4M2V
Genetically engineered Carbonic Anhydrase IX in complex with Brinzolamide
Summary for 4M2V
Entry DOI | 10.2210/pdb4m2v/pdb |
Related | 4M2R 4M2U 4M2W |
Descriptor | Carbonic anhydrase 2, ZINC ION, (+)-4-ETHYLAMINO-3,4-DIHYDRO-2-(METHOXY)PROPYL-2H-THIENO[3,2-E]-1,2-THIAZINE-6-SULFONAMIDE-1,1-DIOXIDE, ... (4 entities in total) |
Functional Keywords | carbonic anhydrase ix mimic, lyase-lyase inhibitor complex, lyase/lyase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm : P00918 |
Total number of polymer chains | 1 |
Total formula weight | 29235.28 |
Authors | Pinard, M.P.,Boone, C.D.,Rife, B.D.,Supuran, C.T.,Mckenna, R. (deposition date: 2013-08-05, release date: 2013-11-06, Last modification date: 2024-02-28) |
Primary citation | Pinard, M.A.,Boone, C.D.,Rife, B.D.,Supuran, C.T.,McKenna, R. Structural study of interaction between brinzolamide and dorzolamide inhibition of human carbonic anhydrases. Bioorg.Med.Chem., 21:7210-7215, 2013 Cited by PubMed: 24090602DOI: 10.1016/j.bmc.2013.08.033 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.718 Å) |
Structure validation
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