M.R.N.
Deposit date:2010-08-03
Release date:2011-04-13
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.41 Å)
Cite:Crystal structure of Salmonella typhimurium 2-methylcitrate synthase: Insights on domain movement and substrate specificity
J.Struct.Biol., 174, 2011
7F27
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BU of 7f27 by Molmil
Crystal structure of polyketide ketosynthase
Descriptor: 3-oxoacyl-(Acyl-carrier-protein) synthase
Authors:Kim, Y, Lee, W.C.
Deposit date:2021-06-10
Release date:2022-06-15
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.806 Å)
Cite:Structural basis of the complementary activity of two ketosynthases in aryl polyene biosynthesis.
Sci Rep, 11, 2021
7F28
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BU of 7f28 by Molmil
Crystal structure of a bacterial ketosynthase
Descriptor: Ketoacyl_synth_N domain-containing protein, Putative 3-oxoacyl-[ACP] synthase FabV
Authors:Lee, W.C, Kim, Y.
Deposit date:2021-06-10
Release date:2022-06-15
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.877 Å)
Cite:Structural basis of the complementary activity of two ketosynthases in aryl polyene biosynthesis.
Sci Rep, 11, 2021
3OYT
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BU of 3oyt by Molmil
1.84 Angstrom resolution crystal structure of 3-oxoacyl-(acyl carrier protein) synthase I (fabB) from Yersinia pestis CO92
Descriptor: 1,2-ETHANEDIOL, 3-oxoacyl-[acyl-carrier-protein] synthase I, DI(HYDROXYETHYL)ETHER, ...
Authors:Halavaty, A.S, Wawrzak, Z, Onopriyenko, O, Peterson, S, Savchenko, A, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2010-09-23
Release date:2011-01-12
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.84 Å)
Cite:1.84 Angstrom resolution crystal structure of 3-oxoacyl-(acyl carrier protein) synthase I (fabB) from Yersinia pestis CO92
To be Published
7M7E
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BU of 7m7e by Molmil
6-Deoxyerythronolide B synthase (DEBS) hybrid module (M3/1) in complex with antibody fragment 1B2
Descriptor: 1B2 (heavy chain), 1B2 (light chain), 6-deoxyerythronolide-B synthase EryA2, ...
Authors:Cogan, D.P, Zhang, K, Chiu, W, Khosla, C.
Deposit date:2021-03-28
Release date:2021-11-17
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Mapping the catalytic conformations of an assembly-line polyketide synthase module.
Science, 374, 2021
7R49
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BU of 7r49 by Molmil
Crystal structure of the L. plantarum acyl carrier protein synthase (AcpS)in complex with D-alanyl carrier protein (DltC1)
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 4'-PHOSPHOPANTETHEINE, D-alanyl carrier protein 1, ...
Authors:Nikolopoulos, N, Ravaud, S, Simorre, J.P, Grangeasse, C.
Deposit date:2022-02-08
Release date:2022-08-03
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:DltC acts as an interaction hub for AcpS, DltA and DltB in the teichoic acid D-alanylation pathway of Lactiplantibacillus plantarum.
Sci Rep, 12, 2022
7M7G
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BU of 7m7g by Molmil
6-Deoxyerythronolide B synthase (DEBS) module 1 in complex with antibody fragment 1B2: State 2
Descriptor: 1B2 (heavy chain), 1B2 (light chain), EryAI,6-deoxyerythronolide-B synthase EryA3, ...
Authors:Cogan, D.P, Zhang, K, Chiu, W, Khosla, C.
Deposit date:2021-03-28
Release date:2021-11-17
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Mapping the catalytic conformations of an assembly-line polyketide synthase module.
Science, 374, 2021
7M7H
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BU of 7m7h by Molmil
6-Deoxyerythronolide B synthase (DEBS) module 1 in complex with antibody fragment 1B2: State 1'
Descriptor: 1B2 (heavy chain), 1B2 (light chain), EryAI,6-deoxyerythronolide-B synthase EryA3, ...
Authors:Cogan, D.P, Zhang, K, Chiu, W, Khosla, C.
Deposit date:2021-03-28
Release date:2021-11-17
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Mapping the catalytic conformations of an assembly-line polyketide synthase module.
Science, 374, 2021
7M7F
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BU of 7m7f by Molmil
6-Deoxyerythronolide B synthase (DEBS) module 1 in complex with antibody fragment 1B2: State 1
Descriptor: 1B2 (heavy chain), 1B2 (light chain), EryAI,6-deoxyerythronolide-B synthase EryA3, ...
Authors:Cogan, D.P, Zhang, K, Chiu, W, Khosla, C.
Deposit date:2021-03-28
Release date:2021-11-17
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Mapping the catalytic conformations of an assembly-line polyketide synthase module.
Science, 374, 2021
6HXO
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BU of 6hxo by Molmil
Structure of the citryl-CoA lyase core module of Chlorobium limicola ATP citrate lyase (space group P21)
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ATP-citrate lyase alpha-subunit, CITRATE ANION
Authors:Verstraete, K, Verschueren, K.
Deposit date:2018-10-17
Release date:2019-04-10
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structure of ATP citrate lyase and the origin of citrate synthase in the Krebs cycle.
Nature, 568, 2019

221716

數據於2024-06-26公開中

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