PDB: 8880 resultsInfo pagesStatus searchChemie searchBIRD

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6WC5	Crystal Structure of a Ternary MEF2B/NKX2-5/myocardin enhancer DNA Complex Descriptor: Homeobox protein Nkx-2.5, Myocardin enhancer DNA, Myocyte-specific enhancer factor 2B Authors: Chen, L, Lei, X. Deposit date: 2020-03-29 Release date: 2020-07-22 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Crystal Structures of Ternary Complexes of MEF2 and NKX2-5 Bound to DNA Reveal a Disease Related Protein-Protein Interaction Interface. J.Mol.Biol., 432, 2020
6WC2	Crystal Structure of a Ternary MEF2 Chimera/NKX2-5/myocardin enhancer DNA Complex Descriptor: Homeobox protein Nkx-2.5, MEF2 Chimera,Myocyte-specific enhancer factor 2B,Myocyte-specific enhancer factor 2A, Myocardin Enhancer DNA Authors: Lei, X, Chen, L. Deposit date: 2020-03-29 Release date: 2020-07-22 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Crystal Structures of Ternary Complexes of MEF2 and NKX2-5 Bound to DNA Reveal a Disease Related Protein-Protein Interaction Interface. J.Mol.Biol., 432, 2020
3QIP	Structure of HIV-1 reverse transcriptase in complex with an RNase H inhibitor and nevirapine Descriptor: 11-CYCLOPROPYL-5,11-DIHYDRO-4-METHYL-6H-DIPYRIDO[3,2-B:2',3'-E][1,4]DIAZEPIN-6-ONE, 5,6-dihydroxy-2-[(2-phenyl-1H-indol-3-yl)methyl]pyrimidine-4-carboxylic acid, CHLORIDE ION, ... Authors: Lansdon, E.B, Kirschberg, T.A. Deposit date: 2011-01-27 Release date: 2011-04-20 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.0926 Å) Cite: Structural and Binding Analysis of Pyrimidinol Carboxylic Acid and N-Hydroxy Quinazolinedione HIV-1 RNase H Inhibitors. Antimicrob.Agents Chemother., 55, 2011
8W7M	Yeast replisome in state V Descriptor: ADENOSINE-5'-DIPHOSPHATE, Cell division control protein 45, DNA (71-mer), ... Authors: Dang, S, Zhai, Y, Feng, J, Yu, D, Xu, Z. Deposit date: 2023-08-30 Release date: 2023-12-06 Method: ELECTRON MICROSCOPY (4.12 Å) Cite: Synergism between CMG helicase and leading strand DNA polymerase at replication fork. Nat Commun, 14, 2023
8W7S	Yeast replisome in state IV Descriptor: Cell division control protein 45, DNA (71-mer), DNA polymerase alpha-binding protein, ... Authors: Dang, S, Zhai, Y, Feng, J, Yu, D. Deposit date: 2023-08-31 Release date: 2023-12-20 Method: ELECTRON MICROSCOPY (7.39 Å) Cite: Synergism between CMG helicase and leading strand DNA polymerase at replication fork. Nat Commun, 14, 2023
6FBI	KlenTaq DNA polymerase in a closed, ternary complex with dGpNHpp bound in the active site Descriptor: 1,2-ETHANEDIOL, 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]guanosine, DNA (5'-D(*AP*AP*AP*CP*GP*TP*GP*GP*CP*CP*GP*TP*GP*GP*TP*C)-3'), ... Authors: Kropp, H.M, Diederichs, K, Marx, A. Deposit date: 2017-12-19 Release date: 2018-09-26 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Snapshots of a modified nucleotide moving through the confines of a DNA polymerase. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6EUY	Structure of the midlink and cap-binding domains of influenza A polymerase PB2 subunit with a bound azaindazole cap-binding inhibitor Descriptor: (2~{S},3~{S})-3-[[5-fluoranyl-2-(5-fluoranyl-1~{H}-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid, Polymerase basic protein 2, SULFATE ION Authors: Cusack, S, Gaudon, S. Deposit date: 2017-10-31 Release date: 2017-12-13 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (3 Å) Cite: Capped RNA primer binding to influenza polymerase and implications for the mechanism of cap-binding inhibitors. Nucleic Acids Res., 46, 2018
