5B8I
| Crystal structure of Calcineurin A and Calcineurin B in complex with FKBP12 and FK506 from Coccidioides immitis RS | Descriptor: | 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 8-DEETHYL-8-[BUT-3-ENYL]-ASCOMYCIN, ... | Authors: | Seattle Structural Genomics Center for Infectious Disease (SSGCID), Fox III, D, Dranow, D.M, Lorimer, D.D, Edwards, T.E. | Deposit date: | 2015-05-03 | Release date: | 2015-05-20 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Harnessing calcineurin-FK506-FKBP12 crystal structures from invasive fungal pathogens to develop antifungal agents. Nat Commun, 10, 2019
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3IVD
| Putative 5'-Nucleotidase (c4898) from Escherichia Coli in complex with Uridine | Descriptor: | CHLORIDE ION, FE (III) ION, MANGANESE (II) ION, ... | Authors: | Ramagopal, U.A, Toro, R, Burley, S.K, Almo, S.C, New York SGX Research Center for Structural Genomics (NYSGXRC) | Deposit date: | 2009-08-31 | Release date: | 2009-09-29 | Last modified: | 2021-02-10 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Putative 5'-Nucleotidase (c4898) from Escherichia Coli in complex with Uridine To be Published
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3C5W
| Complex between PP2A-specific methylesterase PME-1 and PP2A core enzyme | Descriptor: | PP2A A subunit, PP2A C subunit, PP2A-specific methylesterase PME-1 | Authors: | Xing, Y, Li, Z, Chen, Y, Stock, J, Jeffrey, P.D, Shi, Y. | Deposit date: | 2008-02-01 | Release date: | 2008-04-15 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structural mechanism of demethylation and inactivation of protein phosphatase 2A. Cell(Cambridge,Mass.), 133, 2008
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1OI8
| 5'-Nucleotidase (E. coli) with an Engineered Disulfide Bridge (P90C, L424C) | Descriptor: | CARBONATE ION, MANGANESE (II) ION, PROTEIN USHA, ... | Authors: | Schultz-Heienbrok, R, Maier, T, Straeter, N. | Deposit date: | 2003-06-10 | Release date: | 2004-06-10 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Trapping a 96 Degree Domain Rotation in Two Distinct Conformations by Engineered Disulfide Bridges Protein Sci., 13, 2004
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1OIE
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2O8G
| Rat pp1c gamma complexed with mouse inhibitor-2 | Descriptor: | MANGANESE (II) ION, Protein phosphatase inhibitor 2, Serine/threonine-protein phosphatase PP1-gamma catalytic subunit | Authors: | Hurley, T.D. | Deposit date: | 2006-12-12 | Release date: | 2007-07-17 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural basis for regulation of protein phosphatase 1 by inhibitor-2. J.Biol.Chem., 282, 2007
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2O8A
| rat PP1cgamma complexed with mouse inhibitor-2 | Descriptor: | Protein phosphatase inhibitor 2, Serine/threonine-protein phosphatase PP1-gamma catalytic subunit | Authors: | Hurley, T.D. | Deposit date: | 2006-12-12 | Release date: | 2007-07-17 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.61 Å) | Cite: | Structural basis for regulation of protein phosphatase 1 by inhibitor-2. J.Biol.Chem., 282, 2007
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2NYL
| Crystal structure of Protein Phosphatase 2A (PP2A) holoenzyme with the catalytic subunit carboxyl terminus truncated | Descriptor: | MANGANESE (II) ION, Protein phosphatase 2, regulatory subunit A (PR 65), ... | Authors: | Xing, Y, Xu, Y, Chen, Y, Chao, Y, Lin, Z, Shi, Y. | Deposit date: | 2006-11-20 | Release date: | 2006-12-12 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (3.8 Å) | Cite: | Structure of the Protein Phosphatase 2A Holoenzyme. Cell(Cambridge,Mass.), 127, 2006
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2QFR
| Crystal structure of red kidney bean purple acid phosphatase with bound sulfate | Descriptor: | 2-acetamido-2-deoxy-alpha-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, FE (III) ION, ... | Authors: | Guddat, L.W, Schenk, G, Gahan, L.R, Elliot, T.W, Leung, E. | Deposit date: | 2007-06-27 | Release date: | 2008-10-14 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Crystal structures of a purple acid phosphatase, representing different steps of this enzyme's catalytic cycle. Bmc Struct.Biol., 8, 2008
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2QFP
| Crystal structure of red kidney bean purple acid phosphatase in complex with fluoride | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, FE (III) ION, FLUORIDE ION, ... | Authors: | Guddat, L.W, Schenk, G.S, Gahan, L.R, Elliot, T.W, Leung, E. | Deposit date: | 2007-06-27 | Release date: | 2008-10-14 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal structures of a purple acid phosphatase, representing different steps of this enzyme's catalytic cycle. Bmc Struct.Biol., 8, 2008
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2NYM
| Crystal Structure of Protein Phosphatase 2A (PP2A) with C-terminus truncated catalytic subunit | Descriptor: | MANGANESE (II) ION, Protein phosphatase 2, Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform, ... | Authors: | Chen, Y, Xing, Y, Xu, Y, Chao, Y, Lin, Z, Jeffrey, P.D, Shi, Y. | Deposit date: | 2006-11-21 | Release date: | 2006-12-12 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (3.6 Å) | Cite: | Structure of the Protein Phosphatase 2A Holoenzyme. Cell(Cambridge,Mass.), 127, 2006
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2P6B
