6G3Q

Crystal structure of human carbonic anhydrase II in complex with the inhibitor famotidine

Summary for 6G3Q

Entry DOI	10.2210/pdb6g3q/pdb
Descriptor	Carbonic anhydrase 2, ZINC ION, famotidine, ... (5 entities in total)
Functional Keywords	lyase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	29786.03
Authors	Ferraroni, M.,Supuran, C.T.,Angeli, A. (deposition date: 2018-03-26, release date: 2018-11-28, Last modification date: 2025-10-01)
Primary citation	Angeli, A.,Ferraroni, M.,Supuran, C.T. Famotidine, an Antiulcer Agent, Strongly InhibitsHelicobacter pyloriand Human Carbonic Anhydrases. ACS Med Chem Lett, 9:1035-1038, 2018 Cited by PubMed Abstract: Famotidine, an antiulcer drug incorporating a sulfamide motif, was investigated as carbonic anhydrase inhibitor (CAI). It acts as a nanomolar inhibitor of several human (hCA II, VI, VII and XII) and CAs. The high resolution X-ray structures of famotidine bound to hCA I and II revealed interesting aspects related to its CA inhibition mechanism, offering the possibility to develop antibacterials with a novel mechanism of action. PubMed: 30344913 DOI: 10.1021/acsmedchemlett.8b00334 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.01 Å)

Structure validation