PDB: 5425 resultsInfo pagesStatus searchChemie searchBIRD

---

1XNA	NMR SOLUTION STRUCTURE OF THE SINGLE-STRAND BREAK REPAIR PROTEIN XRCC1-N-TERMINAL DOMAIN Descriptor: PROTEIN (DNA-REPAIR PROTEIN XRCC1) Authors: Marintchev, A, Mullen, G.P. Deposit date: 1999-02-27 Release date: 1999-09-01 Last modified: 2023-12-27 Method: SOLUTION NMR Cite: Solution structure of the single-strand break repair protein XRCC1 N-terminal domain. Nat.Struct.Biol., 6, 1999
1XNT	NMR SOLUTION STRUCTURE OF THE SINGLE-STRAND BREAK REPAIR PROTEIN XRCC1-N-TERMINAL DOMAIN Descriptor: PROTEIN (DNA-REPAIR PROTEIN XRCC1) Authors: Marintchev, A, Mullen, G.P. Deposit date: 1999-02-27 Release date: 1999-09-01 Last modified: 2023-12-27 Method: SOLUTION NMR Cite: Solution structure of the single-strand break repair protein XRCC1 N-terminal domain. Nat.Struct.Biol., 6, 1999
2ZO1	Mouse NP95 SRA domain DNA specific complex 2 Descriptor: 1,2-ETHANEDIOL, DNA (5'-D(*DGP*DTP*DCP*DAP*DGP*(5CM)P*DGP*DCP*DAP*DAP*DTP*DGP*DG)-3'), DNA (5'-D(*DTP*DCP*DCP*DAP*DTP*DGP*DCP*DGP*DCP*DTP*DGP*DAP*DC)-3'), ... Authors: Hashimoto, H, Horton, J.R, Cheng, X. Deposit date: 2008-05-05 Release date: 2008-09-09 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (1.96 Å) Cite: The SRA domain of UHRF1 flips 5-methylcytosine out of the DNA helix Nature, 455, 2008
3N5G	Crystal Structure of histidine-tagged human thymidylate synthase Descriptor: SULFATE ION, Thymidylate synthase Authors: Pozzi, C, Cardinale, D, Guaitoli, G, Tondi, D, Luciani, R, Myllykallio, H, Ferrari, S, Costi, M.P, Mangani, S. Deposit date: 2010-05-25 Release date: 2011-06-08 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.27 Å) Cite: Protein-protein interface-binding peptides inhibit the cancer therapy target human thymidylate synthase. Proc.Natl.Acad.Sci.USA, 108, 2011
1CWC	IMPROVED BINDING AFFINITY FOR CYCLOPHILIN A BY A CYCLOSPORIN DERIVATIVE SINGLY MODIFIED AT ITS EFFECTOR DOMAIN Descriptor: CYCLOSPORIN A, PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A Authors: Mikol, V. Deposit date: 1995-09-06 Release date: 1996-01-29 Last modified: 2024-06-05 Method: X-RAY DIFFRACTION (1.86 Å) Cite: Improved Binding Affinity for Cyclophilin a by a Cyclosporin Derivative Singly Modified at its Effector Domain. J.Med.Chem., 37, 1994
1CWF	HUMAN CYCLOPHILIN A COMPLEXED WITH 2-VAL CYCLOSPORIN Descriptor: CYCLOSPORIN D, PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A Authors: Mikol, V, Kallen, J, Taylor, P, Walkinshaw, M.D. Deposit date: 1998-04-30 Release date: 1998-07-15 Last modified: 2024-06-05 Method: X-RAY DIFFRACTION (1.86 Å) Cite: X-Ray Structures and Analysis of 11 Cyclosporin Derivatives Complexed with Cyclophilin A. J.Mol.Biol., 283, 1998
2ZVM	Crystal structure of PCNA in complex with DNA polymerase iota fragment Descriptor: DNA polymerase iota, Proliferating cell nuclear antigen Authors: Hishiki, A, Hashimoto, H, Hanafusa, T, Kamei, K, Ohashi, E, Shimizu, T, Ohmori, H, Sato, M. Deposit date: 2008-11-11 Release date: 2009-02-10 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structural Basis for Novel Interactions between Human Translesion Synthesis Polymerases and Proliferating Cell Nuclear Antigen J.Biol.Chem., 284, 2009
1CWA	X-RAY STRUCTURE OF A MONOMERIC CYCLOPHILIN A-CYCLOSPORIN A CRYSTAL COMPLEX AT 2.1 ANGSTROMS RESOLUTION Descriptor: CYCLOSPORIN A, PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A Authors: Mikol, V, Kallen, J, Walkinshaw, M.D. Deposit date: 1995-09-06 Release date: 1996-01-29 Last modified: 2024-06-05 Method: X-RAY DIFFRACTION (2.1 Å) Cite: X-Ray Structure of a Monomeric Cyclophilin A-Cyclosporin a Crystal Complex at 2.1 A Resolution. J.Mol.Biol., 234, 1993
1XJL	Structure of human annexin A2 in the presence of calcium ions Descriptor: Annexin A2, CALCIUM ION Authors: Rosengarth, A, Luecke, H. Deposit date: 2004-09-23 Release date: 2004-11-09 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.59 Å) Cite: Annexin A2: Does it induce membrane aggregation by a new multimeric state of the protein? Annexins, 1, 2004
