6HXW
structure of human CD73 in complex with antibody IPH53
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | 5'-nucleotidase | polymer | 527 | 58678.8 | 2 | UniProt (P21589) Pfam (PF00149) Pfam (PF02872) In PDB | Homo sapiens (Human) | 5'-NT,Ecto-5'-nucleotidase |
| 2 | C, H | IPH53 heavy chain | polymer | 231 | 25144.2 | 2 | synthetic construct | ||
| 3 | D, L | IPH53 light chain | polymer | 209 | 23008.5 | 2 | synthetic construct | ||
| 4 | A, B | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) | |||
| 5 | A, B | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
| 6 | water | water | 18.0 | 810 | Chemie (HOH) |
Sequence modifications
A, B: 27 - 553 (UniProt: P21589)
| PDB | External Database | Details |
|---|---|---|
| His 548 | Phe 548 | conflict |
| His 549 | Ser 549 | conflict |
| His 550 | Thr 550 | conflict |
| His 551 | Gly 551 | conflict |
| His 552 | Ser 552 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 213662.9 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 704.1 | |
| All* | Total formula weight | 214366.9 |
