7TU5
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![BU of 7tu5 by Molmil](/molmil-images/mine/7tu5) | Structure of the L. blandensis dGTPase in the apo form | Descriptor: | MAGNESIUM ION, dGTP triphosphohydrolase | Authors: | Klemm, B.P, Sikkema, A.P, Hsu, A.L, Borgnia, M.J, Schaaper, R.M. | Deposit date: | 2022-02-02 | Release date: | 2022-06-01 | Last modified: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (2.1 Å) | Cite: | High-resolution structures of the SAMHD1 dGTPase homolog from Leeuwenhoekiella blandensis reveal a novel mechanism of allosteric activation by dATP. J.Biol.Chem., 298, 2022
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7TU6
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![BU of 7tu6 by Molmil](/molmil-images/mine/7tu6) | Structure of the L. blandensis dGTPase bound to dATP | Descriptor: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, MAGNESIUM ION, dGTP triphosphohydrolase | Authors: | Klemm, B.P, Sikkema, A.P, Hsu, A.L, Borgnia, M.J, Schaaper, R.M. | Deposit date: | 2022-02-02 | Release date: | 2022-06-01 | Last modified: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | High-resolution structures of the SAMHD1 dGTPase homolog from Leeuwenhoekiella blandensis reveal a novel mechanism of allosteric activation by dATP. J.Biol.Chem., 298, 2022
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7TU7
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![BU of 7tu7 by Molmil](/molmil-images/mine/7tu7) | Structure of the L. blandensis dGTPase H125A mutant bound to dGTP | Descriptor: | 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, dGTP triphosphohydrolase | Authors: | Klemm, B.P, Sikkema, A.P, Hsu, A.L, Borgnia, M.J, Schaaper, R.M. | Deposit date: | 2022-02-02 | Release date: | 2022-06-01 | Last modified: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (2.5 Å) | Cite: | High-resolution structures of the SAMHD1 dGTPase homolog from Leeuwenhoekiella blandensis reveal a novel mechanism of allosteric activation by dATP. J.Biol.Chem., 298, 2022
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7TU8
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![BU of 7tu8 by Molmil](/molmil-images/mine/7tu8) | Structure of the L. blandensis dGTPase H125A mutant bound to dGTP and dATP | Descriptor: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Klemm, B.P, Sikkema, A.P, Hsu, A.L, Borgnia, M.J, Schaaper, R.M. | Deposit date: | 2022-02-02 | Release date: | 2022-06-01 | Last modified: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (2.6 Å) | Cite: | High-resolution structures of the SAMHD1 dGTPase homolog from Leeuwenhoekiella blandensis reveal a novel mechanism of allosteric activation by dATP. J.Biol.Chem., 298, 2022
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7U65
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![BU of 7u65 by Molmil](/molmil-images/mine/7u65) | Structure of E. coli dGTPase bound to T7 bacteriophage protein Gp1.2 | Descriptor: | Deoxyguanosinetriphosphate triphosphohydrolase, Inhibitor of dGTPase | Authors: | Klemm, B.P, Hsu, A.L, Borgnia, M.J, Schaaper, R.M. | Deposit date: | 2022-03-03 | Release date: | 2022-08-31 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Mechanism by which T7 bacteriophage protein Gp1.2 inhibits Escherichia coli dGTPase. Proc.Natl.Acad.Sci.USA, 119, 2022
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7U66
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![BU of 7u66 by Molmil](/molmil-images/mine/7u66) | Structure of E. coli dGTPase bound to T7 bacteriophage protein Gp1.2 and dGTP | Descriptor: | 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, Deoxyguanosinetriphosphate triphosphohydrolase, Inhibitor of dGTPase, ... | Authors: | Klemm, B.P, Dillard, L.B, Borgnia, M.J, Schaaper, R.M. | Deposit date: | 2022-03-03 | Release date: | 2022-08-31 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Mechanism by which T7 bacteriophage protein Gp1.2 inhibits Escherichia coli dGTPase. Proc.Natl.Acad.Sci.USA, 119, 2022
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7U67
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![BU of 7u67 by Molmil](/molmil-images/mine/7u67) | Structure of E. coli dGTPase bound to T7 bacteriophage protein Gp1.2 and GTP | Descriptor: | Deoxyguanosinetriphosphate triphosphohydrolase, GUANOSINE-5'-TRIPHOSPHATE, Inhibitor of dGTPase, ... | Authors: | Klemm, B.P, Hsu, A.L, Borgnia, M.J, Schaaper, R.M. | Deposit date: | 2022-03-03 | Release date: | 2022-08-31 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (2.5 Å) | Cite: | Mechanism by which T7 bacteriophage protein Gp1.2 inhibits Escherichia coli dGTPase. Proc.Natl.Acad.Sci.USA, 119, 2022
