6W9W
| R80A PCNA mutant defective in BIR | Descriptor: | Proliferating cell nuclear antigen | Authors: | Ripley, B.M, Washington, M.T. | Deposit date: | 2020-03-23 | Release date: | 2020-09-23 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | Structural analysis of PCNA mutant proteins defective in BIR, FF248-249AA and R80A To be Published
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6WAC
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6FZK
| NMR structure of UB2H, regulatory domain of PBP1b from E. coli | Descriptor: | Penicillin-binding protein 1B | Authors: | Simorre, J.P, Maya Martinez, R.C, Bougault, C, Egan, A.J.F, Vollmer, W. | Deposit date: | 2018-03-15 | Release date: | 2019-02-20 | Last modified: | 2024-06-19 | Method: | SOLUTION NMR | Cite: | Induced conformational changes activate the peptidoglycan synthase PBP1B. Mol. Microbiol., 110, 2018
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5ZUT
| Crystal Structure of Yeast PCNA in Complex with N24 Peptide | Descriptor: | N24, Proliferating cell nuclear antigen | Authors: | Cheng, X.Y, Kuang, X.L, Zhou, Y, Xia, X.M, SU, Z.D. | Deposit date: | 2018-05-08 | Release date: | 2018-05-30 | Last modified: | 2024-06-05 | Method: | X-RAY DIFFRACTION (2.82 Å) | Cite: | Crystal Structure of Yeast PCNA in Complex with N24 Peptide To Be Published
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6AC7
| Structure of a (3+1) hybrid G-quadruplex in the PARP1 promoter | Descriptor: | 5'-D(*TP*GP*GP*GP*GP*TP*CP*CP*GP*AP*GP*GP*CP*GP*GP*GP*GP*CP*TP*TP*GP*GP*G)-3' | Authors: | Sengar, A, Vandana, J.J, Chambers, V.S, Di Antonio, M, Winnerdy, F.R, Balasubramanian, S, Phan, A.T. | Deposit date: | 2018-07-25 | Release date: | 2019-02-27 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Structure of a (3+1) hybrid G-quadruplex in the PARP1 promoter. Nucleic Acids Res., 47, 2019
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117E
| THE R78K AND D117E ACTIVE SITE VARIANTS OF SACCHAROMYCES CEREVISIAE SOLUBLE INORGANIC PYROPHOSPHATASE: STRUCTURAL STUDIES AND MECHANISTIC IMPLICATIONS | Descriptor: | MANGANESE (II) ION, PHOSPHATE ION, PROTEIN (INORGANIC PYROPHOSPHATASE) | Authors: | Tuominen, V, Heikinheimo, P, Kajander, T, Torkkel, T, Hyytia, T, Kapyla, J, Lahti, R, Cooperman, B.S, Goldman, A. | Deposit date: | 1998-09-15 | Release date: | 1998-12-23 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | The R78K and D117E active-site variants of Saccharomyces cerevisiae soluble inorganic pyrophosphatase: structural studies and mechanistic implications. J.Mol.Biol., 284, 1998
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4L60
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7AOP
| Structure of NUDT15 in complex with inhibitor TH8321 | Descriptor: | 2-azanyl-9-cyclohexyl-8-(2-methoxyphenyl)-3~{H}-purine-6-thione, MAGNESIUM ION, Nucleotide triphosphate diphosphatase NUDT15 | Authors: | Rehling, D, Zhang, S.M, Helleday, T, Stenmark, P. | Deposit date: | 2020-10-14 | Release date: | 2021-06-02 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | NUDT15-mediated hydrolysis limits the efficacy of anti-HCMV drug ganciclovir. Cell Chem Biol, 28, 2021
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7AOM
| Structure of NUDT15 in complex with Ganciclovir triphosphate | Descriptor: | Ganciclovir triphosphate, MAGNESIUM ION, Nucleotide triphosphate diphosphatase NUDT15 | Authors: | Rehling, D, Zhang, S.M, Helleday, T, Stenmark, P. | Deposit date: | 2020-10-14 | Release date: | 2021-06-02 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | NUDT15-mediated hydrolysis limits the efficacy of anti-HCMV drug ganciclovir. Cell Chem Biol, 28, 2021
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4L6P
