PDB: 50 resultsInfo pagesStatus searchChemie searchBIRD

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6TR0	Solution structure of U2AF2 RRM1,2 Descriptor: Splicing factor U2AF 65 kDa subunit Authors: Kang, H.-S, Sattler, M. Deposit date: 2019-12-17 Release date: 2020-05-06 Last modified: 2024-06-19 Method: SOLUTION NMR Cite: An autoinhibitory intramolecular interaction proof-reads RNA recognition by the essential splicing factor U2AF2. Proc.Natl.Acad.Sci.USA, 117, 2020
5W0H	Structure of U2AF65 (U2AF2) RRM2 at 1.11 Angstrom Resolution Descriptor: Splicing factor U2AF 65 kDa subunit Authors: Agrawal, A.A, Jenkins, J.L, Kielkopf, C.L. Deposit date: 2017-05-30 Release date: 2018-04-11 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.11 Å) Cite: Cancer-Associated Mutations Mapped on High-Resolution Structures of the U2AF2 RNA Recognition Motifs. Biochemistry, 56, 2017
5W0G	Structure of U2AF65 (U2AF2) RRM1 at 1.07 resolution Descriptor: 2-(2-{2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHANOL, ACETATE ION, Splicing factor U2AF 65 kDa subunit, ... Authors: Agrawal, A.A, Jenkins, J.L, Kielkopf, C.L. Deposit date: 2017-05-30 Release date: 2018-04-11 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.07 Å) Cite: Cancer-Associated Mutations Mapped on High-Resolution Structures of the U2AF2 RNA Recognition Motifs. Biochemistry, 56, 2017
7SN6	U2AF65 UHM BOUND TO SF3B155 ULM5 Descriptor: ISOPROPYL ALCOHOL, Splicing factor 3B subunit 1, Splicing factor U2AF 65 kDa subunit Authors: Loerch, S, Jenkins, J.L, Kielkopf, C.L. Deposit date: 2021-10-27 Release date: 2022-07-27 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.8 Å) Cite: A UHM-ULM interface with unusual structural features contributes to U2AF2 and SF3B1 association for pre-mRNA splicing. J.Biol.Chem., 298, 2022
7S3A	Crystal structure of intact U2AF65 RRM-region bound to AdML-C5 oligonucleotide Descriptor: DNA/RNA (5'-R(P*UP*UP*(UD)P*CP*U)-D(P*(BRU))-R(P*CP*C)-3'), SODIUM ION, Splicing factor U2AF 65 kDa subunit Authors: Jenkins, J.L, Henderson, S, Kielkopf, C.L. Deposit date: 2021-09-05 Release date: 2022-05-25 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.48 Å) Cite: Pre-mRNA splicing factor U2AF2 recognizes distinct conformations of nucleotide variants at the center of the pre-mRNA splice site signal. Nucleic Acids Res., 50, 2022
7S3B	Crystal structure of intact U2AF65 RRM-region bound to AdML-G5 oligonucleotide Descriptor: DI(HYDROXYETHYL)ETHER, DNA/RNA (5'-R(P*UP*UP*(UD)P*GP*U)-D(P*(BRU))-R(P*CP*C)-3'), Splicing factor U2AF 65 kDa subunit Authors: Jenkins, J.L, Henderson, S, Kielkopf, C.L. Deposit date: 2021-09-05 Release date: 2022-05-25 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (1.89 Å) Cite: Pre-mRNA splicing factor U2AF2 recognizes distinct conformations of nucleotide variants at the center of the pre-mRNA splice site signal. Nucleic Acids Res., 50, 2022
7S3C	Crystal structure of intact U2AF65 RRM-region bound to AdML-A5 oligonucleotide Descriptor: DNA/RNA (5'-R(P*UP*UP*(UD)P*AP*U)-D(P*(BRU))-R(P*CP*C)-3'), Splicing factor U2AF 65 kDa subunit Authors: Glasser, E, Jenkins, J.L, Kielkopf, C.L. Deposit date: 2021-09-05 Release date: 2022-05-25 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.51 Å) Cite: Pre-mRNA splicing factor U2AF2 recognizes distinct conformations of nucleotide variants at the center of the pre-mRNA splice site signal. Nucleic Acids Res., 50, 2022
6XLV	Crystal structure of leukemia-associated N196K mutant of U2AF65 bound to AdML splice site Descriptor: DNA/RNA (5'-R(P*UP*UP*(UD)P*UP*U)-D(P*(BRU))-R(P*CP*C)-3'), Splicing factor U2AF 65 kDa subunit Authors: Maji, D, Jenkins, J.L, Kielkopf, C.L. Deposit date: 2020-06-29 Release date: 2020-10-07 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Representative cancer-associated U2AF2 mutations alter RNA interactions and splicing. J.Biol.Chem., 295, 2020
