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6S0M
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BU of 6s0m by Molmil
Structural and dynamic studies provide insights into specificity and allosteric regulation of Ribonuclease AS, a key enzyme in mycobacterial virulence
Descriptor: 3'-5' exoribonuclease, MAGNESIUM ION, RNA (5'-R(P*G)-3')
Authors:Berisio, R, Romano, M.
Deposit date:2019-06-17
Release date:2019-08-28
Last modified:2024-05-15
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural and dynamic studies provide insights into specificity and allosteric regulation of ribonuclease as, a key enzyme in mycobacterial virulence.
J.Biomol.Struct.Dyn., 38, 2020
7TTO
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BU of 7tto by Molmil
P450 (OxyA) from kistamicin biosynthesis, mixed heme conformation
Descriptor: PROTOPORPHYRIN IX CONTAINING FE, cytochrome P450 hydroxylase
Authors:Greule, A, Izore, T, Cryle, M.J.
Deposit date:2022-02-01
Release date:2022-05-11
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:The Cytochrome P450 OxyA from the Kistamicin Biosynthesis Cyclization Cascade is Highly Sensitive to Oxidative Damage.
Front Chem, 10, 2022
1M6M
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BU of 1m6m by Molmil
V68N MET MYOGLOBIN
Descriptor: PROTEIN (MYOGLOBIN), PROTOPORPHYRIN IX CONTAINING FE
Authors:Murshudov, G.N, Krzywda, S, Brzozowski, A.M, Jaskolski, M, Scott, E.E, Klizas, S.A, Gibson, Q.H, Olson, J.S, Wilkinson, A.J.
Deposit date:1998-08-13
Release date:1998-08-19
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Stabilizing bound O2 in myoglobin by valine68 (E11) to asparagine substitution.
Biochemistry, 37, 1998
7TTB
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BU of 7ttb by Molmil
P450 (OxyA) from kistamicin biosynthesis, Y99F mutant
Descriptor: GLYCEROL, PROTOPORPHYRIN IX CONTAINING FE, Putative cytochrome P450 hydroxylase
Authors:Greule, A, Izore, T, Cryle, M.J.
Deposit date:2022-02-01
Release date:2022-05-11
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.801592 Å)
Cite:The Cytochrome P450 OxyA from the Kistamicin Biosynthesis Cyclization Cascade is Highly Sensitive to Oxidative Damage.
Front Chem, 10, 2022
1CR8
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BU of 1cr8 by Molmil
LOW DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN COMPLEMENT REPEAT 8
Descriptor: CALCIUM ION, PROTEIN (LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN)
Authors:Huang, W, Dolmer, K, Gettins, P.G.W.
Deposit date:1998-12-14
Release date:1998-12-23
Last modified:2023-12-27
Method:SOLUTION NMR
Cite:NMR solution structure of complement-like repeat CR8 from the low density lipoprotein receptor-related protein.
J.Biol.Chem., 274, 1999
3L6C
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BU of 3l6c by Molmil
X-ray crystal structure of rat serine racemase in complex with malonate a potent inhibitor
Descriptor: MALONATE ION, MANGANESE (II) ION, PYRIDOXAL-5'-PHOSPHATE, ...
Authors:Smith, M.A, Mack, V, Ebneth, A, Moraes, I, Felicetti, B, Wood, M, Schonfeld, D, Mather, O, Cesura, A, Barker, J.
Deposit date:2009-12-23
Release date:2010-01-26
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The structure of mammalian serine racemase: evidence for conformational changes upon inhibitor binding.
J.Biol.Chem., 285, 2010
1MNO
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BU of 1mno by Molmil
V68N MYOGLOBIN OXY FORM
Descriptor: OXYGEN MOLECULE, PROTEIN (MYOGLOBIN), PROTOPORPHYRIN IX CONTAINING FE
Authors:Murshudov, G.N, Krzywda, S, Brzozowski, A.M, Jaskolski, M, Scott, E.E, Klizas, S.A, Gibson, Q.H, Olson, J.S, Wilkinson, A.J.
Deposit date:1998-08-13
Release date:1998-08-19
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Stabilizing bound O2 in myoglobin by valine68 (E11) to asparagine substitution.
Biochemistry, 37, 1998
7RNL
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BU of 7rnl by Molmil
Yeast CTP Synthase (Ura7) H360R Filament bound to Substrates
Descriptor: CTP synthase, CYTIDINE-5'-TRIPHOSPHATE, MAGNESIUM ION
Authors:Hansen, J.M, Lynch, E.M, Farrell, D.P, DiMaio, F, Quispe, J, Kollman, J.M.
Deposit date:2021-07-29
Release date:2021-11-24
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Cryo-EM structures of CTP synthase filaments reveal mechanism of pH-sensitive assembly during budding yeast starvation.
Elife, 10, 2021
7RMF
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BU of 7rmf by Molmil
Substrate-bound Ura7 filament at low pH
Descriptor: CTP synthase
Authors:Hansen, J.M, Lynch, E.M, Farrell, D.P, DiMaio, F, Quispe, J, Kollman, J.M.
