PDB: 342 resultsInfo pagesStatus searchChemie searchBIRD

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2H5I	Crystal structure of caspase-3 with inhibitor Ac-DEVD-Cho Descriptor: Ac-DEV(ASJ), caspase-3, p12 subunit, ... Authors: Fang, B, Boross, P.I, Tozser, J, Weber, I.T. Deposit date: 2006-05-26 Release date: 2006-09-19 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.69 Å) Cite: Structural and kinetic analysis of caspase-3 reveals role for s5 binding site in substrate recognition J.Mol.Biol., 360, 2006
2H48	Crystal structure of human caspase-1 (Cys362->Ala, Cys364->Ala, Cys397->Ala) in complex with 3-[2-(2-benzyloxycarbonylamino-3-methyl-butyrylamino)-propionylamino]-4-oxo-pentanoic acid (z-VAD-FMK) Descriptor: Caspase 1, isoform gamma, N-[(benzyloxy)carbonyl]-L-valyl-N-[(2S)-1-carboxy-4-fluoro-3-oxobutan-2-yl]-L-alaninamide Authors: Scheer, J.M, Wells, J.A, Romanowski, M.J. Deposit date: 2006-05-23 Release date: 2006-06-06 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2.2 Å) Cite: A common allosteric site and mechanism in caspases Proc.Natl.Acad.Sci.USA, 103, 2006
2H54	Crystal structure of human caspase-1 (Thr388->Ala) in complex with 3-[2-(2-benzyloxycarbonylamino-3-methyl-butyrylamino)-propionylamino]-4-oxo-pentanoic acid (z-VAD-FMK) Descriptor: Caspase-1, N-[(benzyloxy)carbonyl]-L-valyl-N-[(2S)-1-carboxy-4-fluoro-3-oxobutan-2-yl]-L-alaninamide Authors: Scheer, J.M, Wells, J.A, Romanowski, M.J. Deposit date: 2006-05-25 Release date: 2008-03-11 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.8 Å) Cite: An allosteric circuit in caspase-1. J.Mol.Biol., 381, 2008
2H51	Crystal structure of human caspase-1 (Glu390->Asp and Arg286->Lys) in complex with 3-[2-(2-benzyloxycarbonylamino-3-methyl-butyrylamino)-propionylamino]-4-oxo-pentanoic acid (z-VAD-FMK) Descriptor: Caspase-1, N-[(benzyloxy)carbonyl]-L-valyl-N-[(2S)-1-carboxy-4-fluoro-3-oxobutan-2-yl]-L-alaninamide Authors: Scheer, J.M, Wells, J.A, Romanowski, M.J. Deposit date: 2006-05-25 Release date: 2008-03-11 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2.1 Å) Cite: An allosteric circuit in caspase-1. J.Mol.Biol., 381, 2008
2H4Y	Crystal structure of human caspase-1 (Arg286->Lys) in complex with 3-[2-(2-benzyloxycarbonylamino-3-methyl-butyrylamino)-propionylamino]-4-oxo-pentanoic acid (z-VAD-FMK) Descriptor: Caspase-1, N-[(benzyloxy)carbonyl]-L-valyl-N-[(2S)-1-carboxy-4-fluoro-3-oxobutan-2-yl]-L-alaninamide Authors: Scheer, J.M, Wells, J.A, Romanowski, M.J. Deposit date: 2006-05-25 Release date: 2008-03-11 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.9 Å) Cite: An allosteric circuit in caspase-1. J.Mol.Biol., 381, 2008
2H4W	Crystal structure of human caspase-1 (Glu390->Asp) in complex with 3-[2-(2-benzyloxycarbonylamino-3-methyl-butyrylamino)-propionylamino]-4-oxo-pentanoic acid (z-VAD-FMK) Descriptor: Caspase-1, N-[(benzyloxy)carbonyl]-L-valyl-N-[(2S)-1-carboxy-4-fluoro-3-oxobutan-2-yl]-L-alaninamide Authors: Scheer, J.M, Wells, J.A, Romanowski, M.J. Deposit date: 2006-05-25 Release date: 2008-03-11 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2 Å) Cite: An allosteric circuit in caspase-1. J.Mol.Biol., 381, 2008
2H65	Crystal strusture of caspase-3 with inhibitor Ac-VDVAD-Cho Descriptor: Ac-VDVAD-Cho, caspase-3, p12 subunit, ... Authors: Fang, B, Boross, P.I, Tozser, J, Weber, I.T. Deposit date: 2006-05-30 Release date: 2006-09-19 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structural and kinetic analysis of caspase-3 reveals role for s5 binding site in substrate recognition J.Mol.Biol., 360, 2006
