1BWC

STRUCTURE OF HUMAN GLUTATHIONE REDUCTASE COMPLEXED with AJOENE INHIBITOR AND SUBVERSIVE SUBSTRATE

Summary for 1BWC

Entry DOI	10.2210/pdb1bwc/pdb
Descriptor	PROTEIN (GLUTATHIONE REDUCTASE), CHLORIDE ION, FLAVIN-ADENINE DINUCLEOTIDE, ... (5 entities in total)
Functional Keywords	oxidoreductase, flavoenzyme, redox-active center
Biological source	Homo sapiens (human)
Cellular location	Isoform Mitochondrial: Mitochondrion. Isoform Cytoplasmic: Cytoplasm: P00390
Total number of polymer chains	1
Total formula weight	52619.52
Authors	Gallwitz, H.,Bonse, S.,Martinez-Cruz, A.,Schlichting, I.,Schumacher, K.,Krauth-Siegel, R.L. (deposition date: 1998-09-23, release date: 1999-07-20, Last modification date: 2023-08-09)
Primary citation	Gallwitz, H.,Bonse, S.,Martinez-Cruz, A.,Schlichting, I.,Schumacher, K.,Krauth-Siegel, R.L. Ajoene is an inhibitor and subversive substrate of human glutathione reductase and Trypanosoma cruzi trypanothione reductase: crystallographic, kinetic, and spectroscopic studies. J.Med.Chem., 42:364-372, 1999 Cited by PubMed: 9986706 DOI: 10.1021/jm980471k PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation