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1DN2
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BU of 1dn2 by Molmil
FC FRAGMENT OF HUMAN IGG1 IN COMPLEX WITH AN ENGINEERED 13 RESIDUE PEPTIDE DCAWHLGELVWCT-NH2
Descriptor: ENGINEERED PEPTIDE, IMMUNOGLOBULIN LAMBDA HEAVY CHAIN, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:DeLano, W.L, Ultsch, M.H, de Vos, A.M, Wells, J.A.
Deposit date:1999-12-15
Release date:2000-05-17
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Convergent solutions to binding at a protein-protein interface.
Science, 287, 2000
1DNW
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HUMAN MYELOPEROXIDASE-CYANIDE-THIOCYANATE COMPLEX
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETIC ACID, CALCIUM ION, ...
Authors:Blair-Johnson, M, Fiedler, T.J, Fenna, R.E.
Deposit date:1999-12-16
Release date:2001-12-21
Last modified:2024-12-25
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Human myeloperoxidase: structure of a cyanide complex and its interaction with bromide and thiocyanate substrates at 1.9 A resolution.
Biochemistry, 40, 2001
3H6Z
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BU of 3h6z by Molmil
Crystal Structure of the Four MBT Repeats of Drosophila melanogaster Sfmbt in Complex with Peptide RHR (me)K VLR
Descriptor: 'HR(MLZ)VLR, Polycomb protein Sfmbt, beta-D-fructofuranose-(2-1)-alpha-D-glucopyranose
Authors:Grimm, C, Mueller, C.W.
Deposit date:2009-04-24
Release date:2009-06-16
Last modified:2021-11-10
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Molecular recognition of histone lysine methylation by the Polycomb group repressor dSfmbt
Embo J., 28, 2009
6ZX1
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BU of 6zx1 by Molmil
OMPD-domain of human UMPS in complex with 6-Aza-UMP at 1.0 Angstroms resolution
Descriptor: 6-AZA URIDINE 5'-MONOPHOSPHATE, PROLINE, SULFATE ION, ...
Authors:Tittmann, K, Rindfleisch, S, Krull, M.
Deposit date:2020-07-29
Release date:2022-02-23
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (1 Å)
Cite:Ground-state destabilization by electrostatic repulsion is not a driving force in orotidine-5-monophosphate decarboxylase catalysis
Nat Catal, 5, 2022
6ZX0
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BU of 6zx0 by Molmil
OMPD-domain of human UMPS in complex with the substrate OMP at 1.25 Angstroms resolution
Descriptor: GLYCEROL, OROTIDINE-5'-MONOPHOSPHATE, SULFATE ION, ...
Authors:Tittmann, K, Rindfleisch, S, Krull, M.
Deposit date:2020-07-29
Release date:2022-02-23
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Ground-state destabilization by electrostatic repulsion is not a driving force in orotidine-5-monophosphate decarboxylase catalysis
Nat Catal, 5, 2022
6ZWY
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BU of 6zwy by Molmil
OMPD-domain of human UMPS in complex with UMP at 1.0 Angstroms resolution
Descriptor: GLYCEROL, PROLINE, URIDINE-5'-MONOPHOSPHATE, ...
Authors:Tittmann, K, Rindfleisch, S.
Deposit date:2020-07-29
Release date:2022-02-23
Last modified:2024-10-09
Method:X-RAY DIFFRACTION (1 Å)
Cite:Ground-state destabilization by electrostatic repulsion is not a driving force in orotidine-5-monophosphate decarboxylase catalysis
Nat Catal, 5, 2022
6ZX3
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BU of 6zx3 by Molmil
OMPD-domain of human UMPS in complex with 6-thiocarboxamido-UMP at 1.15 Angstroms resolution
Descriptor: GLYCEROL, PROLINE, SULFATE ION, ...
Authors:Tittmann, K, Rindfleisch, S, Schimdt, T.
Deposit date:2020-07-29
Release date:2022-02-23
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.15 Å)
Cite:Ground-state destabilization by electrostatic repulsion is not a driving force in orotidine-5-monophosphate decarboxylase catalysis
Nat Catal, 5, 2022
6ZX2
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BU of 6zx2 by Molmil
OMPD-domain of human UMPS in complex with 6-carboxamido-UMP at 1.2 Angstroms resolution
Descriptor: PROLINE, SULFATE ION, Uridine 5'-monophosphate synthase, ...
Authors:Tittmann, K, Rindfleisch, S, Schimdt, T.
Deposit date:2020-07-29
Release date:2022-02-23
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Ground-state destabilization by electrostatic repulsion is not a driving force in orotidine-5-monophosphate decarboxylase catalysis
Nat Catal, 5, 2022
3H9Z
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BU of 3h9z by Molmil
Crystal structure of the IgE-Fc3-4 domains
Descriptor: AMMONIUM ION, Ig epsilon chain C region, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
Authors:Wurzburg, B.A.
Deposit date:2009-04-30
Release date:2009-09-08
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Conformational flexibility in immunoglobulin E-Fc 3-4 revealed in multiple crystal forms.
