3DK9
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![BU of 3dk9 by Molmil](/molmil-images/mine/3dk9) | Catalytic cycle of human glutathione reductase near 1 A resolution | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, Glutathione reductase, SULFATE ION | Authors: | Berkholz, D.S, Faber, H.R, Savvides, S.N, Karplus, P.A. | Deposit date: | 2008-06-24 | Release date: | 2008-08-05 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (0.95 Å) | Cite: | Catalytic cycle of human glutathione reductase near 1 A resolution. J.Mol.Biol., 382, 2008
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3DK8
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![BU of 3dk8 by Molmil](/molmil-images/mine/3dk8) | Catalytic cycle of human glutathione reductase near 1 A resolution | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, GLUTATHIONE, GLYCEROL, ... | Authors: | Berkholz, D.S, Faber, H.R, Savvides, S.N, Karplus, P.A. | Deposit date: | 2008-06-24 | Release date: | 2008-08-05 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.1 Å) | Cite: | Catalytic cycle of human glutathione reductase near 1 A resolution. J.Mol.Biol., 382, 2008
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3DJJ
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![BU of 3djj by Molmil](/molmil-images/mine/3djj) | Catalytic cycle of human glutathione reductase near 1 A resolution | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, Glutathione reductase, ... | Authors: | Berkholz, D.S, Faber, H.R, Savvides, S.N, Karplus, P.A. | Deposit date: | 2008-06-23 | Release date: | 2008-08-05 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.1 Å) | Cite: | Catalytic cycle of human glutathione reductase near 1 A resolution. J.Mol.Biol., 382, 2008
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3DK4
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![BU of 3dk4 by Molmil](/molmil-images/mine/3dk4) | Catalytic cycle of human glutathione reductase near 1 A resolution | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, GLUTATHIONE, Glutathione reductase, ... | Authors: | Berkholz, D.S, Faber, H.R, Savvides, S.N, Karplus, P.A. | Deposit date: | 2008-06-24 | Release date: | 2008-08-05 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.2 Å) | Cite: | Catalytic cycle of human glutathione reductase near 1 A resolution. J.Mol.Biol., 382, 2008
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3GRS
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![BU of 3grs by Molmil](/molmil-images/mine/3grs) | |
2GH5
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![BU of 2gh5 by Molmil](/molmil-images/mine/2gh5) | Crystal Structure of human Glutathione Reductase complexed with a Fluoro-Analogue of the Menadione Derivative M5 | Descriptor: | 6-(3-METHYL-1,4-DIOXO-1,4-DIHYDRONAPHTHALEN-2-YL)HEXANOIC ACID, FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, ... | Authors: | Fritz-Wolf, K, Winzer, A, Bauer, H, Schirmer, H, Davioud-Charvet, E. | Deposit date: | 2006-03-25 | Release date: | 2006-09-26 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | A fluoro analogue of the menadione derivative 6-[2'-(3'-methyl)-1',4'-naphthoquinolyl]hexanoic acid is a suicide substrate of glutathione reductase. Crystal structure of the alkylated human enzyme J.Am.Chem.Soc., 128, 2006
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1GSN
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![BU of 1gsn by Molmil](/molmil-images/mine/1gsn) | HUMAN GLUTATHIONE REDUCTASE MODIFIED BY DINITROSOGLUTATHIONE | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, GLUTATHIONE, GLUTATHIONE REDUCTASE, ... | Authors: | Becker, K, Savvides, S.N, Keese, M, Schirmer, R.H, Karplus, P.A. | Deposit date: | 1998-02-21 | Release date: | 1998-05-27 | Last modified: | 2011-12-07 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Enzyme inactivation through sulfhydryl oxidation by physiologic NO-carriers. Nat.Struct.Biol., 5, 1998
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1DNC
