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5WG8
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BU of 5wg8 by Molmil
Structure of PP5C with LB-100; 7-oxabicyclo[2.2.1]heptane-2,3-dicarbonyl moiety modeled in the density
Descriptor: (1S,2R,3S,4R)-3-(4-methylpiperazine-1-carbonyl)-7-oxabicyclo[2.2.1]heptane-2-carboxylic acid, (4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, ...
Authors:D'Arcy, B.M, Swingle, M.R, Honkanen, R.E, Prakash, A.
Deposit date:2017-07-13
Release date:2018-07-18
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:The Antitumor Drug LB-100 Is a Catalytic Inhibitor of Protein Phosphatase 2A (PPP2CA) and 5 (PPP5C) Coordinating with the Active-Site Catalytic Metals in PPP5C.
Mol. Cancer Ther., 18, 2019
5W0W
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BU of 5w0w by Molmil
Crystal structure of Protein Phosphatase 2A bound to TIPRL
Descriptor: MANGANESE (II) ION, Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform, Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform, ...
Authors:Wu, C, Zheng, A, Li, J, Satyshur, K, Xing, Y.
Deposit date:2017-06-01
Release date:2018-01-17
Last modified:2020-01-01
Method:X-RAY DIFFRACTION (3.8 Å)
Cite:Methylation-regulated decommissioning of multimeric PP2A complexes.
Nat Commun, 8, 2017
3P71
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BU of 3p71 by Molmil
Crystal structure of the complex of LCMT-1 and PP2A
Descriptor: 5'-{[(3S)-3-amino-3-carboxypropyl](ethyl)amino}-5'-deoxyadenosine, DI(HYDROXYETHYL)ETHER, Leucine carboxyl methyltransferase 1, ...
Authors:Xing, Y, Stanevich, V, Satyshur, K.A, Jiang, L.
Deposit date:2010-10-11
Release date:2011-02-16
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:The Structural Basis for Tight Control of PP2A Methylation and Function by LCMT-1.
Mol.Cell, 41, 2011
3LL8
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BU of 3ll8 by Molmil
Crystal Structure of Calcineurin in Complex with AKAP79 Peptide
Descriptor: AKAP79 peptide, CALCIUM ION, Calcineurin subunit B type 1, ...
Authors:Li, H, Hogan, P.G.
Deposit date:2010-01-28
Release date:2011-01-12
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2 Å)
Cite:Balanced interactions of calcineurin with AKAP79 regulate Ca(2+)-calcineurin-NFAT signaling.
Nat.Struct.Mol.Biol., 19, 2012
4V0W
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BU of 4v0w by Molmil
The crystal structure of mouse PP1G in complex with truncated human PPP1R15B (631-669)
Descriptor: MANGANESE (II) ION, PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 15B, SERINE/THREONINE-PROTEIN PHOSPHATASE PP1-GAMMA CATALYTIC SUBUNIT
Authors:Chen, R, Yan, Y, Casado, A.C, Ron, D, Read, R.J.
Deposit date:2014-09-18
Release date:2015-03-25
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:G-actin provides substrate-specificity to eukaryotic initiation factor 2 alpha holophosphatases.
Elife, 4, 2015
7CUN
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BU of 7cun by Molmil
The structure of human Integrator-PP2A complex
Descriptor: Integrator complex subunit 1, Integrator complex subunit 11, Integrator complex subunit 2, ...
Authors:Zheng, H, Qi, Y, Liu, W, Li, J, Wang, J, Xu, Y.
Deposit date:2020-08-23
Release date:2020-11-25
Last modified:2020-12-09
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Identification of Integrator-PP2A complex (INTAC), an RNA polymerase II phosphatase.
Science, 370, 2020
7DOG
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BU of 7dog by Molmil
Crystal structure of a nuclease and capping domain of SbcD from Staphylococcus aureus
Descriptor: MANGANESE (II) ION, Nuclease SbcCD subunit D
Authors:Lee, J, Ha, N.-C.
Deposit date:2020-12-14
Release date:2021-05-05
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.91 Å)
Cite:Crystal structure of the nuclease and capping domain of SbcD from Staphylococcus aureus.
J.Microbiol, 59, 2021
4WWL
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BU of 4wwl by Molmil
E. coli 5'-nucleotidase mutant I521C labeled with MTSL (intermediate form)
Descriptor: CARBONATE ION, GLYCEROL, Protein UshA, ...
Authors:Krug, U, Paithankar, K.S, Schultz-Heienbrok, R, Strater, N.
Deposit date:2014-11-11
Release date:2014-11-26
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.23 Å)
Cite:E. coli 5'-nucleotidase mutant I521C labeled with MTSL (intermediate form)
To Be Published
4DT2
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BU of 4dt2 by Molmil
Crystal structure of red kidney bean purple acid phosphatase in complex with Maybridge fragment CC27209
Descriptor: (2,2-dimethyl-2,3-dihydro-1-benzofuran-7-yl)methanol, 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Feder, D, Hussein, W.M, Clayton, D.J, Kan, M, Schenk, G, McGeary, R.P, Guddat, L.W.
