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4MQ9	Crystal structure of Thermus thermophilus RNA polymerase holoenzyme in complex with GE23077 Descriptor: (2Z)-2-methylbut-2-enoic acid, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... Authors: Ho, M.X, Arnold, E, Ebright, R.H, Zhang, Y, Tuske, S. Deposit date: 2013-09-16 Release date: 2014-05-07 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (3.35 Å) Cite: GE23077 binds to the RNA polymerase 'i' and 'i+1' sites and prevents the binding of initiating nucleotides. Elife, 3, 2014
3UGP	Crystal structure of RNA-polymerase sigma subunit domain 2 complexed with -10 promoter element ssDNA oligo (TATAAT) Descriptor: 5'-D(*TP*GP*TP*AP*TP*AP*AP*TP*GP*GP*G)-3', POTASSIUM ION, RNA polymerase sigma factor Authors: Feklistov, A, Darst, S.A. Deposit date: 2011-11-02 Release date: 2011-12-07 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.697 Å) Cite: Structural basis for promoter-10 element recognition by the bacterial RNA polymerase sigma subunit. Cell(Cambridge,Mass.), 147, 2011
7ZF2	Protomeric substructure from an octameric assembly of M. tuberculosis RNA polymerase in complex with sigma-b initiation factor Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: Trapani, S, Bron, P, Lai Kee Him, J, Brodolin, K, Morichaud, Z, Vishwakarma, R. Deposit date: 2022-03-31 Release date: 2023-02-08 Last modified: 2024-03-27 Method: ELECTRON MICROSCOPY (3.86 Å) Cite: Structural basis of the mycobacterial stress-response RNA polymerase auto-inhibition via oligomerization. Nat Commun, 14, 2023
7P5X	Mycobacterial RNAP with transcriptional activator PafBC Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: Mueller, A.U, Kummer, E, Schilling, C.M, Ban, N, Weber-Ban, E. Deposit date: 2021-07-15 Release date: 2021-12-22 Method: ELECTRON MICROSCOPY (3.2 Å) Cite: Transcriptional control of mycobacterial DNA damage response by sigma adaptation. Sci Adv, 7, 2021
8AD1	RNA polymerase at U-rich pause bound to RNA putL triple mutant - pause prone, closed clamp state Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: Dey, S, Weixlbaumer, A. Deposit date: 2022-07-07 Release date: 2022-10-19 Last modified: 2022-11-02 Method: ELECTRON MICROSCOPY (4.1 Å) Cite: Structural insights into RNA-mediated transcription regulation in bacteria. Mol.Cell, 82, 2022
4X8K	Mycobacterium tuberculosis RbpA-SID in complex with SigmaA domain 2 Descriptor: 1,2-ETHANEDIOL, RNA polymerase sigma factor SigA, RNA polymerase-binding protein RbpA, ... Authors: Hubin, E.A, Flack, J.E, Tabib-Salazar, A, Paget, M.S, Darst, S.A, Campbell, E.A. Deposit date: 2014-12-10 Release date: 2015-06-03 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.202 Å) Cite: Structural, functional, and genetic analyses of the actinobacterial transcription factor RbpA. Proc.Natl.Acad.Sci.USA, 112, 2015
8U3B	Cryo-EM structure of E. coli NarL-transcription activation complex at 3.2A Descriptor: DNA (69-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... Authors: Liu, B, Kompaniiets, D, Wang, D. Deposit date: 2023-09-07 Release date: 2024-01-17 Last modified: 2024-02-21 Method: ELECTRON MICROSCOPY (3.23 Å) Cite: Structural basis for transcription activation by the nitrate-responsive regulator NarL. Nucleic Acids Res., 52, 2024
7C17	The cryo-EM structure of E. coli CueR transcription activation complex with fully duplex promoter DNA Descriptor: DNA (72-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... Authors: Fang, C.L, Zhang, Y. Deposit date: 2020-05-02 Release date: 2020-09-30 Last modified: 2024-03-27 Method: ELECTRON MICROSCOPY (4.22 Å) Cite: CueR activates transcription through a DNA distortion mechanism. Nat.Chem.Biol., 17, 2021
3LEV	HIV-1 antibody 2F5 in complex with epitope scaffold ES2 Descriptor: 2F5 ANTIBODY HEAVY CHAIN, 2F5 ANTIBODY LIGHT CHAIN, ADENOSINE-5'-TRIPHOSPHATE, ... Authors: Ofek, G, Guenaga, F.J, Schief, W.R, Skinner, J, Baker, D, Wyatt, R, Kwong, P.D. Deposit date: 2010-01-15 Release date: 2010-09-29 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Elicitation of structure-specific antibodies by epitope scaffolds. Proc.Natl.Acad.Sci.USA, 107, 2010
