1CHO
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![BU of 1cho by Molmil](/molmil-images/mine/1cho) | CRYSTAL AND MOLECULAR STRUCTURES OF THE COMPLEX OF ALPHA-*CHYMOTRYPSIN WITH ITS INHIBITOR TURKEY OVOMUCOID THIRD DOMAIN AT 1.8 ANGSTROMS RESOLUTION | Descriptor: | ALPHA-CHYMOTRYPSIN A, TURKEY OVOMUCOID THIRD DOMAIN (OMTKY3) | Authors: | Fujinaga, M, Sielecki, A.R, Read, R.J, Ardelt, W, Laskowskijunior, M, James, M.N.G. | Deposit date: | 1988-03-04 | Release date: | 1988-07-16 | Last modified: | 2017-11-29 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal and molecular structures of the complex of alpha-chymotrypsin with its inhibitor turkey ovomucoid third domain at 1.8 A resolution. J.Mol.Biol., 195, 1987
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1TSR
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![BU of 1tsr by Molmil](/molmil-images/mine/1tsr) | P53 CORE DOMAIN IN COMPLEX WITH DNA | Descriptor: | DNA (5'-D(*AP*TP*AP*AP*TP*TP*GP*GP*GP*CP*AP*AP*GP*TP*CP*TP*A P*GP*GP*AP*A)-3'), DNA (5'-D(*TP*TP*TP*CP*CP*TP*AP*GP*AP*CP*TP*TP*GP*CP*CP*CP*A P*AP*TP*TP*A)-3'), PROTEIN (P53 TUMOR SUPPRESSOR), ... | Authors: | Cho, Y, Gorina, S, Jeffrey, P, Pavletich, N. | Deposit date: | 1995-07-28 | Release date: | 1996-01-29 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations. Science, 265, 1994
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1CHG
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![BU of 1chg by Molmil](/molmil-images/mine/1chg) | CHYMOTRYPSINOGEN,2.5 ANGSTROMS CRYSTAL STRUCTURE, COMPARISON WITH ALPHA-CHYMOTRYPSIN,AND IMPLICATIONS FOR ZYMOGEN ACTIVATION | Descriptor: | CHYMOTRYPSINOGEN A | Authors: | Freer, S.T, Kraut, J, Robertus, J.D, Wright, H.T, Xuong, N.H. | Deposit date: | 1975-03-01 | Release date: | 1976-11-22 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Chymotrypsinogen: 2.5-angstrom crystal structure, comparison with alpha-chymotrypsin, and implications for zymogen activation. Biochemistry, 9, 1970
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1CGI
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![BU of 1cgi by Molmil](/molmil-images/mine/1cgi) | THREE-DIMENSIONAL STRUCTURE OF THE COMPLEXES BETWEEN BOVINE CHYMOTRYPSINOGEN*A AND TWO RECOMBINANT VARIANTS OF HUMAN PANCREATIC SECRETORY TRYPSIN INHIBITOR (KAZAL-TYPE) | Descriptor: | ALPHA-CHYMOTRYPSINOGEN, PANCREATIC SECRETORY TRYPSIN INHIBITOR (KAZAL TYPE) VARIANT 3 | Authors: | Hecht, H.J, Szardenings, M, Collins, J, Schomburg, D. | Deposit date: | 1991-10-08 | Release date: | 1993-10-31 | Last modified: | 2024-06-05 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Three-dimensional structure of the complexes between bovine chymotrypsinogen A and two recombinant variants of human pancreatic secretory trypsin inhibitor (Kazal-type). J.Mol.Biol., 220, 1991
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1CGJ
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![BU of 1cgj by Molmil](/molmil-images/mine/1cgj) | THREE-DIMENSIONAL STRUCTURE OF THE COMPLEXES BETWEEN BOVINE CHYMOTRYPSINOGEN*A AND TWO RECOMBINANT VARIANTS OF HUMAN PANCREATIC SECRETORY TRYPSIN INHIBITOR (KAZAL-TYPE) | Descriptor: | ALPHA-CHYMOTRYPSINOGEN, PANCREATIC SECRETORY TRYPSIN INHIBITOR (KAZAL TYPE) VARIANT 4 | Authors: | Hecht, H.J, Szardenings, M, Collins, J, Schomburg, D. | Deposit date: | 1991-10-08 | Release date: | 1993-10-31 | Last modified: | 2024-06-05 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Three-dimensional structure of the complexes between bovine chymotrypsinogen A and two recombinant variants of human pancreatic secretory trypsin inhibitor (Kazal-type). J.Mol.Biol., 220, 1991
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3TS8
