PDB: 1553 resultsInfo pagesStatus searchChemie searchBIRD

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4CNX	Surface residue engineering of bovine carbonic anhydrase to an extreme halophilic enzyme for potential application in postcombustion CO2 capture Descriptor: CARBONIC ANHYDRASE 2, DI(HYDROXYETHYL)ETHER, ZINC ION Authors: Warden, A, Newman, J, Peat, T.S, Seabrook, S, Williams, M, Dojchinov, G, Haritos, V. Deposit date: 2014-01-25 Release date: 2015-02-04 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (1.23 Å) Cite: Rational Engineering of a Mesohalophilic Carbonic Anhydrase to an Extreme Halotolerant Biocatalyst. Nat.Commun., 6, 2015
1YDC	STRUCTURAL BASIS OF INHIBITOR AFFINITY TO VARIANTS OF HUMAN CARBONIC ANHYDRASE II Descriptor: CARBONIC ANHYDRASE II, MERCURY (II) ION, ZINC ION Authors: Nair, S.K, Christianson, D.W. Deposit date: 1994-12-22 Release date: 1995-02-14 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Structural basis of inhibitor affinity to variants of human carbonic anhydrase II. Biochemistry, 34, 1995
2FNK	Activation of Human Carbonic Anhydrase II by exogenous proton donors Descriptor: Carbonic anhydrase 2, ZINC ION Authors: Bhatt, D, Fisher, S.Z, Tu, C, McKenna, R, Silverman, D.N. Deposit date: 2006-01-11 Release date: 2006-11-28 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Location of binding sites in small molecule rescue of human carbonic anhydrase II. Biophys.J., 92, 2007
1I9M	CARBONIC ANHYDRASE II (F131V) COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(2,4-DIFLUOROPHENYL)METHYL]-BENZAMIDE Descriptor: 4-(AMINOSULFONYL)-N-[(2,4-DIFLUOROPHENYL)METHYL]-BENZAMIDE, CARBONIC ANHYDRASE II, MERCURY (II) ION, ... Authors: Kim, C.-Y, Chandra, P.P, Jain, A, Christianson, D.W. Deposit date: 2001-03-20 Release date: 2001-03-28 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.84 Å) Cite: Fluoroaromatic-fluoroaromatic interactions between inhibitors bound in the crystal lattice of human carbonic anhydrase II. J.Am.Chem.Soc., 123, 2001
6FE2	Three dimensional structure of human carbonic anhydrase IX Descriptor: Carbonic anhydrase 9, ZINC ION Authors: Leitans, J, Tars, K. Deposit date: 2017-12-28 Release date: 2018-07-04 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.87 Å) Cite: Novel fluorinated carbonic anhydrase IX inhibitors reduce hypoxia-induced acidification and clonogenic survival of cancer cells. Oncotarget, 9, 2018
6QN2	Three dimensional structure of human carbonic anhydrase IX in complex with benzenesulfonamide Descriptor: Carbonic anhydrase 9, ZINC ION, methyl 4-[(4-chloranyl-2-cyclohexylsulfanyl-5-sulfamoyl-phenyl)carbonylamino]butanoate Authors: Leitans, J, Tars, K. Deposit date: 2019-02-08 Release date: 2020-02-26 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Halogenated and di-substituted benzenesulfonamides as selective inhibitors of carbonic anhydrase isoforms. Eur.J.Med.Chem., 185, 2020
6QN0	Three dimensional structure of human carbonic anhydrase XII in complex with benzenesulfonamide Descriptor: Carbonic anhydrase 12, ZINC ION, ~{N}-butyl-4-chloranyl-2-(2-phenylethylsulfanyl)-5-sulfamoyl-benzamide Authors: Dvinskis, E, Leitans, J, Tars, K. Deposit date: 2019-02-08 Release date: 2020-02-26 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.89 Å) Cite: Halogenated and di-substituted benzenesulfonamides as selective inhibitors of carbonic anhydrase isoforms. Eur.J.Med.Chem., 185, 2020
1I9P	CARBONIC ANHYDRASE II (F131V) COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(2,4,6-TRIFLUOROPHENYL)METHYL]-BENZAMIDE Descriptor: 4-(AMINOSULFONYL)-N-[(2,4,6-TRIFLUOROPHENYL)METHYL]-BENZAMIDE, CARBONIC ANHYDRASE II, MERCURY (II) ION, ... Authors: Kim, C.-Y, Chandra, P.P, Jain, A, Christianson, D.W. Deposit date: 2001-03-20 Release date: 2001-03-28 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.92 Å) Cite: Fluoroaromatic-fluoroaromatic interactions between inhibitors bound in the crystal lattice of human carbonic anhydrase II. J.Am.Chem.Soc., 123, 2001
