4M2V
Genetically engineered Carbonic Anhydrase IX in complex with Brinzolamide
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Carbonic anhydrase 2 | polymer | 257 | 28786.4 | 1 | UniProt (P00918) Pfam (PF00194) In PDB | Homo sapiens (human) | Carbonate dehydratase II, Carbonic anhydrase C, CAC, Carbonic anhydrase II, CA-II |
2 | A | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
3 | A | (+)-4-ETHYLAMINO-3,4-DIHYDRO-2-(METHOXY)PROPYL-2H-THIENO[3,2-E]-1,2-THIAZINE-6-SULFONAMIDE-1,1-DIOXIDE | non-polymer | 383.5 | 1 | Chemie (BZ1) | |||
4 | water | water | 18.0 | 78 | Chemie (HOH) |
Sequence modifications
A: 4 - 261 (UniProt: P00918)
PDB | External Database | Details |
---|---|---|
Ala 9 | Lys 9 | engineered mutation |
Ser 65 | Ala 65 | engineered mutation |
Gln 67 | Asn 67 | engineered mutation |
Thr 69 | Glu 69 | engineered mutation |
Leu 91 | Ile 91 | engineered mutation |
Val 131 | Phe 130 | engineered mutation |
Glu 170 | Lys 169 | engineered mutation |
Ala 204 | Leu 203 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 28786.4 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 448.9 | |
All* | Total formula weight | 29235.3 |