6EUW	Crystal structure of the cap-binding domain of the PB2 subunit of influenza A/H5N1 polymerase bound to an azaindazole inhibitor Descriptor: (2~{S},3~{S})-3-[[5-fluoranyl-2-(5-fluoranyl-1~{H}-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid, GLYCEROL, Polymerase basic protein 2 Authors: Cusack, S, Gaudon, S. Deposit date: 2017-10-31 Release date: 2017-12-13 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1 Å) Cite: Capped RNA primer binding to influenza polymerase and implications for the mechanism of cap-binding inhibitors. Nucleic Acids Res., 46, 2018
5OXJ	Crystal structure of KlenTaq mutant M747K in a closed ternary complex with a O6-MeG:BenziTP base pair Descriptor: ACETATE ION, DNA polymerase I, thermostable, ... Authors: Betz, K, Diederichs, K, Marx, A. Deposit date: 2017-09-06 Release date: 2017-11-29 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2 Å) Cite: Structural basis for the selective incorporation of an artificial nucleotide opposite a DNA adduct by a DNA polymerase. Chem. Commun. (Camb.), 53, 2017
5TWQ	Post-catalytic nicked complex of human Polymerase Mu with newly incorporated UTP Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, DNA (5'-D(*CP*GP*GP*CP*AP*TP*AP*CP*G)-3'), ... Authors: Moon, A.F, Pryor, J.M, Ramsden, D.A, Kunkel, T.A, Bebenek, K, Pedersen, L.C. Deposit date: 2016-11-14 Release date: 2017-07-05 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Structural accommodation of ribonucleotide incorporation by the DNA repair enzyme polymerase Mu. Nucleic Acids Res., 45, 2017
2P40	Crystal Structure of Dengue Methyltransferase in Complex with 7MeGpppG Descriptor: 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE-5'-GUANOSINE, SULFATE ION, type II methyltransferase Authors: Egloff, M.P, Marseilles Structural Genomics Program @ AFMB (MSGP) Deposit date: 2007-03-11 Release date: 2007-08-28 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2.701 Å) Cite: Structural and functional analysis of methylation and 5'-RNA sequence requirements of short capped RNAs by the methyltransferase domain of dengue virus NS5 J.Mol.Biol., 372, 2007
2GV9	Crystal structure of the Herpes Simplex virus type 1 DNA polymerase Descriptor: DNA polymerase, GUANIDINE, MERCURY (II) ION, ... Authors: Liu, S. Deposit date: 2006-05-02 Release date: 2006-05-16 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.68 Å) Cite: Crystal structure of the herpes simplex virus 1 DNA polymerase. J.Biol.Chem., 281, 2006
8ICU	DNA POLYMERASE BETA (POL B) (E.C.2.7.7.7) COMPLEXED WITH SEVEN BASE PAIRS OF DNA; SOAKED IN THE PRESENCE OF DDATP (1 MILLIMOLAR) AND MNCL2 (5 MILLIMOLAR) Descriptor: 2',3'-DIDEOXYADENOSINE-5'-TRIPHOSPHATE, DNA (5'-D(*CP*AP*TP*TP*AP*GP*AP*A)-3'), DNA (5'-D(*TP*CP*TP*AP*AP*TP*GP*A)-3'), ... Authors: Pelletier, H, Sawaya, M.R. Deposit date: 1995-12-15 Release date: 1996-11-15 Last modified: 2023-08-02 Method: X-RAY DIFFRACTION (3 Å) Cite: A structural basis for metal ion mutagenicity and nucleotide selectivity in human DNA polymerase beta Biochemistry, 35, 1996
