PDB: 2471 resultsInfo pagesStatus searchChemie searchBIRD

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1ERJ	CRYSTAL STRUCTURE OF THE C-TERMINAL WD40 DOMAIN OF TUP1 Descriptor: TRANSCRIPTIONAL REPRESSOR TUP1 Authors: Sprague, E.R, Redd, M.J, Johnson, A.D, Wolberger, C. Deposit date: 2000-04-06 Release date: 2000-07-26 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structure of the C-terminal domain of Tup1, a corepressor of transcription in yeast. EMBO J., 19, 2000
3VL1	Crystal structure of yeast Rpn14 Descriptor: 26S proteasome regulatory subunit RPN14 Authors: Kim, S, Nishide, A, Saeki, Y, Takagi, K, Tanaka, K, Kato, K, Mizushima, T. Deposit date: 2011-11-28 Release date: 2012-05-02 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (1.6 Å) Cite: New crystal structure of the proteasome-dedicated chaperone Rpn14 at 1.6 A resolution Acta Crystallogr.,Sect.F, 68, 2012
2G99	Structural basis for the specific recognition of methylated histone H3 lysine 4 by the WD-40 protein WDR5 Descriptor: Histone H3, WD-repeat protein 5 Authors: Chai, J, Han, Z, Wang, H, Shen, Y. Deposit date: 2006-03-06 Release date: 2006-09-06 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Structural basis for the specific recognition of methylated histone H3 lysine 4 by the WD-40 protein WDR5 To be published
2H6Q	Histone H3 recognition and presentation by the WDR5 module of the MLL1 complex Descriptor: Histone H3 K4-Me3 9-residue peptide, WD-repeat protein 5 Authors: Ruthenburg, A.J, Wang, W.-K, Graybosch, D.M, Li, H, Allis, C.D, Patel, D.J, Verdine, G.L. Deposit date: 2006-06-01 Release date: 2006-07-04 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.87 Å) Cite: Histone H3 recognition and presentation by the WDR5 module of the MLL1 complex. Nat.Struct.Mol.Biol., 13, 2006
1GXR	WD40 Region of Human Groucho/TLE1 Descriptor: CALCIUM ION, TRANSDUCIN-LIKE ENHANCER PROTEIN 1 Authors: Pearl, L.H, Roe, S.M, Pickles, L.M. Deposit date: 2002-04-10 Release date: 2002-06-13 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (1.65 Å) Cite: Crystal Structure of the C-Terminal Wd40 Repeat Domain of the Human Groucho/Tle1 Transcriptional Corepressor Structure, 10, 2002
1YFQ	High resolution S. cerevisiae Bub3 mitotic checkpoint protein Descriptor: ACETATE ION, CALCIUM ION, Cell cycle arrest protein BUB3 Authors: Wilson, D.K, Cerna, D, Chew, E. Deposit date: 2005-01-03 Release date: 2005-01-11 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.1 Å) Cite: The 1.1-a structure of the spindle checkpoint protein bub3p reveals functional regions. J.Biol.Chem., 280, 2005
5HQG	WD40 domain of Human E3 Ubiquitin Ligase COP1 (RFWD2) Descriptor: E3 ubiquitin-protein ligase RFWD2 Authors: Uljon, S, Blacklow, S.C. Deposit date: 2016-01-21 Release date: 2016-04-20 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2 Å) Cite: Structural Basis for Substrate Selectivity of the E3 Ligase COP1. Structure, 24, 2016
5WP3	Crystal Structure of EED in complex with EB22 Descriptor: EB22, Polycomb protein EED, UNKNOWN ATOM OR ION Authors: Dong, C, Tempel, W, Zhu, L, Moody, J.D, Baker, D, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) Deposit date: 2017-08-03 Release date: 2017-09-13 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.55 Å) Cite: First critical repressive H3K27me3 marks in embryonic stem cells identified using designed protein inhibitor. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5I2T	Domain characterization of the WD protein Pwp2 and their relevance in ribosome biogenesis Descriptor: Periodic tryptophan protein 2, SULFATE ION Authors: Fribourg, S, Boissier, F. Deposit date: 2016-02-09 Release date: 2017-06-21 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.543 Å) Cite: Pwp2 mediates UTP-B assembly via two structurally independent domains. Sci Rep, 7, 2017
