6A7C
Human dihydrofolate reductase complexed with NADPH and BT1
Summary for 6A7C
Entry DOI | 10.2210/pdb6a7c/pdb |
Descriptor | Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 5-(3-{3-[(2,4-diamino-6-ethylpyrimidin-5-yl)oxy]propoxy}phenyl)-6-ethylpyrimidine-2,4-diamine, ... (5 entities in total) |
Functional Keywords | dhfr, antifolate, inhibitor, oxidoreductase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 22807.63 |
Authors | Vanichtanankul, J.,Tarnchompoo, B.,Chitnumsub, P.,Kamchonwongpaisan, S.,Yuthavong, Y. (deposition date: 2018-07-02, release date: 2019-04-10, Last modification date: 2023-11-22) |
Primary citation | Tarnchompoo, B.,Chitnumsub, P.,Jaruwat, A.,Shaw, P.J.,Vanichtanankul, J.,Poen, S.,Rattanajak, R.,Wongsombat, C.,Tonsomboon, A.,Decharuangsilp, S.,Anukunwithaya, T.,Arwon, U.,Kamchonwongpaisan, S.,Yuthavong, Y. Hybrid Inhibitors of Malarial Dihydrofolate Reductase with Dual Binding Modes That Can Forestall Resistance. ACS Med Chem Lett, 9:1235-1240, 2018 Cited by PubMed: 30613332DOI: 10.1021/acsmedchemlett.8b00389 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.06 Å) |
Structure validation
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