8ICX	DNA POLYMERASE BETA (POL B) (E.C.2.7.7.7) COMPLEXED WITH SEVEN BASE PAIRS OF DNA; SOAKED IN THE PRESENCE OF DTTP (1 MILLIMOLAR) AND MNCL2 (5 MILLIMOLAR) Descriptor: DNA (5'-D(*CP*AP*TP*TP*AP*GP*AP*A)-3'), DNA (5'-D(*TP*CP*TP*AP*AP*TP*G)-3'), MANGANESE (II) ION, ... Authors: Pelletier, H, Sawaya, M.R. Deposit date: 1995-12-15 Release date: 1996-11-15 Last modified: 2023-08-02 Method: X-RAY DIFFRACTION (3 Å) Cite: A structural basis for metal ion mutagenicity and nucleotide selectivity in human DNA polymerase beta Biochemistry, 35, 1996
8ICV	DNA POLYMERASE BETA (POL B) (E.C.2.7.7.7) COMPLEXED WITH SEVEN BASE PAIRS OF DNA; SOAKED IN THE PRESENCE OF DGTP (1 MILLIMOLAR) AND MNCL2 (5 MILLIMOLAR) Descriptor: 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, DNA (5'-D(*CP*AP*TP*TP*AP*GP*AP*A)-3'), DNA (5'-D(*TP*CP*TP*AP*AP*TP*GP*G)-3'), ... Authors: Pelletier, H, Sawaya, M.R. Deposit date: 1996-01-04 Release date: 1996-11-15 Last modified: 2023-08-02 Method: X-RAY DIFFRACTION (3.2 Å) Cite: A structural basis for metal ion mutagenicity and nucleotide selectivity in human DNA polymerase beta Biochemistry, 35, 1996
8ICY	DNA POLYMERASE BETA (E.C.2.7.7.7)/DNA COMPLEX + THYMIDINE-5'-TRIPHOSPHATE, SOAKED IN THE PRESENCE OF DTTP AND MNCL2 Descriptor: DNA (5'-D(*CP*AP*TP*TP*AP*GP*AP*A)-3'), DNA (5'-D(*TP*CP*TP*AP*AP*TP*GP*T)-3'), MANGANESE (II) ION, ... Authors: Pelletier, H, Sawaya, M.R. Deposit date: 1995-12-15 Release date: 1995-12-15 Last modified: 2023-08-02 Method: X-RAY DIFFRACTION (3.1 Å) Cite: A structural basis for metal ion mutagenicity and nucleotide selectivity in human DNA polymerase beta Biochemistry, 35, 1996
8ICW	DNA POLYMERASE BETA (POL B) (E.C.2.7.7.7) COMPLEXED WITH SEVEN BASE PAIRS OF DNA; SOAKED IN THE PRESENCE OF DTTP (1 MILLIMOLAR) AND MNCL2 (5 MILLIMOLAR) Descriptor: DNA (5'-D(*CP*AP*TP*TP*AP*GP*AP*A)-3'), DNA (5'-D(*TP*CP*TP*AP*AP*TP*GP*T)-3'), MANGANESE (II) ION, ... Authors: Pelletier, H, Sawaya, M.R. Deposit date: 1995-12-15 Release date: 1996-11-15 Last modified: 2023-08-02 Method: X-RAY DIFFRACTION (3.3 Å) Cite: A structural basis for metal ion mutagenicity and nucleotide selectivity in human DNA polymerase beta Biochemistry, 35, 1996
8ICR	DNA POLYMERASE BETA (POL B) (E.C.2.7.7.7) COMPLEXED WITH SEVEN BASE PAIRS OF DNA; SOAKED IN THE PRESENCE OF DATP (1 MILLIMOLAR) AND MNCL2 (5 MILLIMOLAR) Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, DNA (5'-D(*CP*AP*TP*TP*AP*GP*AP*A)-3'), DNA (5'-D(*TP*CP*TP*AP*AP*TP*GP*A)-3'), ... Authors: Pelletier, H, Sawaya, M.R. Deposit date: 1996-01-04 Release date: 1996-11-15 Last modified: 2023-08-02 Method: X-RAY DIFFRACTION (2.9 Å) Cite: A structural basis for metal ion mutagenicity and nucleotide selectivity in human DNA polymerase beta Biochemistry, 35, 1996
8ICN	DNA POLYMERASE BETA (POL B) (E.C.2.7.7.7) COMPLEXED WITH SEVEN BASE PAIRS OF DNA; SOAKED IN THE PRESENCE OF ATP (1 MILLIMOLAR) AND MNCL2 (5 MILLIMOLAR) Descriptor: ADENOSINE-5'-TRIPHOSPHATE, DNA (5'-D(*CP*AP*TP*TP*AP*GP*AP*A)-3'), DNA (5'-D(*TP*CP*TP*AP*AP*TP*GP*A)-3'), ... Authors: Pelletier, H, Sawaya, M.R. Deposit date: 1995-12-15 Release date: 1996-11-15 Last modified: 2023-08-02 Method: X-RAY DIFFRACTION (2.8 Å) Cite: A structural basis for metal ion mutagenicity and nucleotide selectivity in human DNA polymerase beta. Biochemistry, 35, 1996
