2ZGP
 
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3P1D
 | | Crystal structure of the bromodomain of human CREBBP in complex with N-Methyl-2-pyrrolidone (NMP) | | Descriptor: | 1-methylpyrrolidin-2-one, CREB-binding protein, POTASSIUM ION, ... | | Authors: | Filippakopoulos, P, Picaud, S, Feletar, I, Fedorov, O, Muniz, J, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Weigelt, J, Bountra, C, Knapp, S, Structural Genomics Consortium (SGC) | | Deposit date: | 2010-09-30 | | Release date: | 2010-11-24 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (1.86 Å) | | Cite: | Histone recognition and large-scale structural analysis of the human bromodomain family.
Cell(Cambridge,Mass.), 149, 2012
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3P6F
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2ZGO
 | | Crystal structure of AAL mutant H59Q complex with lactose | | Descriptor: | Anti-tumor lectin, beta-D-galactopyranose-(1-4)-beta-D-glucopyranose | | Authors: | Li, D.F, Yang, N, Wang, D.C. | | Deposit date: | 2008-01-23 | | Release date: | 2009-01-20 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structural basis for the tumor cell apoptosis-inducing activity of an antitumor lectin from the edible mushroom Agrocybe aegerita
J.Mol.Biol., 387, 2009
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2HM8
 | | Solution Structure of the C-terminal MA-3 domain of Pdcd4 | | Descriptor: | Pdcd4 C-terminal MA-3 domain | | Authors: | Waters, L.C, Veverka, V, Bohm, M, Muskett, F.W, Choong, P.T, Klempnauer, K.H, Carr, M.D. | | Deposit date: | 2006-07-11 | | Release date: | 2007-02-20 | | Last modified: | 2024-05-29 | | Method: | SOLUTION NMR | | Cite: | Structure of the C-terminal MA-3 domain of the tumour suppressor protein Pdcd4 and characterization of its interaction with eIF4A
Oncogene, 26, 2007
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2Z4G
 | | Histidinol Phosphate Phosphatase from Thermus thermophilus HB8 | | Descriptor: | FE (III) ION, GLYCEROL, Histidinol phosphatase, ... | | Authors: | Omi, R. | | Deposit date: | 2007-06-17 | | Release date: | 2007-11-27 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Crystal Structure of Monofunctional Histidinol Phosphate Phosphatase from Thermus thermophilus HB8.
Biochemistry, 46, 2007
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3C9B
 | | Crystal structure of SeMet Vps75 | | Descriptor: | Vacuolar protein sorting-associated protein 75 | | Authors: | Keck, J.L, Berndsen, C.E, Tsubota, T, Lindner, S.E, Lee, S, Holton, J.M, Kaufman, P.D, Denu, J.M. | | Deposit date: | 2008-02-15 | | Release date: | 2008-08-12 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.42 Å) | | Cite: | Molecular functions of the histone acetyltransferase chaperone complex Rtt109-Vps75
Nat.Struct.Mol.Biol., 15, 2008
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3CD2
 | | LIGAND INDUCED CONFORMATIONAL CHANGES IN THE CRYSTAL STRUCTURES OF PNEUMOCYSTIS CARINII DIHYDROFOLATE REDUCTASE COMPLEXES WITH FOLATE AND NADP+ | | Descriptor: | DIHYDROFOLATE REDUCTASE, METHOTREXATE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | | Authors: | Cody, V, Galitsky, N, Rak, D, Luft, J, Pangborn, W, Queener, S. | | Deposit date: | 1999-03-16 | | Release date: | 2000-03-29 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Ligand-induced conformational changes in the crystal structures of Pneumocystis carinii dihydrofolate reductase complexes with folate and NADP+.
