5DIS
 
 | | Crystal structure of a CRM1-RanGTP-SPN1 export complex bound to a 113 amino acid FG-repeat containing fragment of Nup214 | | Descriptor: | Exportin-1, GTP-binding nuclear protein Ran, GUANOSINE-5'-TRIPHOSPHATE, ... | | Authors: | Monecke, T, Port, S.A, Dickmanns, A, Kehlenbach, R.H, Ficner, R. | | Deposit date: | 2015-09-01 | | Release date: | 2015-11-04 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (2.85 Å) | | Cite: | Structural and Functional Characterization of CRM1-Nup214 Interactions Reveals Multiple FG-Binding Sites Involved in Nuclear Export.
Cell Rep, 13, 2015
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3FHC
 | | Crystal structure of human Dbp5 in complex with Nup214 | | Descriptor: | ATP-dependent RNA helicase DDX19B, Nuclear pore complex protein Nup214 | | Authors: | von Moeller, H, Conti, E. | | Deposit date: | 2008-12-09 | | Release date: | 2009-02-17 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | The mRNA export protein DBP5 binds RNA and the cytoplasmic nucleoporin NUP214 in a mutually exclusive manner
Nat.Struct.Mol.Biol., 16, 2009
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3FMP
 | | Crystal structure of the nucleoporin Nup214 in complex with the DEAD-box helicase Ddx19 | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ATP-dependent RNA helicase DDX19B, Nuclear pore complex protein Nup214 | | Authors: | Napetschnig, J, Debler, E.W, Blobel, G, Hoelz, A. | | Deposit date: | 2008-12-22 | | Release date: | 2009-05-19 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (3.19 Å) | | Cite: | Structural and functional analysis of the interaction between the nucleoporin Nup214 and the DEAD-box helicase Ddx19.
Proc.Natl.Acad.Sci.USA, 106, 2009
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3FMO
 | | Crystal structure of the nucleoporin Nup214 in complex with the DEAD-box helicase Ddx19 | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ATP-dependent RNA helicase DDX19B, GLYCEROL, ... | | Authors: | Napetschnig, J, Debler, E.W, Blobel, G, Hoelz, A. | | Deposit date: | 2008-12-22 | | Release date: | 2009-05-19 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2.51 Å) | | Cite: | Structural and functional analysis of the interaction between the nucleoporin Nup214 and the DEAD-box helicase Ddx19.
Proc.Natl.Acad.Sci.USA, 106, 2009
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2OIT
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3FHT
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6LK8
 | | Structure of Xenopus laevis Cytoplasmic Ring subunit. | | Descriptor: | GATOR complex protein SEC13, MGC154553 protein, MGC83295 protein, ... | | Authors: | Shi, Y, Huang, G, Yan, C, Zhang, Y. | | Deposit date: | 2019-12-18 | | Release date: | 2021-07-21 | | Last modified: | 2024-05-29 | | Method: | ELECTRON MICROSCOPY (5.5 Å) | | Cite: | Structure of the cytoplasmic ring of the Xenopus laevis nuclear pore complex by cryo-electron microscopy single particle analysis.
Cell Res., 30, 2020
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7TDZ
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7TBM
 | | Composite structure of the dilated human nuclear pore complex (NPC) generated with a 37A in situ cryo-ET map of CD4+ T cell NPC | | Descriptor: | DDX19, NUP107 CTD, NUP107 NTD, ... | | Authors: | Bley, C.J, Nie, S, Mobbs, G.W, Petrovic, S, Gres, A.T, Liu, X, Mukherjee, S, Harvey, S, Huber, F.M, Lin, D.H, Brown, B, Tang, A.W, Rundlet, E.J, Correia, A.R, Chen, S, Regmi, S.G, Stevens, T.A, Jette, C.A, Dasso, M, Patke, A, Palazzo, A.F, Kossiakoff, A.A, Hoelz, A. | | Deposit date: | 2021-12-22 | | Release date: | 2022-06-15 | | Last modified: | 2022-06-22 | | Method: | ELECTRON MICROSCOPY (37 Å) | | Cite: | Architecture of the cytoplasmic face of the nuclear pore.
