6VPO
 
 | | Cryo-EM structure of microtubule-bound KLP61F motor domain in the AMPPNP state | | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, Kinesin-like protein Klp61F, ... | | Authors: | Bodrug, T, Wilson-Kubalek, E.M, Nithianantham, S, Debs, G, Sindelar, C.V, Milligan, R, Al-Bassam, J. | | Deposit date: | 2020-02-04 | | Release date: | 2020-02-19 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (4.4 Å) | | Cite: | The kinesin-5 tail domain directly modulates the mechanochemical cycle of the motor domain for anti-parallel microtubule sliding.
Elife, 9, 2020
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8CLA
 | | Z-SBTubA4 photoswitch bound to tubulin-DARPin D1 complex | | Descriptor: | 2-methoxy-5-[2-(5,6,7-trimethoxy-1,3-benzothiazol-2-yl)ethyl]phenol, CALCIUM ION, Designed Ankyrin Repeat Protein (DARPIN) D1, ... | | Authors: | Wranik, M, Bertrand, Q, Kepa, M.W, Weinert, T, Steinmetz, M, Standfuss, J. | | Deposit date: | 2023-02-16 | | Release date: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | A multi-reservoir extruder for time-resolved serial protein crystallography and compound screening at X-ray free electron lasers
To Be Published
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8CGZ
 | | tubulin-AB8939 complex | | Descriptor: | AB-8939, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ... | | Authors: | Varela, P.F, Gigant, B. | | Deposit date: | 2023-02-06 | | Release date: | 2024-08-14 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (2.527 Å) | | Cite: | Development of AB8939, a Novel Colchicine-like Microtubule Synthetic Destabilizer with the Ability to Overcome Multidrug Resistance
TO BE PUBLISHED
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3VOB
 | | Staphylococcus aureus FtsZ with PC190723 | | Descriptor: | 3-[(6-chloro[1,3]thiazolo[5,4-b]pyridin-2-yl)methoxy]-2,6-difluorobenzamide, CALCIUM ION, Cell division protein FtsZ, ... | | Authors: | Yamane, J, Matsui, T, Mogi, N, Yamaguchi, H, Takemoto, H, Yao, M, Tanaka, I. | | Deposit date: | 2012-01-20 | | Release date: | 2012-08-29 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.703 Å) | | Cite: | Structural reorganization of the bacterial cell-division protein FtsZ from Staphylococcus aureus
Acta Crystallogr.,Sect.D, 68, 2012
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6UNX
 | | Structure of E. coli FtsZ(L178E)-GTP complex | | Descriptor: | Cell division protein FtsZ, GUANOSINE-5'-TRIPHOSPHATE | | Authors: | Schumacher, M.A. | | Deposit date: | 2019-10-13 | | Release date: | 2020-02-05 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (1.4 Å) | | Cite: | High-resolution crystal structures of Escherichia coli FtsZ bound to GDP and GTP.
Acta Crystallogr.,Sect.F, 76, 2020
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3UT5
 | | Tubulin-Colchicine-Ustiloxin: Stathmin-like domain complex | | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | | Authors: | Ranaivoson, F.M, Gigant, B, Knossow, M. | | Deposit date: | 2011-11-25 | | Release date: | 2012-08-01 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (2.73 Å) | | Cite: | Structural plasticity of tubulin assembly probed by vinca-domain ligands.
Acta Crystallogr.,Sect.D, 68, 2012
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6VE7
 | | The inner junction complex of Chlamydomonas reinhardtii doublet microtubule | | Descriptor: | Cilia- and flagella-associated protein 20, FAP276, FAP52, ... | | Authors: | Khalifa, A.A.Z, Ichikawa, M, Bui, K.H. | | Deposit date: | 2019-12-30 | | Release date: | 2020-02-05 | | Last modified: | 2024-10-09 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | The inner junction complex of the cilia is an interaction hub that involves tubulin post-translational modifications.
Elife, 9, 2020
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3V3T
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3VOA
 | | Staphylococcus aureus FtsZ 12-316 GDP-form | | Descriptor: | CALCIUM ION, Cell division protein FtsZ, GUANOSINE-5'-DIPHOSPHATE | | Authors: | Yamane, J, Matsui, T, Mogi, N, Yao, M, Tanaka, I. | | Deposit date: | 2012-01-20 | | Release date: | 2012-08-29 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (1.73 Å) | | Cite: | Structural reorganization of the bacterial cell-division protein FtsZ from Staphylococcus aureus
Acta Crystallogr.,Sect.D, 68, 2012
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3VO9
 | | Staphylococcus aureus FtsZ apo-form (SeMet) | | Descriptor: | Cell division protein FtsZ | | Authors: | Matsui, T, Yamane, J, Mogi, N, Yao, M, Tanaka, I. | | Deposit date: | 2012-01-20 | | Release date: | 2012-08-29 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (2.706 Å) | | Cite: | Structural reorganization of the bacterial cell-division protein FtsZ from Staphylococcus aureus
Acta Crystallogr.,Sect.D, 68, 2012
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3WGL
 | | STAPHYLOCOCCUS AUREUS FTSZ T7 mutant substituted for GAN bound with GDP, DeltaT7GAN-GDP | | Descriptor: | Cell division protein FtsZ, GUANOSINE-5'-DIPHOSPHATE | | Authors: | Han, X, Matsui, T, Yu, J, Tanaka, I, Yao, M. | | Deposit date: | 2013-08-06 | | Release date: | 2013-12-25 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (3.066 Å) | | Cite: | Structural change in FtsZ Induced by intermolecular interactions between bound GTP and the T7 loop
J.Biol.Chem., 289, 2014
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3WGJ
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3WGM
 | | STAPHYLOCOCCUS AUREUS FTSZ T7 mutant substituted for GAN bound with GTP, DeltaT7GAN-GTP | | Descriptor: | Cell division protein FtsZ, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION | | Authors: | Han, X, Matsui, T, Yu, J, Tanaka, I, Yao, M. | | Deposit date: | 2013-08-06 | | Release date: | 2013-12-25 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.091 Å) | | Cite: | Structural change in FtsZ Induced by intermolecular interactions between bound GTP and the T7 loop
J.Biol.Chem., 289, 2014
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3WGK
 | | STAPHYLOCOCCUS AUREUS FTSZ T7 mutant substituted for GAG, DeltaT7GAG-GDP | | Descriptor: | Cell division protein FtsZ, GUANOSINE-5'-DIPHOSPHATE | | Authors: | Han, X, Matsui, T, Yu, J, Tanaka, I, Yao, M. | | Deposit date: | 2013-08-06 | | Release date: | 2013-12-25 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.799 Å) | | Cite: | Structural change in FtsZ Induced by intermolecular interactions between bound GTP and the T7 loop
J.Biol.Chem., 289, 2014
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8IXD
 | | GMPCPP-Alpha1C/Beta2A-microtubule decorated with kinesin non-seam region | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, Kinesin-1 heavy chain, ... | | Authors: | Zheng, W, Zhao, Q.Y, Diao, L, Bao, L, Cong, Y. | | Deposit date: | 2023-03-31 | | Release date: | 2023-08-16 | | Last modified: | 2023-10-25 | | Method: | ELECTRON MICROSCOPY (4.4 Å) | | Cite: | Cryo-EM of alpha-tubulin isotype-containing microtubules revealed a contracted structure of alpha 4A/ beta 2A microtubules.
Acta Biochim.Biophys.Sin., 55, 2023
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8IXF
 | | GMPCPP-Alpha4A/Beta2A-microtubule decorated with kinesin non-seam region | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, Kinesin-1 heavy chain, ... | | Authors: | Zheng, W, Zhao, Q.Y, Diao, L, Bao, L, Cong, Y. | | Deposit date: | 2023-03-31 | | Release date: | 2023-08-16 | | Last modified: | 2023-10-25 | | Method: | ELECTRON MICROSCOPY (4.4 Å) | | Cite: | Cryo-EM of alpha-tubulin isotype-containing microtubules revealed a contracted structure of alpha 4A/ beta 2A microtubules.
Acta Biochim.Biophys.Sin., 55, 2023
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3WGN
 | | STAPHYLOCOCCUS AUREUS FTSZ bound with GTP-gamma-S | | Descriptor: | 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, Cell division protein FtsZ | | Authors: | Matsui, T, Mogi, N, Tanaka, I, Yao, M. | | Deposit date: | 2013-08-06 | | Release date: | 2013-12-25 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.606 Å) | | Cite: | Structural change in FtsZ Induced by intermolecular interactions between bound GTP and the T7 loop
J.Biol.Chem., 289, 2014
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8F1A
 | | Apo KIF20A[1-565] class-1 in complex with a microtubule | | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, Kinesin-like protein KIF20A, ... | | Authors: | Benoit, M.P.M.H, Asenjo, A.B, Crozet, V, Ranaivoson, F.M, Houdusse, A, Sosa, H. | | Deposit date: | 2022-11-04 | | Release date: | 2023-09-20 | | Last modified: | 2023-10-04 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Nucleotide-free structures of KIF20A illuminate atypical mechanochemistry in this kinesin-6.
Open Biology, 13, 2023
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6BR1
 | | Tubulin-RB3_SLD-TTL in complex with heterocyclic pyrimidine compound 4a | | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-chloro-4-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)pyrido[2,3-d]pyrimidine, CALCIUM ION, ... | | Authors: | Kumar, G, Wang, Y, Li, W, White, S.W. | | Deposit date: | 2017-11-29 | | Release date: | 2018-06-27 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (2.304 Å) | | Cite: | Heterocyclic-Fused Pyrimidines as Novel Tubulin Polymerization Inhibitors Targeting the Colchicine Binding Site: Structural Basis and Antitumor Efficacy.
J. Med. Chem., 61, 2018
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8F18
 | | Apo KIF20A[1-565] class-2 in complex with a microtubule | | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, Kinesin-like protein KIF20A, ... | | Authors: | Benoit, M.P.M.H, Asenjo, A.B, Crozet, V, Ranaivoson, F.M, Houdusse, A, Sosa, H. | | Deposit date: | 2022-11-04 | | Release date: | 2023-09-20 | | Last modified: | 2023-10-04 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Nucleotide-free structures of KIF20A illuminate atypical mechanochemistry in this kinesin-6.
Open Biology, 13, 2023
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8G3D
 | | 48-nm doublet microtubule from Tetrahymena thermophila strain K40R | | Descriptor: | B2B3_fMIP, B5B6_fMIP, CFAM166A, ... | | Authors: | Black, C.S, Kubo, S, Yang, S.K, Bui, K.H. | | Deposit date: | 2023-02-07 | | Release date: | 2023-06-14 | | Last modified: | 2024-10-30 | | Method: | ELECTRON MICROSCOPY (3.7 Å) | | Cite: | Native doublet microtubules from Tetrahymena thermophila reveal the importance of outer junction proteins.
Nat Commun, 14, 2023
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8G2Z
 | | 48-nm doublet microtubule from Tetrahymena thermophila strain CU428 | | Descriptor: | B2B3_fMIP, B5B6_fMIP, CFAM166A, ... | | Authors: | Black, C.S, Kubo, S, Yang, S.K, Bui, K.H. | | Deposit date: | 2023-02-06 | | Release date: | 2023-06-14 | | Last modified: | 2024-12-25 | | Method: | ELECTRON MICROSCOPY (4.1 Å) | | Cite: | Native doublet microtubules from Tetrahymena thermophila reveal the importance of outer junction proteins.
Nat Commun, 14, 2023
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9C6R
 | | Blood cell-specific tubulin in complex with Cryptophycin-52 | | Descriptor: | Cryptophycin 52, Detyrosinated tubulin alpha-1A chain, GUANOSINE-5'-DIPHOSPHATE, ... | | Authors: | Montecinos, F. | | Deposit date: | 2024-06-08 | | Release date: | 2025-01-01 | | Last modified: | 2025-01-29 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Structure of blood cell-specific tubulin and demonstration of dimer spacing compaction in a single protofilament.
J.Biol.Chem., 301, 2024
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9C6S
 | | 18-mer blood cell-specific tubulin in complex with Cryptophycin-52 | | Descriptor: | Cryptophycin 52, Detyrosinated tubulin alpha-1A chain, GUANOSINE-5'-DIPHOSPHATE, ... | | Authors: | Montecinos, F. | | Deposit date: | 2024-06-08 | | Release date: | 2025-01-01 | | Last modified: | 2025-05-14 | | Method: | ELECTRON MICROSCOPY (3.52 Å) | | Cite: | Structure of blood cell-specific tubulin and demonstration of dimer spacing compaction in a single protofilament.
J.Biol.Chem., 301, 2024
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4ATX
 | | Rigor kinesin motor domain with an ordered neck-linker, docked on tubulin dimer, modelled into the 8A cryo-EM map of doublecortin- microtubules decorated with kinesin | | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, KINESIN-1 HEAVY CHAIN, ... | | Authors: | Liu, J.S, Schubert, C.R, Fu, X, Fourniol, F.J, Jaiswal, J.K, Houdusse, A, Stultz, C.M, Moores, C.A, Walsh, C.A. | | Deposit date: | 2012-05-10 | | Release date: | 2012-09-26 | | Last modified: | 2024-05-08 | | Method: | ELECTRON MICROSCOPY (8.2 Å) | | Cite: | Molecular Basis for Specific Regulation of Neuronal Kinesin- 3 Motors by Doublecortin Family Proteins.
Mol.Cell, 47, 2012
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