Biochemistry, 38, 1999
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2MJ2
 | | Structure of the dimerization domain of the human polyoma, JC virus agnoprotein is an amphipathic alpha-helix. | | Descriptor: | Agnoprotein | | Authors: | Coric, P, Saribas, S.A, Abou-Gharbia, M, Childers, W, White, M, Bouaziz, S, Safak, M. | | Deposit date: | 2013-12-23 | | Release date: | 2014-04-23 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | The structure of the dimerization domain of the human polyoma, JC virus agnoprotein is an amphipathic alpha-helix
J.Virol., 2014
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3P1C
 | | Crystal structure of the bromodomain of human CREBBP in complex with acetylated lysine | | Descriptor: | CREB-binding protein, N(6)-ACETYLLYSINE, POTASSIUM ION, ... | | Authors: | Filippakopoulos, P, Picaud, S, Feletar, I, Fedorov, O, Muniz, J, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Weigelt, J, Bountra, C, Knapp, S, Structural Genomics Consortium (SGC) | | Deposit date: | 2010-09-30 | | Release date: | 2010-11-24 | | Last modified: | 2023-12-06 | | Method: | X-RAY DIFFRACTION (1.82 Å) | | Cite: | Histone recognition and large-scale structural analysis of the human bromodomain family.
Cell(Cambridge,Mass.), 149, 2012
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3P6C
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3P3P
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3P9I
 | | Crystal structure of perennial ryegrass LpOMT1 complexed with S-adenosyl-L-homocysteine and sinapaldehyde | | Descriptor: | (2E)-3-(4-hydroxy-3,5-dimethoxyphenyl)prop-2-enal, BETA-MERCAPTOETHANOL, Caffeic acid O-methyltransferase, ... | | Authors: | Louie, G.V, Noel, J.P, Bowman, M.E. | | Deposit date: | 2010-10-17 | | Release date: | 2011-01-12 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Structure-Function Analyses of a Caffeic Acid O-Methyltransferase from Perennial Ryegrass Reveal the Molecular Basis for Substrate Preference.
Plant Cell, 22, 2010
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3TYS
 | | Crystal structure of transcriptional regulator VanUg, Form II | | Descriptor: | Predicted transcriptional regulator | | Authors: | Stogios, P.J, Evdokimova, E, Wawrzak, Z, Depardieu, F, Courvalin, P, Shabalin, I, Chruszcz, M, Minor, W, Savchenko, A, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID) | | Deposit date: | 2011-09-26 | | Release date: | 2011-10-12 | | Last modified: | 2023-12-06 | | Method: | X-RAY DIFFRACTION (1.121 Å) | | Cite: | Crystal structure of transcriptional regulator VanUg, Form II
TO BE PUBLISHED
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3CAA
 | | CLEAVED ANTICHYMOTRYPSIN A347R | | Descriptor: | ANTICHYMOTRYPSIN | | Authors: | Lukacs, C.M, Christianson, D.W. | | Deposit date: | 1997-08-18 | | Release date: | 1998-02-25 | | Last modified: | 2024-05-22 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Engineering an anion-binding cavity in antichymotrypsin modulates the "spring-loaded" serpin-protease interaction.
Biochemistry, 37, 1998
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2ZGN
 | | crystal structure of recombinant Agrocybe aegerita lectin, rAAL, complex with galactose | | Descriptor: | Anti-tumor lectin, beta-D-galactopyranose | | Authors: | Yang, N, Li, D.F, Wang, D.C. | | Deposit date: | 2008-01-23 | | Release date: | 2009-01-20 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Structural basis for the tumor cell apoptosis-inducing activity of an antitumor lectin from the edible mushroom Agrocybe aegerita
J.Mol.Biol., 387, 2009
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2BRO
 | | Structure-based Design of Novel Chk1 Inhibitors: Insights into Hydrogen Bonding and Protein-Ligand Affinity | | Descriptor: | (2R)-3-{[(4Z)-5,6-DIPHENYL-6,7-DIHYDRO-4H-PYRROLO[2,3-D]PYRIMIDIN-4-YLIDENE]AMINO}PROPANE-1,2-DIOL, SERINE/THREONINE-PROTEIN KINASE CHK1 | | Authors: | Foloppe, N, Fisher, L.M, Howes, R, Kierstan, P, Potter, A, Robertson, A.G.S, Surgenor, A.E. | | Deposit date: | 2005-05-09 | | Release date: | 2005-05-12 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Structure-Based Design of Novel Chk1 Inhibitors: Insights Into Hydrogen Bonding and Protein-Ligand Affinity.