5X21	Crystal structure of Thermus thermophilus transcription initiation complex with GpA and pseudouridimycin (PUM) Descriptor: (1S)-1,4-anhydro-5-[(N-carbamimidoylglycyl-N~2~-hydroxy-L-glutaminyl)amino]-5-deoxy-1-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-D-ribitol, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... Authors: Zhang, Y, Ebright, R. Deposit date: 2017-01-29 Release date: 2017-07-05 Last modified: 2022-10-12 Method: X-RAY DIFFRACTION (3.323 Å) Cite: Antibacterial Nucleoside-Analog Inhibitor of Bacterial RNA Polymerase. Cell, 169, 2017
5X22	Crystal structure of Thermus thermophilus transcription initiation complex with GpA and CMPcPP Descriptor: 5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]methyl}phosphoryl]cytidine, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... Authors: Zhang, Y, Ebright, R. Deposit date: 2017-01-29 Release date: 2017-07-05 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (3.35 Å) Cite: Antibacterial Nucleoside-Analog Inhibitor of Bacterial RNA Polymerase. Cell, 169, 2017
2CW0	Crystal structure of Thermus thermophilus RNA polymerase holoenzyme at 3.3 angstroms resolution Descriptor: DNA-directed RNA polymerase alpha chain, DNA-directed RNA polymerase beta chain, DNA-directed RNA polymerase beta' chain, ... Authors: Tuske, S, Sarafianos, S.G, Wang, X, Hudson, B, Sineva, E, Mukhopadhyay, J, Birktoft, J.J, Leroy, O, Ismail, S, Clark Jr, A.D, Dharia, C, Napoli, A, Laptenko, O, Lee, J, Borukhov, S, Ebright, R.H, Arnold, E. Deposit date: 2005-06-15 Release date: 2005-09-20 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (3.3 Å) Cite: Inhibition of bacterial RNA polymerase by streptolydigin: stabilization of a straight-bridge-helix active-center conformation Cell(Cambridge,Mass.), 122, 2005
3LES	2F5 Epitope scaffold ES2 Descriptor: RNA polymerase sigma factor, SULFATE ION Authors: Ofek, G, Guenaga, F.J, Schief, W.R, Skinner, J, Wyatt, R, Baker, D, Kwong, P.D. Deposit date: 2010-01-15 Release date: 2010-09-29 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.77 Å) Cite: Elicitation of structure-specific antibodies by epitope scaffolds. Proc.Natl.Acad.Sci.USA, 107, 2010
5XJ0	T. thermophilus RNA polymerase holoenzyme bound with gp39 and gp76 Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: Ooi, W.Y, Murayama, Y, Mekler, V, Minakhin, L, Severinov, K, Yokoyama, S, Sekine, S. Deposit date: 2017-04-28 Release date: 2017-12-20 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (4.004 Å) Cite: A Thermus phage protein inhibits host RNA polymerase by preventing template DNA strand loading during open promoter complex formation Nucleic Acids Res., 46, 2018
3EQL	Crystal structure of the T. Thermophilus RNA polymerase holoenzyme in complex with antibiotic myxopyronin Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: Vassylyev, D.G, Vassylyeva, M.N, Artsimovitch, I. Deposit date: 2008-09-30 Release date: 2008-10-28 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Transcription inactivation through local refolding of the RNA polymerase structure. Nature, 457, 2009
8JKE	AfsR(T337A) transcription activation complex Descriptor: DNA(65-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... Authors: Wang, Y, Zheng, J. Deposit date: 2023-06-01 Release date: 2024-02-14 Last modified: 2024-04-03 Method: ELECTRON MICROSCOPY (3.67 Å) Cite: Structural and functional characterization of AfsR, an SARP family transcriptional activator of antibiotic biosynthesis in Streptomyces. Plos Biol., 22, 2024
5YIX	Caulobacter crescentus GcrA sigma-interacting domain (SID) in complex with domain 2 of sigma 70 Descriptor: (R,R)-2,3-BUTANEDIOL, Cell cycle regulatory protein GcrA, RNA polymerase sigma factor RpoD, ... Authors: Wu, X, Zhang, Y. Deposit date: 2017-10-06 Release date: 2018-03-21 Last modified: 2024-03-27 Method: X-RAY DIFFRACTION (2.302 Å) Cite: Structural insights into the unique mechanism of transcription activation by Caulobacter crescentus GcrA. Nucleic Acids Res., 46, 2018
