7KBB
 
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7KBA
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8H0B
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8H0A
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7JXT
 | | Ovine COX-1 in complex with the subtype-selective derivative 2a | | Descriptor: | 2-[4,5-bis(2-chlorophenyl)-1H-imidazol-2-yl]-6-(prop-2-en-1-yl)phenyl methoxyacetate, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, PROTOPORPHYRIN IX CONTAINING FE, ... | | Authors: | Ko, Y, Iaselli, M, Miciaccia, M, Friedrich, L, Schneider, G, Scilimati, A, Cingolani, G. | | Deposit date: | 2020-08-27 | | Release date: | 2021-09-01 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (3.35 Å) | | Cite: | Learning from Nature: From a Marine Natural Product to Synthetic Cyclooxygenase-1 Inhibitors by Automated De Novo Design.
Adv Sci, 8, 2021
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7JW5
 | | Crystal structure of WT-CYP199A4 in complex with 4-phenylbenzoic acid | | Descriptor: | CHLORIDE ION, Cytochrome P450, PROTOPORPHYRIN IX CONTAINING FE, ... | | Authors: | Lee, J.H.Z, Bruning, J.B, Bell, S.G. | | Deposit date: | 2020-08-24 | | Release date: | 2021-09-01 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (1.526 Å) | | Cite: | Different Geometric Requirements for Cytochrome P450-Catalyzed Aliphatic Versus Aromatic Hydroxylation Results in Chemoselective Oxidation
Acs Catalysis, 12, 2022
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7JRS
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7JRR
 | | Crystal structures of artificially designed homomeric RNA nanoarchitectures | | Descriptor: | MAGNESIUM ION, MANGANESE (II) ION, RNA (50-MER) | | Authors: | Liu, D, Shao, Y, Piccirilli, J.A, Weizmann, Y. | | Deposit date: | 2020-08-12 | | Release date: | 2021-09-08 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2.16 Å) | | Cite: | Structures of artificially designed discrete RNA nanoarchitectures at near-atomic resolution.
Sci Adv, 7, 2021
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7JQI
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8HJW
 | | Bi-functional malonyl-CoA reductuase from Chloroflexus aurantiacus | | Descriptor: | Short-chain dehydrogenase/reductase SDR | | Authors: | Ahn, J.W, Kim, S. | | Deposit date: | 2022-11-24 | | Release date: | 2023-08-30 | | Method: | ELECTRON MICROSCOPY (4.1 Å) | | Cite: | Cryo-EM structure of bifunctional malonyl-CoA reductase from Chloroflexus aurantiacus reveals a dynamic domain movement for high enzymatic activity.
Int.J.Biol.Macromol., 242, 2023
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8H0C
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7JRT
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7JQH
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8H09
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8HGC
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7JQJ
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8HGT
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8H0D
 | | Structure of the thermolabile hemolysin from Vibrio alginolyticus (in complex with docosahexaenoic acid) | | Descriptor: | 3-PYRIDINIUM-1-YLPROPANE-1-SULFONATE, DOCOSA-4,7,10,13,16,19-HEXAENOIC ACID, MAGNESIUM ION, ... | | Authors: | Ma, Q, Wang, C. | | Deposit date: | 2022-09-28 | | Release date: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (2.01 Å) | | Cite: | Catalytic site flexibility facilitates the substrate and catalytic promiscuity of Vibrio dual lipase/transferase.
Nat Commun, 14, 2023
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8HF1
 | | DmDcr-2/R2D2/LoqsPD with 19bp-dsRNA in Trimer state | | Descriptor: | Dicer-2, isoform A, LD06392p, ... | | Authors: | Su, S, Wang, J, Ma, J. | | Deposit date: | 2022-11-09 | | Release date: | 2023-09-06 | | Method: | ELECTRON MICROSCOPY (3.7 Å) | | Cite: | Structural mechanism of R2D2 and Loqs-PD synergistic modulation on DmDcr-2 oligomers.
Nat Commun, 14, 2023
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7KBE
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7KBD
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7KBF
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3AFF
 | | Crystal structure of the HsaA monooxygenase from M. tuberculosis | | Descriptor: | Hydroxylase, putative | | Authors: | D'Angelo, I, Lin, L.Y, Dresen, C, Tocheva, E.I, Strynadka, N, Eltis, L.D. | | Deposit date: | 2010-02-28 | | Release date: | 2010-05-26 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | A flavin-dependent monooxygenase from Mycobacterium tuberculosis involved in cholesterol catabolism
J.Biol.Chem., 285, 2010
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8H0L
 | | Sulfur binding domain of Hga complexed with phosphorothioated DNA | | Descriptor: | DNA (5'-D(*CP*GP*AP*GP*(PST)P*TP*CP*GP*GP*C)-3'), DNA (5'-D(*GP*CP*CP*GP*AP*AP*CP*TP*CP*G)-3'), MAGNESIUM ION, ... | | Authors: | Liu, G, He, X, Hu, W, Yang, B, Xiao, Q. | | Deposit date: | 2022-09-29 | | Release date: | 2023-09-27 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Characterization of a promiscuous DNA sulfur binding domain and application in site-directed RNA base editing.
Nucleic Acids Res., 51, 2023
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7K9N
 | | Co-crystal structure of alpha glucosidase with compound 2 | | Descriptor: | (1S,2S,3R,4S,5S)-1-(hydroxymethyl)-5-[(9-methoxynonyl)amino]cyclohexane-1,2,3,4-tetrol, 1,2-ETHANEDIOL, Alpha glucosidase 2 alpha neutral subunit, ... | | Authors: | Karade, S.S, Mariuzza, R.A. | | Deposit date: | 2020-09-29 | | Release date: | 2021-09-29 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2.07 Å) | | Cite: | N-Substituted Valiolamine Derivatives as Potent Inhibitors of Endoplasmic Reticulum alpha-Glucosidases I and II with Antiviral Activity.
J.Med.Chem., 64, 2021
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