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6ZYJ
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BU of 6zyj by Molmil
Crystal structure of Hsc70 ATPase domain in complex with ADP and calcium
Descriptor: ACETATE ION, ADENOSINE-5'-DIPHOSPHATE, CALCIUM ION, ...
Authors:Yan, Y, Preissler, S, Ron, D.
Deposit date:2020-08-01
Release date:2020-12-16
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Calcium depletion challenges endoplasmic reticulum proteostasis by destabilising BiP-substrate complexes.
Elife, 9, 2020
7A4V
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BU of 7a4v by Molmil
Crystal structure of lid-truncated ADP-bound BiP in an oligomeric state
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Endoplasmic reticulum chaperone BiP, GLYCEROL, ...
Authors:Perera, L.A, Ron, D.
Deposit date:2020-08-20
Release date:2020-12-16
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.94 Å)
Cite:Calcium depletion challenges endoplasmic reticulum proteostasis by destabilising BiP-substrate complexes.
Elife, 9, 2020
6ZYH
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BU of 6zyh by Molmil
Crystal structure of GRP78 (70kDa heat shock protein 5 / BiP) ATPase domain in complex with ADP and calcium
Descriptor: ADENOSINE-5'-DIPHOSPHATE, CALCIUM ION, Endoplasmic reticulum chaperone BiP
Authors:Yan, Y, Preissler, S, Ron, D.
Deposit date:2020-08-01
Release date:2020-12-16
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:Calcium depletion challenges endoplasmic reticulum proteostasis by destabilising BiP-substrate complexes.
Elife, 9, 2020
7A4U
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BU of 7a4u by Molmil
Crystal structure of lid-truncated apo BiP in an oligomeric state
Descriptor: Endoplasmic reticulum chaperone BiP, GLYCEROL
Authors:Perera, L.A, Ron, D.
Deposit date:2020-08-20
Release date:2020-12-16
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.77 Å)
Cite:Calcium depletion challenges endoplasmic reticulum proteostasis by destabilising BiP-substrate complexes.
Elife, 9, 2020
4JN4
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BU of 4jn4 by Molmil
Allosteric opening of the polypeptide-binding site when an Hsp70 binds ATP
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Chaperone protein DnaK, GLYCEROL, ...
Authors:Qi, R, Sarbeng, E.B, Liu, Q, Le, K.Q, Xu, X, Xu, H, Yang, J, Wong, J.L, Vorvis, C, Hendrickson, W.A, Zhou, L, Liu, Q.
Deposit date:2013-03-14
Release date:2013-05-29
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Allosteric opening of the polypeptide-binding site when an Hsp70 binds ATP.
Nat.Struct.Mol.Biol., 20, 2013
4JWI
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BU of 4jwi by Molmil
Crystal structure of the substrate binding domain of E.coli DnaK in complex with sheep Bac7(35-43)
Descriptor: Cathelicidin-3, Chaperone protein DnaK, SULFATE ION
Authors:Zahn, M, Straeter, N.
Deposit date:2013-03-27
Release date:2013-11-13
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural Identification of DnaK Binding Sites within Bovine and Sheep Bactenecin Bac7.
Protein Pept.Lett., 21, 2014
4JWC
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BU of 4jwc by Molmil
Crystal structure of the substrate binding domain of E.coli DnaK in complex with bovine Bac7(1-16)
Descriptor: Cathelicidin-3, Chaperone protein DnaK, SULFATE ION
Authors:Zahn, M, Straeter, N.
Deposit date:2013-03-27
Release date:2013-11-13
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural Identification of DnaK Binding Sites within Bovine and Sheep Bactenecin Bac7.
Protein Pept.Lett., 21, 2014
4JWE
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BU of 4jwe by Molmil
Crystal structure of the substrate binding domain of E.coli DnaK in complex with sheep Bac7(1-21)
Descriptor: Cathelicidin-3, Chaperone protein DnaK, SULFATE ION
Authors:Zahn, M, Straeter, N.
Deposit date:2013-03-27
Release date:2013-11-13
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structural Identification of DnaK Binding Sites within Bovine and Sheep Bactenecin Bac7.
Protein Pept.Lett., 21, 2014
4JWD
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BU of 4jwd by Molmil
Crystal structure of the substrate binding domain of E.coli DnaK in complex with bovine Bac7(15-28)
Descriptor: Cathelicidin-3, Chaperone protein DnaK, SULFATE ION
Authors:Zahn, M, Straeter, N.
Deposit date:2013-03-27
Release date:2013-11-13
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structural Identification of DnaK Binding Sites within Bovine and Sheep Bactenecin Bac7.
Protein Pept.Lett., 21, 2014
4JNE
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BU of 4jne by Molmil
Allosteric opening of the polypeptide-binding site when an Hsp70 binds ATP
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, GLYCEROL, Hsp70 CHAPERONE DnaK, ...
