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7W0P
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BU of 7w0p by Molmil
Cryo-EM structure of a GPCR-Gi complex with peptide
Descriptor: Apelin receptor early endogenous ligand, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Xu, F, Yue, Y, Liu, L.E, Wu, L.J, Hanson, M.
Deposit date:2021-11-18
Release date:2022-07-27
Method:ELECTRON MICROSCOPY (3.16 Å)
Cite:Structural insight into apelin receptor-G protein stoichiometry.
Nat.Struct.Mol.Biol., 29, 2022
2W07
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BU of 2w07 by Molmil
Structural determinants of polymerization reactivity of the P pilus adaptor subunit PapF
Descriptor: CHAPERONE PROTEIN PAPD, MINOR PILIN SUBUNIT PAPF, SULFATE ION
Authors:Verger, D, Rose, R.J, Paci, E, Costakes, G, Daviter, T, Hultgren, S, Remaut, H, Ashcroft, A.E, Radford, S.E, Waksman, G.
Deposit date:2008-08-12
Release date:2008-11-25
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural Determinants of Polymerization Reactivity of the P Pilus Adaptor Subunit Papf.
Structure, 16, 2008
8DGB
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BU of 8dgb by Molmil
Crystal Structure of SARS-CoV-2 Main Protease (Mpro) Q192T Mutant in Complex with Inhibitor GC376
Descriptor: (1R,2S)-2-({N-[(benzyloxy)carbonyl]-L-leucyl}amino)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid, 3C-like proteinase nsp5
Authors:Lewandowski, E.M, Jacobs, L.M.C, Hu, Y, Tan, H, Wang, J, Chen, Y.
Deposit date:2022-06-23
Release date:2022-07-13
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.87 Å)
Cite:Naturally Occurring Mutations of SARS-CoV-2 Main Protease Confer Drug Resistance to Nirmatrelvir.
Acs Cent.Sci., 9, 2023
6NVT
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BU of 6nvt by Molmil
Crystal structure of TLA-1 extended spectrum Beta-lactamase
Descriptor: ACETATE ION, Beta-lactamase, CHLORIDE ION, ...
Authors:Rudino-Pinera, E, Cifuentes-Castro, V.H, Rodriguez-Almazan, C.
Deposit date:2019-02-05
Release date:2019-12-11
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The crystal structure of ESBL TLA-1 in complex with clavulanic acid reveals a second acylation site.
Biochem.Biophys.Res.Commun., 522, 2020
6APG
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BU of 6apg by Molmil
Trans-acting transferase from Disorazole synthase with malonate
Descriptor: CALCIUM ION, DisD protein, GLYCEROL, ...
Authors:Mathews, I.I, Lyubimov, A.Y, Soltis, S.M, Khosla, C, Robbins, T, Cohen, A.E.
Deposit date:2017-08-17
Release date:2018-04-04
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2 Å)
Cite:The Conformational Flexibility of the Acyltransferase from the Disorazole Polyketide Synthase Is Revealed by an X-ray Free-Electron Laser Using a Room-Temperature Sample Delivery Method for Serial Crystallography.
Biochemistry, 56, 2017
8UKY
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BU of 8uky by Molmil
Crystal structure of BAK in complex with inhibiting antibody 14G6
Descriptor: 1,2-ETHANEDIOL, 14G6 Fab heavy chain, 14G6 Fab light chain, ...
Authors:Miller, M.S, Czabotar, P.E.
Deposit date:2023-10-15
Release date:2024-04-10
Last modified:2024-06-26
Method:X-RAY DIFFRACTION (2.398 Å)
Cite:A novel inhibitory BAK antibody enables assessment of non-activated BAK in cancer cells.
Cell Death Differ., 31, 2024
6NZY
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BU of 6nzy by Molmil
Structural Determination of the Carboxy-terminal portion of ATP-citrate lyase
Descriptor: ACETYL COENZYME *A, ATP-citrate lyase alpha-subunit, GLYCEROL, ...
