2BTE
| Thermus thermophilus Leucyl-tRNA synthetase complexed with a tRNAleu transcript in the post-editing conformation and a post- transfer editing substrate analogue | Descriptor: | 2'-AMINO-2'-DEOXYADENOSINE, AMINOACYL-TRNA SYNTHETASE, LEUCINE, ... | Authors: | Cusack, S, Tukalo, M, Yaremchuk, A, Fukunaga, R, Yokoyama, S. | Deposit date: | 2005-05-31 | Release date: | 2005-09-15 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | The Crystal Structure of Leucyl-tRNA Synthetase Complexed with tRNA(Leu) in the Post-Transfer- Editing Conformation. Nat.Struct.Mol.Biol., 12, 2005
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4O8J
| Crystal structure of RtcA, the RNA 3'-terminal phosphate cyclase from Pyrococcus horikoshii, in complex with rACAAA3'phosphate and adenine. | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ADENOSINE, RNA, ... | Authors: | Desai, K.K, Bingman, C.A, Phillips Jr, G.N, Raines, R.T. | Deposit date: | 2013-12-27 | Release date: | 2014-09-10 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.04 Å) | Cite: | Structure of RNA 3'-phosphate cyclase bound to substrate RNA. Rna, 20, 2014
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2BYT
| Thermus thermophilus Leucyl-tRNA synthetase complexed with a tRNAleu transcript in the post-editing conformation | Descriptor: | LEUCINE, LEUCYL-TRNA SYNTHETASE, MERCURY (II) ION, ... | Authors: | Cusack, S, Tukalo, M, Yaremchuk, A, Fukunaga, R, Yokoyama, S. | Deposit date: | 2005-08-04 | Release date: | 2005-09-15 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | The Crystal Structure of Leucyl-tRNA Synthetase Complexed with tRNA(Leu) in the Post-Transfer-Editing Conformation. Nat.Struct.Mol.Biol., 12, 2005
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5XGQ
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1N77
| Crystal structure of Thermus thermophilus glutamyl-tRNA synthetase complexed with tRNA(Glu) and ATP. | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Glutamyl-tRNA synthetase, MAGNESIUM ION, ... | Authors: | Sekine, S, Nureki, O, Dubois, D.Y, Bernier, S, Chenevert, R, Lapointe, J, Vassylyev, D.G, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2002-11-13 | Release date: | 2003-02-25 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | ATP binding by glutamyl-tRNA synthetase is switched to the productive mode by tRNA binding EMBO J., 22, 2003
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6IY6
| Crystal structure of human cytosolic aspartyl-tRNA synthetase (DRS) in complex with glutathion-S transferase (GST) domains from Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (AIMP2) and glutamyl-prolyl-tRNA synthetase (EPRS) | Descriptor: | Aminoacyl tRNA synthase complex-interacting multifunctional protein 2, Aspartate--tRNA ligase, cytoplasmic, ... | Authors: | Park, S.H, Hahn, H, Han, B.W. | Deposit date: | 2018-12-13 | Release date: | 2019-09-11 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (3.6 Å) | Cite: | The DRS-AIMP2-EPRS subcomplex acts as a pivot in the multi-tRNA synthetase complex. Iucrj, 6, 2019
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1N78
| Crystal structure of Thermus thermophilus glutamyl-tRNA synthetase complexed with tRNA(Glu) and glutamol-AMP. | Descriptor: | GLUTAMOL-AMP, Glutamyl-tRNA synthetase, MAGNESIUM ION, ... | Authors: | Sekine, S, Nureki, O, Dubois, D.Y, Bernier, S, Chenevert, R, Lapointe, J, Vassylyev, D.G, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2002-11-13 | Release date: | 2003-02-25 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | ATP binding by glutamyl-tRNA synthetase is switched to the productive mode by tRNA binding EMBO J., 22, 2003
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6KID
| Crystal structure of human leucyl-tRNA synthetase, ATP-bound form | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, LEUCINE, Leucine--tRNA ligase, ... | Authors: | Kim, S, Son, J, Kim, S, Hwang, K.Y. | Deposit date: | 2019-07-18 | Release date: | 2021-01-27 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (3.15 Å) | Cite: | Leucine-sensing mechanism of leucyl-tRNA synthetase 1 for mTORC1 activation. Cell Rep, 35, 2021