8ICS	DNA POLYMERASE BETA (POL B) (E.C.2.7.7.7) COMPLEXED WITH SEVEN BASE PAIRS OF DNA; SOAKED IN THE PRESENCE OF DCTP (1 MILLIMOLAR) AND MNCL2 (5 MILLIMOLAR) Descriptor: 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, DNA (5'-D(*CP*AP*TP*TP*AP*GP*AP*A)-3'), DNA (5'-D(*TP*CP*TP*AP*AP*TP*G)-3'), ... Authors: Pelletier, H, Sawaya, M.R. Deposit date: 1995-12-15 Release date: 1996-11-15 Last modified: 2023-08-02 Method: X-RAY DIFFRACTION (2.9 Å) Cite: A structural basis for metal ion mutagenicity and nucleotide selectivity in human DNA polymerase beta. Biochemistry, 35, 1996
8ICL	DNA POLYMERASE BETA (POL B) (E.C.2.7.7.7) COMPLEXED WITH SEVEN BASE PAIRS OF DNA; SOAKED IN THE PRESENCE OF DATP (1 MILLIMOLAR) AND NICL2 (5 MILLIMOLAR) Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, DNA (5'-D(*CP*AP*TP*TP*AP*GP*AP*A)-3'), DNA (5'-D(*TP*CP*TP*AP*AP*TP*G)-3'), ... Authors: Pelletier, H, Sawaya, M.R. Deposit date: 1995-12-15 Release date: 1996-11-15 Last modified: 2023-08-02 Method: X-RAY DIFFRACTION (3.1 Å) Cite: A structural basis for metal ion mutagenicity and nucleotide selectivity in human DNA polymerase beta. Biochemistry, 35, 1996
8ICP	DNA POLYMERASE BETA (POL B) (E.C.2.7.7.7) COMPLEXED WITH SEVEN BASE PAIRS OF DNA; SOAKED IN THE PRESENCE OF DATP (1 MILLIMOLAR) AND MNCL2 (5 MILLIMOLAR) Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, DNA (5'-D(*CP*AP*TP*TP*AP*GP*AP*A)-3'), DNA (5'-D(*TP*CP*TP*AP*AP*TP*GP*A)-3'), ... Authors: Pelletier, H, Sawaya, M.R. Deposit date: 1995-12-15 Release date: 1996-11-15 Last modified: 2023-08-02 Method: X-RAY DIFFRACTION (2.9 Å) Cite: A structural basis for metal ion mutagenicity and nucleotide selectivity in human DNA polymerase beta. Biochemistry, 35, 1996
8ICO	DNA POLYMERASE BETA (POL B) (E.C.2.7.7.7) COMPLEXED WITH SEVEN BASE PAIRS OF DNA; SOAKED IN THE PRESENCE OF AZT-TP (1 MILLIMOLAR) AND MNCL2 (5 MILLIMOLAR) Descriptor: 3'-AZIDO-3'-DEOXYTHYMIDINE-5'-TRIPHOSPHATE, DNA (5'-D(*CP*AP*TP*TP*AP*GP*AP*A)-3'), DNA (5'-D(*TP*CP*TP*AP*AP*TP*G)-3'), ... Authors: Pelletier, H, Sawaya, M.R. Deposit date: 1995-12-15 Release date: 1996-11-15 Last modified: 2023-08-02 Method: X-RAY DIFFRACTION (2.7 Å) Cite: A structural basis for metal ion mutagenicity and nucleotide selectivity in human DNA polymerase beta. Biochemistry, 35, 1996
8ICT	DNA POLYMERASE BETA (POL B) (E.C.2.7.7.7) COMPLEXED WITH SEVEN BASE PAIRS OF DNA; SOAKED IN THE PRESENCE OF DCTP (1 MILLIMOLAR) AND MNCL2 (5 MILLIMOLAR) Descriptor: 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, DNA (5'-D(*CP*AP*TP*TP*AP*GP*AP*A)-3'), DNA (5'-D(*TP*CP*TP*AP*AP*TP*G)-3'), ... Authors: Pelletier, H, Sawaya, M.R. Deposit date: 1995-12-15 Release date: 1996-11-15 Last modified: 2023-08-02 Method: X-RAY DIFFRACTION (3.1 Å) Cite: A structural basis for metal ion mutagenicity and nucleotide selectivity in human DNA polymerase beta Biochemistry, 35, 1996
8ICK	DNA POLYMERASE BETA (POL B) (E.C.2.7.7.7) COMPLEXED WITH SEVEN BASE PAIRS OF DNA; SOAKED IN THE PRESENCE OF DATP (1 MILLIMOLAR), MGCL2 (5 MILLIMOLAR), AND MNCL2 (5 MILLIMOLAR) Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, DNA (5'-D(*CP*AP*TP*TP*AP*GP*AP*A)-3'), DNA (5'-D(*TP*CP*TP*AP*AP*TP*GP*A)-3'), ... Authors: Pelletier, H, Sawaya, M.R. Deposit date: 1996-04-19 Release date: 1996-11-15 Last modified: 2023-08-02 Method: X-RAY DIFFRACTION (2.7 Å) Cite: A structural basis for metal ion mutagenicity and nucleotide selectivity in human DNA polymerase beta. Biochemistry, 35, 1996

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