3NAU	Crystal structure of ZHX2 HD2 (zinc-fingers and homeoboxes protein 2, homeodomain 2) Descriptor: SULFATE ION, Zinc fingers and homeoboxes protein 2 Authors: Ren, J, Bird, L.E, Owens, R.J, Stammers, D.K, Oxford Protein Production Facility (OPPF) Deposit date: 2010-06-02 Release date: 2010-07-07 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Novel structural features in two ZHX homeodomains derived from a systematic study of single and multiple domains Bmc Struct.Biol., 10, 2010
1UK1	Crystal structure of human poly(ADP-ribose) polymerase complexed with a potent inhibitor Descriptor: 5-FLUORO-1-[4-(4-PHENYL-3,6-DIHYDROPYRIDIN-1(2H)-YL)BUTYL]QUINAZOLINE-2,4(1H,3H)-DIONE, Poly [ADP-ribose] polymerase-1 Authors: Kinoshita, T. Deposit date: 2003-08-14 Release date: 2004-09-14 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (3 Å) Cite: Rational approaches to discovery of orally active and brain-penetrable quinazolinone inhibitors of poly(ADP-ribose)polymerase J.Med.Chem., 47, 2004
1UK0	Crystal structure of catalytic domain of human poly(ADP-ribose) polymerase with a novel inhibitor Descriptor: 2-{3-[4-(4-FLUOROPHENYL)-3,6-DIHYDRO-1(2H)-PYRIDINYL]PROPYL}-8-METHYL-4(3H)-QUINAZOLINONE, Poly [ADP-ribose] polymerase-1 Authors: Kinoshita, T. Deposit date: 2003-08-13 Release date: 2004-01-27 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (3 Å) Cite: Inhibitor-induced structural change of the active site of human poly(ADP-ribose) polymerase. Febs Lett., 556, 2004
1DFC	CRYSTAL STRUCTURE OF HUMAN FASCIN, AN ACTIN-CROSSLINKING PROTEIN Descriptor: FASCIN Authors: Fedorov, A.A, Fedorov, E.V, Ono, S, Matsumura, F, Almo, S.C, Burley, S.K, New York SGX Research Center for Structural Genomics (NYSGXRC) Deposit date: 1999-11-18 Release date: 2000-11-22 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Structure, evolutionary conservation, and conformational dynamics of Homo sapiens fascin-1, an F-actin crosslinking protein. J.Mol.Biol., 400, 2010
1ZKK	Crystal structure of hSET8 in ternary complex with H4 peptide (16-24) and AdoHcy Descriptor: Histone-lysine N-methyltransferase, H4 lysine-20 specific, Peptide corresponding to residues 15-24 of histone H4, ... Authors: Couture, J.-F, Collazo, E, Brunzelle, J.S, Trievel, R.C. Deposit date: 2005-05-03 Release date: 2005-06-07 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.45 Å) Cite: Structural and functional analysis of SET8, a histone H4 Lys-20 methyltransferase Genes Dev., 19, 2005
1RI0	NMR structure of the N-terminal hath domain of human HDGF Descriptor: Hepatoma-derived growth factor Authors: Sue, S.-C, Chen, J.-Y, Huang, T.-H. Deposit date: 2003-11-16 Release date: 2004-11-16 Last modified: 2024-05-29 Method: SOLUTION NMR Cite: Solution Structure and Heparin Interaction of Human Hepatoma-derived Growth Factor J.Mol.Biol., 343, 2004
1RMH	RECOMBINANT CYCLOPHILIN A FROM HUMAN T CELL Descriptor: AAPF PEPTIDE SUBSTRATE, CYCLOPHILIN A Authors: Zhao, Y, Ke, H. Deposit date: 1995-07-31 Release date: 1996-10-14 Last modified: 2017-11-29 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Crystal structure implies that cyclophilin predominantly catalyzes the trans to cis isomerization. Biochemistry, 35, 1996
5SXM	WDR5 in complex with MLL Win motif peptidomimetic Descriptor: ACE-ALA-ARG-THR-GLU-VAL-TYR-NH2, WD repeat-containing protein 5 Authors: Alicea-Velazquez, N.L, Shinsky, S.A, Cosgrove, M.S. Deposit date: 2016-08-09 Release date: 2016-09-07 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2 Å) Cite: Targeted Disruption of the Interaction between WD-40 Repeat Protein 5 (WDR5) and Mixed Lineage Leukemia (MLL)/SET1 Family Proteins Specifically Inhibits MLL1 and SETd1A Methyltransferase Complexes. J.Biol.Chem., 291, 2016
