4IJ0

Structures of DNA duplexes containing O6-carboxymethylguanine, a lesion associated with gastrointestinal cancer, reveal a mechanism for inducing transition mutation

Summary for 4IJ0

Related4ITD
DescriptorDNA (5'-D(*CP*GP*CP*(C6G)P*AP*AP*TP*TP*CP*GP*CP*G)-3'), STRONTIUM ION, 2'-(4-HYDROXYPHENYL)-5-(4-METHYL-1-PIPERAZINYL)-2,5'-BI-BENZIMIDAZOLE, ... (4 entities in total)
Functional Keywordsdamaged dna, o6-carboxymethylguanine, mutagenesis, dna
Total number of polymer chains2
Total molecular weight8130.21
Authors
Zhang, F.,Suzuki, K.,Tsunoda, M.,Wilkinson, O.,Millington, C.L.,Williams, D.M.,Morishita, E.C.,Takenaka, A. (deposition date: 2012-12-20, release date: 2013-05-08, Last modification date: 2014-03-19)
Primary citation
Zhang, F.,Tsunoda, M.,Suzuki, K.,Kikuchi, Y.,Wilkinson, O.,Millington, C.L.,Margison, G.P.,Williams, D.M.,Czarina Morishita, E.,Takenaka, A.
Structures of DNA duplexes containing O6-carboxymethylguanine, a lesion associated with gastrointestinal cancer, reveal a mechanism for inducing pyrimidine transition mutations
Nucleic Acids Res., 41:5524-5532, 2013
PubMed: 23580550 (PDB entries with the same primary citation)
DOI: 10.1093/nar/gkt198
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.54 Å)
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Structure validation

RfreeClashscoreRSRZ outliers0.20600MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload