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PDB: 265 results

6FBD
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BU of 6fbd by Molmil
KlenTaq DNA polymerase processing a modified primer - bearing the modification upstream at the second primer nucleotide.
Descriptor: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]guanosine, DNA (5'-D(*GP*AP*CP*CP*AP*CP*GP*GP*CP*AP*(OH3)P*C)-3'), DNA (5'-D(P*AP*AP*AP*CP*GP*GP*TP*GP*CP*CP*GP*TP*GP*GP*TP*C)-3'), ...
Authors:Kropp, H.M, Diederichs, K, Marx, A.
Deposit date:2017-12-19
Release date:2018-09-26
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.099 Å)
Cite:Snapshots of a modified nucleotide moving through the confines of a DNA polymerase.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6FBG
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BU of 6fbg by Molmil
KlenTaq DNA polymerase processing a modified primer - bearing the modification upstream at the fifth primer nucleotide.
Descriptor: 1,2-ETHANEDIOL, 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]guanosine, DNA (5'-D(*AP*AP*AP*CP*GP*CP*CP*GP*GP*TP*GP*TP*GP*GP*TP*C)-3'), ...
Authors:Kropp, H.M, Diederichs, K, Marx, A.
Deposit date:2017-12-19
Release date:2018-09-26
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.702 Å)
Cite:Snapshots of a modified nucleotide moving through the confines of a DNA polymerase.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6FBH
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BU of 6fbh by Molmil
KlenTaq DNA polymerase processing a modified primer - bearing the modification upstream at the sixth primer nucleotide.
Descriptor: 1,2-ETHANEDIOL, 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]guanosine, DNA (5'-D(*AP*AP*AP*CP*GP*TP*CP*CP*GP*GP*TP*GP*GP*GP*TP*C)-3'), ...
Authors:Kropp, H.M, Diederichs, K, Marx, A.
Deposit date:2017-12-19
Release date:2018-09-26
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Snapshots of a modified nucleotide moving through the confines of a DNA polymerase.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6FBI
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BU of 6fbi by Molmil
KlenTaq DNA polymerase in a closed, ternary complex with dGpNHpp bound in the active site
Descriptor: 1,2-ETHANEDIOL, 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]guanosine, DNA (5'-D(*AP*AP*AP*CP*GP*TP*GP*GP*CP*CP*GP*TP*GP*GP*TP*C)-3'), ...
Authors:Kropp, H.M, Diederichs, K, Marx, A.
Deposit date:2017-12-19
Release date:2018-09-26
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Snapshots of a modified nucleotide moving through the confines of a DNA polymerase.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
3OJU
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BU of 3oju by Molmil
Snapshot of the large fragment of DNA polymerase I from Thermus Aquaticus processing c5 modified thymidies
Descriptor: 2'-deoxy-5-[(1-hydroxy-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)ethynyl]uridine 5'-(tetrahydrogen triphosphate), DNA (5'-D(*AP*AP*AP*AP*GP*GP*CP*GP*CP*CP*GP*TP*GP*GP*TP*C)-3'), DNA (5'-D(*GP*AP*CP*CP*AP*CP*GP*GP*CP*GP*CP*(DOC))-3'), ...
Authors:Marx, A, Diederichs, K, Obeid, S.
Deposit date:2010-08-23
Release date:2010-12-15
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis for the synthesis of nucleobase modified DNA by Thermus aquaticus DNA polymerase.
Proc.Natl.Acad.Sci.USA, 107, 2010
3PO4
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BU of 3po4 by Molmil
Structure of a mutant of the large fragment of DNA polymerase I from Thermus aquaticus in complex with a blunt-ended DNA and ddATP
Descriptor: 2',3'-dideoxyadenosine triphosphate, DNA (5'-D(*GP*AP*CP*CP*AP*CP*GP*GP*CP*GP*CP*(2DA))-3'), DNA (5'-D(*TP*GP*CP*GP*CP*CP*GP*TP*GP*GP*TP*C)-3'), ...
Authors:Marx, A, Diederichs, K, Obeid, S.
Deposit date:2010-11-22
Release date:2011-06-15
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Learning from Directed Evolution: Thermus aquaticus DNA Polymerase Mutants with Translesion Synthesis Activity.
Chembiochem, 12, 2011
3PO5
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BU of 3po5 by Molmil
Structure of a mutant of the large fragment of DNA polymerase I from Thermus Auqaticus in complex with an abasic site and ddATP
Descriptor: 2',3'-dideoxyadenosine triphosphate, DNA (5'-D(*GP*AP*CP*CP*AP*CP*GP*GP*CP*GP*CP*(2DA))-3'), DNA (5'-D(P*(3DR)P*TP*GP*CP*GP*CP*CP*GP*TP*GP*GP*TP*C)-3'), ...
