8YY8
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![BU of 8yy8 by Molmil](/molmil-images/mine/8yy8) | Fzd7 -Gs complex | Descriptor: | Frizzled-7, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Chen, B, Xu, L, Han, G.W, Xu, F. | Deposit date: | 2024-04-03 | Release date: | 2024-04-24 | Method: | ELECTRON MICROSCOPY (3.22 Å) | Cite: | Cryo-EM structure of constitutively active human Frizzled 7 in complex with heterotrimeric G s . Cell Res., 31, 2021
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1NXB
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![BU of 1nxb by Molmil](/molmil-images/mine/1nxb) | |
2LQN
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![BU of 2lqn by Molmil](/molmil-images/mine/2lqn) | Solution structure of CRKL | Descriptor: | Crk-like protein | Authors: | Jankowski, W, Saleh, T, Kalodimos, C. | Deposit date: | 2012-03-09 | Release date: | 2012-05-16 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Domain organization differences explain Bcr-Abl's preference for CrkL over CrkII. Nat.Chem.Biol., 8, 2012
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2LQW
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![BU of 2lqw by Molmil](/molmil-images/mine/2lqw) | |
1FRA
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![BU of 1fra by Molmil](/molmil-images/mine/1fra) | |
3EI0
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![BU of 3ei0 by Molmil](/molmil-images/mine/3ei0) | |
3EHZ
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![BU of 3ehz by Molmil](/molmil-images/mine/3ehz) | |
6ENS
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![BU of 6ens by Molmil](/molmil-images/mine/6ens) | Structure of mouse wild-type RKIP | Descriptor: | ACETATE ION, GLYCEROL, Phosphatidylethanolamine-binding protein 1 | Authors: | Hirschbeck, M, Koelmel, W, Schindelin, H, Lorenz, K, Kisker, C. | Deposit date: | 2017-10-06 | Release date: | 2017-12-13 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Conserved salt-bridge competition triggered by phosphorylation regulates the protein interactome. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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6ENT
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![BU of 6ent by Molmil](/molmil-images/mine/6ent) | Structure of the rat RKIP variant delta143-146 | Descriptor: | CHLORIDE ION, Phosphatidylethanolamine-binding protein 1, ZINC ION | Authors: | Koelmel, W, Hirschbeck, M, Schindelin, H, Lorenz, K, Kisker, C. | Deposit date: | 2017-10-06 | Release date: | 2017-12-13 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.66 Å) | Cite: | Conserved salt-bridge competition triggered by phosphorylation regulates the protein interactome. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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8SL3
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![BU of 8sl3 by Molmil](/molmil-images/mine/8sl3) | Human adenylyl Cyclase 5 in complex with Gbg | Descriptor: | Adenylate cyclase type 5, GERAN-8-YL GERAN, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Yen, Y.C, Tesmer, J.J.G. | Deposit date: | 2023-04-20 | Release date: | 2024-04-03 | Last modified: | 2024-04-24 | Method: | ELECTRON MICROSCOPY (7 Å) | Cite: | Structure of adenylyl cyclase 5 in complex with G beta gamma offers insights into ADCY5-related dyskinesia. Nat.Struct.Mol.Biol., 2024
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6VU5
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![BU of 6vu5 by Molmil](/molmil-images/mine/6vu5) | Structure of G-alpha-q bound to its chaperone Ric-8A | Descriptor: | Guanine nucleotide-binding protein G(q) subunit alpha, Resistance to inhibitors of cholinesterase-8A (Ric-8A) | Authors: | Seven, A.B, Hilger, D. | Deposit date: | 2020-02-14 | Release date: | 2020-03-18 | Last modified: | 2020-03-25 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Structures of G alpha Proteins in Complex with Their Chaperone Reveal Quality Control Mechanisms. Cell Rep, 30, 2020
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2FQC
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![BU of 2fqc by Molmil](/molmil-images/mine/2fqc) | Solution structure of conotoxin pl14a | Descriptor: | Alpha/kappa-conotoxin pl14a | Authors: | Craik, D.J, Daly, N.L. | Deposit date: | 2006-01-18 | Release date: | 2006-07-18 | Last modified: | 2020-06-24 | Method: | SOLUTION NMR | Cite: | A Novel Conotoxin Inhibitor of Kv1.6 Channel and nAChR Subtypes Defines a New Superfamily of Conotoxins Biochemistry, 45, 2006
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2MTT
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![BU of 2mtt by Molmil](/molmil-images/mine/2mtt) | Non-reducible analogues of alpha-conotoxin RgIA: [3,12]-cis dicarba RgIA | Descriptor: | Dicarba Analogues of alpha-Conotoxin RgIA | Authors: | Chhabra, S, Robinson, S.D, Norton, R.S. | Deposit date: | 2014-08-31 | Release date: | 2014-11-26 | Last modified: | 2023-12-27 | Method: | SOLUTION NMR | Cite: | Dicarba Analogues of alpha-Conotoxin RgIA. Structure, Stability, and Activity at Potential Pain Targets. J.Med.Chem., 57, 2014
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2MTO
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![BU of 2mto by Molmil](/molmil-images/mine/2mto) | Non-reducible analogues of alpha-conotoxin RgIA: [2,8]-cis dicarba RgIA | Descriptor: | Alpha-conotoxin RgIA | Authors: | Chhabra, S, Robinson, S, Norton, R. | Deposit date: | 2014-08-26 | Release date: | 2014-11-26 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | Dicarba Analogues of alpha-Conotoxin RgIA. Structure, Stability, and Activity at Potential Pain Targets. J.Med.Chem., 57, 2014