Deposit date:2021-07-27
Release date:2021-11-24
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (7.3 Å)
Cite:Cryo-EM structures of CTP synthase filaments reveal mechanism of pH-sensitive assembly during budding yeast starvation.
Elife, 10, 2021
7RL5
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BU of 7rl5 by Molmil
Yeast CTP Synthase (URA8) filament bound to CTP at low pH
Descriptor: CTP synthase, CYTIDINE-5'-TRIPHOSPHATE
Authors:Hansen, J.M, Lynch, E.M, Farrell, D.P, DiMaio, F, Quispe, J, Kollman, J.M.
Deposit date:2021-07-23
Release date:2021-11-24
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Cryo-EM structures of CTP synthase filaments reveal mechanism of pH-sensitive assembly during budding yeast starvation.
Elife, 10, 2021
7RMO
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BU of 7rmo by Molmil
Yeast CTP Synthase (Ura7) Bundle bound to Products at low pH
Descriptor: CTP synthase, CYTIDINE-5'-TRIPHOSPHATE
Authors:Hansen, J.M, Lynch, E.M, Farrell, D.P, DiMaio, F, Quispe, J, Kollman, J.M.
Deposit date:2021-07-27
Release date:2021-11-24
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (7 Å)
Cite:Cryo-EM structures of CTP synthase filaments reveal mechanism of pH-sensitive assembly during budding yeast starvation.
Elife, 10, 2021
7RL0
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BU of 7rl0 by Molmil
Yeast CTP Synthase (URA8) Filament bound to ATP/UTP at low pH
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, CTP synthase, MAGNESIUM ION, ...
Authors:Hansen, J.M, Lynch, E.M, Farrell, D.P, DiMaio, F, Quispe, J, Kollman, J.M.
Deposit date:2021-07-22
Release date:2021-11-24
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Cryo-EM structures of CTP synthase filaments reveal mechanism of pH-sensitive assembly during budding yeast starvation.
Elife, 10, 2021
6XQ8
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BU of 6xq8 by Molmil
Receptor for Advanced Glycation End Products VC1 domain in complex with Fragments 1 & 11
Descriptor: 3-phenoxyphenol, 7-methyl-3-phenyl-1H-indole-2-carboxylic acid, ACETATE ION, ...
Authors:Salay, L.E, Kozlyuk, N, Gilston, B.A, Gogliotti, R.D, Christov, P.P, Kim, K, Ovee, M, Waterson, A.G, Chazin, W.J.
Deposit date:2020-07-09
Release date:2021-07-14
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:A fragment-based approach to discovery of Receptor for Advanced Glycation End products inhibitors.
Proteins, 89, 2021
6XQ5
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BU of 6xq5 by Molmil
Receptor for Advanced Glycation End Products VC1 domain in complex with Fragment 1
Descriptor: 7-methyl-3-phenyl-1H-indole-2-carboxylic acid, ACETATE ION, Advanced glycosylation end product-specific receptor, ...
Authors:Salay, L.E, Kozlyuk, N, Gilston, B.A, Gogliotti, R.D, Christov, P.P, Kim, K, Ovee, M, Waterson, A.G, Chazin, W.J.
Deposit date:2020-07-09
Release date:2021-07-14
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:A fragment-based approach to discovery of Receptor for Advanced Glycation End products inhibitors.
Proteins, 89, 2021
5K7X
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BU of 5k7x by Molmil
Fully ligated Adenylosuccinate Synthetase from Pyrococcus horikoshii OT3 with GTP, IMP and Hadacidin
Descriptor: Adenylosuccinate synthetase, GUANOSINE-5'-TRIPHOSPHATE, HADACIDIN, ...
Authors:Xie, Y, Cheng, Z.
Deposit date:2016-05-27
Release date:2016-12-07
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.803 Å)
Cite:Crystal structure of hypothetical adenylosuccinate synthetase, PH0438 from Pyrococcus horikoshii OT3
To Be Published
6XQ7
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BU of 6xq7 by Molmil
Receptor for Advanced Glycation End Products VC1 domain in complex with Fragment 5
Descriptor: 5-bromo-3-methyl-1H-indole-2-carboxylic acid, ACETATE ION, Advanced glycosylation end product-specific receptor, ...
Authors:Salay, L.E, Kozlyuk, N, Gilston, B.A, Gogliotti, R.D, Christov, P.P, Kim, K, Ovee, M, Waterson, A.G, Chazin, W.J.
Deposit date:2020-07-09
Release date:2021-07-14
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:A fragment-based approach to discovery of Receptor for Advanced Glycation End products inhibitors.
Proteins, 89, 2021
7MIS
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BU of 7mis by Molmil
Cryo-EM structure of SidJ-SdeC-CaM reaction intermediate complex
Descriptor: ADENOSINE MONOPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, ...
Authors:Osinski, A, Black, M.H, Pawlowski, K, Chen, Z, Li, Y, Tagliabracci, V.S.