3WOD	RNA polymerase-gp39 complex Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: Tagami, S, Sekine, S, Minakhin, L, Esyunina, D, Akasaka, R, Shirouzu, M, Kulbachinskiy, A, Severinov, K, Yokoyama, S. Deposit date: 2013-12-26 Release date: 2014-03-12 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (3.6 Å) Cite: Structural basis for promoter specificity switching of RNA polymerase by a phage factor. Genes Dev., 28, 2014
8DY9	Streptomyces venezuelae RNAP unconstrained open promoter complex with WhiA and WhiB transcription factors Descriptor: DNA (38-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... Authors: Lilic, M, Campbell, E.A. Deposit date: 2022-08-03 Release date: 2023-03-01 Last modified: 2024-06-12 Method: ELECTRON MICROSCOPY (3.12 Å) Cite: Structural basis of dual activation of cell division by the actinobacterial transcription factors WhiA and WhiB. Proc.Natl.Acad.Sci.USA, 120, 2023
8DY7	Streptomyces venezuelae RNAP transcription open promoter complex with WhiA and WhiB transcription factors Descriptor: DNA (71-MER), DNA (78-MER), DNA-directed RNA polymerase subunit alpha, ... Authors: Lilic, M, Campbell, E.A. Deposit date: 2022-08-03 Release date: 2023-03-01 Last modified: 2024-06-12 Method: ELECTRON MICROSCOPY (3.18 Å) Cite: Structural basis of dual activation of cell division by the actinobacterial transcription factors WhiA and WhiB. Proc.Natl.Acad.Sci.USA, 120, 2023
2BE5	Crystal structure of the T. Thermophilus RNA polymerase holoenzyme in complex with inhibitor tagetitoxin Descriptor: DNA-directed RNA polymerase alpha chain, DNA-directed RNA polymerase beta chain, DNA-directed RNA polymerase beta' chain, ... Authors: Vassylyev, D.G, Svetlov, V, Vassylyeva, M.N, Perederina, A, Igarashi, N, Matsugaki, N, Wakatsuki, S, Artsimovitch, I, RIKEN Structural Genomics/Proteomics Initiative (RSGI) Deposit date: 2005-10-22 Release date: 2005-11-08 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Structural basis for transcription inhibition by tagetitoxin Nat.Struct.Mol.Biol., 12, 2005
3DXJ	Crystal structure of thermus thermophilus rna polymerase holoenzyme in complex with the antibiotic myxopyronin Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, BACTERIAL RNA POLYMERASE BETA SUBUNIT; CHAIN C, M, ... Authors: Das, K, Arnold, E. Deposit date: 2008-07-24 Release date: 2008-10-14 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (3 Å) Cite: The RNA polymerase "switch region" is a target for inhibitors. Cell(Cambridge,Mass.), 135, 2008
3UGO	Crystal structure of RNA-polymerase sigma subunit domain 2 complexed with -10 promoter element ssDNA oligo (TACAAT) Descriptor: 5'-D(*TP*GP*TP*AP*CP*AP*AP*TP*GP*GP*G)-3', POTASSIUM ION, RNA polymerase sigma factor Authors: Feklistov, A, Darst, S.A. Deposit date: 2011-11-02 Release date: 2011-12-07 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.096 Å) Cite: Structural basis for promoter-10 element recognition by the bacterial RNA polymerase sigma subunit. Cell(Cambridge,Mass.), 147, 2011
1SIG	CRYSTAL STRUCTURE OF A SIGMA70 SUBUNIT FRAGMENT FROM ESCHERICHIA COLI RNA POLYMERASE Descriptor: RNA POLYMERASE PRIMARY SIGMA FACTOR Authors: Malhotra, A, Severinova, E, Darst, S.A. Deposit date: 1997-02-18 Release date: 1997-05-15 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Crystal structure of a sigma 70 subunit fragment from E. coli RNA polymerase. Cell(Cambridge,Mass.), 87, 1996
1SMY	Structural basis for transcription regulation by alarmone ppGpp Descriptor: DNA-directed RNA polymerase alpha chain, DNA-directed RNA polymerase beta chain, DNA-directed RNA polymerase beta' chain, ... Authors: Artsimovitch, I, Patlan, V, Sekine, S, Vassylyeva, M.N, Hosaka, T, Ochi, K, Yokoyama, S, Vassylyev, D.G, RIKEN Structural Genomics/Proteomics Initiative (RSGI) Deposit date: 2004-03-10 Release date: 2004-05-18 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Structural basis for transcription regulation by alarmone ppGpp Cell(Cambridge,Mass.), 117, 2004

 

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