J.Mol.Biol., 393, 2009
4N8Y
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BU of 4n8y by Molmil
Crystal structure of a trap periplasmic solute binding protein from bradyrhizobium sp. btai1 b (bbta_0128), target EFI-510056 (bbta_0128), complex with alpha/beta-d-galacturonate
Descriptor: Putative TRAP-type C4-dicarboxylate transport system, binding periplasmic protein (DctP subunit), alpha-D-galactopyranuronic acid, ...
Authors:Vetting, M.W, Al Obaidi, N.F, Morisco, L.L, Wasserman, S.R, Sojitra, S, Stead, M, Attonito, J.D, Scott Glenn, A, Chowdhury, S, Evans, B, Hillerich, B, Love, J, Seidel, R.D, Imker, H.J, Gerlt, J.A, Almo, S.C, Enzyme Function Initiative (EFI)
Deposit date:2013-10-18
Release date:2013-11-20
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Experimental strategies for functional annotation and metabolism discovery: targeted screening of solute binding proteins and unbiased panning of metabolomes.
Biochemistry, 54, 2015
7A4Q
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BU of 7a4q by Molmil
The Crystal structure of RO4613269 bound to CK2alpha
Descriptor: 2-methoxyimino-5-(quinolin-6-ylmethyl)-1,3-thiazol-4-one, Casein kinase II subunit alpha
Authors:Brear, P, Hyvonen, M.
Deposit date:2020-08-20
Release date:2022-06-08
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.42 Å)
Cite:Chemical proteomics reveals the target landscape of 1,000 kinase inhibitors.
Nat.Chem.Biol., 2023
4MNP
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BU of 4mnp by Molmil
Structure of the Sialic Acid Binding Protein from Fusobacterium Nucleatum subsp. nucleatum ATCC 25586
Descriptor: N-acetyl-beta-neuraminic acid, N-acetylneuraminate-binding protein
Authors:Thanuja, G, Ramaswamy, S.
Deposit date:2013-09-11
Release date:2014-07-09
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Bacterial periplasmic sialic acid-binding proteins exhibit a conserved binding site.
Acta Crystallogr.,Sect.D, 70, 2014
3HG4
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BU of 3hg4 by Molmil
Human alpha-galactosidase catalytic mechanism 3. Covalent intermediate
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Guce, A.I, Clark, N.E, Garman, S.C.
Deposit date:2009-05-13
Release date:2009-11-24
Last modified:2024-11-06
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Catalytic mechanism of human alpha-galactosidase.
J.Biol.Chem., 285, 2010
3HG5
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BU of 3hg5 by Molmil
Human alpha-galactosidase catalytic mechanism 4. Product bound
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETIC ACID, Alpha-galactosidase A, ...
Authors:Guce, A.I, Clark, N.E, Garman, S.C.
Deposit date:2009-05-13
Release date:2009-11-24
Last modified:2024-11-06
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Catalytic mechanism of human alpha-galactosidase.
J.Biol.Chem., 285, 2010
4MVW
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BU of 4mvw by Molmil
Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor 1-{3-[(3,5-dichlorobenzyl)amino]propyl}-3-thiophen-3-ylurea (Chem 1433)
Descriptor: 1-{3-[(3,5-dichlorobenzyl)amino]propyl}-3-thiophen-3-ylurea, DIMETHYL SULFOXIDE, GLYCEROL, ...
Authors:Koh, C.Y, Kim, J.E, Wetzel, A.B, de van der Schueren, W.J, Shibata, S, Liu, J, Zhang, Z, Fan, E, Verlinde, C.L.M.J, Hol, W.G.J.
Deposit date:2013-09-24
Release date:2014-04-30
Last modified:2024-11-20
Method:X-RAY DIFFRACTION (2.901 Å)
Cite:Structures of Trypanosoma brucei Methionyl-tRNA Synthetase with Urea-Based Inhibitors Provide Guidance for Drug Design against Sleeping Sickness.
Plos Negl Trop Dis, 8, 2014
3HG2
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BU of 3hg2 by Molmil
Human alpha-galactosidase catalytic mechanism 1. Empty active site
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETIC ACID, Alpha-galactosidase A, ...
Authors:Guce, A.I, Clark, N.E, Garman, S.C.
Deposit date:2009-05-13
Release date:2009-11-24
Last modified:2024-10-09
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Catalytic mechanism of human alpha-galactosidase.
J.Biol.Chem., 285, 2010
4N17
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BU of 4n17 by Molmil
Crystal structure of a TRAP periplasmic solute binding protein from Burkholderia ambifaria (BAM_6123), Target EFI-510059, With bound beta-D-galacturonate
Descriptor: CALCIUM ION, CHLORIDE ION, TRAP dicarboxylate transporter, ...
Authors:Vetting, M.W, Toro, R, Bhosle, R, Al Obaidi, N.F, Zhao, S, Stead, M, Attonito, J.D, Scott Glenn, A, Chowdhury, S, Evans, B, Hillerich, B, Love, J, Seidel, R.D, Imker, H.J, Jacobson, M.P, Gerlt, J.A, Almo, S.C, Enzyme Function Initiative (EFI)
Deposit date:2013-10-03
Release date:2013-10-16
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.501 Å)
Cite:Experimental strategies for functional annotation and metabolism discovery: targeted screening of solute binding proteins and unbiased panning of metabolomes.