Authors:Nguyen, V.H, Fraser, M.E.
Deposit date:2019-02-14
Release date:2019-12-18
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Identification of the active site residues in ATP-citrate lyase's carboxy-terminal portion.
Protein Sci., 28, 2019
8DCZ
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BU of 8dcz by Molmil
Crystal Structure of SARS-CoV-2 Main Protease (Mpro) M165Y Mutant in Complex with Nirmatrelvir
Descriptor: (1R,2S,5S)-N-{(1E,2S)-1-imino-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-6,6-dimethyl-3-[3-methyl-N-(trifluoroacetyl)-L-valyl]-3-azabicyclo[3.1.0]hexane-2-carboxamide, 3C-like proteinase nsp5
Authors:Lewandowski, E.M, Hu, Y, Tan, H, Wang, J, Chen, Y.
Deposit date:2022-06-17
Release date:2022-07-13
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.38 Å)
Cite:Naturally Occurring Mutations of SARS-CoV-2 Main Protease Confer Drug Resistance to Nirmatrelvir.
Acs Cent.Sci., 9, 2023
8V84
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BU of 8v84 by Molmil
60S ribosome biogenesis intermediate (Dbp10 catalytic structure - Overall map)
Descriptor: 25S rRNA (cytosine(2870)-C(5))-methyltransferase, 60S ribosomal protein L13-A, 60S ribosomal protein L14-A, ...
Authors:Cruz, V.E, Weirich, C.S, Peddada, N, Erzberger, J.P.
Deposit date:2023-12-04
Release date:2024-05-01
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:The DEAD-box ATPase Dbp10/DDX54 initiates peptidyl transferase center formation during 60S ribosome biogenesis.
Nat Commun, 15, 2024
8V83
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BU of 8v83 by Molmil
60S ribosome biogenesis intermediate (Dbp10 pre-catalytic structure - Overall map)
Descriptor: 25S rRNA (cytosine(2870)-C(5))-methyltransferase, 60S ribosomal protein L13-A, 60S ribosomal protein L14-A, ...
Authors:Cruz, V.E, Weirich, C.S, Peddada, N, Erzberger, J.P.
Deposit date:2023-12-04
Release date:2024-05-01
Method:ELECTRON MICROSCOPY (2.53 Å)
Cite:The DEAD-box ATPase Dbp10/DDX54 initiates peptidyl transferase center formation during 60S ribosome biogenesis.
Nat Commun, 15, 2024
5T96
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BU of 5t96 by Molmil
Crystal structure of the infectious salmon anemia virus (ISAV) HE viral receptor complex
Descriptor: 4-O-acetyl-5-acetamido-3,5-dideoxy-L-glycero-alpha-D-galacto-non-2-ulopyranosonic acid, FORMIC ACID, GLYCEROL, ...
Authors:Cook, J.D, Sultana, A, Lee, J.E.
Deposit date:2016-09-09
Release date:2017-03-22
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of the infectious salmon anemia virus receptor complex illustrates a unique binding strategy for attachment.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
6O08
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BU of 6o08 by Molmil
Gluconobacter Ene-Reductase (GluER)
Descriptor: ACETATE ION, CHLORIDE ION, FLAVIN MONONUCLEOTIDE, ...
Authors:Garfinkle, S.E, Jeffrey, P, Hyster, T.K.
Deposit date:2019-02-15
Release date:2019-06-26
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.798 Å)
Cite:Photoexcitation of flavoenzymes enables a stereoselective radical cyclization.
Science, 364, 2019
8DEV
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BU of 8dev by Molmil
Cryo-electron microscopy structure of Neisseria gonorrhoeae multidrug efflux pump MtrD with colistin complex
Descriptor: Colistin, Efflux pump membrane transporter, PHOSPHATIDYLETHANOLAMINE
Authors:Lyu, M, Yu, E.W.