5IGO	WD40 domain of Arabidopsis thaliana E3 Ubiquitin Ligase COP1 in complex with peptide from Trib1 Descriptor: E3 ubiquitin-protein ligase COP1, Tribbles homolog 1 Authors: Uljon, S, Blacklow, S.C. Deposit date: 2016-02-28 Release date: 2016-04-20 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Structural Basis for Substrate Selectivity of the E3 Ligase COP1. Structure, 24, 2016
2CO0	WDR5 and unmodified Histone H3 complex at 2.25 Angstrom Descriptor: HISTONE H3 DIMETHYL-LYSINE 4, WD-REPEAT PROTEIN 5 Authors: Ruthenburg, A.J, Wang, W, Graybosch, D.M, Li, H, Allis, C.D, Patel, D.J, Verdine, G.L. Deposit date: 2006-05-25 Release date: 2006-07-03 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.25 Å) Cite: Histone H3 Recognition and Presentation by the Wdr5 Module of the Mll1 Complex Nat.Struct.Mol.Biol., 13, 2006
2CNX	WDR5 and Histone H3 Lysine 4 dimethyl complex at 2.1 angstrom Descriptor: HISTONE H3 DIMETHYL-LYSINE 4, WD-REPEAT PROTEIN 5 Authors: Ruthenburg, A.J, Wang, W, Graybosch, D.M, Li, H, Allis, C.D, Patel, D.J, Verdine, G.L. Deposit date: 2006-05-25 Release date: 2006-07-03 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Histone H3 Recognition and Presentation by the Wdr5 Module of the Mll1 Complex Nat.Struct.Mol.Biol., 13, 2006
2CE8	An EH1 peptide bound to the Groucho-TLE WD40 domain. Descriptor: EH1 PEPTIDE, TRANSDUCIN-LIKE ENHANCER PROTEIN 1 Authors: Pickles, L.M, Roe, S.M, Pearl, L.H. Deposit date: 2006-02-03 Release date: 2006-06-14 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.03 Å) Cite: Molecular Recognition of Transcriptional Repressor Motifs by the Wd Domain of the Groucho/Tle Corepressor. Mol.Cell, 22, 2006
2CE9	A WRPW peptide bound to the Groucho-TLE WD40 domain. Descriptor: TRANSDUCIN-LIKE ENHANCER PROTEIN 1, WRPW PEPTIDE Authors: Pickles, L.M, Roe, S.M, Pearl, L.H. Deposit date: 2006-02-03 Release date: 2006-06-14 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.12 Å) Cite: Molecular Recognition of Transcriptional Repressor Motifs by the Wd Domain of the Groucho/Tle Corepressor. Mol.Cell, 22, 2006
2G9A	Structural basis for the specific recognition of methylated histone H3 lysine 4 by the WD-40 protein WDR5 Descriptor: Histone H3, WD-repeat protein 5 Authors: Chai, J, Han, Z, Wang, H, Shen, Y. Deposit date: 2006-03-06 Release date: 2006-09-06 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Structural basis for the specific recognition of methylated histone H3 lysine 4 by the WD-40 protein WDR5 To be published
4GM8	Crystal structure of human WD repeat domain 5 with compound MM-102 Descriptor: MM-102, WD repeat-containing protein 5 Authors: Karatas, H, Townsend, E.C, Chen, Y, Bernard, D, Cao, F, Liu, L, Lei, M, Dou, Y, Wang, S. Deposit date: 2012-08-15 Release date: 2013-07-31 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.601 Å) Cite: High-affinity, small-molecule peptidomimetic inhibitors of MLL1/WDR5 protein-protein interaction. J.Am.Chem.Soc., 135, 2013
4GM9	Crystal structure of human WD repeat domain 5 with compound MM-401 Descriptor: MM-401, WD repeat-containing protein 5 Authors: Karatas, H, Townsend, E.C, Chen, Y, Bernard, D, Liu, L, Dou, Y, Lei, M, Wang, S. Deposit date: 2012-08-15 Release date: 2014-02-19 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Crystal structure of human WD repeat domain 5 with compound MM-401 To be Published
4GM3	Crystal structure of human WD repeat domain 5 with compound MM-101 Descriptor: MM-101, WD repeat-containing protein 5 Authors: Karatas, H, Townsend, E.C, Chen, Y, Bernard, D, Cao, F, Liu, L, Lei, M, Dou, Y, Wang, S. Deposit date: 2012-08-15 Release date: 2013-07-31 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (3.393 Å) Cite: High-affinity, small-molecule peptidomimetic inhibitors of MLL1/WDR5 protein-protein interaction. J.Am.Chem.Soc., 135, 2013