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![BU of 1dnc by Molmil](/molmil-images/mine/1dnc) | HUMAN GLUTATHIONE REDUCTASE MODIFIED BY DIGLUTATHIONE-DINITROSO-IRON | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, GLUTATHIONE, GLUTATHIONE REDUCTASE, ... | Authors: | Becker, K, Savvides, S.N, Keese, M, Schirmer, R.H, Karplus, P.A. | Deposit date: | 1998-02-20 | Release date: | 1998-05-27 | Last modified: | 2011-12-07 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Enzyme inactivation through sulfhydryl oxidation by physiologic NO-carriers. Nat.Struct.Biol., 5, 1998
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3DJG
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![BU of 3djg by Molmil](/molmil-images/mine/3djg) | Catalytic cycle of human glutathione reductase near 1 A resolution | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, Glutathione reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | Authors: | Berkholz, D.S, Faber, H.R, Savvides, S.N, Karplus, P.A. | Deposit date: | 2008-06-23 | Release date: | 2008-08-05 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Catalytic cycle of human glutathione reductase near 1 A resolution. J.Mol.Biol., 382, 2008
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1GRB
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![BU of 1grb by Molmil](/molmil-images/mine/1grb) | |
1K4Q
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![BU of 1k4q by Molmil](/molmil-images/mine/1k4q) | Human Glutathione Reductase Inactivated by Peroxynitrite | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, Glutathione Reductase | Authors: | Savvides, S.N, Scheiwein, M, Boehme, C.C, Arteel, G.E, Karplus, P.A, Becker, K, Schirmer, R.H. | Deposit date: | 2001-10-08 | Release date: | 2002-01-30 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Crystal structure of the antioxidant enzyme glutathione reductase inactivated by peroxynitrite. J.Biol.Chem., 277, 2002
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1GRG
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![BU of 1grg by Molmil](/molmil-images/mine/1grg) | |
1XAN
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![BU of 1xan by Molmil](/molmil-images/mine/1xan) | |
1GRF
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![BU of 1grf by Molmil](/molmil-images/mine/1grf) | |
1GRE
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![BU of 1gre by Molmil](/molmil-images/mine/1gre) | |
1GRA
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![BU of 1gra by Molmil](/molmil-images/mine/1gra) | |
1BWC
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![BU of 1bwc by Molmil](/molmil-images/mine/1bwc) | STRUCTURE OF HUMAN GLUTATHIONE REDUCTASE COMPLEXED with AJOENE INHIBITOR AND SUBVERSIVE SUBSTRATE | Descriptor: | 3-(PROP-2-ENE-1-SULFINYL)-PROPENE-1-THIOL, CHLORIDE ION, FLAVIN-ADENINE DINUCLEOTIDE, ... | Authors: | Gallwitz, H, Bonse, S, Martinez-Cruz, A, Schlichting, I, Schumacher, K, Krauth-Siegel, R.L. | Deposit date: | 1998-09-23 | Release date: | 1999-07-20 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Ajoene is an inhibitor and subversive substrate of human glutathione reductase and Trypanosoma cruzi trypanothione reductase: crystallographic, kinetic, and spectroscopic studies. J.Med.Chem., 42, 1999
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3SQP
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![BU of 3sqp by Molmil](/molmil-images/mine/3sqp) | Structure of human glutathione reductase complexed with pyocyanin, an agent with antimalarial activity | Descriptor: | 5-methylphenazin-1(5H)-one, FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, ... | Authors: | Fritz-Wolf, K, Schirmer, R.H, Koenig, I, Goebel, U. | Deposit date: | 2011-07-06 | Release date: | 2011-09-14 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.21 Å) | Cite: | The bacterial redox signaller pyocyanin as an antiplasmodial agent: comparisons with its thioanalog methylene blue. Redox Rep., 16, 2011
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1GRT