Deposit date:2022-06-21
Release date:2022-09-14
Last modified:2022-11-09
Method:ELECTRON MICROSCOPY (3.08 Å)
Cite:Structural Basis of Peptide-Based Antimicrobial Inhibition of a Resistance-Nodulation-Cell Division Multidrug Efflux Pump.
Microbiol Spectr, 10, 2022
4OMC
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BU of 4omc by Molmil
X-ray structure of human furin in complex with the competitive inhibitor meta-guanidinomethyl-Phac-RVR-Amba
Descriptor: CALCIUM ION, FORMIC ACID, Furin, ...
Authors:Dahms, S.O, Than, M.E.
Deposit date:2014-01-27
Release date:2014-04-09
Last modified:2014-05-28
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:X-ray Structures of Human Furin in Complex with Competitive Inhibitors.
Acs Chem.Biol., 9, 2014
5CSY
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BU of 5csy by Molmil
Disproportionating enzyme 1 from Arabidopsis - acarbose soak
Descriptor: 1,2-ETHANEDIOL, 4-alpha-glucanotransferase DPE1, chloroplastic/amyloplastic, ...
Authors:O'Neill, E.C, Stevenson, C.E.M, Tantanarat, K, Latousakis, D, Donaldson, M.I, Rejzek, M, Limpaseni, T, Smith, A.M, Field, R.A, Lawson, D.M.
Deposit date:2015-07-23
Release date:2015-11-04
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structural Dissection of the Maltodextrin Disproportionation Cycle of the Arabidopsis Plastidial Disproportionating Enzyme 1 (DPE1).
J.Biol.Chem., 290, 2015
4WHW
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BU of 4whw by Molmil
Direct photocapture of bromodomains using tropolone chemical probes
Descriptor: 1,2-ETHANEDIOL, 2-methoxy-4-{1-[2-(morpholin-4-yl)ethyl]-2-(2-phenylethyl)-1H-benzimidazol-5-yl}cyclohepta-2,4,6-trien-1-one, Bromodomain-containing protein 4
Authors:Hett, E.C, Piatnitski Chekler, E.L, Basak, A, Bonin, P.D, Denny, R.A, Flick, A.C, Geoghegan, K.F, Liu, S, Pletcher, M.T, Robinson, R.P, Sahasrabudhe, P, Salter, S, Stock, I.A, Jones, L.H.
Deposit date:2014-09-23
Release date:2015-10-28
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.345 Å)
Cite:Direct photocapture of bromodomains using tropolone chemical probes
To Be Published
5KAA
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BU of 5kaa by Molmil
Protein Tyrosine Phosphatase 1B Delta helix 7, P185G mutant, open state
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, GLYCEROL, ...
Authors:Choy, M.S, Machado, L.E.S.F, Peti, W, Page, R.
Deposit date:2016-06-01
Release date:2017-03-08
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.968 Å)
Cite:Conformational Rigidity and Protein Dynamics at Distinct Timescales Regulate PTP1B Activity and Allostery.
Mol. Cell, 65, 2017
8D9O
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BU of 8d9o by Molmil
De Novo Photosynthetic Reaction Center Protein in Apo-State
Descriptor: CADMIUM ION, Reaction Center Maquette
Authors:Ennist, N.M, Stayrook, S.E, Dutton, P.L, Moser, C.C.
Deposit date:2022-06-10
Release date:2022-09-28
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Rational design of photosynthetic reaction center protein maquettes.
Front Mol Biosci, 9, 2022
1O5A
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BU of 1o5a by Molmil
Dissecting and Designing Inhibitor Selectivity Determinants at the S1 site Using an Artificial Ala190 Protease (Ala190 uPA)
Descriptor: 3-{5-[AMINO(IMINIO)METHYL]-1H-INDOL-2-YL}-1,1'-BIPHENYL-2-OLATE, CITRIC ACID, Urokinase-type plasminogen activator
Authors:Katz, B.A, Luong, C, Ho, J.D, Somoza, J.R, Gjerstad, E, Tang, J, Williams, S.R, Verner, E, Mackman, R.L, Young, W.B, Sprengeler, P.A, Chan, H, Mortara, K, Janc, J.W, McGrath, M.E.
