6B41
Menin bound to M-525
Summary for 6B41
Entry DOI | 10.2210/pdb6b41/pdb |
Descriptor | Menin, methyl {(1S,2R)-2-[(S)-cyano[1-({1-[4-({1-[4-(dimethylamino)butanoyl]azetidin-3-yl}sulfonyl)phenyl]azetidin-3-yl}methyl)piperidin-4-yl](3-fluorophenyl)methyl]cyclopentyl}carbamate, praseodymium triacetate, ... (4 entities in total) |
Functional Keywords | covalent inhibitor, men1 syndrome, leukemia, protein binding-inhibitor complex, protein binding/inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Nucleus : O00255 |
Total number of polymer chains | 1 |
Total formula weight | 63070.33 |
Authors | Stuckey, J.A. (deposition date: 2017-09-25, release date: 2018-01-24, Last modification date: 2023-10-04) |
Primary citation | Xu, S.,Aguilar, A.,Xu, T.,Zheng, K.,Huang, L.,Stuckey, J.,Chinnaswamy, K.,Bernard, D.,Fernandez-Salas, E.,Liu, L.,Wang, M.,McEachern, D.,Przybranowski, S.,Foster, C.,Wang, S. Design of the First-in-Class, Highly Potent Irreversible Inhibitor Targeting the Menin-MLL Protein-Protein Interaction. Angew. Chem. Int. Ed. Engl., 57:1601-1605, 2018 Cited by PubMed: 29284071DOI: 10.1002/anie.201711828 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.61 Å) |
Structure validation
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