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![BU of 1grt by Molmil](/molmil-images/mine/1grt) | HUMAN GLUTATHIONE REDUCTASE A34E/R37W MUTANT | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, GLUTATHIONE REDUCTASE | Authors: | Stoll, V.S, Simpson, S.J, Krauth-Siegel, R.L, Walsh, C.T, Pai, E.F. | Deposit date: | 1996-12-17 | Release date: | 1997-06-16 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Glutathione reductase turned into trypanothione reductase: structural analysis of an engineered change in substrate specificity. Biochemistry, 36, 1997
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5GRT
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![BU of 5grt by Molmil](/molmil-images/mine/5grt) | HUMAN GLUTATHIONE REDUCTASE A34E, R37W MUTANT, GLUTATHIONYLSPERMIDINE COMPLEX | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, GLUTATHIONE REDUCTASE, GLUTATHIONYLSPERMIDINE DISULFIDE | Authors: | Stoll, V.S, Simpson, S.J, Krauth-Siegel, R.L, Walsh, C.T, Pai, E.F. | Deposit date: | 1997-02-12 | Release date: | 1997-08-12 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Glutathione reductase turned into trypanothione reductase: structural analysis of an engineered change in substrate specificity. Biochemistry, 36, 1997
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4GR1
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![BU of 4gr1 by Molmil](/molmil-images/mine/4gr1) | |
3GRT
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![BU of 3grt by Molmil](/molmil-images/mine/3grt) | HUMAN GLUTATHIONE REDUCTASE A34E, R37W MUTANT, OXIDIZED TRYPANOTHIONE COMPLEX | Descriptor: | 2-AMINO-4-[4-(4-AMINO-4-CARBOXY-BUTYRYLAMINO)-5,8,19,22-TETRAOXO-1,2-DITHIA-6,9,13,18,21-PENTAAZA-CYCLOTETRACOS-23-YLCARBAMOYL]-BUTYRIC ACID, FLAVIN-ADENINE DINUCLEOTIDE, GLUTATHIONE REDUCTASE | Authors: | Stoll, V.S, Simpson, S.J, Krauth-Siegel, R.L, Walsh, C.T, Pai, E.F. | Deposit date: | 1997-02-12 | Release date: | 1997-08-12 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Glutathione reductase turned into trypanothione reductase: structural analysis of an engineered change in substrate specificity. Biochemistry, 36, 1997
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2AAQ
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![BU of 2aaq by Molmil](/molmil-images/mine/2aaq) | Crystal Structure Analysis of the human Glutahione Reductase, complexed with GoPI | Descriptor: | 2-(2-PHENYL-3-PYRIDIN-2-YL-4,5,6,7-TETRAHYDRO-2H-ISOPHOSPHINDOL-1-YL)PYRIDINE, CHLORIDE ION, FLAVIN-ADENINE DINUCLEOTIDE, ... | Authors: | Urig, S, Fritz-Wolf, K, Reau, R, Herold-Mende, C, Toth, K, Davioud-Charvet, E, Becker, K. | Deposit date: | 2005-07-14 | Release date: | 2006-04-04 | Last modified: | 2017-10-11 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Undressing of Phosphine Gold(I) Complexes as Irreversible Inhibitors of Human Disulfide Reductases. Angew.Chem.Int.Ed.Engl., 45, 2006
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2GRT
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![BU of 2grt by Molmil](/molmil-images/mine/2grt) | HUMAN GLUTATHIONE REDUCTASE A34E, R37W MUTANT, OXIDIZED GLUTATHIONE COMPLEX | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, GLUTATHIONE REDUCTASE, OXIDIZED GLUTATHIONE DISULFIDE | Authors: | Stoll, V.S, Simpson, S.J, Krauth-Siegel, R.L, Walsh, C.T, Pai, E.F. | Deposit date: | 1997-02-12 | Release date: | 1997-08-12 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Glutathione reductase turned into trypanothione reductase: structural analysis of an engineered change in substrate specificity. Biochemistry, 36, 1997
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4GRT
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![BU of 4grt by Molmil](/molmil-images/mine/4grt) | HUMAN GLUTATHIONE REDUCTASE A34E, R37W MUTANT, MIXED DISULFIDE BETWEEN TRYPANOTHIONE AND THE ENZYME | Descriptor: | BIS(GAMMA-GLUTAMYL-CYSTEINYL-GLYCINYL)SPERMIDINE, FLAVIN-ADENINE DINUCLEOTIDE, GLUTATHIONE REDUCTASE | Authors: | Stoll, V.S, Simpson, S.J, Krauth-Siegel, R.L, Walsh, C.T, Pai, E.F. | Deposit date: | 1997-02-12 | Release date: | 1997-08-12 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Glutathione reductase turned into trypanothione reductase: structural analysis of an engineered change in substrate specificity. Biochemistry, 36, 1997
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