J.Med.Chem., 48, 2005
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3TYR
 | | Crystal structure of transcriptional regulator VanUg, Form I | | Descriptor: | Transcriptional regulator | | Authors: | Stogios, P.J, Evdokimova, E, Wawrzak, Z, Dong, A, Depardieu, F, Courvalin, P, Shabalin, I, Chruszcz, M, Minor, W, Savchenko, A, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID) | | Deposit date: | 2011-09-26 | | Release date: | 2011-10-12 | | Last modified: | 2022-04-13 | | Method: | X-RAY DIFFRACTION (1.699 Å) | | Cite: | Crystal structure of transcriptional regulator VanUg, Form I
TO BE PUBLISHED
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2HYM
 | | NMR based Docking Model of the Complex between the Human Type I Interferon Receptor and Human Interferon alpha-2 | | Descriptor: | Interferon alpha-2, Soluble IFN alpha/beta receptor | | Authors: | Quadt-Akabayov, S.R, Chill, J.H, Levy, R, Kessler, N, Anglister, J. | | Deposit date: | 2006-08-07 | | Release date: | 2006-10-10 | | Last modified: | 2022-03-09 | | Method: | SOLUTION NMR | | Cite: | Determination of the human type I interferon receptor binding site on human interferon-alpha2 by cross saturation and an NMR-based model of the complex
Protein Sci., 15, 2006
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2ME4
 | | HIV-1 gp41 clade C Membrane Proximal External Region peptide in DPC micelle | | Descriptor: | Envelope glycoprotein gp160 | | Authors: | Sun, Z.J, Wagner, G, Reinherz, E.L, Kim, M, Song, L, Choi, J, Cheng, Y, Chowdhury, B, Bellot, G, Shih, W. | | Deposit date: | 2013-09-20 | | Release date: | 2013-10-09 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | Disruption of Helix-Capping Residues 671 and 674 Reveals a Role in HIV-1 Entry for a Specialized Hinge Segment of the Membrane Proximal External Region of gp41.
J.Mol.Biol., 426, 2014
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2MFU
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3CVA
 | | Human Bcl-xL containing a Trp to Ala mutation at position 137 | | Descriptor: | Apoptosis regulator Bcl-X | | Authors: | Feng, Y, Zhang, L, Hu, T, Shen, X, Chen, K, Jiang, H, Liu, D. | | Deposit date: | 2008-04-18 | | Release date: | 2009-03-24 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | A conserved hydrophobic core at Bcl-x(L) mediates its structural stability and binding affinity with BH3-domain peptide of pro-apoptotic protein
Arch.Biochem.Biophys., 484, 2009
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2ZGS
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2C06
 | | NMR-based model of the complex of the toxin Kid and a 5-nucleotide substrate RNA fragment (AUACA) | | Descriptor: | 5'-R(*AP*UP*AP*CP*AP)-3', KID TOXIN PROTEIN | | Authors: | Kamphuis, M.B, Bonvin, A.M.J.J, Monti, M.C, Lemonnier, M, Munoz-Gomez, A, Van Den Heuvel, R.H.H, Diaz-Orejas, R, Boelens, R. | | Deposit date: | 2005-08-25 | | Release date: | 2006-02-08 | | Last modified: | 2024-06-19 | | Method: | SOLUTION NMR | | Cite: | Model for RNA Binding and the Catalytic Site of the Rnase Kid of the Bacterial Pard Toxin-Antitoxin System.
J.Mol.Biol., 357, 2006
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4DWZ
 | | Crystal Structure of Ton_0340 | | Descriptor: | Hypothetical protein TON_0340, ZINC ION | | Authors: | Lee, S.G, Lee, K.H, Cha, S.S, Oh, B.H. | | Deposit date: | 2012-02-27 | | Release date: | 2013-01-16 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Experimental phasing using zinc anomalous scattering
Acta Crystallogr.,Sect.D, 68, 2012
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