Authors:Marx, A, Diederichs, K, Obeid, S.
Deposit date:2010-11-22
Release date:2011-06-15
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.39 Å)
Cite:Learning from Directed Evolution: Thermus aquaticus DNA Polymerase Mutants with Translesion Synthesis Activity.
Chembiochem, 12, 2011
3OJS
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BU of 3ojs by Molmil
Snapshots of the large fragment of DNA polymerase I from Thermus Aquaticus processing C5 modified thymidines
Descriptor: 2'-deoxy-5-[9-(3-{[4-(diethylamino)-4-oxobutanoyl]amino}propyl)-18-ethyl-5,8,14,17-tetraoxo-4,9,13,18-tetraazaicos-1-yn-1-yl]uridine 5'-(tetrahydrogen triphosphate), ACETATE ION, DNA (5'-D(*AP*AP*AP*AP*GP*GP*CP*GP*CP*CP*GP*TP*GP*GP*TP*C)-3'), ...
Authors:Marx, A, Diederichs, K, Obeid, S.
Deposit date:2010-08-23
Release date:2010-12-15
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural basis for the synthesis of nucleobase modified DNA by Thermus aquaticus DNA polymerase.
Proc.Natl.Acad.Sci.USA, 107, 2010
3RRG
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BU of 3rrg by Molmil
Ternary Structure of the large fragment of Taq DNA polymerase bound to an abasic site and a ddGTP
Descriptor: (5'-D(*AP*AP*AP*(3DR)P*CP*GP*CP*GP*CP*CP*GP*TP*GP*GP*TP*C)-3'), (5'-D(*GP*AP*CP*CP*AP*CP*GP*GP*CP*GP*CP*(DDG))-3'), 2'-3'-DIDEOXYGUANOSINE-5'-TRIPHOSPHATE, ...
Authors:Marx, A, Diederichs, K, Obeid, S.
Deposit date:2011-04-29
Release date:2012-02-15
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Amino Acid templating mechanisms in selection of nucleotides opposite abasic sites by a family a DNA polymerase.
J.Biol.Chem., 287, 2012
3PY8
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BU of 3py8 by Molmil
Crystal structure of a mutant of the large fragment of DNA polymerase I from thermus aquaticus in a closed ternary complex with DNA and ddCTP
Descriptor: 2',3'-DIDEOXYCYTIDINE 5'-TRIPHOSPHATE, DNA (5'-D(*AP*A*AP*GP*GP*GP*CP*GP*CP*CP*GP*TP*GP*GP*TP*C)-3'), DNA (5'-D(*GP*AP*CP*CP*AP*CP*GP*GP*CP*GP*CP*(DOC))-3'), ...
Authors:Schnur, A, Marx, A, Welte, W, Diederichs, K.
Deposit date:2010-12-12
Release date:2011-06-15
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.74 Å)
Cite:Learning from Directed Evolution: Thermus aquaticus DNA Polymerase Mutants with Translesion Synthesis Activity.
Chembiochem, 12, 2011
3RRH
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BU of 3rrh by Molmil
Ternary Structure of the large fragment of Taq DNA polymerase bound to an abasic site and a ddTTP
Descriptor: (5'-D(*AP*AP*AP*(3DR)P*AP*GP*CP*GP*CP*CP*GP*TP*GP*GP*TP*C)-3'), (5'-D(*GP*AP*CP*CP*AP*CP*GP*GP*CP*GP*CP*(2DT))-3'), ACETATE ION, ...
Authors:Marx, A, Diederichs, K, Obeid, S.
Deposit date:2011-04-29
Release date:2012-02-15
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Amino Acid templating mechanisms in selection of nucleotides opposite abasic sites by a family a DNA polymerase.
J.Biol.Chem., 287, 2012
3RR7
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BU of 3rr7 by Molmil
Binary Structure of the large fragment of Taq DNA polymerase bound to an abasic site
Descriptor: (5'-D(*AP*AP*AP*(3DR)P*GP*GP*CP*GP*CP*CP*GP*TP*GP*GP*TP*C)-3'), (5'-D(*GP*AP*CP*CP*AP*CP*GP*GP*CP*GP*CP*(DOC))-3'), DNA polymerase I, ...
Authors:Marx, A, Diederichs, K, Obeid, S.
Deposit date:2011-04-29
Release date:2012-02-15
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Amino Acid templating mechanisms in selection of nucleotides opposite abasic sites by a family a DNA polymerase.
J.Biol.Chem., 287, 2012
3RR8
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BU of 3rr8 by Molmil
Ternary Structure of the large fragment of Taq DNA polymerase bound to an abasic site and a ddGTP
Descriptor: (5'-D(*AP*AP*AP*(3DR)P*CP*GP*CP*GP*CP*CP*GP*TP*GP*GP*TP*C)-3'), (5'-D(*GP*AP*CP*CP*AP*CP*GP*GP*CP*GP*CP*(DDG))-3'), 2'-3'-DIDEOXYGUANOSINE-5'-TRIPHOSPHATE, ...
