8QXU
 
 | | In situ structure average of GroEL14-GroES7 complexes with wide GroEL7 trans ring conformation in Escherichia coli cytosol obtained by cryo electron tomography | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Chaperonin GroEL, ... | | Authors: | Wagner, J, Caravajal, A.I, Beck, F, Bracher, A, Wan, W, Bohn, S, Koerner, R, Baumeister, W, Fernandez-Busnadiego, R, Hartl, F.U. | | Deposit date: | 2023-10-25 | | Release date: | 2024-07-03 | | Method: | ELECTRON MICROSCOPY (12 Å) | | Cite: | Visualizing chaperonin function in situ by cryo-electron tomography
Nature, 2024
|
|
8QXV
 | | In situ structure average of GroEL14-GroES7 complexes with narrow GroEL7 trans ring conformation in Escherichia coli cytosol obtained by cryo electron tomography | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Chaperonin GroEL, ... | | Authors: | Wagner, J, Caravajal, A.I, Beck, F, Bracher, A, Wan, W, Bohn, S, Koerner, R, Baumeister, W, Fernandez-Busnadiego, R, Hartl, F.U. | | Deposit date: | 2023-10-25 | | Release date: | 2024-07-03 | | Method: | ELECTRON MICROSCOPY (13.6 Å) | | Cite: | Visualizing chaperonin function in situ by cryo-electron tomography
Nature, 2024
|
|
6UM2
 | | Structure of M-6-P/IGFII Receptor and IGFII complex | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Cation-independent mannose-6-phosphate receptor, Insulin-like growth factor II | | Authors: | Wang, R, Qi, X, Li, X. | | Deposit date: | 2019-10-08 | | Release date: | 2020-02-26 | | Last modified: | 2020-07-29 | | Method: | ELECTRON MICROSCOPY (4.32 Å) | | Cite: | Marked structural rearrangement of mannose 6-phosphate/IGF2 receptor at different pH environments
Sci Adv, 6, 2020
|
|
6VZ4
 | |
6W6M
 | |
8R1G
 | | Dimeric ternary structure of E6AP-E6-p53 | | Descriptor: | Cellular tumor antigen p53, Ubiquitin-like protein SMT3,Protein E6, Ubiquitin-protein ligase E3A, ... | | Authors: | Sandate, C.R, Chakrabory, D, Kater, L, Kempf, G, Thoma, N.H. | | Deposit date: | 2023-11-01 | | Release date: | 2023-12-06 | | Last modified: | 2024-06-19 | | Method: | ELECTRON MICROSCOPY (3.99 Å) | | Cite: | Structural insights into viral hijacking of p53 by E6 and E6AP
Biorxiv, 2023
|
|
6W9T
 | |
6W1Z
 | | ClpAP Engaged1 State bound to RepA-GFP | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP-dependent Clp protease ATP-binding subunit ClpA, ... | | Authors: | Lopez, K.L, Rizo, A.N, Tse, E, Lin, J, Scull, N.W, Thwin, A.C, Lucius, A.L, Shorter, J, Southworth, D.R. | | Deposit date: | 2020-03-04 | | Release date: | 2020-05-06 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (2.7 Å) | | Cite: | Conformational plasticity of the ClpAP AAA+ protease couples protein unfolding and proteolysis.
Nat.Struct.Mol.Biol., 27, 2020
|
|
6W26
 | | Terpenoid Cyclase FgGS in Complex with Mg, Inorganic Pyrophosphate, and Imidazole | | Descriptor: | 1,2-ETHANEDIOL, GLYCEROL, IMIDAZOLE, ... | | Authors: | Herbst-Gervasoni, C.J, Christianson, D.W. | | Deposit date: | 2020-03-05 | | Release date: | 2020-07-08 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2.15 Å) | | Cite: | Discovery of the cryptic function of terpene cyclases as aromatic prenyltransferases.
Nat Commun, 11, 2020
|
|
6W4L
 | | The crystal structure of a single chain H2B-H2A histone chimera from Xenopus laevis | | Descriptor: | Histone H2B 1.1,Histone H2A type 1, PYROPHOSPHATE | | Authors: | Warren, C, Bonanno, J.B, Almo, S.C, Shechter, D. | | Deposit date: | 2020-03-11 | | Release date: | 2020-05-06 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (1.31 Å) | | Cite: | Structure of a single-chain H2A/H2B dimer.
Acta Crystallogr.,Sect.F, 76, 2020
|
|
8QY9
 | |
8QYB
 | |
8QJS
 | | VHL/Elongin B/Elongin C complex with compound 155 | | Descriptor: | (2S,4R)-1-[(2R)-2-[3-[2-(2-methoxyethoxy)ethoxy]-1,2-oxazol-5-yl]-3-methyl-butanoyl]-N-[(1S)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]-4-oxidanyl-pyrrolidine-2-carboxamide, Elongin-B, Elongin-C, ... | | Authors: | Kerry, P.S, Hole, A.J, Perez-Dorado, J.I. | | Deposit date: | 2023-09-13 | | Release date: | 2024-01-17 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (3.191 Å) | | Cite: | PROTACs Targeting BRM (SMARCA2) Afford Selective In Vivo Degradation over BRG1 (SMARCA4) and Are Active in BRG1 Mutant Xenograft Tumor Models.
J.Med.Chem., 67, 2024
|
|
6VVS
 | | Crystal structure of a Mycobacterium smegmatis RNA polymerase transcription initiation complex with antibiotic Sorangicin | | Descriptor: | 1,2-ETHANEDIOL, DNA (26-MER), DNA (31-MER), ... | | Authors: | Lilic, M, Braffman, N, Darst, S.A, Campbell, E.A. | | Deposit date: | 2020-02-18 | | Release date: | 2020-10-21 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (3.112 Å) | | Cite: | The antibiotic sorangicin A inhibits promoter DNA unwinding in a Mycobacterium tuberculosis rifampicin-resistant RNA polymerase.
Proc.Natl.Acad.Sci.USA, 117, 2020
|
|
8RPX
 | | NhoI restriction endonuclease in complex with quadruply methylated DNA target | | Descriptor: | 1,2-ETHANEDIOL, CALCIUM ION, DNA (5'-D(*CP*TP*GP*(5CM)P*AP*GP*(5CM)P*TP*C)-3'), ... | | Authors: | Rafalski, D, Krakowska, K, Gilski, M, Bochtler, M. | | Deposit date: | 2024-01-17 | | Release date: | 2024-07-17 | | Last modified: | 2024-08-07 | | Method: | X-RAY DIFFRACTION (1.81 Å) | | Cite: | Structural analysis of the BisI family of modification dependent restriction endonucleases.
Nucleic Acids Res., 2024
|
|
8QKS
 | | Plasmodium falciparum reticulocyte-binding protein homologue 5 (PfRH5) bound to R5.034 | | Descriptor: | Immunoglobulin lambda variable 1-36, R5034HV, Reticulocyte-binding protein-like protein 5 | | Authors: | Wright, N.D, Barrett, J.R, Bradshaw, W.J, Paterson, N.G, MacLean, E.M, Ferreira, L, McHugh, K, Von Delft, F, Koekemoer, L, Draper, S.J. | | Deposit date: | 2023-09-16 | | Release date: | 2024-07-31 | | Method: | X-RAY DIFFRACTION (3.994 Å) | | Cite: | Analysis of the Diverse Antigenic Landscape of the Malaria Invasion Protein RH5 Identifies a Potent Vaccine-Induced Human Public Antibody Clonotype
To Be Published
|
|
6VUN
 | | Reverse Transcriptase Diabody with R83C Mutation | | Descriptor: | 1,2-ETHANEDIOL, CITRATE ANION, Single-chain Fv | | Authors: | Chesterman, C, Arnold, E. | | Deposit date: | 2020-02-16 | | Release date: | 2021-02-17 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (1.4 Å) | | Cite: | Co-crystallization with diabodies: A case study for the introduction of synthetic symmetry.