1I9Q	CARBONIC ANHYDRASE II (F131V) COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(3,4,5-TRIFLUOROPHENYL)METHYL]-BENZAMIDE Descriptor: 4-(AMINOSULFONYL)-N-[(3,4,5-TRIFLUOROPHENYL)METHYL]-BENZAMIDE, CARBONIC ANHYDRASE II, MERCURY (II) ION, ... Authors: Kim, C.-Y, Chandra, P.P, Jain, A, Christianson, D.W. Deposit date: 2001-03-20 Release date: 2001-03-28 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Fluoroaromatic-fluoroaromatic interactions between inhibitors bound in the crystal lattice of human carbonic anhydrase II. J.Am.Chem.Soc., 123, 2001
1I9L	CARBONIC ANHYDRASE II (F131V) COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(4-FLUOROPHENYL)METHYL]-BENZAMIDE Descriptor: 4-(AMINOSULFONYL)-N-[(4-FLUOROPHENYL)METHYL]-BENZAMIDE, CARBONIC ANHYDRASE II, MERCURY (II) ION, ... Authors: Kim, C.-Y, Chandra, P.P, Jain, A, Christianson, D.W. Deposit date: 2001-03-20 Release date: 2001-03-28 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.93 Å) Cite: Fluoroaromatic-fluoroaromatic interactions between inhibitors bound in the crystal lattice of human carbonic anhydrase II. J.Am.Chem.Soc., 123, 2001
7C5W	Crystal structure of the iota-carbonic anhydrase from cyanobacterium complexed with iodide Descriptor: IODIDE ION, iota-carbonic anhydrase Authors: Senda, M, Senda, T. Deposit date: 2020-05-20 Release date: 2021-04-28 Last modified: 2024-05-29 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Characterization of a novel type of carbonic anhydrase that acts without metal cofactors. Bmc Biol., 19, 2021
7C5X	Crystal structure of the iota-carbonic anhydrase from eukaryotic microalga complexed with bicarbonate Descriptor: BICARBONATE ION, iota-carbonic anhydrase Authors: Senda, M, Senda, T. Deposit date: 2020-05-20 Release date: 2021-04-28 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.55 Å) Cite: Characterization of a novel type of carbonic anhydrase that acts without metal cofactors. Bmc Biol., 19, 2021
7C5V	Crystal structure of the iota-carbonic anhydrase from cyanobacterium complexed with bicarbonate Descriptor: BICARBONATE ION, iota-carbonic anhydrase Authors: Senda, M, Senda, T. Deposit date: 2020-05-20 Release date: 2021-04-28 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.65 Å) Cite: Characterization of a novel type of carbonic anhydrase that acts without metal cofactors. Bmc Biol., 19, 2021
7C5Y	Crystal structure of the iota-carbonic anhydrase from eukaryotic microalga complexed with iodide Descriptor: IODIDE ION, iota-carbonic anhydrase Authors: Senda, M, Senda, T. Deposit date: 2020-05-20 Release date: 2021-04-28 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Characterization of a novel type of carbonic anhydrase that acts without metal cofactors. Bmc Biol., 19, 2021
1BZM	DRUG-PROTEIN INTERACTIONS: STRUCTURE OF SULFONAMIDE DRUG COMPLEXED WITH HUMAN CARBONIC ANHYDRASE I Descriptor: CARBONIC ANHYDRASE I, N-(3-methyl-5-sulfamoyl-1,3,4-thiadiazol-2(3H)-ylidene)acetamide, ZINC ION Authors: Chakravarty, S, Kannan, K.K. Deposit date: 1993-11-28 Release date: 1994-04-30 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2 Å) Cite: Drug-protein interactions. Refined structures of three sulfonamide drug complexes of human carbonic anhydrase I enzyme. J.Mol.Biol., 243, 1994
6QN6	Three dimensional structure of human carbonic anhydrase IX in complex with benzenesulfonamide Descriptor: Carbonic anhydrase 9, ZINC ION, ~{N}-butyl-4-chloranyl-2-(2-phenylethylsulfanyl)-5-sulfamoyl-benzamide Authors: Leitans, J, Tars, K. Deposit date: 2019-02-09 Release date: 2020-02-26 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.25 Å) Cite: Halogenated and di-substituted benzenesulfonamides as selective inhibitors of carbonic anhydrase isoforms. Eur.J.Med.Chem., 185, 2020
6QNL	Three dimensional structure of human carbonic anhydrase XII in complex with benzenesulfonamide Descriptor: Carbonic anhydrase 12, ZINC ION, methyl 4-[(4-chloranyl-2-cyclohexylsulfanyl-5-sulfamoyl-phenyl)carbonylamino]butanoate Authors: Dvinskis, E, Leitans, J, Tars, K. Deposit date: 2019-02-11 Release date: 2020-03-04 Last modified: 2021-10-06 Method: X-RAY DIFFRACTION (1.53 Å) Cite: Halogenated and di-substituted benzenesulfonamides as selective inhibitors of carbonic anhydrase isoforms. Eur.J.Med.Chem., 185, 2020