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7UJN
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![BU of 7ujn by Molmil](/molmil-images/mine/7ujn) | Structure of Human SAMHD1 with Non-Hydrolysable dGTP Analog | Descriptor: | 2'-deoxyguanosine-5'-O-(1-thiotriphosphate), Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | Authors: | Huynh, K.W, Ammirati, M, Han, S. | Deposit date: | 2022-03-31 | Release date: | 2022-07-20 | Last modified: | 2024-02-14 | Method: | ELECTRON MICROSCOPY (2.89 Å) | Cite: | Phosphorylation of SAMHD1 Thr592 increases C-terminal domain dynamics, tetramer dissociation and ssDNA binding kinetics. Nucleic Acids Res., 50, 2022
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7UZW
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![BU of 7uzw by Molmil](/molmil-images/mine/7uzw) | Staphylococcus epidermidis RP62a CRISPR effector subcomplex | Descriptor: | CRISPR system Cms endoribonuclease Csm3, CRISPR system Cms protein Csm4, CRISPR system single-strand-specific deoxyribonuclease Cas10/Csm1 (subtype III-A), ... | Authors: | Smith, E.M, Ferrell, S.H, Tokars, V.L, Mondragon, A. | Deposit date: | 2022-05-09 | Release date: | 2022-07-06 | Last modified: | 2022-08-17 | Method: | ELECTRON MICROSCOPY (3.55 Å) | Cite: | Structures of an active type III-A CRISPR effector complex. Structure, 30, 2022
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7UZX
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![BU of 7uzx by Molmil](/molmil-images/mine/7uzx) | Staphylococcus epidermidis RP62a CRISPR effector subcomplex with non-self target RNA bound | Descriptor: | CRISPR non-self RNA target, CRISPR system Cms endoribonuclease Csm3, CRISPR system Cms protein Csm4, ... | Authors: | Smith, E.M, Ferrell, S.H, Tokars, V.L, Mondragon, A. | Deposit date: | 2022-05-09 | Release date: | 2022-07-06 | Last modified: | 2022-08-17 | Method: | ELECTRON MICROSCOPY (3.49 Å) | Cite: | Structures of an active type III-A CRISPR effector complex. Structure, 30, 2022
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7UZY
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![BU of 7uzy by Molmil](/molmil-images/mine/7uzy) | Staphylococcus epidermidis RP62A CRISPR effector complex with non-self target RNA 2 | Descriptor: | CRISPR system Cms endoribonuclease Csm3, CRISPR system Cms protein Csm2, CRISPR system Cms protein Csm4, ... | Authors: | Smith, E.M, Ferrell, S.H, Tokars, V.L, Mondragon, A. | Deposit date: | 2022-05-09 | Release date: | 2022-07-06 | Last modified: | 2022-08-17 | Method: | ELECTRON MICROSCOPY (4.05 Å) | Cite: | Structures of an active type III-A CRISPR effector complex. Structure, 30, 2022
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7UZZ
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![BU of 7uzz by Molmil](/molmil-images/mine/7uzz) | Staphylococcus epidermidis RP62a CRISPR tall effector complex | Descriptor: | CRISPR system Cms endoribonuclease Csm3, CRISPR system Cms protein Csm2, CRISPR system Cms protein Csm4, ... | Authors: | Smith, E.M, Ferrell, S.H, Tokars, V.L, Mondragon, A. | Deposit date: | 2022-05-09 | Release date: | 2022-07-06 | Last modified: | 2022-08-17 | Method: | ELECTRON MICROSCOPY (4.45 Å) | Cite: | Structures of an active type III-A CRISPR effector complex. Structure, 30, 2022
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7V00
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![BU of 7v00 by Molmil](/molmil-images/mine/7v00) | Staphylococcus epidermidis RP62a CRISPR tall effector complex with bound ATP | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, CRISPR system Cms endoribonuclease Csm3, CRISPR system Cms protein Csm2, ... | Authors: | Smith, E.M, Ferrell, S.H, Tokars, V.L, Mondragon, A. | Deposit date: | 2022-05-09 | Release date: | 2022-07-06 | Last modified: | 2022-08-17 | Method: | ELECTRON MICROSCOPY (3.87 Å) | Cite: | Structures of an active type III-A CRISPR effector complex. Structure, 30, 2022
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7V01
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![BU of 7v01 by Molmil](/molmil-images/mine/7v01) | Staphylococcus epidermidis RP62a CRISPR short effector complex with self RNA target and ATP | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, CRISPR system Cms endoribonuclease Csm3, CRISPR system Cms protein Csm2, ... | Authors: | Smith, E.M, Ferrell, S.H, Tokars, V.L, Mondragon, A. | Deposit date: | 2022-05-09 | Release date: | 2022-07-06 | Last modified: | 2022-08-17 | Method: | ELECTRON MICROSCOPY (3.67 Å) | Cite: | Structures of an active type III-A CRISPR effector complex. Structure, 30, 2022
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7V02
