5WQK
 
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5X0B
 | | Free serine kinase in complex with AMP | | Descriptor: | ADENOSINE MONOPHOSPHATE, Free serine kinase | | Authors: | Nagata, R, Fujihashi, M, Miki, K. | | Deposit date: | 2017-01-20 | | Release date: | 2017-04-12 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | Structural Study on the Reaction Mechanism of a Free Serine Kinase Involved in Cysteine Biosynthesis
ACS Chem. Biol., 12, 2017
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5X0E
 | | Free serine kinase (E30A mutant) in complex with phosphoserine and AMP | | Descriptor: | ADENOSINE MONOPHOSPHATE, Free serine kinase, MAGNESIUM ION, ... | | Authors: | Nagata, R, Fujihashi, M, Miki, K. | | Deposit date: | 2017-01-20 | | Release date: | 2017-04-12 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structural Study on the Reaction Mechanism of a Free Serine Kinase Involved in Cysteine Biosynthesis
ACS Chem. Biol., 12, 2017
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3NM6
 | | Helicobacter pylori MTAN complexed with adenine and tris | | Descriptor: | 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ADENINE, ... | | Authors: | Ronning, D.R, Iacopelli, N.M. | | Deposit date: | 2010-06-21 | | Release date: | 2010-11-24 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (1.602 Å) | | Cite: | Enzyme-ligand interactions that drive active site rearrangements in the Helicobacter pylori 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase.
Protein Sci., 19, 2010
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6DNZ
 | | Trypanosoma brucei PRMT1 enzyme-prozyme heterotetrameric complex with AdoHcy | | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Arginine N-methyltransferase, putative, ... | | Authors: | Hashimoto, H, Kafkova, L, Jordan, K, Read, L.K, Debler, E.W. | | Deposit date: | 2018-06-08 | | Release date: | 2019-06-12 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (2.384 Å) | | Cite: | Structural Basis of Protein Arginine Methyltransferase Activation by a Catalytically Dead Homolog (Prozyme).
J.Mol.Biol., 432, 2020
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3FTF
 | | Crystal structure of A. aeolicus KsgA in complex with RNA and SAH | | Descriptor: | 5'-R(P*AP*AP*CP*CP*GP*UP*AP*GP*GP*GP*GP*AP*AP*CP*CP*UP*GP*CP*GP*GP*UP*U)-3', Dimethyladenosine transferase, POTASSIUM ION, ... | | Authors: | Tu, C, Ji, X. | | Deposit date: | 2009-01-12 | | Release date: | 2009-03-24 | | Last modified: | 2024-11-27 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Structural Basis for Binding of RNA and Cofactor by a KsgA Methyltransferase.
Structure, 17, 2009
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6JZV
 | | Crystal structure of SufU from Bacillus subtilis | | Descriptor: | ZINC ION, Zinc-dependent sulfurtransferase SufU | | Authors: | Fujishiro, T, Takahashi, Y. | | Deposit date: | 2019-05-04 | | Release date: | 2020-05-06 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Cysteine-Persulfide Sulfane Sulfur-Ligated Zn Complex of Sulfur-Carrying SufU in the SufCDSUB System for Fe-S Cluster Biosynthesis.
Inorg.Chem., 2024
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6AA1
 | | Crystal structure of putative amino acid binding periplasmic ABC transporter protein from Candidatus Liberibacter asiaticus bound with citrate | | Descriptor: | 1,2-ETHANEDIOL, CITRIC ACID, DI(HYDROXYETHYL)ETHER, ... | | Authors: | Kumar, P, Kesari, P, Ghosh, D.K, Kumar, P, Sharma, A.K. | | Deposit date: | 2018-07-16 | | Release date: | 2019-06-12 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (1.86 Å) | | Cite: | Crystal structures of a putative periplasmic cystine-binding protein from Candidatus Liberibacter asiaticus: insights into an adapted mechanism of ligand binding.
Febs J., 286, 2019
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4P54
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8ZIO
 | | Crystal structure of the methyltransferase PsiM in complex with SAH and Psilocybin | | Descriptor: | GLYCEROL, Psilocybin, Psilocybin synthase, ... | | Authors: | Meng, C.Y, Wen, Y, Guo, W.T, Wu, B.X. | | Deposit date: | 2024-05-14 | | Release date: | 2025-04-02 | | Method: | X-RAY DIFFRACTION (1.45 Å) | | Cite: | Structural basis for psilocybin biosynthesis.