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1CBW
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![BU of 1cbw by Molmil](/molmil-images/mine/1cbw) | BOVINE CHYMOTRYPSIN COMPLEXED TO BPTI | Descriptor: | BOVINE CHYMOTRYPSIN, BPTI, SULFATE ION | Authors: | Hynes, T.R, Scheidig, A.J, Kossiakoff, A.A. | Deposit date: | 1996-12-22 | Release date: | 1997-07-23 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Crystal structures of bovine chymotrypsin and trypsin complexed to the inhibitor domain of Alzheimer's amyloid beta-protein precursor (APPI) and basic pancreatic trypsin inhibitor (BPTI): engineering of inhibitors with altered specificities. Protein Sci., 6, 1997
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1DLK
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![BU of 1dlk by Molmil](/molmil-images/mine/1dlk) | CRYSTAL STRUCTURE ANALYSIS OF DELTA-CHYMOTRYPSIN BOUND TO A PEPTIDYL CHLOROMETHYL KETONE INHIBITOR | Descriptor: | CHLORIDE ION, Thrombin heavy chain, Thrombin light chain, ... | Authors: | Mac Sweeney, A, Birrane, G, Walsh, M.A, O'Connell, T, Malthouse, J.P.G. | Deposit date: | 1999-12-10 | Release date: | 2000-05-03 | Last modified: | 2018-09-12 | Method: | X-RAY DIFFRACTION (2.14 Å) | Cite: | Crystal structure of delta-chymotrypsin bound to a peptidyl chloromethyl ketone inhibitor. Acta Crystallogr.,Sect.D, 56, 2000
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1VGC
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![BU of 1vgc by Molmil](/molmil-images/mine/1vgc) | GAMMA-CHYMOTRYPSIN L-PARA-CHLORO-1-ACETAMIDO BORONIC ACID INHIBITOR COMPLEX | Descriptor: | GAMMA CHYMOTRYPSIN, L-1-(4-CHLOROPHENYL)-2-(ACETAMIDO)ETHANE BORONIC ACID, SULFATE ION | Authors: | Stoll, V.S, Eger, B.T, Hynes, R.C, Martichonok, V, Jones, J.B, Pai, E.F. | Deposit date: | 1997-05-01 | Release date: | 1997-11-12 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Differences in binding modes of enantiomers of 1-acetamido boronic acid based protease inhibitors: crystal structures of gamma-chymotrypsin and subtilisin Carlsberg complexes. Biochemistry, 37, 1998
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2PCX
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![BU of 2pcx by Molmil](/molmil-images/mine/2pcx) | Crystal structure of p53DBD(R282Q) at 1.54-angstrom Resolution | Descriptor: | Cellular tumor antigen p53, ZINC ION | Authors: | Tu, C, Shaw, G, Ji, X. | Deposit date: | 2007-03-30 | Release date: | 2008-04-08 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.54 Å) | Cite: | Impact of low-frequency hotspot mutation R282Q on the structure of p53 DNA-binding domain as revealed by crystallography at 1.54 angstroms resolution. Acta Crystallogr.,Sect.D, 64, 2008
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2VGC
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![BU of 2vgc by Molmil](/molmil-images/mine/2vgc) | GAMMA-CHYMOTRYPSIN D-PARA-CHLORO-1-ACETAMIDO BORONIC ACID INHIBITOR COMPLEX | Descriptor: | D-1-(4-CHLOROPHENYL)-2-(ACETAMIDO)ETHANE BORONIC ACID, GAMMA CHYMOTRYPSIN, SULFATE ION | Authors: | Stoll, V.S, Eger, B.T, Hynes, R.C, Martichonok, V, Jones, J.B, Pai, E.F. | Deposit date: | 1997-05-01 | Release date: | 1997-11-12 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Differences in binding modes of enantiomers of 1-acetamido boronic acid based protease inhibitors: crystal structures of gamma-chymotrypsin and subtilisin Carlsberg complexes. Biochemistry, 37, 1998
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2P8O
