4PRP
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![BU of 4prp by Molmil](/molmil-images/mine/4prp) | Crystal structure of TK3 TCR-HLA-B*35:01-HPVG-Q5 complex | Descriptor: | Beta-2-microglobulin, Epstein-Barr nuclear antigen 1, MHC class I antigen, ... | Authors: | Yu Chih, L, Rossjohn, J, Gras, S. | Deposit date: | 2014-03-06 | Release date: | 2014-04-16 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | A Molecular Basis for the Interplay between T Cells, Viral Mutants, and Human Leukocyte Antigen Micropolymorphism. J.Biol.Chem., 289, 2014
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6Q3S
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![BU of 6q3s by Molmil](/molmil-images/mine/6q3s) | Engineered Human HLA_A2 MHC Class I molecule in complex with TCR and SV9 peptide | Descriptor: | ACETATE ION, Beta-2-microglobulin, GLYCEROL, ... | Authors: | Meijers, R, Anjanappa, R, Springer, S, Garcia-Alai, M. | Deposit date: | 2018-12-04 | Release date: | 2019-07-24 | Last modified: | 2021-02-03 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | High-throughput peptide-MHC complex generation and kinetic screenings of TCRs with peptide-receptive HLA-A*02:01 molecules. Sci Immunol, 4, 2019
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3HUJ
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![BU of 3huj by Molmil](/molmil-images/mine/3huj) | |
3BZE
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![BU of 3bze by Molmil](/molmil-images/mine/3bze) | The human non-classical major histocompatibility complex molecule HLA-E | Descriptor: | Beta-2-microglobulin, HLA class I histocompatibility antigen, alpha chain E, ... | Authors: | Hoare, H.L, Sullivan, L.C, Ely, L.K, Beddoe, T, Henderson, K.N, Lin, J, Clements, C.S, Reid, H.H, Brooks, A.G, Rossjohn, J. | Deposit date: | 2008-01-17 | Release date: | 2008-04-29 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Subtle changes in peptide conformation profoundly affect recognition of the non-classical MHC class I molecule HLA-E by the CD94-NKG2 natural killer cell receptors J.Mol.Biol., 377, 2008
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4N8V
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![BU of 4n8v by Molmil](/molmil-images/mine/4n8v) | |
1HHK
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![BU of 1hhk by Molmil](/molmil-images/mine/1hhk) | THE ANTIGENIC IDENTITY OF PEPTIDE(SLASH)MHC COMPLEXES: A COMPARISON OF THE CONFORMATION OF FIVE PEPTIDES PRESENTED BY HLA-A2 | Descriptor: | BETA 2-MICROGLOBULIN, CLASS I HISTOCOMPATIBILITY ANTIGEN (HLA-A*0201) (ALPHA CHAIN), NONAMERIC PEPTIDE FROM HTLV-1 TAX PROTEIN (RESIDUES 11-19) | Authors: | Madden, D.R, Garboczi, D.N, Wiley, D.C. | Deposit date: | 1993-06-30 | Release date: | 1993-10-31 | Last modified: | 2024-06-05 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | The antigenic identity of peptide-MHC complexes: a comparison of the conformations of five viral peptides presented by HLA-A2. Cell(Cambridge,Mass.), 75, 1993
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1HHI
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![BU of 1hhi by Molmil](/molmil-images/mine/1hhi) | THE ANTIGENIC IDENTITY OF PEPTIDE(SLASH)MHC COMPLEXES: A COMPARISON OF THE CONFORMATION OF FIVE PEPTIDES PRESENTED BY HLA-A2 | Descriptor: | BETA 2-MICROGLOBULIN, CLASS I HISTOCOMPATIBILITY ANTIGEN (HLA-A*0201) (ALPHA CHAIN), INFLUENZA A MATRIX PROTEIN M1 (RESIDUES 58-66) | Authors: | Madden, D.R, Garboczi, D.N, Wiley, D.C. | Deposit date: | 1993-06-30 | Release date: | 1993-10-31 | Last modified: | 2024-06-05 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | The antigenic identity of peptide-MHC complexes: a comparison of the conformations of five viral peptides presented by HLA-A2. Cell(Cambridge,Mass.), 75, 1993
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4PJ7
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![BU of 4pj7 by Molmil](/molmil-images/mine/4pj7) | Structure of human MR1-5-OP-RU in complex with human MAIT TRBV6-4 TCR | Descriptor: | 1-deoxy-1-({2,6-dioxo-5-[(E)-propylideneamino]-1,2,3,6-tetrahydropyrimidin-4-yl}amino)-D-ribitol, Beta-2-microglobulin, Major histocompatibility complex class I-related gene protein, ... | Authors: | Birkinshaw, R.W, Rossjohn, J. | Deposit date: | 2014-05-12 | Release date: | 2014-07-02 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | A molecular basis underpinning the T cell receptor heterogeneity of mucosal-associated invariant T cells. J.Exp.Med., 211, 2014
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1RU9