Structure, 29, 2021
|
|
6VUO
 | |
8R1O
 | | Structure of C. thermophilum RNA exosome core | | Descriptor: | Exoribonuclease phosphorolytic domain-containing protein, Exoribonuclease-like protein, Exosome complex component MTR3, ... | | Authors: | Lazzaretti, D, Liebau, J, Pilsl, M, Sprangers, R. | | Deposit date: | 2023-11-02 | | Release date: | 2024-07-17 | | Method: | ELECTRON MICROSCOPY (3.19 Å) | | Cite: | Beyond static structures: quantitative dynamics in the eukaryotic RNA exosome complex
Biorxiv, 2024
|
|
8SSK
 | | Citrobacter rodentium contact dependent growth inhibition (CDI) entry and toxin (CdiA-CT) domains | | Descriptor: | ACETATE ION, CALCIUM ION, Contact-dependent inhibitor A, ... | | Authors: | Cuthbert, B.J, Goulding, C.W, Hayes, C.S, Nhan, D.Q. | | Deposit date: | 2023-05-08 | | Release date: | 2024-05-15 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Citrobacter rodentium contact dependent growth inhibition (CDI) entry and toxin (CdiA-CT) domains
To Be Published
|
|
6TA7
 | | CRYSTAL STRUCTURE OF HUMAN G3BP1-NTF2 IN COMPLEX WITH HUMAN CAPRIN1-DERIVED SOLOMON MOTIF | | Descriptor: | CHLORIDE ION, Caprin-1, Ras GTPase-activating protein-binding protein 1, ... | | Authors: | Schulte, T, Achour, A, Panas, M.D, McInerney, G.M. | | Deposit date: | 2019-10-29 | | Release date: | 2021-05-12 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (1.93 Å) | | Cite: | Caprin-1 binding to the critical stress granule protein G3BP1 is regulated by pH
Biorxiv, 2021
|
|
8Q6P
 | | X. laevis CMG dimer bound to dimeric DONSON - MCM ATPase | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, DNA replication licensing factor mcm2, DNA replication licensing factor mcm4-B, ... | | Authors: | Butryn, A, Cvetkovic, M.A, Costa, A. | | Deposit date: | 2023-08-14 | | Release date: | 2023-10-18 | | Last modified: | 2023-11-29 | | Method: | ELECTRON MICROSCOPY (3.53 Å) | | Cite: | The structural mechanism of dimeric DONSON in replicative helicase activation.
Mol.Cell, 83, 2023
|
|
8PPL
 | | MERS-CoV Nsp1 bound to the human 43S pre-initiation complex | | Descriptor: | 18S rRNA, 40S ribosomal protein S10, 40S ribosomal protein S11, ... | | Authors: | Schubert, K, Karousis, E.D, Ban, I, Lapointe, C.P, Leibundgut, M, Baeumlin, E, Kummerant, E, Scaiola, A, Schoenhut, T, Ziegelmueller, J, Puglisi, J.D, Muehlemann, O, Ban, N. | | Deposit date: | 2023-07-07 | | Release date: | 2023-10-18 | | Last modified: | 2024-04-24 | | Method: | ELECTRON MICROSCOPY (2.65 Å) | | Cite: | Universal features of Nsp1-mediated translational shutdown by coronaviruses.
Mol.Cell, 83, 2023
|
|
8Q6O
 | | X. laevis CMG dimer bound to dimeric DONSON - without ATPase | | Descriptor: | Cell division control protein 45 homolog, DNA replication complex GINS protein PSF1, DNA replication complex GINS protein PSF2, ... | | Authors: | Butryn, A, Cvetkovic, M.A, Costa, A. | | Deposit date: | 2023-08-14 | | Release date: | 2023-10-18 | | Last modified: | 2023-11-29 | | Method: | ELECTRON MICROSCOPY (3.14 Å) | | Cite: | The structural mechanism of dimeric DONSON in replicative helicase activation.
Mol.Cell, 83, 2023
|
|
6U0M
 | | Structure of the S. cerevisiae replicative helicase CMG in complex with a forked DNA | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Cell division control protein 45, DNA (15-MER), ... | | Authors: | Yuan, Z, Georgescu, R, Bai, L, Zhang, D, O'Donnell, M, Li, H. | | Deposit date: | 2019-08-14 | | Release date: | 2020-03-25 | | Last modified: | 2024-03-20 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | DNA unwinding mechanism of a eukaryotic replicative CMG helicase.
Nat Commun, 11, 2020
|
|