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6KQY
| Crystal structure of human leucyl-tRNA synthetase, Leucine-bound form | Descriptor: | LEUCINE, Leucine--tRNA ligase, cytoplasmic, ... | Authors: | Kim, S, Son, J, Kim, S, Hwang, K.Y. | Deposit date: | 2019-08-20 | Release date: | 2021-01-27 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Leucine-sensing mechanism of leucyl-tRNA synthetase 1 for mTORC1 activation. Cell Rep, 35, 2021
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6KR7
| Crystal structure of methylated human leucyl-tRNA synthetase, Leu-AMS-bound form | Descriptor: | 5'-O-(L-leucylsulfamoyl)adenosine, LEUCINE, Leucine--tRNA ligase, ... | Authors: | Kim, S, Son, J, Kim, S, Hwang, K.Y. | Deposit date: | 2019-08-21 | Release date: | 2021-01-27 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (4 Å) | Cite: | Leucine-sensing mechanism of leucyl-tRNA synthetase 1 for mTORC1 activation. Cell Rep, 35, 2021
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6KIE
| Crystal structure of human leucyl-tRNA synthetase, Leu-AMS-bound form | Descriptor: | 5'-O-(L-leucylsulfamoyl)adenosine, LEUCINE, Leucine--tRNA ligase, ... | Authors: | Kim, S, Son, J, Kim, S, Hwang, K.Y. | Deposit date: | 2019-07-18 | Release date: | 2021-01-27 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (3.15 Å) | Cite: | Leucine-sensing mechanism of leucyl-tRNA synthetase 1 for mTORC1 activation. Cell Rep, 35, 2021
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6LDK
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1B8A
| ASPARTYL-TRNA SYNTHETASE | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, PROTEIN (ASPARTYL-TRNA SYNTHETASE) | Authors: | Schmitt, E, Moulinier, L, Thierry, J.-C, Moras, D. | Deposit date: | 1999-01-27 | Release date: | 1999-02-02 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Crystal structure of aspartyl-tRNA synthetase from Pyrococcus kodakaraensis KOD: archaeon specificity and catalytic mechanism of adenylate formation. EMBO J., 17, 1998
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3FOZ
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6Q89
| Neisseria gonorrhoeae Leucyl-tRNA Synthetase in Complex with the Intermediate Analog 5'-O-(N-(L-Leucyl)-Sulfamoyl)Adenosine | Descriptor: | 1,2-ETHANEDIOL, 5'-O-(L-leucylsulfamoyl)adenosine, Leucine--tRNA ligase, ... | Authors: | Pang, L, De Graef, S, Strelkov, S.V, Weeks, S.D. | Deposit date: | 2018-12-14 | Release date: | 2019-04-17 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.21 Å) | Cite: | Comparative analysis of pyrimidine substituted aminoacyl-sulfamoyl nucleosides as potential inhibitors targeting class I aminoacyl-tRNA synthetases. Eur.J.Med.Chem., 173, 2019
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8BRW
| Escherichia coli methionyl-tRNA synthetase mutant L13C,I297C | Descriptor: | Methionine--tRNA ligase, ZINC ION | Authors: | Schmitt, E, Mechulam, Y, Nigro, G, Opuu, V, Lazennec-Schurdevin, C, Simonson, T. | Deposit date: | 2022-11-24 | Release date: | 2023-08-16 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.73 Å) | Cite: | Redesigning methionyl-tRNA synthetase for beta-methionine activity with adaptive landscape flattening and experiments. Protein Sci., 32, 2023
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6Q8C
| Neisseria gonorrhoeae Leucyl-tRNA Synthetase in Complex with 5'-O-(N-(L-Leucyl)-Sulfamoyl)Uridine | Descriptor: | 1,2-ETHANEDIOL, 5'-O-(N-(L-Leucyl)-Sulfamoyl)Uridine, Leucine--tRNA ligase, ... | Authors: | Pang, L, De Graef, S, Strelkov, S.V, Weeks, S.D. | Deposit date: | 2018-12-14 | Release date: | 2019-04-17 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.31 Å) | Cite: | Comparative analysis of pyrimidine substituted aminoacyl-sulfamoyl nucleosides as potential inhibitors targeting class I aminoacyl-tRNA synthetases. Eur.J.Med.Chem., 173, 2019
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6Q8B