Science, 376, 2022
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7TBL
 | | Composite structure of the human nuclear pore complex (NPC) cytoplasmic face generated with a 12A cryo-ET map of the purified HeLa cell NPC | | Descriptor: | DDX19, ELYS, GLE1, ... | | Authors: | Bley, C.J, Nie, S, Mobbs, G.W, Petrovic, S, Gres, A.T, Liu, X, Mukherjee, S, Harvey, S, Huber, F.M, Lin, D.H, Brown, B, Tang, A.W, Rundlet, E.J, Correia, A.R, Chen, S, Regmi, S.G, Stevens, T.A, Jette, C.A, Dasso, M, Patke, A, Palazzo, A.F, Kossiakoff, A.A, Hoelz, A. | | Deposit date: | 2021-12-22 | | Release date: | 2022-06-22 | | Last modified: | 2022-06-29 | | Method: | ELECTRON MICROSCOPY (23 Å) | | Cite: | Architecture of the cytoplasmic face of the nuclear pore.
Science, 376, 2022
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7R5K
 | | Human nuclear pore complex (constricted) | | Descriptor: | Aladin, E3 SUMO-protein ligase RanBP2, Nuclear pore complex protein Nup107, ... | | Authors: | Mosalaganti, S, Obarska-Kosinska, A, Siggel, M, Taniguchi, R, Turonova, B, Zimmerli, C.E, Buczak, K, Schmidt, F.H, Margiotta, E, Mackmull, M.T, Hagen, W.J.H, Hummer, G, Kosinski, J, Beck, M. | | Deposit date: | 2022-02-10 | | Release date: | 2022-06-22 | | Last modified: | 2022-06-29 | | Method: | ELECTRON MICROSCOPY (12 Å) | | Cite: | AI-based structure prediction empowers integrative structural analysis of human nuclear pores.
Science, 376, 2022
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7R5J
 | | Human nuclear pore complex (dilated) | | Descriptor: | Aladin, E3 SUMO-protein ligase RanBP2, Nuclear pore complex protein Nup107, ... | | Authors: | Mosalaganti, S, Obarska-Kosinska, A, Siggel, M, Taniguchi, R, Turonova, B, Zimmerli, C.E, Buczak, K, Schmidt, F.H, Margiotta, E, Mackmull, M.T, Hagen, W.J.H, Hummer, G, Kosinski, J, Beck, M. | | Deposit date: | 2022-02-10 | | Release date: | 2022-09-21 | | Last modified: | 2022-12-21 | | Method: | ELECTRON MICROSCOPY (50 Å) | | Cite: | AI-based structure prediction empowers integrative structural analysis of human nuclear pores
Science, 376, 2022
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4JHJ
 | | Crystal structure of Danio rerio Slip1 in complex with Dbp5 | | Descriptor: | DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 19 (DBP5 homolog, yeast), MIF4G domain-containing protein B | | Authors: | Von Moeller, H, Conti, E. | | Deposit date: | 2013-03-05 | | Release date: | 2013-07-10 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (3.25 Å) | | Cite: | Structural and biochemical studies of SLIP1-SLBP identify DBP5 and eIF3g as SLIP1-binding proteins.
Nucleic Acids Res., 41, 2013
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7ZOX
 | | Nup93 in complex with xhNup93-Nb4i and xNup93-Nb2t | | Descriptor: | Nuclear pore complex protein Nup93, xNup93-Nb2t, xhNup93-Nb4i | | Authors: | Fu, Z, Guttler, T, Colom, M.S. | | Deposit date: | 2022-04-26 | | Release date: | 2023-11-08 | | Last modified: | 2024-05-22 | | Method: | ELECTRON MICROSCOPY (4.4 Å) | | Cite: | A checkpoint function for Nup98 in nuclear pore formation suggested by novel inhibitory nanobodies.
Embo J., 2024
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8OZB
 | | Crystal structure of Nup35-Nb complex | | Descriptor: | Nucleoporin NUP35, Nup35 nanobody | | Authors: | Srinivasan, V. | | Deposit date: | 2023-05-08 | | Release date: | 2024-02-28 | | Last modified: | 2024-06-12 | | Method: | X-RAY DIFFRACTION (2.09 Å) | | Cite: | A checkpoint function for Nup98 in nuclear pore formation suggested by novel inhibitory nanobodies.
Embo J., 43, 2024
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1OPL
 | | Structural basis for the auto-inhibition of c-Abl tyrosine kinase | | Descriptor: | 6-(2,6-DICHLOROPHENYL)-2-{[3-(HYDROXYMETHYL)PHENYL]AMINO}-8-METHYLPYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE, MYRISTIC ACID, proto-oncogene tyrosine-protein kinase | | Authors: | Nagar, B, Hantschel, O, Young, M.A, Scheffzek, K, Veach, D, Bornmann, W, Clarkson, B, Superti-Furga, G, Kuriyan, J. | | Deposit date: | 2003-03-06 | | Release date: | 2003-04-08 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (3.42 Å) | | Cite: | Structural basis for the autoinhibition of c-Abl tyrosine kinase
Cell(Cambridge,Mass.), 112, 2003
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8CDT
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8CDS
 | | Crystal structure of the xhNup93-Nb4i VHH antibody | | Descriptor: | 1,2-ETHANEDIOL, 5-Nup93 inhibitory VHH antibody, DI(HYDROXYETHYL)ETHER | | Authors: | Guttler, T, Colom, M.S, Gorlich, D. | | Deposit date: | 2023-02-01 | | Release date: | 2024-02-21 | | Last modified: | 2024-06-12 | | Method: | X-RAY DIFFRACTION (1.53 Å) | | Cite: | A checkpoint function for Nup98 in nuclear pore formation suggested by novel inhibitory nanobodies.