Authors:Marx, A, Diederichs, K, Obeid, S.
Deposit date:2011-04-29
Release date:2012-02-15
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Amino Acid templating mechanisms in selection of nucleotides opposite abasic sites by a family a DNA polymerase.
J.Biol.Chem., 287, 2012
3RTV
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BU of 3rtv by Molmil
Crystal structure of the large fragment of DNA polymerase I from Thermus Aquaticus in a closed ternary complex with natural primer/template DNA
Descriptor: (5'-D(*AP*AP*AP*GP*CP*GP*CP*GP*CP*CP*GP*TP*GP*GP*TP*C)-3'), (5'-D(*GP*AP*CP*CP*AP*CP*GP*GP*CP*GP*CP*(DDG))-3'), 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, ...
Authors:Marx, A, Diederichs, K, Betz, K.
Deposit date:2011-05-04
Release date:2012-05-30
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:KlenTaq polymerase replicates unnatural base pairs by inducing a Watson-Crick geometry.
Nat.Chem.Biol., 8, 2012
1QSS
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BU of 1qss by Molmil
DDGTP-TRAPPED CLOSED TERNARY COMPLEX OF THE LARGE FRAGMENT OF DNA POLYMERASE I FROM THERMUS AQUATICUS
Descriptor: 2'-3'-DIDEOXYGUANOSINE-5'-TRIPHOSPHATE, 5'-D(*AP*CP*CP*GP*CP*GP*CP*CP*GP*TP*GP*GP*TP*C)-3', 5'-D(*GP*AP*CP*CP*AP*CP*GP*GP*CP*GP*CP*(DDG))-3', ...
Authors:Li, Y, Mitaxov, V, Waksman, G.
Deposit date:1999-06-23
Release date:1999-08-16
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure-based design of Taq DNA polymerases with improved properties of dideoxynucleotide incorporation.
Proc.Natl.Acad.Sci.USA, 96, 1999
1QTM
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BU of 1qtm by Molmil
DDTTP-TRAPPED CLOSED TERNARY COMPLEX OF THE LARGE FRAGMENT OF DNA POLYMERASE I FROM THERMUS AQUATICUS
Descriptor: 5'-D(*AP*AP*AP*GP*CP*GP*CP*CP*GP*TP*GP*GP*TP*C)-3', 5'-D(*GP*AP*CP*CP*AP*CP*GP*GP*CP*GP*CP*(2DT))-3', DNA POLYMERASE I, ...
Authors:Li, Y, Mitaxov, V, Waksman, G.
Deposit date:1999-06-28
Release date:1999-08-16
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure-based design of Taq DNA polymerases with improved properties of dideoxynucleotide incorporation.
Proc.Natl.Acad.Sci.USA, 96, 1999
1TAU
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BU of 1tau by Molmil
TAQ POLYMERASE (E.C.2.7.7.7)/DNA/B-OCTYLGLUCOSIDE COMPLEX
Descriptor: 2-O-octyl-beta-D-glucopyranose, DNA (5'-D(*CP*GP*GP*AP*TP*CP*GP*C)-3'), DNA (5'-D(*GP*CP*GP*AP*TP*CP*CP*G)-3'), ...
Authors:Eom, S.H, Wang, J, Steitz, T.A.
Deposit date:1996-06-17
Release date:1997-04-18
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structure of Taq ploymerase with DNA at the polymerase active site.
Nature, 382, 1996
1QSL
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BU of 1qsl by Molmil
KLENOW FRAGMENT COMPLEXED WITH SINGLE-STRANDED SUBSTRATE AND EUROPIUM (III) ION
Descriptor: 5'-D(*GP*CP*TP*TP*AP*CP*GP*C)-3', DNA POLYMERASE I, EUROPIUM ION
Authors:Brautigam, C.A, Aschheim, K, Steitz, T.A.
Deposit date:1999-06-22
Release date:1999-06-30
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural elucidation of the binding and inhibitory properties of lanthanide (III) ions at the 3'-5' exonucleolytic active site of the Klenow fragment
Chem.Biol., 6, 1999
1QSY
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BU of 1qsy by Molmil
DDATP-Trapped closed ternary complex of the large fragment of DNA Polymerase I from thermus aquaticus
Descriptor: 2',3'-dideoxyadenosine triphosphate, 5'-D(*AP*TP*TP*GP*CP*GP*CP*CP*TP*P*GP*GP*TP*C)-3', 5'-D(*GP*AP*CP*CP*AP*CP*GP*GP*CP*GP*CP*(2DA))-3', ...
Authors:Li, Y, Mitaxov, V, Waksman, G.