2HBR	Crystal structure of human caspase-1 (Arg286->Ala) in complex with 3-[2-(2-benzyloxycarbonylamino-3-methyl-butyrylamino)-propionylamino]-4-oxo-pentanoic acid (z-VAD-FMK) Descriptor: Caspase-1, N-[(benzyloxy)carbonyl]-L-valyl-N-[(2S)-1-carboxy-4-fluoro-3-oxobutan-2-yl]-L-alaninamide Authors: Scheer, J.M, Wells, J.A, Romanowski, M.J. Deposit date: 2006-06-14 Release date: 2006-06-27 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2.2 Å) Cite: A Common Allosteric Site and Mechanism in Caspases Proc.Natl.Acad.Sci.USA, 103, 2006
2H5J	Crystal strusture of caspase-3 with inhibitor Ac-DMQD-Cho Descriptor: Ac-DMQD-Cho, caspase-3, p12 subunit, ... Authors: Fang, B, Boross, P.I, Tozser, J, Weber, I.T. Deposit date: 2006-05-26 Release date: 2006-09-19 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2 Å) Cite: Structural and kinetic analysis of caspase-3 reveals role for s5 binding site in substrate recognition J.Mol.Biol., 360, 2006
2K7Z	Solution Structure of the Catalytic Domain of Procaspase-8 Descriptor: Caspase-8 Authors: Keller, N, Zerbe, O, Mares, J, Gruetter, M.G. Deposit date: 2008-08-28 Release date: 2009-03-24 Last modified: 2024-05-08 Method: SOLUTION NMR Cite: Structural and biochemical studies on procaspase-8: new insights on initiator caspase activation. Structure, 17, 2009
4PS1	Caspase-8 specific unnatural amino acid peptides Descriptor: (BAL)LQ(HYP)(1U8) PEPTIDE, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, Caspase-8 Authors: Wolan, D.W, Vickers, C.J, Gonzalez-Paez, G.E. Deposit date: 2014-03-06 Release date: 2015-01-21 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (1.731 Å) Cite: Selective inhibition of initiator versus executioner caspases using small peptides containing unnatural amino acids. Acs Chem.Biol., 9, 2014
4QU0	Caspase-3 Y195AV266H Descriptor: ACE-ASP-GLU-VAL-ASP-CHLOROMETHYLKETONE INHIBITOR, AZIDE ION, Caspase-3 Authors: Cade, C, Swartz, P.D, MacKenzie, S.H, Clark, A.C. Deposit date: 2014-07-10 Release date: 2014-11-05 Last modified: 2017-11-22 Method: X-RAY DIFFRACTION (1.954 Å) Cite: Modifying caspase-3 activity by altering allosteric networks. Biochemistry, 53, 2014
4QUE	Caspase-3 Y195FV266H Descriptor: 2,3-DIHYDROXY-1,4-DITHIOBUTANE, ACE-ASP-GLU-VAL-ASP-CHLOROMETHYLKETONE INHIBITOR, AZIDE ION, ... Authors: Cade, C, Swartz, P.D, MacKenzie, S.H, Clark, A.C. Deposit date: 2014-07-10 Release date: 2014-11-05 Last modified: 2017-11-22 Method: X-RAY DIFFRACTION (1.843 Å) Cite: Modifying caspase-3 activity by altering allosteric networks. Biochemistry, 53, 2014
4QU8	Caspase-3 M61A V266H Descriptor: 2,3-DIHYDROXY-1,4-DITHIOBUTANE, ACE-ASP-GLU-VAL-ASP-CHLOROMETHYLKETONE INHIBITOR, CHLORIDE ION, ... Authors: Cade, C, Swartz, P.D, MacKenzie, S.H, Clark, A.C. Deposit date: 2014-07-10 Release date: 2014-11-05 Last modified: 2017-11-22 Method: X-RAY DIFFRACTION (1.715 Å) Cite: Modifying caspase-3 activity by altering allosteric networks. Biochemistry, 53, 2014
4QUH	Caspase-3 T140G Descriptor: (4R)-2-METHYLPENTANE-2,4-DIOL, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, ACE-ASP-GLU-VAL-ASP-CHLOROMETHYLKETONE INHIBITOR, ... Authors: Cade, C, Swartz, P.D, MacKenzie, S.H, Clark, A.C. Deposit date: 2014-07-10 Release date: 2014-11-05 Last modified: 2017-11-22 Method: X-RAY DIFFRACTION (1.759 Å) Cite: Modifying caspase-3 activity by altering allosteric networks. Biochemistry, 53, 2014
4QTX	Caspase-3 Y195A Descriptor: ACE-ASP-GLU-VAL-ASP-CHLOROMETHYLKETONE INHIBITOR, ACETATE ION, Caspase-3 Authors: Cade, C, Swartz, P.D, MacKenzie, S.H, Clark, A.C. Deposit date: 2014-07-09 Release date: 2014-11-05 Last modified: 2017-11-22 Method: X-RAY DIFFRACTION (1.974 Å) Cite: Modifying caspase-3 activity by altering allosteric networks. Biochemistry, 53, 2014
