8GB1

Crystal structure of SAMHD1 dimer bound to deoxyguanosine linked inhibitor

Summary for 8GB1

Entry DOI	10.2210/pdb8gb1/pdb
Descriptor	Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, 5'-O-[(R)-(3-{[(1M)-3'-bromo[1,1'-biphenyl]-3-carbonyl]amino}propoxy)(hydroxy)phosphoryl]-2'-deoxyguanosine, FE (III) ION, ... (4 entities in total)
Functional Keywords	samhd1, dntpase, hydrolase, inhibitor, deoxyguanosine linked inhibitor, hydrolase inhibitor, dimer, dimeric
Biological source	Homo sapiens (human)
Total number of polymer chains	4
Total formula weight	242094.57
Authors	Egleston, M.,Dong, L.,Howlader, A.H.,Bhat, S.,Orris, B.,Bianchet, M.A.,Greenberg, M.M.,Stivers, J.T. (deposition date: 2023-02-24, release date: 2023-06-07, Last modification date: 2023-11-01)
Primary citation	Egleston, M.,Dong, L.,Howlader, A.H.,Bhat, S.,Orris, B.,Bianchet, M.A.,Greenberg, M.M.,Stivers, J.T. Deoxyguanosine-Linked Bifunctional Inhibitor of SAMHD1 dNTPase Activity and Nucleic Acid Binding. Acs Chem.Biol., 18:2200-2210, 2023 Cited by PubMed: 37233733 DOI: 10.1021/acschembio.3c00118 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.46 Å)

Structure validation