7RV5
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7RV3
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7RV8
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![BU of 7rv8 by Molmil](/molmil-images/mine/7rv8) | Crystal structure of the BCL6 BTB domain in complex with OICR-10268 | Descriptor: | DIMETHYL SULFOXIDE, Isoform 2 of B-cell lymphoma 6 protein, N-[5-chloro-2-(morpholin-4-yl)pyridin-4-yl]-2-{5-(3-cyano-4-hydroxy-5-methylphenyl)-3-[3-(1-methyl-1H-pyrazol-4-yl)prop-2-yn-1-yl]-4-oxo-3,4-dihydro-7H-pyrrolo[2,3-d]pyrimidin-7-yl}acetamide | Authors: | Kuntz, D.A, Prive, G.G. | Deposit date: | 2021-08-18 | Release date: | 2022-08-24 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.25 Å) | Cite: | Structure of the BCL6 BTB domain To Be Published
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7RV9
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![BU of 7rv9 by Molmil](/molmil-images/mine/7rv9) | Crystal structure of the BCL6 BTB domain in complex with OICR-10269 | Descriptor: | DIMETHYL SULFOXIDE, Isoform 2 of B-cell lymphoma 6 protein, N-[5-chloro-2-(4-methylpiperazin-1-yl)pyridin-4-yl]-2-{5-(3-cyano-4-hydroxy-5-methylphenyl)-3-[3-(1-methyl-1H-pyrazol-4-yl)prop-2-yn-1-yl]-4-oxo-3,4-dihydro-7H-pyrrolo[2,3-d]pyrimidin-7-yl}acetamide | Authors: | Kuntz, D.A, Prive, G.G. | Deposit date: | 2021-08-18 | Release date: | 2022-08-24 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Structure of the BCL6 BTB domain To Be Published
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7RV7
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![BU of 7rv7 by Molmil](/molmil-images/mine/7rv7) | |
7RV4
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![BU of 7rv4 by Molmil](/molmil-images/mine/7rv4) | |
7RV6
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7RV0
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7RV2
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7RUX
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![BU of 7rux by Molmil](/molmil-images/mine/7rux) | Crystal structure of the BCL6 BTB domain in complex with OICR-8311 | Descriptor: | B-cell lymphoma 6 protein, FORMIC ACID, N-(3-chloropyridin-4-yl)-2-(3-(cyclopropylmethyl)-4-oxo-3,4-dihydro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)acetamide | Authors: | Kuntz, D.A, Prive, G.G. | Deposit date: | 2021-08-18 | Release date: | 2022-11-09 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Crystal structure of the BCL6 BTB domain in complex with OICR-8311 To Be Published
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7RUW
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![BU of 7ruw by Molmil](/molmil-images/mine/7ruw) | Crystal structure of the BCL6 BTB domain in complex with OICR-7859 | Descriptor: | 2-(2-amino-4-oxo-3,4-dihydro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-N-(3-chloropyridin-4-yl)acetamide, B-cell lymphoma 6 protein, CHLORIDE ION, ... | Authors: | Kuntz, D.A, Prive, G.G. | Deposit date: | 2021-08-18 | Release date: | 2022-11-09 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Crystal structure of the BCL6 BTB domain in complex with OICR-7859 To Be Published
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7RUZ
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![BU of 7ruz by Molmil](/molmil-images/mine/7ruz) | Crystal structure of the BCL6 BTB domain in complex with OICR-8445 | Descriptor: | 2-[2-(benzylamino)-4-oxo-3,4-dihydro-7H-pyrrolo[2,3-d]pyrimidin-7-yl]-N-(3-chloropyridin-4-yl)acetamide, B-cell lymphoma 6 protein, CHLORIDE ION, ... | Authors: | Kuntz, D.A, Prive, G.G. | Deposit date: | 2021-08-18 | Release date: | 2022-11-09 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.62 Å) | Cite: | Crystal structure of the BCL6 BTB domain in complex with OICR-8445 To Be Published
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7RV1
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![BU of 7rv1 by Molmil](/molmil-images/mine/7rv1) | Crystal structure of the BCL6 BTB domain in complex with OICR-8826 | Descriptor: | (E)-3-(7-(2-((3-chloropyridin-4-yl)amino)-2-oxoethyl)-3-(3-(1-methyl-1H-pyrazol-4-yl)prop-2-yn-1-yl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)acrylamide, B-cell lymphoma 6 protein, DIMETHYL SULFOXIDE, ... | Authors: | Kuntz, D.A, Prive, G.G. | Deposit date: | 2021-08-18 | Release date: | 2022-11-09 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.17 Å) | Cite: | Crystal structure of the BCL6 BTB domain in complex with OICR-8826 To Be Published
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7RUY
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![BU of 7ruy by Molmil](/molmil-images/mine/7ruy) | Crystal structure of the BCL6 BTB domain in complex with OICR-8388 | Descriptor: | B-cell lymphoma 6 protein, FORMIC ACID, N-(3-chloropyridin-4-yl)-2-(2-{[(2,4-dimethoxyphenyl)methyl]amino}-4-oxo-3,4-dihydro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)acetamide | Authors: | Kuntz, D.A, Prive, G.G. | Deposit date: | 2021-08-18 | Release date: | 2022-11-09 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.27 Å) | Cite: | Crystal structure of the BCL6 BTB domain in complex with OICR-8388 To Be Published
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7T0U
