6HXW

structure of human CD73 in complex with antibody IPH53

Summary for 6HXW

• Entry DOI: 10.2210/pdb6hxw/pdb
• Descriptor: 5'-nucleotidase, IPH53 heavy chain, IPH53 light chain, ... (6 entities in total)
• Functional Keywords: inhibitor antibody, immune system
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 6
• Total formula weight: 214366.93

Authors

Roussel, A.,Amigues, B. (deposition date: 2018-10-18, release date: 2019-08-28, Last modification date: 2020-07-29)

• Primary citation: Perrot, I.,Michaud, H.A.,Giraudon-Paoli, M.,Augier, S.,Docquier, A.,Gros, L.,Courtois, R.,Dejou, C.,Jecko, D.,Becquart, O.,Rispaud-Blanc, H.,Gauthier, L.,Rossi, B.,Chanteux, S.,Gourdin, N.,Amigues, B.,Roussel, A.,Bensussan, A.,Eliaou, J.F.,Bastid, J.,Romagne, F.,Morel, Y.,Narni-Mancinelli, E.,Vivier, E.,Paturel, C.,Bonnefoy, N.; Blocking Antibodies Targeting the CD39/CD73 Immunosuppressive Pathway Unleash Immune Responses in Combination Cancer Therapies.; Cell Rep, 27:2411-2425.e9, 2019; PubMed: 31116985; DOI: 10.1016/j.celrep.2019.04.091

Experimental method

X-RAY DIFFRACTION (2.78 Å)