4GMB	Crystal structure of human WD repeat domain 5 with compound MM-402 Descriptor: MM-402, WD repeat-containing protein 5 Authors: Karatas, H, Townsend, E.C, Chen, Y, Bernard, D, Cao, F, Liu, L, Lei, M, Dou, Y, Wang, S. Deposit date: 2012-08-15 Release date: 2014-02-19 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.781 Å) Cite: Discovery of a Highly Potent, Cell-Permeable Macrocyclic Peptidomimetic (MM-589) Targeting the WD Repeat Domain 5 Protein (WDR5)-Mixed Lineage Leukemia (MLL) Protein-Protein Interaction. J.Med.Chem., 60, 2017
1PEV	Crystal Structure of the Actin Interacting Protein from Caenorhabditis Elegans Descriptor: Actin interacting protein 1 Authors: Vorobiev, S, Mohri, K, Fedorov, A.A, Ono, S, Almo, S.C, Burley, S.K, New York SGX Research Center for Structural Genomics (NYSGXRC) Deposit date: 2003-05-22 Release date: 2003-07-01 Last modified: 2023-08-16 Method: X-RAY DIFFRACTION (2 Å) Cite: Identification of functional residues on Caenorhabditis elegans actin-interacting protein 1 (UNC-78) for disassembly of actin depolymerizing factor/cofilin-bound actin filaments. J.Biol.Chem., 279, 2004
1PGU	YEAST ACTIN INTERACTING PROTEIN 1 (AIP1), Se-Met PROTEIN, MONOCLINIC CRYSTAL FORM Descriptor: Actin interacting protein 1, ZINC ION Authors: Voegtli, W.C, Madrona, A.Y, Wilson, D.K. Deposit date: 2003-05-28 Release date: 2003-07-15 Last modified: 2021-10-27 Method: X-RAY DIFFRACTION (2.3 Å) Cite: The structure of Aip1p, a WD repeat protein that regulates Cofilin-mediated actin depolymerization. J.Biol.Chem., 278, 2003
1PI6	YEAST ACTIN INTERACTING PROTEIN 1 (Aip1), ORTHORHOMBIC CRYSTAL FORM Descriptor: Actin interacting protein 1, ZINC ION Authors: Voegtli, W.C, Madrona, A.Y, Wilson, D.K. Deposit date: 2003-05-29 Release date: 2003-07-15 Last modified: 2023-08-16 Method: X-RAY DIFFRACTION (2.5 Å) Cite: The structure of Aip1p, a WD repeat protein that regulates Cofilin-mediated actin depolymerization. J.Biol.Chem., 278, 2003
2XL3	WDR5 IN COMPLEX WITH AN RBBP5 PEPTIDE AND HISTONE H3 PEPTIDE Descriptor: GLYCEROL, HISTONE H3.1, RETINOBLASTOMA-BINDING PROTEIN 5, ... Authors: Odho, Z, Southall, S.M, Wilson, J.R. Deposit date: 2010-07-19 Release date: 2010-08-04 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Characterisation of a Novel Wdr5 Binding Site that Recruits Rbbp5 Through a Conserved Motif and Enhances Methylation of H3K4 by Mll1. J.Biol.Chem., 285, 2010
1NR0	Two Seven-Bladed Beta-Propeller Domains Revealed By The Structure Of A C. elegans Homologue Of Yeast Actin Interacting Protein 1 (AIP1). Descriptor: Actin interacting protein 1, MANGANESE (II) ION Authors: Vorobiev, S.M, Mohri, K, Ono, S, Almo, S.C, Burley, S.K, New York SGX Research Center for Structural Genomics (NYSGXRC) Deposit date: 2003-01-23 Release date: 2003-07-01 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Identification of Functional Residues on Caenorhabditis elegans Actin-interacting Protein 1 (UNC-78) for Disassembly of Actin Depolymerizing Factor/Cofilin-bound Actin Filaments J.Biol.Chem., 279, 2004
2XL2	WDR5 IN COMPLEX WITH AN RBBP5 PEPTIDE RECRUITED TO NOVEL SITE Descriptor: GLYCEROL, RETINOBLASTOMA-BINDING PROTEIN 5, WD REPEAT-CONTAINING PROTEIN 5 Authors: Odho, Z, Southall, S.M, Wilson, J.R. Deposit date: 2010-07-19 Release date: 2010-08-04 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Characterisation of a Novel Wdr5 Binding Site that Recruits Rbbp5 Through a Conserved Motif and Enhances Methylation of H3K4 by Mll1. J.Biol.Chem., 285, 2010

 

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