Deposit date:2003-09-09
Release date:2004-09-21
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.68 Å)
Cite:Dissecting and designing inhibitor selectivity determinants at the S1 site using an artificial Ala190 protease (Ala190 uPA)
J.Mol.Biol., 344, 2004
7ANU
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BU of 7anu by Molmil
Crystal structure of Pyrococcus abyssi Pbp11
Descriptor: GLYCEROL, IMIDAZOLE, NICKEL (II) ION, ...
Authors:Hogrel, G, Girard, E, Franzetti, B.
Deposit date:2020-10-12
Release date:2021-11-03
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.64 Å)
Cite:Characterization of a small tRNA-binding protein that interacts with the archaeal proteasome complex.
Mol.Microbiol., 118, 2022
3NWD
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BU of 3nwd by Molmil
Glycoprotein B from Herpes simplex virus type 1, Y179S mutant, low-pH
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ...
Authors:Stampfer, S.D, Lou, H, Cohen, G.H, Eisenberg, R.J, Heldwein, E.E.
Deposit date:2010-07-09
Release date:2010-12-01
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.8803 Å)
Cite:Structural basis of local, pH-dependent conformational changes in glycoprotein B from herpes simplex virus type 1.
J.Virol., 84, 2010
7T91
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BU of 7t91 by Molmil
Crystal structure of Zinc finger motif 1 and 2 of GLI1 DNA binding region
Descriptor: Isoform 2 of Zinc finger protein GLI1, ZINC ION
Authors:Wu, M, Zhang, S, Augelli-Szanfran, C.E, Boohaker, R.J.
Deposit date:2021-12-17
Release date:2022-12-21
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Crystal structure of Zinc finger motif 1 and 2 of GLI1 DNA binding region
To Be Published
7AR0
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BU of 7ar0 by Molmil
Co-Crystal Structure of Variant Surface Glycoprotein VSG2 in complex with Nanobody VSG2(NB19)
Descriptor: Nanobody VSG2(NB19), Variant surface glycoprotein MITAT 1.2, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
Authors:Stebbins, C.E, Hempelmann, A.
Deposit date:2020-10-23
Release date:2021-11-03
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.139 Å)
Cite:Nanobody-mediated macromolecular crowding induces membrane fission and remodeling in the African trypanosome.
Cell Rep, 37, 2021
6BDO
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BU of 6bdo by Molmil
Structure of bacterial type II NADH dehydrogenase from Caldalkalibacillus thermarum complexed with a quinone inhibitor HQNO at 2.8A resolution
Descriptor: 2-HEPTYL-4-HYDROXY QUINOLINE N-OXIDE, FAD-dependent pyridine nucleotide-disulfide oxidoreductase, FLAVIN-ADENINE DINUCLEOTIDE
Authors:Cook, G.M, Aragao, D, Nakatani, Y.
Deposit date:2017-10-23
Release date:2018-05-16
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure of the NDH-2 - HQNO inhibited complex provides molecular insight into quinone-binding site inhibitors.
Biochim. Biophys. Acta, 1859, 2018
8UKD
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BU of 8ukd by Molmil
SARS-CoV-2 Omicron-XBB.1.5 3-RBD down Spike Protein Trimer consensus (S-GSAS-Omicron-XBB.1.5)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein
Authors:Zhang, Q.E, Acharya, P.
Deposit date:2023-10-12
Release date:2024-06-19
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:SARS-CoV-2 Omicron-XBB.1.5 3-RBD down Spike Protein Trimer consensus (S-GSAS-Omicron-XBB.1.5)
To Be Published

223790

数据于2024-08-14公开中

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