7QL2
 
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6GK7
 | | Crystal structure of anti-tau antibody dmCBTAU-27.1, double mutant (S31Y, T100I) of CBTAU-27.1, in complex with Tau peptide A8119B (residues 299-318) | | Descriptor: | CHLORIDE ION, HUMAN FAB ANTIBODY FRAGMENT OF CBTAU-27.1(S31Y,T100I), HUMAN TAU PEPTIDE A8119 RESIDUES 299-318 | | Authors: | Steinbacher, S, Mrosek, M, Juraszek, J. | | Deposit date: | 2018-05-18 | | Release date: | 2018-06-13 | | Method: | X-RAY DIFFRACTION (2.95 Å) | | Cite: | A common antigenic motif recognized by naturally occurring human VH5-51/VL4-1 anti-tau antibodies with distinct functionalities.
Acta Neuropathol Commun, 6, 2018
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8Q9J
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8Q9E
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8Q97
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7QJX
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6DC9
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7P66
 | | Globular glial tauopathy type 1 tau filament | | Descriptor: | Microtubule-associated protein tau | | Authors: | Shi, Y, Zhang, W, Yang, Y, Murzin, A.G, Falcon, B, Kotecha, A, van Beers, M, Tarutani, A, Kametani, F, Garringer, H.J, Vidal, R, Hallinan, G.I, Lashley, T, Saito, Y, Murayama, S, Yoshida, M, Tanaka, H, Kakita, A, Ikeuchi, T, Robinson, A.C, Mann, D.M.A, Kovacs, G.G, Revesz, T, Ghetti, B, Hasegawa, M, Goedert, M, Scheres, S.H.W. | | Deposit date: | 2021-07-15 | | Release date: | 2021-09-15 | | Last modified: | 2021-10-27 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Structure-based classification of tauopathies.
Nature, 598, 2021
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7MKF
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8Q7T
 | | Tau - AD-MIA11 | | Descriptor: | Isoform Tau-D of Microtubule-associated protein tau | | Authors: | Lovestam, S, Li, D, Scheres, S.H.W, Goedert, M. | | Deposit date: | 2023-08-17 | | Release date: | 2023-08-30 | | Last modified: | 2024-01-24 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Disease-specific tau filaments assemble via polymorphic intermediates.
Nature, 625, 2024
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7NRV
 | | Paired helical filament from Alzheimer's disease with PET ligand APN-1607 | | Descriptor: | Microtubule-associated protein tau | | Authors: | Shi, Y, Murzin, A.G, Falcon, B, Epstein, A, Machin, J, Tempest, P, Newell, K.L, Vidal, R, Garringer, H.J, Sahara, N, Higuchi, M, Ghetti, B, Jang, M, Scheres, S.H.W, Goedert, M. | | Deposit date: | 2021-03-04 | | Release date: | 2021-03-24 | | Last modified: | 2024-07-10 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Cryo-EM structures of tau filaments from Alzheimer's disease with PET ligand APN-1607.
Acta Neuropathol, 141, 2021
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6TJX
 | | Cryo-EM structure of TypeII tau filaments extracted from the brains of individuals with Corticobasal degeneration | | Descriptor: | Microtubule-associated protein tau | | Authors: | Zhang, W, Murzin, A.G, Falcon, B, Shi, Y, Goedert, M, Scheres, S.H.W. | | Deposit date: | 2019-11-27 | | Release date: | 2020-02-05 | | Last modified: | 2024-05-22 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Novel tau filament fold in corticobasal degeneration.
Nature, 580, 2020
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9EOG
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7QK1
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8Q8D
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8Q8L
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8Q9A
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8Q92
 | | P301S Tau Filaments from the Brains of PS19 Transgenic Mouse Line | | Descriptor: | Microtubule-associated protein tau | | Authors: | Schweighauser, M, Murzin, A.G, Macdonald, J, Lavenir, I, Crowther, R.A, Scheres, S.H.W, Goedert, M. | | Deposit date: | 2023-08-19 | | Release date: | 2023-10-11 | | Last modified: | 2023-10-18 | | Method: | ELECTRON MICROSCOPY (3.05 Å) | | Cite: | Cryo-EM structures of tau filaments from the brains of mice transgenic for human mutant P301S Tau.
Acta Neuropathol Commun, 11, 2023
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7MKG
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7P67
 | | Globular glial tauopathy type 2 tau filament | | Descriptor: | Microtubule-associated protein tau | | Authors: | Shi, Y, Zhang, W, Yang, Y, Murzin, A.G, Falcon, B, Kotecha, A, van Beers, M, Tarutani, A, Kametani, F, Garringer, H.J, Vidal, R, Hallinan, G.I, Lashley, T, Saito, Y, Murayama, S, Yoshida, M, Tanaka, H, Kakita, A, Ikeuchi, T, Robinson, A.C, Mann, D.M.A, Kovacs, G.G, Revesz, T, Ghetti, B, Hasegawa, M, Goedert, M, Scheres, S.H.W. | | Deposit date: | 2021-07-15 | | Release date: | 2021-09-15 | | Last modified: | 2021-10-27 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Structure-based classification of tauopathies.
Nature, 598, 2021
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8Q9O
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8Q9B
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5MP1
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8R3T
 | | Cofactor-free Tau 4R2N isoform | | Descriptor: | Microtubule-associated protein tau | | Authors: | Limorenko, G, Tatli, M, Kolla, R, Nazarov, S, Weil, M.T, Schondorf, D.C, Geist, D, Reinhardt, P, Ehrnhoefer, D.E, Stahlberg, H, Gasparini, L, Lashuel, H.A. | | Deposit date: | 2023-11-10 | | Release date: | 2023-12-06 | | Last modified: | 2024-01-24 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Fully co-factor-free ClearTau platform produces seeding-competent Tau fibrils for reconstructing pathological Tau aggregates.
Nat Commun, 14, 2023
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8AZU
 | | Paired helical tau filaments from high-spin supernatants of aqueous extracts from Alzheimer's disease brains | PHF Tau | | Descriptor: | Microtubule-associated protein tau | | Authors: | Yang, Y, Stern, M.A, Meunier, L.A, Liu, W, Cai, Y.Q, Ericsson, M, Liu, L, Selkoe, J.D, Goedert, M, Scheres, H.W.S. | | Deposit date: | 2022-09-06 | | Release date: | 2023-05-24 | | Last modified: | 2023-07-19 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Abundant A beta fibrils in ultracentrifugal supernatants of aqueous extracts from Alzheimer's disease brains.
Neuron, 111, 2023
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