6XLW	Crystal structure of U2AF65 bound to AdML splice site sequence Descriptor: DI(HYDROXYETHYL)ETHER, DNA/RNA (5'-R(P*UP*UP*(UD)P*UP*U)-D(P*(BRU))-R(P*CP*C)-3'), GLYCEROL, ... Authors: Maji, D, Jenkins, J.L, Kielkopf, C.L. Deposit date: 2020-06-29 Release date: 2020-10-07 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Representative cancer-associated U2AF2 mutations alter RNA interactions and splicing. J.Biol.Chem., 295, 2020
6XLX	Crystal structure of cancer-associated G301D mutant of U2AF65 bound to AdML splice site Descriptor: DNA/RNA (5'-R(P*UP*UP*(UD)P*UP*U)-D(P*(BRU))-R(P*CP*C)-3'), Splicing factor U2AF 65 kDa subunit Authors: Maji, D, Jenkins, J.L, Kielkopf, C.L. Deposit date: 2020-06-29 Release date: 2020-10-07 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Representative cancer-associated U2AF2 mutations alter RNA interactions and splicing. J.Biol.Chem., 295, 2020
9C7A	Crystal structure of R149W neurodevelopmental disease-associated U2AF2 variant Descriptor: DNA/RNA (5'-R(P*UP*U)-D(P*U)-R(P*UP*U)-D(P*(BRU))-R(P*CP*C)-3'), GLYCEROL, SODIUM ION, ... Authors: Maji, D, Jenkins, J.L, Kielkopf, C.L. Deposit date: 2024-06-10 Release date: 2024-10-02 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Recurrent neurodevelopmentally-associated variants of the pre-mRNA splicing factor U2AF2 alter RNA binding affinities and interactions To Be Published
9C7B	Crystal structure of R150H neurodevelopmental disease-associated U2AF2 variant Descriptor: DNA/RNA (5'-R(P*UP*U)-D(P*U)-R(P*UP*U)-D(P*(BRU))-R(P*CP*C)-3'), Splicing factor U2AF 65 kDa subunit Authors: Maji, D, Jenkins, J.L, Kielkopf, C.L. Deposit date: 2024-06-10 Release date: 2024-10-02 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Recurrent neurodevelopmentally-associated variants of the pre-mRNA splicing factor U2AF2 alter RNA binding affinities and interactions To Be Published
8P25	Solution structure of a chimeric U2AF2 RRM2 / FUBP1 N-Box Descriptor: Splicing factor U2AF 65 kDa subunit,Far upstream element-binding protein 1 Authors: Hipp, C, Sattler, M. Deposit date: 2023-05-14 Release date: 2023-07-26 Last modified: 2024-06-19 Method: SOLUTION NMR Cite: FUBP1 is a general splicing factor facilitating 3' splice site recognition and splicing of long introns. Mol.Cell, 83, 2023
7AAF	Structural evolution of the tissue-specific U2AF2 paralog and alternative splicing factor LS2 Descriptor: U2 snRNP auxiliary factor large subunit Authors: Kawale, A.A, Kang, H.S, Sattler, M. Deposit date: 2020-09-04 Release date: 2021-10-06 Last modified: 2024-06-19 Method: SOLUTION NMR Cite: Structural evolution of the tissue-specific U2AF2 paralog and alternative splicing factor LS2 To Be Published
7AAO	Structural evolution of the tissue-specific U2AF2 paralog and alternative splicing factor LS2 Descriptor: U2 snRNP auxiliary factor large subunit Authors: Kawale, A.A, Kang, H.S, Sattler, M. Deposit date: 2020-09-04 Release date: 2021-10-06 Last modified: 2024-06-19 Method: SOLUTION NMR Cite: Structural evolution of the tissue-specific U2AF2 paralog and alternative splicing factor LS2 To Be Published
4YH8	Structure of yeast U2AF complex Descriptor: Splicing factor U2AF 23 kDa subunit, Splicing factor U2AF 59 kDa subunit, ZINC ION Authors: Yoshida, H, Park, S.Y, Urano, T, Obayashi, E. Deposit date: 2015-02-27 Release date: 2015-08-12 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (1.7 Å) Cite: A novel 3' splice site recognition by the two zinc fingers in the U2AF small subunit. Genes Dev., 29, 2015
4FXW	Structure of phosphorylated SF1 complex with U2AF65-UHM domain Descriptor: SULFATE ION, Splicing factor 1, Splicing factor U2AF 65 kDa subunit Authors: Wang, W, Bauer, W.J, Wedekind, J.E, Kielkopf, C.L. Deposit date: 2012-07-03 Release date: 2013-01-16 Last modified: 2017-11-15 Method: X-RAY DIFFRACTION (2.29 Å) Cite: Structure of Phosphorylated SF1 Bound to U2AF(65) in an Essential Splicing Factor Complex. Structure, 21, 2013