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![BU of 1ru9 by Molmil](/molmil-images/mine/1ru9) | Crystal Structure (A) of u.v.-irradiated cationic cyclization antibody 4C6 Fab at pH 4.6 with a data set collected in-house. | Descriptor: | ACETATE ION, BENZOIC ACID, GLYCEROL, ... | Authors: | Zhu, X, Wentworth Jr, P, Wentworth, A.D, Eschenmoser, A, Lerner, R.A, Wilson, I.A. | Deposit date: | 2003-12-11 | Release date: | 2004-03-02 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Probing the antibody-catalyzed water-oxidation pathway at atomic resolution. Proc.Natl.Acad.Sci.USA, 110, 2004
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1A9E
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![BU of 1a9e by Molmil](/molmil-images/mine/1a9e) | DECAMER-LIKE CONFORMATION OF A NANO-PEPTIDE BOUND TO HLA-B3501 DUE TO NONSTANDARD POSITIONING OF THE C-TERMINUS | Descriptor: | BETA-2-MICROGLOBULIN, HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, B-35 B*3501 (ALPHA CHAIN), ... | Authors: | Menssen, R, Orth, P, Ziegler, A, Saenger, W. | Deposit date: | 1998-04-05 | Release date: | 1998-10-21 | Last modified: | 2023-08-02 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Decamer-like conformation of a nona-peptide bound to HLA-B*3501 due to non-standard positioning of the C terminus. J.Mol.Biol., 285, 1999
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4PRH
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![BU of 4prh by Molmil](/molmil-images/mine/4prh) | Crystal structure of TK3 TCR-HLA-B*35:08-HPVG-D5 complex | Descriptor: | Beta-2-microglobulin, Epstein-Barr nuclear antigen 1, MHC class I antigen, ... | Authors: | Yu Chih, L, Rossjohn, J, Gras, S. | Deposit date: | 2014-03-05 | Release date: | 2014-04-30 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | A Molecular Basis for the Interplay between T Cells, Viral Mutants, and Human Leukocyte Antigen Micropolymorphism. J.Biol.Chem., 289, 2014
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15C8
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![BU of 15c8 by Molmil](/molmil-images/mine/15c8) | CATALYTIC ANTIBODY 5C8, FREE FAB | Descriptor: | IGG 5C8 FAB (HEAVY CHAIN), IGG 5C8 FAB (LIGHT CHAIN) | Authors: | Gruber, K, Wilson, I.A. | Deposit date: | 1998-03-18 | Release date: | 1999-03-23 | Last modified: | 2023-08-02 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Ligand-Induced Conformational Changes in a Catalytic Antibody: Comparison of the Bound and Unbound Structure of Fab 5C8 To be Published
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5DVN
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![BU of 5dvn by Molmil](/molmil-images/mine/5dvn) | Fc K392D/K409D homodimer | Descriptor: | Fc-III peptide, Ig gamma-1 chain C region | Authors: | Atwell, S, Leaver-Fay, A, Froning, K.J, Aldaz, H, Pustilnik, A, Lu, F, Huang, F, Yuan, R, Dhanani, S.H, Chamberlain, A.K, Fitchett, J.R, Gutierrez, B, Hendle, J, Demarest, S.J, Kuhlman, B. | Deposit date: | 2015-09-21 | Release date: | 2016-03-30 | Last modified: | 2016-07-06 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Computationally Designed Bispecific Antibodies using Negative State Repertoires. Structure, 24, 2016
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3HKF
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![BU of 3hkf by Molmil](/molmil-images/mine/3hkf) | Murine unglycosylated IgG Fc fragment | Descriptor: | CHLORIDE ION, Igh protein, MAGNESIUM ION | Authors: | Feige, M.J, Nath, S, Catharino, S.R, Weinfurtner, D, Steinbacher, S, Buchner, J. | Deposit date: | 2009-05-23 | Release date: | 2009-11-10 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structure of the murine unglycosylated IgG1 Fc fragment J.Mol.Biol., 391, 2009
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3FJT
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![BU of 3fjt by Molmil](/molmil-images/mine/3fjt) | Crystal structure of a human Fc fragment engineered for extended serum half-life | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Ig gamma-1 chain C region | Authors: | Oganesyan, V, Wu, H, Dall'Acqua, W.F. | Deposit date: | 2008-12-15 | Release date: | 2009-03-24 | Last modified: | 2021-10-20 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural characterization of a human Fc fragment engineered for extended serum half-life. Mol.Immunol., 46, 2009
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5GSX
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![BU of 5gsx by Molmil](/molmil-images/mine/5gsx) | Mouse MHC class I H-2Kd with a MERS-CoV-derived peptide 142-2 | Descriptor: | 10-mer peptide from Spike protein, Beta-2-microglobulin, H-2 class I histocompatibility antigen, ... | Authors: | Liu, K, Chai, Y, Qi, J, Tan, W, Liu, W.J, Gao, G.F. | Deposit date: | 2016-08-17 | Release date: | 2017-06-07 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Protective T Cell Responses Featured by Concordant Recognition of Middle East Respiratory Syndrome Coronavirus-Derived CD8+ T Cell Epitopes and Host MHC. J. Immunol., 198, 2017