1DOA	Structure of the rho family gtp-binding protein cdc42 in complex with the multifunctional regulator rhogdi Descriptor: GERAN-8-YL GERAN, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... Authors: Hoffman, G.R, Nassar, N, Cerione, R.C. Deposit date: 1999-12-20 Release date: 2000-02-09 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Structure of the Rho family GTP-binding protein Cdc42 in complex with the multifunctional regulator RhoGDI. Cell(Cambridge,Mass.), 100, 2000
5T9U	Discovery of a Potent Cyclophilin Inhibitor (Compound 3) based on Structural Simplification of Sanglifehrin A Descriptor: 3-[(3-hydroxyphenyl)methyl]-10,12-dimethoxy-9,11-dimethyl-6-(propan-2-yl)-19-oxa-1,4,7,25-tetraazabicyclo[19.3.1]pentacosa-13,15-diene-2,5,8,20-tetrone, Peptidyl-prolyl cis-trans isomerase A Authors: Appleby, T.C, Steadman, V, Pettit, S, Schmitz, U, Mackman, R.L, Schultz, B. Deposit date: 2016-09-09 Release date: 2017-01-25 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (2.301 Å) Cite: Discovery of Potent Cyclophilin Inhibitors Based on the Structural Simplification of Sanglifehrin A. J. Med. Chem., 60, 2017
5T9Z	Discovery of a Potent Cyclophilin Inhibitor (Compound 6) based on Structural Simplification of Sanglifehrin A Descriptor: 11-[(3-hydroxyphenyl)methyl]-18-methoxy-17-methyl-14-(propan-2-yl)-3-oxa-9,12,15,28-tetraazatricyclo[21.3.1.1~5,9~]octacosa-1(27),21,23,25-tetraene-4,10,13,16-tetrone, Peptidyl-prolyl cis-trans isomerase A Authors: Appleby, T.C, Steadman, V, Pettit, S, Schmitz, U, Mackman, R.L, Schultz, B. Deposit date: 2016-09-09 Release date: 2017-01-25 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Discovery of Potent Cyclophilin Inhibitors Based on the Structural Simplification of Sanglifehrin A. J. Med. Chem., 60, 2017
3O51	Crystal structure of anthranilamide 10 bound to AuroraA Descriptor: N-[4-({3-[5-fluoro-2-(methylideneamino)pyrimidin-4-yl]pyridin-2-yl}oxy)phenyl]-2-(phenylamino)benzamide, cDNA FLJ58295, highly similar to Serine/threonine-protein kinase 6 Authors: Huang, X. Deposit date: 2010-07-27 Release date: 2010-08-18 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (3.2 Å) Cite: Discovery of a potent, selective, and orally bioavailable pyridinyl-pyrimidine phthalazine aurora kinase inhibitor. J.Med.Chem., 53, 2010
5UMS	Crystal structure of middle double PH domain of human FACT complex subunit SSRP1 Descriptor: FACT complex subunit SSRP1 Authors: Su, D, Hu, Q, Thompson, J.R, Botuyan, M.V, Mer, G. Deposit date: 2017-01-29 Release date: 2018-01-31 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.569 Å) Cite: Crystal structure of middle double PH domain of human FACT complex subunit SSRP1 To Be Published
5UWI	Crystal Structure of HDAC5 NES Peptide in complex with CRM1-Ran-RanBP1 Descriptor: Exportin-1, GLYCEROL, GTP-binding nuclear protein Ran, ... Authors: Fung, H.Y.J, Chook, Y.M. Deposit date: 2017-02-21 Release date: 2017-03-22 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.143 Å) Cite: Nuclear export receptor CRM1 recognizes diverse conformations in nuclear export signals. Elife, 6, 2017
3BCH	Crystal Structure of the Human Laminin Receptor Precursor Descriptor: 40S ribosomal protein SA Authors: Jamieson, K.V, Wu, J, Hubbard, S.R, Meruelo, D. Deposit date: 2007-11-12 Release date: 2007-12-04 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.15 Å) Cite: Crystal structure of the human laminin receptor precursor. J.Biol.Chem., 283, 2008
5UWU	Crystal Structure of SMAD4 NES Peptide in complex with CRM1-Ran-RanBP1 Descriptor: CHLORIDE ION, Exportin-1, GLYCEROL, ... Authors: Fung, H.Y.J, Chook, Y.M. Deposit date: 2017-02-21 Release date: 2017-03-22 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.24 Å) Cite: Nuclear export receptor CRM1 recognizes diverse conformations in nuclear export signals. Elife, 6, 2017

<73747576777879808182838485868788>