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![BU of 2p8o by Molmil](/molmil-images/mine/2p8o) | Crystal Structure of a Benzohydroxamic Acid/Vanadate complex bound to chymotrypsin A | Descriptor: | Chymotrypsin A chain A, Chymotrypsin A chain B, Chymotrypsin A chain C, ... | Authors: | Moulin, A, Bell, J.H, Pratt, R.F, Ringe, D. | Deposit date: | 2007-03-22 | Release date: | 2007-05-08 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Inhibition of chymotrypsin by a complex of ortho-vanadate and benzohydroxamic Acid: structure of the inert complex and its mechanistic interpretation. Biochemistry, 46, 2007
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2OCJ
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![BU of 2ocj by Molmil](/molmil-images/mine/2ocj) | |
2VYR
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![BU of 2vyr by Molmil](/molmil-images/mine/2vyr) | Structure of human MDM4 N-terminal domain bound to a single domain antibody | Descriptor: | HUMAN SINGLE DOMAIN ANTIBODY, MDM4 PROTEIN, SULFATE ION | Authors: | Yu, G.W, Vaysburd, M, Allen, M.D, Settanni, G, Fersht, A.R. | Deposit date: | 2008-07-28 | Release date: | 2008-11-25 | Last modified: | 2013-03-06 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structure of Human Mdm4 N-Terminal Domain Bound to a Single-Domain Antibody. J.Mol.Biol., 385, 2009
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2XWR
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2QTJ
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![BU of 2qtj by Molmil](/molmil-images/mine/2qtj) | Solution structure of human dimeric immunoglobulin A | Descriptor: | Ig alpha-1 chain C region, Kappa light chain IgA1 | Authors: | Bonner, A, Furtado, P.B, Almogren, A, Kerr, M.A, Perkins, S.J. | Deposit date: | 2007-08-02 | Release date: | 2008-01-22 | Last modified: | 2024-02-21 | Method: | SOLUTION SCATTERING | Cite: | Implications of the near-planar solution structure of human myeloma dimeric IgA1 for mucosal immunity and IgA nephropathy J.Immunol., 180, 2008
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2QC3
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![BU of 2qc3 by Molmil](/molmil-images/mine/2qc3) | Crystal structure of MCAT from Mycobacterium tuberculosis | Descriptor: | ACETIC ACID, Malonyl CoA-acyl carrier protein transacylase | Authors: | Li, Z, Huang, Y, Ge, J, Bartlam, M, Wang, H, Rao, Z. | Deposit date: | 2007-06-19 | Release date: | 2007-08-28 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | The Crystal Structure of MCAT from Mycobacterium tuberculosis Reveals Three New Catalytic Models. J.Mol.Biol., 371, 2007
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2QEJ
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![BU of 2qej by Molmil](/molmil-images/mine/2qej) | Crystal structure of a Staphylococcus aureus protein (SSL7) in complex with Fc of human IgA1 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, GLYCEROL, ... | Authors: | Ramsland, P.A, Willoughby, N, Trist, H.M, Farrugia, W, Hogarth, P.M, Fraser, J.D, Wines, B.D. | Deposit date: | 2007-06-26 | Release date: | 2007-09-18 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Structural basis for evasion of IgA immunity by Staphylococcus aureus revealed in the complex of SSL7 with Fc of human IgA1 Proc.Natl.Acad.Sci.Usa, 104, 2007
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2P52
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2GMT