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2HN8
| Structural characterization and oligomerization of PB1-F2, a pro-apoptotic influenza A virus protein | Descriptor: | Protein PB1-F2 | Authors: | Bruns, K, Studtrucker, N, Sharma, A, Fossen, T, Mitzner, D, Eissmann, A, Tessmer, U, Roder, R, Henklein, P, Wray, V, Schubert, U. | Deposit date: | 2006-07-12 | Release date: | 2006-11-07 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Structural characterization and oligomerization of PB1-F2, a pro-apoptotic influenza A virus protein. J.Biol.Chem., 282, 2007
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3JZ0
| LinB complexed with clindamycin and AMPCPP | Descriptor: | CLINDAMYCIN, DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, Lincosamide nucleotidyltransferase, ... | Authors: | Morar, M, Wright, G.D. | Deposit date: | 2009-09-22 | Release date: | 2009-11-03 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structure and mechanism of the lincosamide antibiotic adenylyltransferase LinB. Structure, 17, 2009
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3JYY
| SeMet LinB complexed with PPi | Descriptor: | Lincosamide nucleotidyltransferase, MAGNESIUM ION, PYROPHOSPHATE | Authors: | Morar, M, Wright, G.D. | Deposit date: | 2009-09-22 | Release date: | 2009-11-03 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structure and mechanism of the lincosamide antibiotic adenylyltransferase LinB. Structure, 17, 2009
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3KR8
| Human tankyrase 2 - catalytic PARP domain in complex with an inhibitor XAV939 | Descriptor: | 2-[4-(trifluoromethyl)phenyl]-7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidin-4-ol, GLYCEROL, SULFATE ION, ... | Authors: | Karlberg, T, Schutz, P, Arrowsmith, C.H, Berglund, H, Bountra, C, Collins, R, Edwards, A.M, Flodin, S, Flores, A, Graslund, S, Hammarstrom, M, Johansson, A, Johansson, I, Kallas, A, Kotenyova, T, Kotzsch, A, Kraulis, P, Nielsen, T.K, Moche, M, Nordlund, P, Nyman, T, Persson, C, Siponen, M.I, Thorsell, A.G, Tresaugues, L, Van Den Berg, S, Weigelt, J, Welin, M, Wisniewska, M, Schuler, H, Structural Genomics Consortium (SGC) | Deposit date: | 2009-11-18 | Release date: | 2009-12-15 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural basis for the interaction between tankyrase-2 and a potent Wnt-signaling inhibitor. J.Med.Chem., 53, 2010
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8PRK
| THE R78K AND D117E ACTIVE SITE VARIANTS OF SACCHAROMYCES CEREVISIAE SOLUBLE INORGANIC PYROPHOSPHATASE: STRUCTURAL STUDIES AND MECHANISTIC IMPLICATIONS | Descriptor: | MANGANESE (II) ION, PHOSPHATE ION, PROTEIN (INORGANIC PYROPHOSPHATASE) | Authors: | Tuominen, V, Heikinheimo, P, Kajander, T, Torkkel, T, Hyytia, T, Kapyla, J, Lahti, R, Cooperman, B.S, Goldman, A. | Deposit date: | 1998-09-16 | Release date: | 1998-12-23 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | The R78K and D117E active-site variants of Saccharomyces cerevisiae soluble inorganic pyrophosphatase: structural studies and mechanistic implications. J.Mol.Biol., 284, 1998
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4ITD
| Structures of DNA duplexes containing O6-carboxymethylguanine, a lesion associated with gastrointestinal cancer, reveal a mechanism for inducing transition mutation | Descriptor: | 2'-(4-HYDROXYPHENYL)-5-(4-METHYL-1-PIPERAZINYL)-2,5'-BI-BENZIMIDAZOLE, DNA (5'-D(*CP*GP*CP*GP*(C6G)P*AP*TP*TP*CP*GP*CP*G)-3'), MAGNESIUM ION | Authors: | Zhang, F, Suzuki, K, Tsunoda, M, Wilkinson, O, Millington, C.L, Williams, D.M, Morishita, E.C, Takenaka, A. | Deposit date: | 2013-01-18 | Release date: | 2013-05-08 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.94 Å) | Cite: | Structures of DNA duplexes containing O6-carboxymethylguanine, a lesion associated with gastrointestinal cancer, reveal a mechanism for inducing pyrimidine transition mutations Nucleic Acids Res., 41, 2013