Deposit date:1999-06-24
Release date:1999-08-16
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure-based design of Taq DNA polymerases with improved properties of dideoxynucleotide incorporation.
Proc.Natl.Acad.Sci.USA, 96, 1999
1TAQ
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BU of 1taq by Molmil
STRUCTURE OF TAQ DNA POLYMERASE
Descriptor: 2-O-octyl-beta-D-glucopyranose, TAQ DNA POLYMERASE, ZINC ION
Authors:Kim, Y, Eom, S.H, Wang, J, Lee, D.-S, Suh, S.W, Steitz, T.A.
Deposit date:1996-06-04
Release date:1996-12-07
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of Thermus aquaticus DNA polymerase.
Nature, 376, 1995
4C8M
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BU of 4c8m by Molmil
Binary complex of the large fragment of DNA polymerase I from Thermus Aquaticus with the aritificial base pair d5SICS-dNaM at the postinsertion site (sequence context 2)
Descriptor: GLYCEROL, LARGE FRAGMENT OF TAQ DNA POLYMERASE I, MAGNESIUM ION, ...
Authors:Betz, K, Malyshev, D.A, Lavergne, T, Welte, W, Diederichs, K, Romesberg, F.E, Marx, A.
Deposit date:2013-10-01
Release date:2013-12-11
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.568 Å)
Cite:Structural Insights Into DNA Replication without Hydrogen Bonds.
J.Am.Chem.Soc., 135, 2013
4C8N
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BU of 4c8n by Molmil
Binary complex of the large fragment of DNA polymerase I from Thermus Aquaticus with the aritificial base pair dNaM-d5SICS at the postinsertion site (sequence context 3)
Descriptor: LARGE FRAGMENT OF TAQ DNA POLYMERASE I, PRIMER, 5'-D(*AP*CP*CP*AP*CP*GP*GP*CP*GP*CP*LHOP)-3', ...
Authors:Betz, K, Malyshev, D.A, Lavergne, T, Welte, W, Diederichs, K, Romesberg, F.E, Marx, A.
Deposit date:2013-10-01
Release date:2013-12-11
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:Structural Insights Into DNA Replication without Hydrogen Bonds.
J.Am.Chem.Soc., 135, 2013
4BWM
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BU of 4bwm by Molmil
KlenTaq mutant in complex with a RNA/DNA hybrid
Descriptor: 2',3'-DIDEOXYCYTIDINE 5'-TRIPHOSPHATE, 5'-D(*GP*AP*CP*CP*AP*CP*GP*GP*CP*GP*CP*DOCP)-3', 5'-R(*AP*AP*AP*GP*GP*GP*CP*GP*CP*CP*GP*UP*GP*GP*UP*C)-3', ...
Authors:Blatter, N, Bergen, K, Welte, W, Diederichs, K, Marx, A.
Deposit date:2013-07-03
Release date:2013-09-18
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.749 Å)
Cite:Structure and Function of an RNA-Reading Thermostable DNA Polymerase.
Angew.Chem.Int.Ed.Engl., 52, 2013
4C8L
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BU of 4c8l by Molmil
Binary complex of the large fragment of DNA polymerase I from Thermus Aquaticus with the artificial base pair dNaM-d5SICS at the postinsertion site (sequence context 1)
Descriptor: 5'-D(*AP*CP*CP*AP*CP*GP*GP*CP*GP*CP*LHOP)-3', 5'-D(*AP*GP*BMNP*GP*CP*GP*CP*CP*GP*TP*GP*GP*TP)-3', DNA POLYMERASE I, ...
Authors:Betz, K, Malyshev, D.A, Lavergne, T, Welte, W, Diederichs, K, Romesberg, F.E, Marx, A.
Deposit date:2013-10-01
Release date:2013-12-11
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural Insights Into DNA Replication without Hydrogen Bonds.
J.Am.Chem.Soc., 135, 2013
4C8K
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BU of 4c8k by Molmil
Crystal structure of the large fragment of DNA polymerase I from Thermus Aquaticus in a partially closed complex with the artificial base pair d5SICS-dNaMTP
Descriptor: ((2R,3S,5R)-3-hydroxy-5-(3-methoxynaphthalen-2-yl)methyl-tetrahydrogen-triphosphate, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 5'-D(*AP*AP*C*LHOP*GP*GP*CP*GP*CP*CP*GP*TP*GP*GP*TP*C)-3', ...
Authors:Betz, K, Malyshev, D.A, Lavergne, T, Welte, W, Diederichs, K, Romesberg, F.E, Marx, A.
Deposit date:2013-10-01
Release date:2013-12-11
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.17 Å)
Cite:Structural Insights Into DNA Replication without Hydrogen Bonds.
J.Am.Chem.Soc., 135, 2013

221716

數據於2024-06-26公開中

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