5CRU
 
 | | Crystal structure of the Bro domain of HD-PTP | | Descriptor: | Tyrosine-protein phosphatase non-receptor type 23 | | Authors: | Lee, J, Ku, B, Kim, S.J. | | Deposit date: | 2015-07-23 | | Release date: | 2016-02-24 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Structural Study of the HD-PTP Bro1 Domain in a Complex with the Core Region of STAM2, a Subunit of ESCRT-0
Plos One, 11, 2016
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6SJ4
 | | Amidohydrolase, AHS with substrate analog | | Descriptor: | 1,2-ETHANEDIOL, 3-(3-hydroxyphenyl)carbonyloxybenzoic acid, Amidohydrolase, ... | | Authors: | Naismith, J.H, Song, H. | | Deposit date: | 2019-08-12 | | Release date: | 2020-01-15 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (1.81 Å) | | Cite: | The Biosynthesis of the Benzoxazole in Nataxazole Proceeds via an Unstable Ester and has Synthetic Utility.
Angew.Chem.Int.Ed.Engl., 59, 2020
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6SYC
 | | Crystal structure of the lysozyme in presence of bromophenol blue at pH 6.5 | | Descriptor: | CHLORIDE ION, IMIDAZOLE, Lysozyme, ... | | Authors: | Camara-Artigas, A, Plaza-Garrido, M, Salinas-Garcia, M.C. | | Deposit date: | 2019-09-27 | | Release date: | 2020-09-09 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (1.38 Å) | | Cite: | Lysozyme crystals dyed with bromophenol blue: where has the dye gone?
Acta Crystallogr D Struct Biol, 76, 2020
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6T0L
 | | Crystal structure of CYP124 in complex with inhibitor compound 5' | | Descriptor: | CHLORIDE ION, CYP124 in complex with inhibitor compound 5', DI(HYDROXYETHYL)ETHER, ... | | Authors: | Bukhdruker, S, Marin, E, Varaksa, T, Gilep, A, Strushkevich, N, Borshchevskiy, V. | | Deposit date: | 2019-10-03 | | Release date: | 2020-10-14 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Metabolic Fate of Human Immunoactive Sterols in Mycobacterium tuberculosis.
J.Mol.Biol., 433, 2021
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8BTL
 | | Crystal structure of a complex between the E2 conjugating enzyme UBE2A and the E3 ligase module from UBR4 | | Descriptor: | Ubiquitin conjugating enzyme E2 A, ZINC ION, cDNA FLJ12511 fis, ... | | Authors: | Virdee, S, Mabbitt, P.D, Barnsby-Greer, L. | | Deposit date: | 2022-11-29 | | Release date: | 2023-12-13 | | Last modified: | 2024-04-17 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | UBE2A and UBE2B are recruited by an atypical E3 ligase module in UBR4.
Nat.Struct.Mol.Biol., 31, 2024
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4G45
 | | Structure of cytochrome CYP121 in complex with 2-methylquinolin-6-amine | | Descriptor: | 2-methylquinolin-6-amine, Cytochrome P450 121, PROTOPORPHYRIN IX CONTAINING FE, ... | | Authors: | Hudson, S.A, McLean, K.J, Surade, S, Yang, Y.-Q, Leys, D, Ciulli, A, Munro, A.W, Abell, C. | | Deposit date: | 2012-07-16 | | Release date: | 2012-09-05 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (1.53 Å) | | Cite: | Application of Fragment Screening and Merging to the Discovery of Inhibitors of the Mycobacterium tuberculosis Cytochrome P450 CYP121
Angew.Chem.Int.Ed.Engl., 51, 2012
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6MXX
 | | Structure of 53BP1 tandem Tudor domains in complex with small molecule UNC2991 | | Descriptor: | FORMIC ACID, N-[3-(tert-butylamino)propyl]-3-iodobenzamide, PHOSPHATE ION, ... | | Authors: | Cui, G, Botuyan, M.V, Mer, G. | | Deposit date: | 2018-10-31 | | Release date: | 2019-11-27 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (2.298 Å) | | Cite: | An autoinhibited state of 53BP1 revealed by small molecule antagonists and protein engineering.
Nat Commun, 14, 2023
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6SEX
 | | X-ray structure of the gold/lysozyme adduct formed upon 21h exposure of protein crystals to compound 1 | | Descriptor: | 1,2-ETHANEDIOL, ACETATE ION, DIMETHYL SULFOXIDE, ... | | Authors: | Ferraro, G, Giorgio, A, Merlino, A. | | Deposit date: | 2019-07-30 | | Release date: | 2019-09-18 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (1.78 Å) | | Cite: | Protein-mediated disproportionation of Au(i): insights from the structures of adducts of Au(iii) compounds bearing N,N-pyridylbenzimidazole derivatives with lysozyme.