5CXT	Crystal structure of a RNA-binding protein 39 (RBM39) in complex with fragment of splicing factor (U2AF) from Unknown at 2.20 A resolution Descriptor: RNA-binding protein 39, Splicing factor U2AF 65 kDa subunit Authors: Joint Center for Structural Genomics (JCSG), Partnership for T-Cell Biology (TCELL) Deposit date: 2015-07-29 Release date: 2015-10-14 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.2 Å) Cite: UHM-ULM interactions in the RBM39-U2AF65 splicing-factor complex. Acta Crystallogr D Struct Biol, 72, 2016
4Z2X	Crystal structure of a RNA binding domain of a U2 small nuclear ribonucleoprotein auxiliary factor 2 (U2AF) from mouse at 2.15 A resolution Descriptor: Splicing factor U2AF 65 kDa subunit Authors: Joint Center for Structural Genomics (JCSG), Partnership for T-Cell Biology (TCELL) Deposit date: 2015-03-30 Release date: 2015-04-08 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.15 Å) Cite: Crystal structure of a RNA binding domain of a U2 small nuclear ribonucleoprotein auxiliary factor 2 (U2AF) from mouse at 2.15 A resolution To be published
2HZC	Crystal structure of the N-terminal RRM of the U2AF large subunit Descriptor: HEXAETHYLENE GLYCOL, Splicing factor U2AF 65 kDa subunit, ZINC ION Authors: Thickman, K.R, Sickmier, E.A, Kielkopf, C.L. Deposit date: 2006-08-08 Release date: 2006-08-29 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (1.47 Å) Cite: Alternative Conformations at the RNA-binding Surface of the N-terminal U2AF(65) RNA Recognition Motif. J.Mol.Biol., 366, 2007
2M0G	Structure, phosphorylation and U2AF65 binding of the Nterminal Domain of splicing factor 1 during 3 splice site Recognition Descriptor: Splicing factor 1, Splicing factor U2AF 65 kDa subunit Authors: Madl, T, Sattler, M, Zhang, Y, Bagdiul, I, Kern, T, Kang, H, Zou, P, Maeusbacher, N, Sieber, S.A, Kraemer, A. Deposit date: 2012-10-25 Release date: 2013-01-30 Last modified: 2024-05-01 Method: SOLUTION NMR Cite: Structure, phosphorylation and U2AF65 binding of the N-terminal domain of splicing factor 1 during 3'-splice site recognition. Nucleic Acids Res., 41, 2013
2M52	NMR Structure of the third RNA Recognition Motif (RRM) of U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) 2 Descriptor: Splicing factor U2AF 65 kDa subunit Authors: Dutta, S.K, Serrano, P, Geralt, M, Wuthrich, K, Joint Center for Structural Genomics (JCSG), Partnership for T-Cell Biology (TCELL) Deposit date: 2013-02-12 Release date: 2013-03-27 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: NMR Structure of the third RNA Recognition Motif (RRM) of U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) 2 To be Published
5EV1	Structure I of Intact U2AF65 Recognizing a 3' Splice Site Signal Descriptor: DI(HYDROXYETHYL)ETHER, DNA/RNA (5'-R(*UP*UP*U)-D(P*UP*UP*(BRU)P*U)-R(P*UP*U)-3'), SODIUM ION, ... Authors: Agrawal, A.A, Jenkins, J.L, Kielkopf, C.L. Deposit date: 2015-11-19 Release date: 2016-02-24 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.037 Å) Cite: An extended U2AF(65)-RNA-binding domain recognizes the 3' splice site signal. Nat Commun, 7, 2016
5EV2	Structure II of Intact U2AF65 Recognizing the 3' Splice Site Signal Descriptor: 1,4-DIETHYLENE DIOXIDE, DI(HYDROXYETHYL)ETHER, DNA (5'-R(P*UP*U)-D(P*UP*U)-R(P*U)-D(P*UP*(BRU)P*U)-3'), ... Authors: Agrawal, A.A, Jenkins, J.L, Kielkopf, C.L. Deposit date: 2015-11-19 Release date: 2016-02-24 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (1.86 Å) Cite: An extended U2AF(65)-RNA-binding domain recognizes the 3' splice site signal. Nat Commun, 7, 2016
5EV3	Structure III of Intact U2AF65 Recognizing the 3' Splice Site Signal Descriptor: DNA/RNA (5'-R(P*UP*U)-D(P*U)-R(P*UP*U)-D(P*(BRU)P*UP*U)-3'), Splicing factor U2AF 65 kDa subunit Authors: Agrawal, A.A, Jenkins, J.L, Kielkopf, C.L. Deposit date: 2015-11-19 Release date: 2016-02-24 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (1.5 Å) Cite: An extended U2AF(65)-RNA-binding domain recognizes the 3' splice site signal. Nat Commun, 7, 2016

 

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