1I9N	CARBONIC ANHYDRASE II (F131V) COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(2,5-DIFLUOROPHENYL)METHYL]-BENZAMIDE Descriptor: 4-(AMINOSULFONYL)-N-[(2,5-DIFLUOROPHENYL)METHYL]-BENZAMIDE, CARBONIC ANHYDRASE II, MERCURY (II) ION, ... Authors: Kim, C.-Y, Chandra, P.P, Jain, A, Christianson, D.W. Deposit date: 2001-03-20 Release date: 2001-03-28 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.86 Å) Cite: Fluoroaromatic-fluoroaromatic interactions between inhibitors bound in the crystal lattice of human carbonic anhydrase II. J.Am.Chem.Soc., 123, 2001
1RZE	X-RAY ANALYSIS OF METAL SUBSTITUTED HUMAN CARBONIC ANHYDRASE II DERIVATIVES Descriptor: CARBONIC ANHYDRASE II, NICKEL (II) ION, SULFATE ION Authors: Hakansson, K, Wehnert, A, Liljas, A. Deposit date: 1993-05-25 Release date: 1993-10-31 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.9 Å) Cite: X-ray analysis of metal-substituted human carbonic anhydrase II derivatives. Acta Crystallogr.,Sect.D, 50, 1994
1HUH	DIFFERENCES IN ANIONIC INHIBITION OF HUMAN CARBONIC ANHYDRASE I REVEALED FROM THE STRUCTURES OF IODIDE AND GOLD CYANIDE INHIBITOR COMPLEXES Descriptor: CARBONIC ANHYDRASE I, IODIDE ION, ZINC ION Authors: Kumar, V, Kannan, K.K. Deposit date: 1993-10-28 Release date: 1994-04-30 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Differences in anionic inhibition of human carbonic anhydrase I revealed from the structures of iodide and gold cyanide inhibitor complexes. Acta Crystallogr.,Sect.D, 50, 1994
1I9O	CARBONIC ANHYDRASE II (F131V) COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(2,3,4-TRIFLUOROPHENYL)METHYL]-BENZAMIDE Descriptor: 4-(AMINOSULFONYL)-N-[(2,3,4-TRIFLUOROPHENYL)METHYL]-BENZAMIDE, CARBONIC ANHYDRASE II, MERCURY (II) ION, ... Authors: Kim, C.-Y, Chandra, P.P, Jain, A, Christianson, D.W. Deposit date: 2001-03-20 Release date: 2001-03-28 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.86 Å) Cite: Fluoroaromatic-fluoroaromatic interactions between inhibitors bound in the crystal lattice of human carbonic anhydrase II. J.Am.Chem.Soc., 123, 2001
1HUG	Differences in anionic inhibition of Human Carbonic Anhydrase I revealed from the structures of iodide and gold cyanide inhibitor complexes Descriptor: CARBONIC ANHYDRASE I, GOLD (I) CYANIDE ION, ZINC ION Authors: Kumar, V, Kannan, K.K. Deposit date: 1993-10-28 Release date: 1994-04-30 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2 Å) Cite: Differences in anionic inhibition of human carbonic anhydrase I revealed from the structures of iodide and gold cyanide inhibitor complexes. Acta Crystallogr.,Sect.D, 50, 1994
1RZD	X-RAY ANALYSIS OF METAL SUBSTITUTED HUMAN CARBONIC ANHYDRASE II DERIVATIVES Descriptor: CARBONIC ANHYDRASE II, MANGANESE (II) ION, SULFATE ION Authors: Hakansson, K, Wehnert, A, Liljas, A. Deposit date: 1993-05-25 Release date: 1993-10-31 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.9 Å) Cite: X-ray analysis of metal-substituted human carbonic anhydrase II derivatives. Acta Crystallogr.,Sect.D, 50, 1994
1RZB	X-RAY ANALYSIS OF METAL SUBSTITUTED HUMAN CARBONIC ANHYDRASE II DERIVATIVES Descriptor: CARBONIC ANHYDRASE II, COBALT (II) ION, SULFATE ION Authors: Hakansson, K, Wehnert, A, Liljas, A. Deposit date: 1993-05-25 Release date: 1993-10-31 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.8 Å) Cite: X-ray analysis of metal-substituted human carbonic anhydrase II derivatives. Acta Crystallogr.,Sect.D, 50, 1994
1RZA	X-RAY ANALYSIS OF METAL SUBSTITUTED HUMAN CARBONIC ANHYDRASE II DERIVATIVES Descriptor: CARBONIC ANHYDRASE II, COBALT (II) ION, OXYGEN MOLECULE Authors: Hakansson, K, Wehnert, A, Liljas, A. Deposit date: 1993-05-25 Release date: 1993-10-31 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.9 Å) Cite: X-ray analysis of metal-substituted human carbonic anhydrase II derivatives. Acta Crystallogr.,Sect.D, 50, 1994

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