Deposit date:2021-04-17
Release date:2021-08-18
Last modified:2021-11-17
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Structural and mechanistic basis for protein glutamylation by the kinase fold.
Mol.Cell, 81, 2021
6XQ9
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BU of 6xq9 by Molmil
Receptor for Advanced Glycation End Products VC1 domain in complex with Fragments 1 & 13
Descriptor: 4-(3-hydroxyphenoxy)benzoic acid, 7-methyl-3-phenyl-1H-indole-2-carboxylic acid, ACETATE ION, ...
Authors:Salay, L.E, Kozlyuk, N, Gilston, B.A, Gogliotti, R.D, Christov, P.P, Kim, K, Ovee, M, Waterson, A.G, Chazin, W.J.
Deposit date:2020-07-09
Release date:2021-07-14
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:A fragment-based approach to discovery of Receptor for Advanced Glycation End products inhibitors.
Proteins, 89, 2021
7MIR
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BU of 7mir by Molmil
Cryo-EM structure of SidJ-SdeA-CaM reaction intermediate complex
Descriptor: ADENOSINE MONOPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, ...
Authors:Osinski, A, Black, M.H, Pawlowski, K, Chen, Z, Li, Y, Tagliabracci, V.S.
Deposit date:2021-04-17
Release date:2021-08-18
Last modified:2024-05-29
Method:ELECTRON MICROSCOPY (2.5 Å)
Cite:Structural and mechanistic basis for protein glutamylation by the kinase fold.
Mol.Cell, 81, 2021
2QWY
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BU of 2qwy by Molmil
SAM-II riboswitch bound to S-adenosylmethionine
Descriptor: CESIUM ION, MAGNESIUM ION, PHOSPHATE ION, ...
Authors:Gilbert, S.D, Rambo, R.P, Van Tyne, D, Batey, R.T.
Deposit date:2007-08-10
Release date:2008-01-22
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure of the SAM-II riboswitch bound to S-adenosylmethionine.
Nat.Struct.Mol.Biol., 15, 2008
5M96
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BU of 5m96 by Molmil
Synthesis and biological evaluation of new triazolo and imidazolopyridine RORgt inverse agonists
Descriptor: Nuclear receptor ROR-gamma, ~{N}-[8-[[(3~{S})-4-cyclopentylcarbonyl-3-methyl-piperazin-1-yl]methyl]-7-methyl-imidazo[1,2-a]pyridin-6-yl]-2-methyl-pyrimidine-5-carboxamide
Authors:Kallen, J.
Deposit date:2016-10-31
Release date:2016-12-14
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.77 Å)
Cite:Synthesis and Biological Evaluation of New Triazolo- and Imidazolopyridine ROR gamma t Inverse Agonists.
ChemMedChem, 11, 2016
1MWD
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BU of 1mwd by Molmil
WILD TYPE DEOXY MYOGLOBIN
Descriptor: PROTEIN (MYOGLOBIN), PROTOPORPHYRIN IX CONTAINING FE
Authors:Murshudov, G.N, Krzywda, S, Brzozowski, A.M, Jaskolski, M, Scott, E.E, Klizas, A.A, Gibson, Q.H, Olson, J.S, Wilkinson, A.J.
Deposit date:1998-08-11
Release date:1998-08-19
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Stabilizing bound O2 in myoglobin by valine68 (E11) to asparagine substitution.
Biochemistry, 37, 1998
5XPJ
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BU of 5xpj by Molmil
Crystal Structure of Periplasmic glucose binding protein ppGBP deletion mutant- Del-ppGBP
Descriptor: Binding protein component of ABC sugar transporter
Authors:Pandey, S, Phale, P.S, Bhaumik, P.
Deposit date:2017-06-02
Release date:2018-10-10
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural modulation of a periplasmic sugar-binding protein probes into its evolutionary ancestry.
J. Struct. Biol., 204, 2018
4QY3
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BU of 4qy3 by Molmil
THE CRYSTAL STRUCTURE OF THE COMPLEX of HCAII WITH AN ORTHO-SUBSTITUTED BENZOIC ACID
Descriptor: 2-[(S)-benzylsulfinyl]benzoic acid, 4-(HYDROXYMERCURY)BENZOIC ACID, Carbonic anhydrase 2, ...
Authors:D'Ambrosio, K, De Simone, G.
Deposit date:2014-07-23
Release date:2014-12-03
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Out of the active site binding pocket for carbonic anhydrase inhibitors.
Chem.Commun.(Camb.), 51, 2014
8E94
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BU of 8e94 by Molmil
PYD-106-bound Human GluN1a-GluN2C NMDA receptor in intact conformation
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Chou, T.-H, Furukawa, H.
Deposit date:2022-08-26
Release date:2022-12-07
Last modified:2022-12-14
Method:ELECTRON MICROSCOPY (3.72 Å)
Cite:Structural insights into assembly and function of GluN1-2C, GluN1-2A-2C, and GluN1-2D NMDARs.
Mol.Cell, 82, 2022

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数据于2024-09-11公开中

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