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2MTU
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![BU of 2mtu by Molmil](/molmil-images/mine/2mtu) | Non-reducible analogues of alpha-conotoxin RgIA: [3,12]-trans dicarba RgIA | Descriptor: | Dicarba Analogues of alpha-Conotoxin RgIA | Authors: | Chhabra, S, Robinson, S.D, Norton, R.S. | Deposit date: | 2014-09-01 | Release date: | 2014-11-26 | Last modified: | 2023-12-27 | Method: | SOLUTION NMR | Cite: | Dicarba Analogues of alpha-Conotoxin RgIA. Structure, Stability, and Activity at Potential Pain Targets. J.Med.Chem., 57, 2014
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4EKC
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![BU of 4ekc by Molmil](/molmil-images/mine/4ekc) | |
7AR7
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![BU of 7ar7 by Molmil](/molmil-images/mine/7ar7) | Cryo-EM structure of Arabidopsis thaliana complex-I (open conformation) | Descriptor: | (1S)-2-{[{[(2R)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL STEARATE, (7S)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSAN-1-AMINIUM 4-OXIDE, 1,2-DICAPROYL-SN-PHOSPHATIDYL-L-SERINE, ... | Authors: | Klusch, N, Kuelbrandt, W. | Deposit date: | 2020-10-23 | Release date: | 2022-03-02 | Method: | ELECTRON MICROSCOPY (3.72 Å) | Cite: | A ferredoxin bridge connects the two arms of plant mitochondrial complex I. Plant Cell, 33, 2021
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4EKD
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![BU of 4ekd by Molmil](/molmil-images/mine/4ekd) | |
4GNK
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![BU of 4gnk by Molmil](/molmil-images/mine/4gnk) | Crystal structure of Galphaq in complex with full-length human PLCbeta3 | Descriptor: | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3, CALCIUM ION, GUANOSINE-5'-DIPHOSPHATE, ... | Authors: | Lyon, A.M, Tesmer, J.J.G. | Deposit date: | 2012-08-17 | Release date: | 2013-02-06 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (4 Å) | Cite: | Full-length G alpha (q)-phospholipase C-beta 3 structure reveals interfaces of the C-terminal coiled-coil domain. Nat.Struct.Mol.Biol., 20, 2013
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1HJE
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3PFQ
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![BU of 3pfq by Molmil](/molmil-images/mine/3pfq) | Crystal Structure and Allosteric Activation of Protein Kinase C beta II | Descriptor: | CALCIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Protein kinase C beta type, ... | Authors: | Leonard, T.A, Rozycki, B, Saidi, L.F, Hummer, G, Hurley, J.H. | Deposit date: | 2010-10-28 | Release date: | 2011-02-02 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (4 Å) | Cite: | Crystal Structure and Allosteric Activation of Protein Kinase C beta II Cell(Cambridge,Mass.), 144, 2011
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4QJ4
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![BU of 4qj4 by Molmil](/molmil-images/mine/4qj4) | Structure of a fragment of human phospholipase C-beta3 delta472-569, bound to IP3 and in complex with Galphaq | Descriptor: | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3, CALCIUM ION, D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE, ... | Authors: | Lyon, A.M, Tesmer, J.J.G. | Deposit date: | 2014-06-03 | Release date: | 2014-10-22 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Molecular mechanisms of phospholipase C beta 3 autoinhibition. Structure, 22, 2014
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4QJ3
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![BU of 4qj3 by Molmil](/molmil-images/mine/4qj3) | Structure of a fragment of human phospholipase C-beta3 delta472-559, in complex with Galphaq | Descriptor: | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3, CALCIUM ION, GUANOSINE-5'-DIPHOSPHATE, ... | Authors: | Lyon, A.M, Tesmer, J.J.G. | Deposit date: | 2014-06-03 | Release date: | 2014-10-22 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Molecular mechanisms of phospholipase C beta 3 autoinhibition. Structure, 22, 2014
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4QJ5
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![BU of 4qj5 by Molmil](/molmil-images/mine/4qj5) | Structure of a fragment of human phospholipase C-beta3 delta472-581, bound to IP3 and in complex with Galphaq | Descriptor: | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3, CALCIUM ION, D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE, ... | Authors: | Lyon, A.M, Tesmer, J.J.G. | Deposit date: | 2014-06-03 | Release date: | 2014-10-22 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (3.41 Å) | Cite: | Molecular mechanisms of phospholipase C beta 3 autoinhibition. Structure, 22, 2014
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4Z90
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![BU of 4z90 by Molmil](/molmil-images/mine/4z90) | ELIC bound with the anesthetic isoflurane in the resting state | Descriptor: | (2R)-2-chloro-2-(difluoromethoxy)-1,1,1-trifluoroethane, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Gamma-aminobutyric-acid receptor subunit beta-1 | Authors: | Chen, Q, Kinde, M, Arjunan, P, Cohen, A, Xu, Y, Tang, P. | Deposit date: | 2015-04-09 | Release date: | 2015-09-16 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Direct Pore Binding as a Mechanism for Isoflurane Inhibition of the Pentameric Ligand-gated Ion Channel ELIC. Sci Rep, 5, 2015
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