4QUD	Caspase-3 T140F Descriptor: ACE-ASP-GLU-VAL-ASP-CHLOROMETHYLKETONE INHIBITOR, Caspase-3 Authors: Cade, C, Swartz, P.D, MacKenzie, S.H, Clark, A.C. Deposit date: 2014-07-10 Release date: 2014-11-05 Last modified: 2017-11-22 Method: X-RAY DIFFRACTION (1.995 Å) Cite: Modifying caspase-3 activity by altering allosteric networks. Biochemistry, 53, 2014
4PS0	Caspase-8 specific unnatural amino acid peptides Descriptor: (BAL)LQ(HYP)(1U8) PEPTIDE, Caspase-3 Authors: Wolan, D.W, Vickers, C.J, Gonzalez-Paez, G.E. Deposit date: 2014-03-06 Release date: 2015-01-21 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (1.63 Å) Cite: Selective inhibition of initiator versus executioner caspases using small peptides containing unnatural amino acids. Acs Chem.Biol., 9, 2014
4QTY	Caspase-3 E190A Descriptor: ACE-ASP-GLU-VAL-ASP-CHLOROMETHYLKETONE INHIBITOR, AZIDE ION, Caspase-3, ... Authors: Cade, C, Swartz, P.D, MacKenzie, S.H, Clark, A.C. Deposit date: 2014-07-09 Release date: 2014-11-05 Last modified: 2017-11-22 Method: X-RAY DIFFRACTION (1.602 Å) Cite: Modifying caspase-3 activity by altering allosteric networks. Biochemistry, 53, 2014
4QU5	Caspase-3 T140V Descriptor: ACE-ASP-GLU-VAL-ASP-CHLOROMETHYLKETONE INHIBITOR, Caspase-3 Authors: Cade, C, Swartz, P.D, MacKenzie, S.H, Clark, A.C. Deposit date: 2014-07-10 Release date: 2014-11-05 Last modified: 2017-11-22 Method: X-RAY DIFFRACTION (1.908 Å) Cite: Modifying caspase-3 activity by altering allosteric networks. Biochemistry, 53, 2014
4QUI	Caspase-3 F128AV266H Descriptor: 2,3-DIHYDROXY-1,4-DITHIOBUTANE, ACE-ASP-GLU-VAL-ASP-CHLOROMETHYLKETONE INHIBITOR, CHLORIDE ION, ... Authors: Cade, C, Swartz, P.D, MacKenzie, S.H, Clark, A.C. Deposit date: 2014-07-10 Release date: 2014-11-05 Last modified: 2017-11-22 Method: X-RAY DIFFRACTION (1.758 Å) Cite: Modifying caspase-3 activity by altering allosteric networks. Biochemistry, 53, 2014
4PRZ	Caspase-8 specific unnatural amino acid peptides Descriptor: (ACE)LET(1U8) PEPTIDE, Caspase-8, DITHIANE DIOL Authors: Wolan, D.W, Vickers, C.J, Gonzalez-Paez, G.E. Deposit date: 2014-03-06 Release date: 2015-01-21 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (2.123 Å) Cite: Selective inhibition of initiator versus executioner caspases using small peptides containing unnatural amino acids. Acs Chem.Biol., 9, 2014
4PRY	Caspase-8 specific unnatural amino acid peptides Descriptor: Ac-LETD-CHO, Caspase-3 Authors: Wolan, D.W, Gonzalez-Paez, G.E, Vickers, C.J. Deposit date: 2014-03-06 Release date: 2015-01-21 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Selective inhibition of initiator versus executioner caspases using small peptides containing unnatural amino acids. Acs Chem.Biol., 9, 2014
4QU9	Caspase-3 F128A Descriptor: ACE-ASP-GLU-VAL-ASP-CHLOROMETHYLKETONE INHIBITOR, AZIDE ION, Caspase-3 Authors: Cade, C, Swartz, P.D, MacKenzie, S.H, Clark, A.C. Deposit date: 2014-07-10 Release date: 2014-11-05 Last modified: 2017-11-22 Method: X-RAY DIFFRACTION (1.561 Å) Cite: Modifying caspase-3 activity by altering allosteric networks. Biochemistry, 53, 2014
4QUJ	Caspase-3 T140GV266H Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, ACE-ASP-GLU-VAL-ASP-CHLOROMETHYLKETONE INHIBITOR, AZIDE ION, ... Authors: Cade, C, Swartz, P.D, MacKenzie, S.H, Clark, A.C. Deposit date: 2014-07-10 Release date: 2014-11-05 Last modified: 2017-11-22 Method: X-RAY DIFFRACTION (1.498 Å) Cite: Modifying caspase-3 activity by altering allosteric networks. Biochemistry, 53, 2014

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