Biochemistry, 54, 2015
3HG3
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BU of 3hg3 by Molmil
Human alpha-galactosidase catalytic mechanism 2. Substrate bound
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-galactosidase A, ...
Authors:Guce, A.I, Clark, N.E, Garman, S.C.
Deposit date:2009-05-13
Release date:2009-11-24
Last modified:2024-11-27
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Catalytic mechanism of human alpha-galactosidase.
J.Biol.Chem., 285, 2010
4MS4
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BU of 4ms4 by Molmil
Crystal structure of the extracellular domain of human GABA(B) receptor bound to the agonist baclofen
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Gamma-aminobutyric acid type B receptor subunit 1, Gamma-aminobutyric acid type B receptor subunit 2, ...
Authors:Geng, Y, Bush, M, Mosyak, L, Wang, F, Fan, Q.R.
Deposit date:2013-09-18
Release date:2013-12-11
Last modified:2024-11-06
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural mechanism of ligand activation in human GABA(B) receptor.
Nature, 504, 2013
4N91
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BU of 4n91 by Molmil
Crystal structure of a trap periplasmic solute binding protein from anaerococcus prevotii dsm 20548 (Apre_1383), target EFI-510023, with bound alpha/beta d-glucuronate
Descriptor: CHLORIDE ION, TETRAETHYLENE GLYCOL, TRAP dicarboxylate transporter, ...
Authors:Vetting, M.W, Al Obaidi, N.F, Morisco, L.L, Wasserman, S.R, Sojitra, S, Stead, M, Attonito, J.D, Scott Glenn, A, Chowdhury, S, Evans, B, Hillerich, B, Love, J, Seidel, R.D, Imker, H.J, Gerlt, J.A, Almo, S.C, Enzyme Function Initiative (EFI)
Deposit date:2013-10-18
Release date:2013-11-13
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Experimental strategies for functional annotation and metabolism discovery: targeted screening of solute binding proteins and unbiased panning of metabolomes.
Biochemistry, 54, 2015
3HI7
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BU of 3hi7 by Molmil
Crystal structure of human diamine oxidase
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Amiloride-sensitive amine oxidase, CALCIUM ION, ...
Authors:McGrath, A.P, Guss, J.M.
Deposit date:2009-05-19
Release date:2009-10-20
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.799 Å)
Cite:Structure and inhibition of human diamine oxidase
Biochemistry, 48, 2009
3HII
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BU of 3hii by Molmil
Crystal structure of human diamine oxidase in complex with the inhibitor pentamidine
Descriptor: 1,5-BIS(4-AMIDINOPHENOXY)PENTANE, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Amiloride-sensitive amine oxidase, ...
Authors:McGrath, A.P, Guss, J.M.
Deposit date:2009-05-20
Release date:2009-10-20
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.149 Å)
Cite:Structure and inhibition of human diamine oxidase
Biochemistry, 48, 2009
3HIG
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BU of 3hig by Molmil
Crystal structure of human diamine oxidase in complex with the inhibitor berenil
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Amiloride-sensitive amine oxidase, BERENIL, ...
Authors:McGrath, A.P, Guss, J.M.
Deposit date:2009-05-19
Release date:2009-10-20
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:Structure and inhibition of human diamine oxidase
Biochemistry, 48, 2009
4MVX
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BU of 4mvx by Molmil
Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor 1-{3-[(3,5-dichlorobenzyl)amino]propyl}-3-phenylurea (Chem 1356)
Descriptor: 1-{3-[(3,5-dichlorobenzyl)amino]propyl}-3-phenylurea, DIMETHYL SULFOXIDE, GLYCEROL, ...
Authors:Koh, C.Y, Kim, J.E, Wetzel, A.B, de van der Schueren, W.J, Shibata, S, Liu, J, Zhang, Z, Fan, E, Verlinde, C.L.M.J, Hol, W.G.J.
Deposit date:2013-09-24
Release date:2014-04-30
Last modified:2024-11-27
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Structures of Trypanosoma brucei Methionyl-tRNA Synthetase with Urea-Based Inhibitors Provide Guidance for Drug Design against Sleeping Sickness.
Plos Negl Trop Dis, 8, 2014
4N93
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BU of 4n93 by Molmil
Alternative substrates of Mycobacterium tuberculosis anthranilate phosphoribosyl transferase
Descriptor: 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, 2-amino-6-methylbenzoic acid, Anthranilate phosphoribosyltransferase, ...
Authors:Castell, A, Short, F.L, Lott, J.S.
Deposit date:2013-10-19
Release date:2014-04-23
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:Alternative substrates reveal catalytic cycle and key binding events in the reaction catalysed by anthranilate phosphoribosyltransferase from Mycobacterium tuberculosis.
Biochem.J., 461, 2014

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数据于2025-10-08公开中

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