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![BU of 7v02 by Molmil](/molmil-images/mine/7v02) | Staphylococcus epidermidis RP62A CRISPR short effector complex | Descriptor: | CRISPR system Cms endoribonuclease Csm3, CRISPR system Cms protein Csm2, CRISPR system Cms protein Csm4, ... | Authors: | Smith, E.M, Ferrell, S.H, Tokars, V.L, Mondragon, A. | Deposit date: | 2022-05-09 | Release date: | 2022-07-06 | Last modified: | 2022-08-17 | Method: | ELECTRON MICROSCOPY (4.97 Å) | Cite: | Structures of an active type III-A CRISPR effector complex. Structure, 30, 2022
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7W1F
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![BU of 7w1f by Molmil](/molmil-images/mine/7w1f) | Crystal structure of the dNTP triphosphohydrolase PA1124 from Pseudomonas aeruginosa | Descriptor: | NICKEL (II) ION, Probable deoxyguanosinetriphosphate triphosphohydrolase | Authors: | Oh, H.B, Song, W.S, Lee, K.C, Park, S.C, Yoon, S.I. | Deposit date: | 2021-11-19 | Release date: | 2022-03-23 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Structural analysis of the dNTP triphosphohydrolase PA1124 from Pseudomonas aeruginosa. Biochem.Biophys.Res.Commun., 589, 2022
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8ACU
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![BU of 8acu by Molmil](/molmil-images/mine/8acu) | |
8BMW
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![BU of 8bmw by Molmil](/molmil-images/mine/8bmw) | SsoCsm | Descriptor: | CRISPR-associated Cas7 paralog (Type III-D), CRISPR-associated protein Cas10 (Type III-D), CRISPR-associated protein Cas5 (Type III-D), ... | Authors: | Spagnolo, L, White, M.F. | Deposit date: | 2022-11-11 | Release date: | 2023-03-01 | Last modified: | 2023-03-22 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Structure of the Saccharolobus solfataricus type III-D CRISPR effector. Curr Res Struct Biol, 5, 2023
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8D94
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![BU of 8d94 by Molmil](/molmil-images/mine/8d94) | SAMHD1-DNA complex | Descriptor: | CALCIUM ION, DNA (5'-D(P*TP*GP*T)-3'), Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, ... | Authors: | Hollis, T.J, Batalis, S.M. | Deposit date: | 2022-06-09 | Release date: | 2023-07-05 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.44 Å) | Cite: | SAMHD1-DNA complex To Be Published
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8D9J
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![BU of 8d9j by Molmil](/molmil-images/mine/8d9j) | SAMHD1-DNA complex | Descriptor: | CALCIUM ION, DNA (5'-D(*CP*AP*AP*TP*G)-3'), Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, ... | Authors: | Hollis, T.J, Batalis, S.M. | Deposit date: | 2022-06-10 | Release date: | 2023-07-05 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.82 Å) | Cite: | SAMHD1-DNA complex To Be Published
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8GB1
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![BU of 8gb1 by Molmil](/molmil-images/mine/8gb1) | Crystal structure of SAMHD1 dimer bound to deoxyguanosine linked inhibitor | Descriptor: | 5'-O-[(R)-(3-{[(1M)-3'-bromo[1,1'-biphenyl]-3-carbonyl]amino}propoxy)(hydroxy)phosphoryl]-2'-deoxyguanosine, Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, FE (III) ION | Authors: | Egleston, M, Dong, L, Howlader, A.H, Bhat, S, Orris, B, Bianchet, M.A, Greenberg, M.M, Stivers, J.T. | Deposit date: | 2023-02-24 | Release date: | 2023-06-07 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.46 Å) | Cite: | Deoxyguanosine-Linked Bifunctional Inhibitor of SAMHD1 dNTPase Activity and Nucleic Acid Binding. Acs Chem.Biol., 18, 2023
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8GB2
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![BU of 8gb2 by Molmil](/molmil-images/mine/8gb2) | Crystal structure of Apo-SAMHD1 | Descriptor: | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, FE (III) ION | Authors: | Egleston, M, Dong, L, Howlader, A.H, Bhat, S, Orris, B, Bianchet, M.A, Greenberg, M.M, Stivers, J.T. | Deposit date: | 2023-02-24 | Release date: | 2023-06-07 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (3.07 Å) | Cite: | Deoxyguanosine-Linked Bifunctional Inhibitor of SAMHD1 dNTPase Activity and Nucleic Acid Binding. Acs Chem.Biol., 18, 2023
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8JGO
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![BU of 8jgo by Molmil](/molmil-images/mine/8jgo) | |
8JGP
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![BU of 8jgp by Molmil](/molmil-images/mine/8jgp) | |
8JGQ
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![BU of 8jgq by Molmil](/molmil-images/mine/8jgq) | |