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![BU of 2gmt by Molmil](/molmil-images/mine/2gmt) | THREE-DIMENSIONAL STRUCTURE OF CHYMOTRYPSIN INACTIVATED WITH (2S) N-ACETYL-L-ALANYL-L-PHENYLALANYL-CHLOROETHYL KETONE: IMPLICATIONS FOR THE MECHANISM OF INACTIVATION OF SERINE PROTEASES BY CHLOROKETONES | Descriptor: | (2S) N-ACETYL-L-ALANYL-ALPHAL-PHENYLALANYL-CHLOROETHYLKETONE, GAMMA-CHYMOTRYPSIN | Authors: | Kreutter, K, Steinmetz, A.C.U, Liang, T.-C, Prorok, M, Abeles, R, Ringe, D. | Deposit date: | 1994-09-07 | Release date: | 1994-11-01 | Last modified: | 2024-06-05 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Three-dimensional structure of chymotrypsin inactivated with (2S)-N-acetyl-L-alanyl-L-phenylalanyl alpha-chloroethane: implications for the mechanism of inactivation of serine proteases by chloroketones. Biochemistry, 33, 1994
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6ZNC
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![BU of 6znc by Molmil](/molmil-images/mine/6znc) | Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Human wild-type p53DBD bound to DNA and MQ: wt-DNA-MQ (I) | Descriptor: | (2~{R})-2-methyl-1-azabicyclo[2.2.2]octan-3-one, (2~{S})-2-methyl-1-azabicyclo[2.2.2]octan-3-one, Cellular tumor antigen p53, ... | Authors: | Rozenberg, H, Degtjarik, O, Diskin-Posner, Y, Shakked, Z. | Deposit date: | 2020-07-06 | Release date: | 2021-12-08 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.64 Å) | Cite: | Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Nat Commun, 12, 2021
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2IOO
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![BU of 2ioo by Molmil](/molmil-images/mine/2ioo) | Crystal structure of the mouse p53 core domain | Descriptor: | Cellular tumor antigen p53, ZINC ION | Authors: | Ho, W.C, Luo, C, Zhao, K, Chai, X, Fitzgerald, M.X, Marmorstein, R. | Deposit date: | 2006-10-10 | Release date: | 2006-12-05 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.02 Å) | Cite: | High-resolution structure of the p53 core domain: implications for binding small-molecule stabilizing compounds. Acta Crystallogr.,Sect.D, 62, 2006
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7B4N
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![BU of 7b4n by Molmil](/molmil-images/mine/7b4n) | Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Human wild-type p53DBD bound to DNA and MQ: wt-DNA-MQ (II) | Descriptor: | (2~{R})-2-methyl-1-azabicyclo[2.2.2]octan-3-one, (2~{S})-2-methyl-1-azabicyclo[2.2.2]octan-3-one, Cellular tumor antigen p53, ... | Authors: | Rozenberg, H, Diskin-Posner, Y, Degtjarik, O, Shakked, Z. | Deposit date: | 2020-12-02 | Release date: | 2021-12-08 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.32 Å) | Cite: | Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Nat Commun, 12, 2021
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7B49
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![BU of 7b49 by Molmil](/molmil-images/mine/7b49) | Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Human p53DBD-R273H mutant bound to DNA and MQ: R273H-DNA-MQ | Descriptor: | (2~{R})-2-methyl-1-azabicyclo[2.2.2]octan-3-one, (2~{S})-2-methyl-1-azabicyclo[2.2.2]octan-3-one, 1,2-ETHANEDIOL, ... | Authors: | Rozenberg, H, Degtjarik, O, Shakked, Z. | Deposit date: | 2020-12-02 | Release date: | 2021-12-08 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.42 Å) | Cite: | Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Nat Commun, 12, 2021
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7B48
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![BU of 7b48 by Molmil](/molmil-images/mine/7b48) | Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Human p53DBD-R273H mutant bound to MQ: R273H-MQ (II) | Descriptor: | (2~{S})-2-methyl-1-azabicyclo[2.2.2]octan-3-one, 1,2-ETHANEDIOL, ACETATE ION, ... | Authors: | Degtjarik, O, Rozenberg, H, Shakked, Z. | Deposit date: | 2020-12-02 | Release date: | 2021-12-08 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Nat Commun, 12, 2021
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