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1ZT1
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![BU of 1zt1 by Molmil](/molmil-images/mine/1zt1) | crystal structure of class I MHC H-2Kk in complex with an octapeptide | Descriptor: | Beta-2-microglobulin, CHLORIDE ION, H-2 class I histocompatibility antigen, ... | Authors: | Kellenberger, C, Roussel, A, Malissen, B. | Deposit date: | 2005-05-26 | Release date: | 2005-10-18 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | The H-2Kk MHC peptide-binding groove anchors the backbone of an octameric antigenic peptide in an unprecedented mode. J Immunol., 175, 2005
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1KC5
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![BU of 1kc5 by Molmil](/molmil-images/mine/1kc5) | CRYSTAL STRUCTURE OF ANTIBODY PC287 IN COMPLEX WITH PS1 PEPTIDE | Descriptor: | PC287 Immunoglobulin, PS1 peptide | Authors: | Nair, D.T, Singh, K, Siddiqui, Z, Nayak, B.P, Rao, K.V, Salunke, D.M. | Deposit date: | 2001-11-07 | Release date: | 2002-07-24 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Epitope recognition by diverse antibodies suggests conformational convergence in an antibody response. J.Immunol., 168, 2002
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1KCS
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![BU of 1kcs by Molmil](/molmil-images/mine/1kcs) | CRYSTAL STRUCTURE OF ANTIBODY PC282 IN COMPLEX WITH PS1 PEPTIDE | Descriptor: | PC282 IMMUNOGLOBULIN, PS1 peptide | Authors: | Nair, D.T, Singh, K, Siddiqui, Z, Nayak, B.P, Rao, K.V.S, Salunke, D.M. | Deposit date: | 2001-11-11 | Release date: | 2002-05-11 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Epitope recognition by diverse antibodies suggests conformational convergence in an antibody response. J.Immunol., 168, 2002
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5B39
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![BU of 5b39 by Molmil](/molmil-images/mine/5b39) | KIR3DL1*015 in complex with HLA-B*57:01 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Beta-2-microglobulin, HLA class I histocompatibility antigen, ... | Authors: | Vivian, J.P, Rossjohn, J. | Deposit date: | 2016-02-12 | Release date: | 2016-03-30 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Killer cell immunoglobulin-like receptor 3DL1 polymorphism defines distinct hierarchies of HLA class I recognition J.Exp.Med., 213, 2016
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1LNU
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![BU of 1lnu by Molmil](/molmil-images/mine/1lnu) | CRYSTAL STRUCTURE OF CLASS II MHC MOLECULE IAb BOUND TO EALPHA3K PEPTIDE | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, H-2 class II histocompatibility antigen, A beta chain, ... | Authors: | Liu, X, Dai, S, Crawford, F, Fruge, R, Marrack, P, Kappler, J. | Deposit date: | 2002-05-03 | Release date: | 2002-08-14 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Alternate interactions define the binding of peptides to the MHC molecule IA(b). Proc.Natl.Acad.Sci.USA, 99, 2002
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5DVO
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![BU of 5dvo by Molmil](/molmil-images/mine/5dvo) | Fc K392D/K409D homodimer | Descriptor: | Ig gamma-1 chain C region, SULFATE ION | Authors: | Atwell, S, Leaver-Fay, A, Froning, K.J, Aldaz, H, Pustilnik, A, Lu, F, Huang, F, Yuan, R, Dhanani, S.H, Chamberlain, A.K, Fitchett, J.R, Gutierrez, B, Hendle, J, Demarest, S.J, Kuhlman, B. | Deposit date: | 2015-09-21 | Release date: | 2016-03-30 | Last modified: | 2016-04-27 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Computationally Designed Bispecific Antibodies using Negative State Repertoires. Structure, 24, 2016
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1VAC
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![BU of 1vac by Molmil](/molmil-images/mine/1vac) | |
1VAD
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![BU of 1vad by Molmil](/molmil-images/mine/1vad) | |
5HYS
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![BU of 5hys by Molmil](/molmil-images/mine/5hys) | Structure of IgE complexed with omalizumab | Descriptor: | Epididymis luminal protein 214, Ig epsilon chain C region, SULFATE ION, ... | Authors: | Pennington, L.F, Tarchevskaya, S.S, Sathiyamoorthy, K, Jardetzky, T.S. | Deposit date: | 2016-02-01 | Release date: | 2016-06-01 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural basis of omalizumab therapy and omalizumab-mediated IgE exchange. Nat Commun, 7, 2016
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