| Neisseria gonorrhoeae Leucyl-tRNA Synthetase in Complex with 5'-O-(N-(L-Leucyl)-Sulfamoyl)N3-methyluridine | Descriptor: | 1,2-ETHANEDIOL, Leucine--tRNA ligase, MAGNESIUM ION, ... | Authors: | Pang, L, De Graef, S, Strelkov, S.V, Weeks, S.D. | Deposit date: | 2018-12-14 | Release date: | 2019-04-17 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Comparative analysis of pyrimidine substituted aminoacyl-sulfamoyl nucleosides as potential inhibitors targeting class I aminoacyl-tRNA synthetases. Eur.J.Med.Chem., 173, 2019
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2ZUE
| Crystal structure of Pyrococcus horikoshii arginyl-tRNA synthetase complexed with tRNA(Arg) and an ATP analog (ANP) | Descriptor: | Arginyl-tRNA synthetase, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | Authors: | Konno, M, Sumida, T, Uchikawa, E, Mori, Y, Yanagisawa, T, Sekine, S, Yokoyama, S. | Deposit date: | 2008-10-16 | Release date: | 2009-08-18 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Modeling of tRNA-assisted mechanism of Arg activation based on a structure of Arg-tRNA synthetase, tRNA, and an ATP analog (ANP) Febs J., 276, 2009
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2ZUF
| Crystal structure of Pyrococcus horikoshii arginyl-tRNA synthetase complexed with tRNA(Arg) | Descriptor: | Arginyl-tRNA synthetase, tRNA-Arg | Authors: | Konno, M, Sumida, T, Uchikawa, E, Mori, Y, Yanagisawa, T, Sekine, S, Yokoyama, S. | Deposit date: | 2008-10-16 | Release date: | 2009-08-18 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Modeling of tRNA-assisted mechanism of Arg activation based on a structure of Arg-tRNA synthetase, tRNA, and an ATP analog (ANP) Febs J., 276, 2009
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1OBC
| LEUCYL-TRNA SYNTHETASE FROM THERMUS THERMOPHILUS COMPLEXED WITH A POST-TRANSFER EDITING SUBSTRATE ANALOGUE | Descriptor: | 2'-AMINO-2'-DEOXYADENOSINE, LEUCINE, LEUCYL-TRNA SYNTHETASE, ... | Authors: | Cusack, S, Yaremchuk, A, Tukalo, M. | Deposit date: | 2003-01-30 | Release date: | 2003-05-09 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural and Mechanistic Basis of Pre- and Posttransfer Editing by Leucyl-tRNA Synthetase Mol.Cell, 11, 2003
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5JLD
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1GSG
| Structure of E.coli glutaminyl-tRNA synthetase complexed with trnagln and ATP at 2.8 Angstroms resolution | Descriptor: | GLUTAMINYL-TRNA SYNTHETASE, TRNAGLN | Authors: | Rould, M.A, Perona, J.J, Soell, D, Steitz, T.A. | Deposit date: | 1990-04-03 | Release date: | 1992-02-24 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structure of E. coli glutaminyl-tRNA synthetase complexed with tRNA(Gln) and ATP at 2.8 A resolution. Science, 246, 1989
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1U0B
| Crystal structure of cysteinyl-tRNA synthetase binary complex with tRNACys | Descriptor: | Cysteine--tRNA ligase, ZINC ION, cysteinyl tRNA | Authors: | Hauenstein, S, Zhang, C.M, Hou, Y.M, Perona, J.J. | Deposit date: | 2004-07-13 | Release date: | 2004-11-23 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Shape-selective RNA recognition by cysteinyl-tRNA synthetase Nat.Struct.Mol.Biol., 11, 2004
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7AP3
| Crystal structure of E. coli tyrosyl-tRNA synthetase in complex with TyrS7HMDDA | Descriptor: | SODIUM ION, Tyrosine--tRNA ligase, [(2~{R},3~{S},4~{R},5~{R})-5-[7-azanyl-5-(hydroxymethyl)benzimidazol-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methyl ~{N}-[(2~{S})-2-azanyl-3-(4-hydroxyphenyl)propanoyl]sulfamate | Authors: | De Graef, S, Pang, L, Strelkov, S.V, Weeks, S.D. | Deposit date: | 2020-10-15 | Release date: | 2020-10-28 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Synthesis and Biological Evaluation of 1,3-Dideazapurine-Like 7-Amino-5-Hydroxymethyl-Benzimidazole Ribonucleoside Analogues as Aminoacyl-tRNA Synthetase Inhibitors. Molecules, 25, 2020
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