Dalton Trans, 48, 2019
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8QNN
 | | Crystal structure of a Class A beta-lactamase from Nocardia cyriacigeorgica | | Descriptor: | Beta-lactamase, CITRATE ANION | | Authors: | Feuillard, J, Couston, J, Benito, Y, Hodille, E, Dumitrescu, O, Blaise, M. | | Deposit date: | 2023-09-27 | | Release date: | 2024-01-17 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (1.25 Å) | | Cite: | Biochemical and structural characterization of a class A beta-lactamase from Nocardia cyriacigeorgica.
Acta Crystallogr.,Sect.F, 80, 2024
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6SJG
 | | Cryo-EM structure of the RecBCD no Chi negative control complex | | Descriptor: | Forked DNA substrate, RecBCD enzyme subunit RecB, RecBCD enzyme subunit RecC, ... | | Authors: | Cheng, K, Wilkinson, M, Wigley, D.B. | | Deposit date: | 2019-08-13 | | Release date: | 2020-01-01 | | Last modified: | 2024-05-22 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | A conformational switch in response to Chi converts RecBCD from phage destruction to DNA repair.
Nat.Struct.Mol.Biol., 27, 2020
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4NFP
 | | Crystal Structure Analysis of the 16mer GCAGNCUUAAGUCUGC containing 8-aza-7-deaza-7-ethynyl Adenosine | | Descriptor: | FORMAMIDE, GCAG(A7E)CUUAAGUCUGC | | Authors: | Beal, P.A, Fisher, A.J, Phelps, K.J, Ibarra-Soza, J.M, Zheng, Y. | | Deposit date: | 2013-10-31 | | Release date: | 2014-07-02 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Click Modification of RNA at Adenosine: Structure and Reactivity of 7-Ethynyl- and 7-Triazolyl-8-aza-7-deazaadenosine in RNA.
Acs Chem.Biol., 9, 2014
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4NFQ
 | | Crystal Structure Analysis of the 16mer GCAGNCUUAAGUCUGC containing 7-triazolyl-8-aza-7-deazaadenosine | | Descriptor: | GCAG(7AT)CUUAAGUCUGC | | Authors: | Beal, P.A, Fisher, A.J, Phelps, K.J, Ibarra-Soza, J.M, Zheng, Y. | | Deposit date: | 2013-10-31 | | Release date: | 2014-07-02 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Click Modification of RNA at Adenosine: Structure and Reactivity of 7-Ethynyl- and 7-Triazolyl-8-aza-7-deazaadenosine in RNA.
Acs Chem.Biol., 9, 2014
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8K1Y
 | | Crystal structure of human serum albumin and ruthenium Val complex adduct | | Descriptor: | Albumin, CHLORIDE ION, DIMETHYL SULFOXIDE, ... | | Authors: | Gong, W.J, Xie, L.L, Wang, W.M, Wang, H.F. | | Deposit date: | 2023-07-11 | | Release date: | 2024-07-17 | | Method: | X-RAY DIFFRACTION (2.15 Å) | | Cite: | Crystal structure of human serum albumin and ruthenium VaL complex adduct
To Be Published
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8BA8
 | | CryoEM structure of GroEL-ADP.BeF3-Rubisco. | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, Chaperonin GroEL, ... | | Authors: | Gardner, S, Saibil, H.R. | | Deposit date: | 2022-10-11 | | Release date: | 2023-12-27 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Structural basis of substrate progression through the bacterial chaperonin cycle.
Proc Natl Acad Sci U S A, 120, 2023
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6SMT
 | | S-enantioselective imine reductase from Mycobacterium smegmatis | | Descriptor: | (2S)-2-ethylhexan-1-ol, 1,2-ETHANEDIOL, 6-phosphogluconate dehydrogenase, ... | | Authors: | Meyer, T, Zumbraegel, N, Geerds, C, Groeger, H, Niemann, H.H. | | Deposit date: | 2019-08-22 | | Release date: | 2020-08-12 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (1.55 Å) | | Cite: | Structural Characterization of an S -enantioselective Imine Reductase from Mycobacterium Smegmatis .
Biomolecules, 10, 2020
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8BA9
 | | CryoEM structure of GroEL-GroES-ADP.AlF3-Rubisco. | | Descriptor: | 60 kDa chaperonin, ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, ... | | Authors: | Gardner, S, Saibil, H.R. | | Deposit date: | 2022-10-11 | | Release date: | 2023-12-27 | | Method: | ELECTRON MICROSCOPY (3.7 Å) | | Cite: | Structural basis of substrate progression through the bacterial chaperonin cycle.
Proc Natl Acad Sci U S A, 120, 2023
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8BW8
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6UIE
 | | Structure of the cytoplasmic domain of the T3SS sorting platform protein PscK from P. aeruginosa | | Descriptor: | CHLORIDE ION, Type III export protein PscK | | Authors: | Muthuramalingam, M, Lovell, S, Battaile, K.P, Picking, W.D. | | Deposit date: | 2019-09-30 | | Release date: | 2020-10-07 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (2.55 Å) | | Cite: | The Structures of SctK and SctD from Pseudomonas aeruginosa Reveal the Interface of the Type III Secretion System Basal Body and Sorting Platform.
J.Mol.Biol., 432, 2020
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8BW9
 | | Cryo-EM structure of the RAF activating complex KSR-MEK-CNK-HYP | | Descriptor: | Connector enhancer of KSR protein CNK, Dual specificity mitogen-activated protein kinase kinase dSOR1, KSR, ... | | Authors: | Maisonneuve, P, Fronzes, R, Sicheri, F. | | Deposit date: | 2022-12-06 | | Release date: | 2024-02-21 | | Last modified: | 2024-07-31 | | Method: | ELECTRON MICROSCOPY (3.32 Å) | | Cite: | The CNK-HYP scaffolding complex promotes RAF activation by enhancing KSR-MEK interaction.
Nat.Struct.Mol.Biol., 31, 2024
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8BAN
 | | Secretagogin (mouse) in complex with its target peptide from SNAP-25 | | Descriptor: | CALCIUM ION, Green fluorescent protein,Synaptosomal-associated protein 25, Secretagogin | | Authors: | Schnell, R, Szodorai, E. | | Deposit date: | 2022-10-11 | | Release date: | 2024-04-03 | | Last modified: | 2024-10-09 | | Method: | X-RAY DIFFRACTION (2.35 Å) | | Cite: | A hydrophobic groove in secretagogin allows for alternate interactions with SNAP-25 and syntaxin-4 in endocrine tissues.
Proc.Natl.Acad.Sci.USA, 121, 2024
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7ZO5
 | | L1 metallo-beta-lactamase in complex with a mecillinam degradation product | | Descriptor: | (2~{R},4~{S})-2-[(1~{R})-2-(azepan-1-yl)-1-formamido-2-oxidanylidene-ethyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid, Metallo-beta-lactamase L1, SULFATE ION, ... | | Authors: | Hinchliffe, P, Spencer, J. | | Deposit date: | 2022-04-24 | | Release date: | 2023-03-08 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (1.43 Å) | | Cite: | Interactions of hydrolyzed beta-lactams with the L1 metallo-beta-lactamase: Crystallography supports stereoselective binding of cephem/carbapenem products.
J.Biol.Chem., 299, 2023
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7ZO2
 | | L1 metallo-beta-lactamase complex with hydrolysed doripenem | | Descriptor: | (2~{S},3~{R},4~{S})-2-[(2~{S},3~{R})-1,3-bis(oxidanyl)-1-oxidanylidene-butan-2-yl]-3-methyl-4-[(3~{S},5~{S})-5-[(sulfamoylamino)methyl]pyrrolidin-3-yl]sulfanyl-3,4-dihydro-2~{H}-pyrrole-5-carboxylic acid, CHLORIDE ION, Metallo-beta-lactamase L1, ... | | Authors: | Hinchliffe, P, Spencer, J. | | Deposit date: | 2022-04-24 | | Release date: | 2023-03-08 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (1.49 Å) | | Cite: | Interactions of hydrolyzed beta-lactams with the L1 metallo-beta-lactamase: Crystallography supports stereoselective binding of cephem/carbapenem products.
J.Biol.Chem., 299, 2023
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8A3D
 | | Human mature large subunit of the ribosome with eIF6 and homoharringtonine bound | | Descriptor: | (3beta)-O~3~-[(2R)-2,6-dihydroxy-2-(2-methoxy-2-oxoethyl)-6-methylheptanoyl]cephalotaxine, 28S ribosomal RNA, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... | | Authors: | Faille, A, Warren, A.J, Dent, K.C. | | Deposit date: | 2022-06-08 | | Release date: | 2023-03-08 | | Last modified: | 2024-07-24 | | Method: | ELECTRON MICROSCOPY (1.67 Å) | | Cite: | The chemical landscape of the human ribosome at 1.67 angstrom resolution.
Biorxiv, 2023
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5D40
 | | Crystal structure of the 5-selective H176Y mutant of Cytochrome TxtE | | Descriptor: | CHLORIDE ION, GLYCEROL, P450-like protein, ... | | Authors: | Cahn, J.K.B, Dodani, S.C, Arnold, F.H. | | Deposit date: | 2015-08-06 | | Release date: | 2016-06-22 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (1.51 Å) | | Cite: | Discovery of a regioselectivity switch in nitrating P450s guided by molecular dynamics simulations and Markov models.
Nat.Chem., 8, 2016
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4NPD
 | | High-resolution structure of C domain of staphylococcal protein A at cryogenic temperature | | Descriptor: | Immunoglobulin G-binding protein A, THIOCYANATE ION, ZINC ION | | Authors: | Deis, L.N, Pemble IV, C.W, Oas, T.G, Richardson, J.S, Richardson, D.C. | | Deposit date: | 2013-11-21 | | Release date: | 2014-10-08 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (0.9 Å) | | Cite: | Multiscale conformational heterogeneity in staphylococcal protein a: possible determinant of functional plasticity.
Structure, 22, 2014
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