Embo J., 43, 2024
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7VCI
 | | Structure of Xenopus laevis NPC nuclear ring asymmetric unit | | Descriptor: | GATOR complex protein SEC13, MGC154553 protein, MGC83295 protein, ... | | Authors: | Tai, L, Zhu, Y, Sun, F. | | Deposit date: | 2021-09-03 | | Release date: | 2022-02-02 | | Last modified: | 2022-07-13 | | Method: | ELECTRON MICROSCOPY (8.1 Å) | | Cite: | 8 angstrom structure of the outer rings of the Xenopus laevis nuclear pore complex obtained by cryo-EM and AI.
Protein Cell, 13, 2022
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7VOP
 | | Cryo-EM structure of Xenopus laevis nuclear pore complex cytoplasmic ring subunit | | Descriptor: | GATOR complex protein SEC13, IL4I1 protein, MGC154553 protein, ... | | Authors: | Tai, L, Zhu, Y, Sun, F. | | Deposit date: | 2021-10-14 | | Release date: | 2022-02-02 | | Last modified: | 2022-07-13 | | Method: | ELECTRON MICROSCOPY (8.7 Å) | | Cite: | 8 angstrom structure of the outer rings of the Xenopus laevis nuclear pore complex obtained by cryo-EM and AI.
Protein Cell, 13, 2022
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7NOW
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7NQA
 | | Crystal structure of Nucleoporin-98 nanobody MS98-6 complex solved at 2.2A resolution | | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Anti-Nup98 Nanobody MS98-6, Nuclear pore complex protein Nup98-Nup96, ... | | Authors: | Sola-Colom, M, Trakhanov, S, Goerlich, D. | | Deposit date: | 2021-03-01 | | Release date: | 2021-07-21 | | Last modified: | 2024-05-22 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | A checkpoint function for Nup98 in nuclear pore formation suggested by novel inhibitory nanobodies.
Embo J., 2024
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3PEU
 | | S. cerevisiae Dbp5 L327V C-terminal domain bound to Gle1 H337R and IP6 | | Descriptor: | ATP-dependent RNA helicase DBP5, GLYCEROL, INOSITOL HEXAKISPHOSPHATE, ... | | Authors: | Montpetit, B, Thomsen, N.D, Helmke, K.J, Seeliger, M.A, Berger, J.M, Weis, K. | | Deposit date: | 2010-10-27 | | Release date: | 2011-03-23 | | Last modified: | 2020-10-14 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | A conserved mechanism of DEAD-box ATPase activation by nucleoporins and InsP(6) in mRNA export.
Nature, 472, 2011
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3PEW
 | | S. cerevisiae Dbp5 L327V bound to RNA and ADP BeF3 | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ATP-dependent RNA helicase DBP5, BERYLLIUM TRIFLUORIDE ION, ... | | Authors: | Montpetit, B, Thomsen, N.D, Helmke, K.J, Seeliger, M.A, Berger, J.M, Weis, K. | | Deposit date: | 2010-10-27 | | Release date: | 2011-03-23 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (1.501 Å) | | Cite: | A conserved mechanism of DEAD-box ATPase activation by nucleoporins and InsP(6) in mRNA export.
Nature, 472, 2011
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3PEV
 | | S. cerevisiae Dbp5 L327V C-terminal domain bound to Gle1 and IP6 | | Descriptor: | ATP-dependent RNA helicase DBP5, GLYCEROL, INOSITOL HEXAKISPHOSPHATE, ... | | Authors: | Montpetit, B, Thomsen, N.D, Helmke, K.J, Seeliger, M.A, Berger, J.M, Weis, K. | | Deposit date: | 2010-10-27 | | Release date: | 2011-03-23 | | Last modified: | 2020-10-14 | | Method: | X-RAY DIFFRACTION (2.499 Å) | | Cite: | A conserved mechanism of DEAD-box ATPase activation by nucleoporins and InsP(6) in mRNA export.
Nature, 472, 2011
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