Nat Commun, 16, 2025
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3NM5
 | | Helicobacter pylori MTAN complexed with Formycin A | | Descriptor: | (1S)-1-(7-amino-1H-pyrazolo[4,3-d]pyrimidin-3-yl)-1,4-anhydro-D-ribitol, MTA/SAH nucleosidase | | Authors: | Ronning, D.R, Iacopelli, N.M. | | Deposit date: | 2010-06-21 | | Release date: | 2010-11-24 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Enzyme-ligand interactions that drive active site rearrangements in the Helicobacter pylori 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase.
Protein Sci., 19, 2010
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8ZIH
 | | Crystal structure of the methyltransferase PsiM in complex with SAH | | Descriptor: | Psilocybin synthase, S-ADENOSYL-L-HOMOCYSTEINE | | Authors: | Meng, C.Y, Wen, Y, Guo, W.T, Wu, B.X. | | Deposit date: | 2024-05-14 | | Release date: | 2025-04-02 | | Method: | X-RAY DIFFRACTION (1.31 Å) | | Cite: | Structural basis for psilocybin biosynthesis.
Nat Commun, 16, 2025
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5X0G
 | | Free serine kinase (E30A mutant) in complex with ADP | | Descriptor: | 2-hydroxy-3-[4-(2-hydroxy-3-sulfopropyl)piperazin-1-yl]propane-1-sulfonic acid, ADENOSINE MONOPHOSPHATE, ADENOSINE-5'-DIPHOSPHATE, ... | | Authors: | Nagata, R, Fujihashi, M, Miki, K. | | Deposit date: | 2017-01-20 | | Release date: | 2017-04-12 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structural Study on the Reaction Mechanism of a Free Serine Kinase Involved in Cysteine Biosynthesis
ACS Chem. Biol., 12, 2017
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4CCZ
 | | Crystal structure of human 5-methyltetrahydrofolate-homocysteine methyltransferase, the homocysteine and folate binding domains | | Descriptor: | (6S)-5,6,7,8-TETRAHYDROFOLATE, METHIONINE SYNTHASE | | Authors: | Vollmar, M, Kiyani, W, Krojer, T, Goubin, S, Burgess-Brown, N, von Delft, F, Oppermann, U, Edwards, A, Arrowsmith, C, Bountra, C, Yue, W.W. | | Deposit date: | 2013-10-29 | | Release date: | 2013-11-27 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Crystal Structure of Human 5-Methyltetrahydrofolate-Homocysteine Methyltransferase, the Homocysteine and Folate Binding Domains
To be Published
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2YTZ
 | | Complex structure of Trm1 from Pyrococcus horikoshii with S-adenosyl-L-Homocystein in the orthorhombic crystal-lattice | | Descriptor: | N(2),N(2)-dimethylguanosine tRNA methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE, SULFATE ION | | Authors: | Ihsanawati, Shirouzu, M, Bessho, Y, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2007-04-05 | | Release date: | 2007-10-09 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.65 Å) | | Cite: | Crystal Structure of tRNA N(2),N(2)-Guanosine Dimethyltransferase Trm1 from Pyrococcus horikoshii
J.Mol.Biol., 383, 2008
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3IVA
 | | Structure of the B12-dependent Methionine Synthase (MetH) C-teminal half with AdoHcy bound | | Descriptor: | COBALAMIN, Methionine synthase, NITRATE ION, ... | | Authors: | Pattridge, K.A, Koutmos, M, Smith, J.L. | | Deposit date: | 2009-08-31 | | Release date: | 2009-11-24 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Insights into the reactivation of cobalamin-dependent methionine synthase.
Proc.Natl.Acad.Sci.USA, 106, 2009
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5CCE
 | | Joint X-ray/neutron structure of wild type MTAN complexed with SRH and adenine | | Descriptor: | 5'-Methylthioadenosine Nucleosidase, ADENINE, S-ribosylhomocysteine, ... | | Authors: | Banco, M.T, Kovalevsky, A.Y, Ronning, D.R. | | Deposit date: | 2015-07-02 | | Release date: | 2016-11-16 | | Last modified: | 2023-09-27 | | Method: | NEUTRON DIFFRACTION (2.5 Å), X-RAY DIFFRACTION | | Cite: | Neutron structures of the Helicobacter pylori 5'-methylthioadenosine nucleosidase highlight proton sharing and protonation states.