Deposit date:2012-02-20
Release date:2012-09-19
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Identification of purple acid phosphatase inhibitors by fragment-based screening: promising new leads for osteoporosis therapeutics.
Chem.Biol.Drug Des., 80, 2012
5UI1
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BU of 5ui1 by Molmil
Crystal Structure of Human Protein Phosphatase 5C (PP5C) in complex with a triazole inhibitor
Descriptor: 5-phenyl-1H-1,2,3-triazole-4-carboxylic acid, MANGANESE (II) ION, Serine/threonine-protein phosphatase 5
Authors:Chattopadhyay, D, Swingle, M.R, Salter, E.A, Banerjee, S, Honkanen, R.E.
Deposit date:2017-01-12
Release date:2018-01-17
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:Crystal Structure Human PP5C in Complex with an Inhibitor
To Be Published
4XPN
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BU of 4xpn by Molmil
Crystal Structure of Protein Phosphate 1 complexed with PP1 binding domain of GADD34
Descriptor: GLYCEROL, MANGANESE (II) ION, PHOSPHATE ION, ...
Authors:Choy, M.S, Peti, W, Page, R.
Deposit date:2015-01-17
Release date:2015-07-01
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.285 Å)
Cite:Structural and Functional Analysis of the GADD34:PP1 eIF2 alpha Phosphatase.
Cell Rep, 11, 2015
4DHL
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BU of 4dhl by Molmil
Crystal structure of red kidney bean purple acid phosphatase in complex with Maybridge fragment MO07123
Descriptor: 1,2-ETHANEDIOL, 2-(4-methylphenyl)-1,3-thiazole-4-carboxylic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Feder, D, Clayton, D.J, Hussein, W.M, Schenk, G, McGeary, R, Guddat, L.W.
Deposit date:2012-01-29
Release date:2012-12-12
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Identification of purple acid phosphatase inhibitors by fragment-based screening: promising new leads for osteoporosis therapeutics.
Chem.Biol.Drug Des., 80, 2012
5SVE
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BU of 5sve by Molmil
Structure of Calcineurin in complex with NFATc1 LxVP peptide
Descriptor: CALCIUM ION, Calcineurin subunit B type 1, FE (III) ION, ...
Authors:Sheftic, S.R, Page, R, Peti, W.
Deposit date:2016-08-05
Release date:2017-01-11
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.596 Å)
Cite:Investigating the human Calcineurin Interaction Network using the pi LxVP SLiM.
Sci Rep, 6, 2016
1FJM
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BU of 1fjm by Molmil
Protein serine/threonine phosphatase-1 (alpha isoform, type 1) complexed with microcystin-LR toxin
Descriptor: BETA-MERCAPTOETHANOL, MANGANESE (II) ION, PROTEIN SERINE/THREONINE PHOSPHATASE-1 (ALPHA ISOFORM, ...
Authors:Goldberg, J, Nairn, A.C, Kuriyan, J.
Deposit date:1995-12-17
Release date:1996-06-20
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Three-dimensional structure of the catalytic subunit of protein serine/threonine phosphatase-1.
Nature, 376, 1995
3ZTV
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BU of 3ztv by Molmil
Structure of Haemophilus influenzae NAD nucleotidase (NadN)
Descriptor: ADENOSINE, GLYCEROL, NAD NUCLEOTIDASE, ...
Authors:Garavaglia, S, Bruzzone, S, Cassani, C, Canella, L, Allegrone, G, Sturla, L, Mannino, E, Millo, E, De Flora, A, Rizzi, M.
Deposit date:2011-07-12
Release date:2011-12-14
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:The High-Resolution Crystal Structure of Periplasmic Haemophilus Influenzae Nad Nucleotidase Reveals a Novel Enzymatic Function of Human Cd73 Related to Nad Metabolism.
Biochem.J., 441, 2012
3ZU0
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BU of 3zu0 by Molmil
Structure of Haemophilus influenzae NAD nucleotidase (NadN)
Descriptor: NAD NUCLEOTIDASE, PHOSPHATE ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, ...
Authors:Garavaglia, S, Bruzzone, S, Cassani, C, Canella, L, Allegrone, G, Sturla, L, Mannino, E, Millo, E, De Flora, A, Rizzi, M.
Deposit date:2011-07-13
Release date:2011-12-14
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.001 Å)
Cite:The High-Resolution Crystal Structure of Periplasmic Haemophilus Influenzae Nad Nucleotidase Reveals a Novel Enzymatic Function of Human Cd73 Related to Nad Metabolism.