| Crystal Structure of Human Calcineurin in Complex with PVIVIT Peptide | Descriptor: | CALCIUM ION, Calcineurin subunit B isoform 1, Calmodulin-dependent calcineurin A subunit alpha isoform, ... | Authors: | Li, H, Zhang, L, Rao, A, Harrison, S.C, Hogan, P.G. | Deposit date: | 2007-03-16 | Release date: | 2007-06-05 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structure of calcineurin in complex with PVIVIT peptide: Portrait of a low-affinity signalling interaction J.Mol.Biol., 369, 2007
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1OID
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1S95
| Structure of serine/threonine protein phosphatase 5 | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, MANGANESE (II) ION, PHOSPHATE ION, ... | Authors: | Swingle, M.R, Honkanen, R.E, Ciszak, E.M. | Deposit date: | 2004-02-03 | Release date: | 2004-08-24 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structural basis for the catalytic activity of human serine/threonine protein phosphatase-5. J.Biol.Chem., 279, 2004
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1S70
| Complex between protein ser/thr phosphatase-1 (delta) and the myosin phosphatase targeting subunit 1 (MYPT1) | Descriptor: | 130 kDa myosin-binding subunit of smooth muscle myosin phophatase (M130), MANGANESE (II) ION, Serine/threonine protein phosphatase PP1-beta (or delta) catalytic subunit, ... | Authors: | Kerff, F, Terrak, M, Dominguez, R. | Deposit date: | 2004-01-28 | Release date: | 2004-06-22 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structural basis of protein phosphatase 1 regulation Nature, 429, 2004
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5HQN
| Catalytic domain of murine Acid Sphingomyelinase (ASMase, ASM, SMPD1) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Gorelik, A, Illes, K, Heinz, L.X, Superti-Furga, G, Nagar, B. | Deposit date: | 2016-01-21 | Release date: | 2016-07-06 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Crystal structure of mammalian acid sphingomyelinase. Nat Commun, 7, 2016
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5HPE
| Phosphatase domain of PP5 bound to a phosphomimetic Cdc37 substrate peptide | Descriptor: | COBALT HEXAMMINE(III), MANGANESE (II) ION, Serine/threonine-protein phosphatase 5,Hsp90 co-chaperone Cdc37 | Authors: | Oberoi, J, Mariotti, L, Vaughan, C. | Deposit date: | 2016-01-20 | Release date: | 2016-07-27 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.27 Å) | Cite: | Structural and functional basis of protein phosphatase 5 substrate specificity. Proc.Natl.Acad.Sci.USA, 113, 2016
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5IOH
| RepoMan-PP1a (protein phosphatase 1, alpha isoform) holoenzyme complex | Descriptor: | Cell division cycle-associated protein 2, Serine/threonine-protein phosphatase PP1-alpha catalytic subunit | Authors: | Kumar, G.S, Peti, W, Page, R. | Deposit date: | 2016-03-08 | Release date: | 2016-10-05 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.566 Å) | Cite: | The Ki-67 and RepoMan mitotic phosphatases assemble via an identical, yet novel mechanism. Elife, 5, 2016
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5I85
| aSMase with zinc and phosphocholine | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, PHOSPHOCHOLINE, ... | Authors: | Zhou, Y.F, Wei, R.R. | Deposit date: | 2016-02-18 | Release date: | 2016-09-07 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Human acid sphingomyelinase structures provide insight to molecular basis of Niemann-Pick disease. Nat Commun, 7, 2016
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5I81
| aSMase with zinc | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, SULFATE ION, ... | Authors: | Zhou, Y.F, Wei, R.R. | Deposit date: | 2016-02-18 | Release date: | 2016-09-07 | Last modified: | 2021-03-24 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Human acid sphingomyelinase structures provide insight to molecular basis of Niemann-Pick disease. Nat Commun, 7, 2016
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5I8R
| aSMase with zinc | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Sphingomyelin phosphodiesterase, ... | Authors: | Zhou, Y.F, Wei, R.R. | Deposit date: | 2016-02-19 | Release date: | 2016-09-07 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (3.646 Å) | Cite: | Human acid sphingomyelinase structures provide insight to molecular basis of Niemann-Pick disease. Nat Commun, 7, 2016
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5FC1
| Murine SMPDL3A in complex with sulfate | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Gorelik, A, Illes, K, Superti-Furga, G, Nagar, B. | Deposit date: | 2015-12-14 | Release date: | 2016-01-27 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (1.389 Å) | Cite: | Structural Basis for Nucleotide Hydrolysis by the Acid Sphingomyelinase-like Phosphodiesterase SMPDL3A. J.Biol.Chem., 291, 2016
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5H7W
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5INB
| RepoMan-PP1g (protein phosphatase 1, gamma isoform) holoenzyme complex | Descriptor: | Cell division cycle-associated protein 2, GLYCEROL, MALONATE ION, ... | Authors: | Kumar, G.S, Peti, W, Page, R. | Deposit date: | 2016-03-07 | Release date: | 2016-10-05 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | The Ki-67 and RepoMan mitotic phosphatases assemble via an identical, yet novel mechanism. Elife, 5, 2016
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5J28
| Ki67-PP1g (protein phosphatase 1, gamma isoform) holoenzyme complex | Descriptor: | Antigen KI-67, MALONATE ION, SODIUM ION, ... | Authors: | Kumar, G.S, Peti, W, Page, R. | Deposit date: | 2016-03-29 | Release date: | 2016-10-05 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | The Ki-67 and RepoMan mitotic phosphatases assemble via an identical, yet novel mechanism. Elife, 5, 2016
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