Proc. Natl. Acad. Sci. U.S.A., 113, 2016
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3OYP
 | | HCV NS3/4A in complex with ligand 3 | | Descriptor: | Non-structural protein 4A, Peptidomimetic inhibitor, Serine protease NS3, ... | | Authors: | Hagel, M, Niu, D, St.Martin, T, Sheets, M.P, Qiao, L, Bernard, H, Karp, R.M, Zhu, Z, Labenski, M.T, Chaturvedi, P.C, Nacht, M, Westlin, W.F, Petter, R.C, Singh, J. | | Deposit date: | 2010-09-23 | | Release date: | 2010-12-01 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (2.76 Å) | | Cite: | Selective irreversible inhibition of a protease by targeting a noncatalytic cysteine.
Nat.Chem.Biol., 7, 2011
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3NM4
 | | Helicobacter pylori MTAN | | Descriptor: | 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, MTA/SAH nucleosidase | | Authors: | Ronning, D.R, Iacopelli, N.M. | | Deposit date: | 2010-06-21 | | Release date: | 2010-11-24 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Enzyme-ligand interactions that drive active site rearrangements in the Helicobacter pylori 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase.
Protein Sci., 19, 2010
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7FBO
 | | geranyl pyrophosphate C6-methyltransferase BezA binding with S-adenosylhomocysteine | | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, BezA, S-ADENOSYL-L-HOMOCYSTEINE | | Authors: | Tsutsumi, H, Moriwaki, Y, Terada, T, Shimizu, K, Katsuyama, Y, Ohnishi, Y. | | Deposit date: | 2021-07-12 | | Release date: | 2021-12-01 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.56 Å) | | Cite: | Structural and Molecular Basis of the Catalytic Mechanism of Geranyl Pyrophosphate C6-Methyltransferase: Creation of an Unprecedented Farnesyl Pyrophosphate C6-Methyltransferase.
Angew.Chem.Int.Ed.Engl., 61, 2022
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2P41
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2Z67
 | | Crystal structure of archaeal O-phosphoseryl-tRNA(Sec) selenium transferase (SepSecS) | | Descriptor: | O-phosphoseryl-tRNA(Sec) selenium transferase, PYRIDOXAL-5'-PHOSPHATE, SULFATE ION | | Authors: | Araiso, Y, Ishitani, R, Pailouer, S, Oshikane, H, Domae, N, Soll, D, Nureki, O. | | Deposit date: | 2007-07-23 | | Release date: | 2008-04-29 | | Last modified: | 2025-03-26 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Structural insights into RNA-dependent eukaryal and archaeal selenocysteine formation.
Nucleic Acids Res., 36, 2008
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2P3Q
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3GU3
 | | Crystal Structure of the methyltransferase BC_2162 in complex with S-Adenosyl-L-Homocysteine from Bacillus cereus, Northeast Structural Genomics Consortium Target BcR20 | | Descriptor: | ACETATE ION, Methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE | | Authors: | Forouhar, F, Neely, H, Seetharaman, J, Ciano, C, Ma, L, Zhao, L, Everett, J.K, Nair, R, Acton, T.B, Rost, B, Montelione, G.T, Tong, L, Hunt, J.F, Northeast Structural Genomics Consortium (NESG) | | Deposit date: | 2009-03-28 | | Release date: | 2009-04-07 | | Last modified: | 2024-11-27 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Northeast Structural Genomics Consortium Target BcR20
To be Published
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3SL7
 | | Crystal structure of CBS-pair protein, CBSX2 from Arabidopsis thaliana | | Descriptor: | ACETATE ION, CBS domain-containing protein CBSX2, GLYCEROL | | Authors: | Jeong, B.-C, Lee, M.-R, Song, H.K. | | Deposit date: | 2011-06-24 | | Release date: | 2011-11-09 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (1.905 Å) | | Cite: | Single cystathionine beta-synthase domain-containing proteins modulate development by regulating the thioredoxin system in Arabidopsis
Plant Cell, 23, 2011
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