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2KWQ
| Mcm10 C-terminal DNA binding domain | Descriptor: | Protein MCM10 homolog, ZINC ION | Authors: | Robertson, P.D, Chagot, B, Chazin, W.J, Eichman, B.F. | Deposit date: | 2010-04-15 | Release date: | 2010-05-19 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Solution NMR structure of the C-terminal DNA binding domain of Mcm10 reveals a conserved MCM motif. J.Biol.Chem., 285, 2010
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4IJ0
| Structures of DNA duplexes containing O6-carboxymethylguanine, a lesion associated with gastrointestinal cancer, reveal a mechanism for inducing transition mutation | Descriptor: | 2'-(4-HYDROXYPHENYL)-5-(4-METHYL-1-PIPERAZINYL)-2,5'-BI-BENZIMIDAZOLE, DNA (5'-D(*CP*GP*CP*(C6G)P*AP*AP*TP*TP*CP*GP*CP*G)-3'), STRONTIUM ION | Authors: | Zhang, F, Suzuki, K, Tsunoda, M, Wilkinson, O, Millington, C.L, Williams, D.M, Morishita, E.C, Takenaka, A. | Deposit date: | 2012-12-20 | Release date: | 2013-05-08 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.54 Å) | Cite: | Structures of DNA duplexes containing O6-carboxymethylguanine, a lesion associated with gastrointestinal cancer, reveal a mechanism for inducing pyrimidine transition mutations Nucleic Acids Res., 41, 2013
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1Y7X
| Solution structure of a two-repeat fragment of major vault protein | Descriptor: | Major vault protein | Authors: | Kozlov, G, Vavelyuk, O, Minailiuc, O, Banville, D, Gehring, K, Ekiel, I. | Deposit date: | 2004-12-10 | Release date: | 2005-12-20 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Solution structure of a two-repeat fragment of major vault protein. J.Mol.Biol., 356, 2006
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3FWL
| Crystal Structure of the Full-Length Transglycosylase PBP1b from Escherichia coli | Descriptor: | MOENOMYCIN, Penicillin-binding protein 1B | Authors: | Sung, M.T, Lai, Y.T, Huang, C.Y, Chou, L.Y, Wong, C.H, Ma, C. | Deposit date: | 2009-01-19 | Release date: | 2009-06-02 | Last modified: | 2017-11-01 | Method: | X-RAY DIFFRACTION (3.086 Å) | Cite: | Crystal structure of the membrane-bound bifunctional transglycosylase PBP1b from Escherichia coli. Proc.Natl.Acad.Sci.USA, 106, 2009
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2OD8
| Structure of a peptide derived from Cdc9 bound to PCNA | Descriptor: | DNA ligase I, mitochondrial precursor, Proliferating cell nuclear antigen | Authors: | Chapados, B.R, Tainer, J.A. | Deposit date: | 2006-12-21 | Release date: | 2007-05-01 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | The C-terminal domain of yeast PCNA is required for physical and functional interactions with Cdc9 DNA ligase. Nucleic Acids Res., 35, 2007
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4ESV
| A New Twist on the Translocation Mechanism of Helicases from the Structure of DnaB with its Substrates | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 5'-D(P*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*T)-3', 5'-D(P*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*T)-3', ... | Authors: | Itsathitphaisarn, O, Wing, R.A, Eliason, W.K, Wang, J, Steitz, T.A. | Deposit date: | 2012-04-23 | Release date: | 2012-10-24 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | The Hexameric Helicase DnaB Adopts a Nonplanar Conformation during Translocation. Cell(Cambridge,Mass.), 151, 2012
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