Biochem.J., 441, 2012
6HMS
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BU of 6hms by Molmil
Cryo-EM map of DNA polymerase D from Pyrococcus abyssi in complex with DNA
Descriptor: DNA (5'-D(*GP*AP*GP*AP*CP*GP*GP*GP*CP*CP*GP*CP*GP*TP*C)-3'), DNA (5'-D(P*TP*GP*AP*CP*GP*CP*GP*GP*CP*CP*CP*GP*TP*CP*TP*C)-3'), DNA polymerase II large subunit,DNA polymerase II large subunit, ...
Authors:Raia, P, Carroni, M, Sauguet, L.
Deposit date:2018-09-12
Release date:2019-01-30
Last modified:2024-05-15
Method:ELECTRON MICROSCOPY (7.1 Å)
Cite:Structure of the DP1-DP2 PolD complex bound with DNA and its implications for the evolutionary history of DNA and RNA polymerases.
PLoS Biol., 17, 2019
6HWR
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BU of 6hwr by Molmil
Red kidney bean purple acid phosphatase in complex with adenosine divanadate
Descriptor: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Feder, D, Gahan, L.R, McGeary, R.P, Guddat, L.W, Schenk, G.
Deposit date:2018-10-13
Release date:2019-04-03
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:The Binding Mode of an ADP Analogue to a Metallohydrolase Mimics the Likely Transition State.
Chembiochem, 20, 2019
4YKE
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BU of 4yke by Molmil
Crystal structure of eukaryotic Mre11 catalytic domain from Chaetomium thermophilum
Descriptor: MANGANESE (II) ION, Mre11
Authors:Seifert, F.U, Lammens, K, Hopfner, K.-P.
Deposit date:2015-03-04
Release date:2015-06-03
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.783 Å)
Cite:Structure of the catalytic domain of Mre11 from Chaetomium thermophilum.
Acta Crystallogr.,Sect.F, 71, 2015
6HXW
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BU of 6hxw by Molmil
structure of human CD73 in complex with antibody IPH53
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 5'-nucleotidase, IPH53 heavy chain, ...
Authors:Roussel, A, Amigues, B.
Deposit date:2018-10-18
Release date:2019-08-28
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.78 Å)
Cite:Blocking Antibodies Targeting the CD39/CD73 Immunosuppressive Pathway Unleash Immune Responses in Combination Cancer Therapies.
Cell Rep, 27, 2019
4DSY
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BU of 4dsy by Molmil
Crystal structure of red kidney bean purple acid phosphatase in complex with Maybridge fragment CC24201
Descriptor: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 5-phenylpyridine-3-carboxylic acid, ...
Authors:Feder, D, Hussein, W.M, Clayton, D.J, Kan, M, Schenk, G, McGeary, R.P, Guddat, L.W.
Deposit date:2012-02-20
Release date:2012-09-19
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Identification of purple acid phosphatase inhibitors by fragment-based screening: promising new leads for osteoporosis therapeutics.
Chem.Biol.Drug Des., 80, 2012
7BBJ
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BU of 7bbj by Molmil
CD73 in complex with the humanized antagonistic antibody mAb19
Descriptor: 5'-nucleotidase, MAGNESIUM ION, ZINC ION, ...
Authors:Boettcher, J, Han, F.
Deposit date:2020-12-17
Release date:2021-12-29
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.72 Å)
Cite:A Novel Antagonistic CD73 Antibody for Inhibition of the Immunosuppressive Adenosine Pathway.
Mol.Cancer Ther., 20, 2021
5UKI
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BU of 5uki by Molmil
Mn2+ and Zn2+ requirements for the lariat debranching enzyme, Dbr1
Descriptor: MANGANESE (II) ION, RNA lariat debranching enzyme, putative, ...
Authors:Macbeth, M.R, Ransey, L.
Deposit date:2017-01-22
Release date:2018-02-21
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of the Entamoeba histolytica RNA lariat debranching enzyme EhDbr1 reveals a catalytic Zn2+/Mn2+heterobinucleation.
FEBS Lett., 591, 2017
3ZK4
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BU of 3zk4 by Molmil
Structure of purple acid phosphatase PPD1 isolated from yellow lupin (Lupinus luteus) seeds
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, DIPHOSPHONUCLEOTIDE PHOSPHATASE 1, ...
Authors:Antonyuk, S.V, Strange, R.W.
Deposit date:2013-01-21
Release date:2014-01-29
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:The Structure of a Purple Acid Phosphatase Involved in Plant Growth and Pathogen Defence Exhibits a Novel Immunoglobulin-Like Fold
Iucrj, 1, 2014
3V4Y
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BU of 3v4y by Molmil
Crystal Structure of the first Nuclear PP1 holoenzyme
Descriptor: GLYCEROL, MANGANESE (II) ION, Nuclear inhibitor of protein phosphatase 1, ...
Authors:Page, R, Peti, W, O'Connell, N.E, Nichols, S.
Deposit date:2011-12-15
Release date:2012-10-31
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.098 Å)
Cite:The Molecular Basis for Substrate Specificity of the Nuclear NIPP1:PP1 Holoenzyme.
Structure, 20, 2012

222415

数据于2024-07-10公开中

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