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![BU of 7t0u by Molmil](/molmil-images/mine/7t0u) | Crystal structure of the BCL6 BTB domain in complex with OICR-12387 | Descriptor: | 3-chloro-5-{7-[2-({5-chloro-2-[(2S)-2-methyl-4-(oxetan-3-yl)piperazin-1-yl]pyridin-4-yl}amino)-2-oxoethyl]-3-methyl-4-oxo-2-(trifluoromethyl)-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl}-2-hydroxybenzamide, CHLORIDE ION, DIMETHYL SULFOXIDE, ... | Authors: | Kuntz, D.A, Prive, G.G. | Deposit date: | 2021-11-30 | Release date: | 2022-11-09 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.49 Å) | Cite: | Crystal structure of the BCL6 BTB domain in complex with OICR-12387 To Be Published
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7T0T
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![BU of 7t0t by Molmil](/molmil-images/mine/7t0t) | Crystal structure of the BCL6 BTB domain in complex with OICR-10562 | Descriptor: | DIMETHYL SULFOXIDE, Isoform 2 of B-cell lymphoma 6 protein, N-[5-chloro-2-(morpholin-4-yl)pyridin-4-yl]-2-[5-(3-cyano-4-hydroxy-5-methylphenyl)-3-methyl-2-(1-methyl-1H-pyrazol-4-yl)-4-oxo-3,4-dihydro-7H-pyrrolo[2,3-d]pyrimidin-7-yl]acetamide | Authors: | Kuntz, D.A, Prive, G.G. | Deposit date: | 2021-11-30 | Release date: | 2022-12-14 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal structure of the BCL6 BTB domain in complex with OICR-10562 To Be Published
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7T0S
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![BU of 7t0s by Molmil](/molmil-images/mine/7t0s) | Crystal structure of the BCL6 BTB domain in complex with OICR-11864 | Descriptor: | 3-chloro-5-{1-[2-({5-chloro-2-[(3S)-3-methylmorpholin-4-yl]pyridin-4-yl}amino)-2-oxoethyl]-4-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl}-2-hydroxybenzamide, CHLORIDE ION, GLYCEROL, ... | Authors: | Kuntz, D.A, Prive, G.G. | Deposit date: | 2021-11-30 | Release date: | 2022-12-14 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.86 Å) | Cite: | Crystal structure of the BCL6 BTB domain in complex with OICR-11864 To Be Published
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6B41
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![BU of 6b41 by Molmil](/molmil-images/mine/6b41) | Menin bound to M-525 | Descriptor: | Menin, methyl {(1S,2R)-2-[(S)-cyano[1-({1-[4-({1-[4-(dimethylamino)butanoyl]azetidin-3-yl}sulfonyl)phenyl]azetidin-3-yl}methyl)piperidin-4-yl](3-fluorophenyl)methyl]cyclopentyl}carbamate, praseodymium triacetate | Authors: | Stuckey, J.A. | Deposit date: | 2017-09-25 | Release date: | 2018-01-24 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.61 Å) | Cite: | Design of the First-in-Class, Highly Potent Irreversible Inhibitor Targeting the Menin-MLL Protein-Protein Interaction. Angew. Chem. Int. Ed. Engl., 57, 2018
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8A0X
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8A0W
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![BU of 8a0w by Molmil](/molmil-images/mine/8a0w) | |
5Y6O
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![BU of 5y6o by Molmil](/molmil-images/mine/5y6o) | |
6A7E
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![BU of 6a7e by Molmil](/molmil-images/mine/6a7e) | Human dihydrofolate reductase complexed with NADPH and BT2 | Descriptor: | 5-(4-{3-[(2,4-diamino-6-ethylpyrimidin-5-yl)oxy]propoxy}phenyl)-6-ethylpyrimidine-2,4-diamine, Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | Authors: | Vanichtanankul, J, Tarnchompoo, B, Chitnumsub, P, Kamchonwongpaisan, S, Yuthavong, Y. | Deposit date: | 2018-07-02 | Release date: | 2019-04-10 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Hybrid Inhibitors of Malarial Dihydrofolate Reductase with Dual Binding Modes That Can Forestall Resistance. ACS Med Chem Lett, 9, 2018
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6A7C
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![BU of 6a7c by Molmil](/molmil-images/mine/6a7c) | Human dihydrofolate reductase complexed with NADPH and BT1 | Descriptor: | 5-(3-{3-[(2,4-diamino-6-ethylpyrimidin-5-yl)oxy]propoxy}phenyl)-6-ethylpyrimidine-2,4-diamine, Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | Authors: | Vanichtanankul, J, Tarnchompoo, B, Chitnumsub, P, Kamchonwongpaisan, S, Yuthavong, Y. | Deposit date: | 2018-07-02 | Release date: | 2019-04-10 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.06 Å) | Cite: | Hybrid Inhibitors of Malarial Dihydrofolate Reductase with Dual Binding Modes That Can Forestall Resistance. ACS Med Chem Lett, 9, 2018
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6SLO
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![BU of 6slo by Molmil](/molmil-images/mine/6slo) | Crystal structure of PUF60 UHM domain in complex with 7,8 dimethoxyperphenazine | Descriptor: | 2-[4-[3-(8-chloranyl-2,3-dimethoxy-phenothiazin-10-yl)propyl]piperazin-1-yl]ethanol, MAGNESIUM ION, Thioredoxin,Poly(U)-binding-splicing factor PUF60 | Authors: | Jagtap, P.K.A, Kubelka, T, Bach, T, Sattler, M. | Deposit date: | 2019-08-20 | Release date: | 2020-09-09 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.94 Å) | Cite: | Identification of phenothiazine derivatives as UHM-binding inhibitors of early spliceosome assembly. Nat Commun, 11, 2020
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8R3V
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![BU of 8r3v by Molmil](/molmil-images/mine/8r3v) | |