Authors:Qi, R, Sarbeng, E.B, Liu, Q, Le, K.Q, Xu, X, Xu, H, Yang, J, Wong, J.L, Vorvis, C, Hendrickson, W.A, Zhou, L, Liu, Q.
Deposit date:2013-03-15
Release date:2013-05-29
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:Allosteric opening of the polypeptide-binding site when an Hsp70 binds ATP.
Nat.Struct.Mol.Biol., 20, 2013
5AQX
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BU of 5aqx by Molmil
Fragment-based screening of HSP70 sheds light on the functional role of ATP-binding site residues
Descriptor: (1R,2S,3R,5R)-3-((5-(benzyloxy)quinazolin-4-yl)amino)-5-(hydroxymethyl)cyclopentane-1,2-diol, CHLORIDE ION, DIMETHYL SULFOXIDE, ...
Authors:Jones, A.M, Westwood, I.M, Osborne, J.D, Matthews, T.P, Cheeseman, M.D, Rowlands, M.G, Jeganathan, F, Burke, R, Lee, D, Kadi, N, Liu, M, Richards, M, McAndrew, C, Yahya, N, Dobson, S.E, Jones, K, Workman, P, Collins, I, van Montfort, R.L.M.
Deposit date:2015-09-22
Release date:2016-10-05
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.12 Å)
Cite:A fragment-based approach applied to a highly flexible target: Insights and challenges towards the inhibition of HSP70 isoforms.
Sci Rep, 6, 2016
4JNF
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BU of 4jnf by Molmil
Allosteric opening of the polypeptide-binding site when an Hsp70 binds ATP
Descriptor: Hsp70 CHAPERONE DnaK
Authors:Qi, R, Sarbeng, E.B, Liu, Q, Le, K.Q, Xu, X, Xu, H, Yang, J, Wong, J.L, Vorvis, C, Hendrickson, W.A, Zhou, L, Liu, Q.
Deposit date:2013-03-15
Release date:2013-05-29
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.621 Å)
Cite:Allosteric opening of the polypeptide-binding site when an Hsp70 binds ATP.
Nat.Struct.Mol.Biol., 20, 2013
4J8F
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BU of 4j8f by Molmil
Crystal structure of a fusion protein containing the NBD of Hsp70 and the middle domain of Hip
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Heat shock 70 kDa protein 1A/1B, Hsc70-interacting protein, ...
Authors:Li, Z, Bracher, A.
Deposit date:2013-02-14
Release date:2013-07-03
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structure and function of Hip, an attenuator of the Hsp70 chaperone cycle.
Nat.Struct.Mol.Biol., 20, 2013
5AQY
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BU of 5aqy by Molmil
Fragment-based screening of HSP70 sheds light on the functional role of ATP-binding site residues
Descriptor: 1,2-ETHANEDIOL, ADENOSINE, DIMETHYL SULFOXIDE, ...
Authors:Jones, A.M, Westwood, I.M, Osborne, J.D, Matthews, T.P, Cheeseman, M.D, Rowlands, M.G, Jeganathan, F, Burke, R, Lee, D, Kadi, N, Liu, M, Richards, M, McAndrew, C, Yahya, N, Dobson, S.E, Jones, K, Workman, P, Collins, I, van Montfort, R.L.M.
Deposit date:2015-09-22
Release date:2016-10-05
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.56 Å)
Cite:A fragment-based approach applied to a highly flexible target: Insights and challenges towards the inhibition of HSP70 isoforms.
Sci Rep, 6, 2016
4KBO
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BU of 4kbo by Molmil
Crystal structure of the human Mortalin (GRP75) ATPase domain in the apo form
Descriptor: SODIUM ION, Stress-70 protein, mitochondrial
Authors:Amick, J, Page, R.C, Nix, J.C, Misra, S.
Deposit date:2013-04-23
Release date:2014-04-02
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure of the nucleotide-binding domain of mortalin, the mitochondrial Hsp70 chaperone.
Protein Sci., 23, 2014
5BPM
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BU of 5bpm by Molmil
Crystal structure of unhydrolyzed ATP bound human Hsp70 NBD double mutant E268Q+R272K.
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, CHLORIDE ION, Heat shock 70 kDa protein 1A, ...
Authors:Narayanan, D, Engh, R.A.
Deposit date:2015-05-28
Release date:2016-09-14
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:Nucleotide binding to variants of the HSP70-NBD.
To Be Published
5BPL
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BU of 5bpl by Molmil
Crystal structure of ADP and Pi bound human Hsp70 NBD mutant R272K.
Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, ...
Authors:Narayanan, D, Engh, R.A.
Deposit date:2015-05-28
Release date:2016-09-14
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Nucleotide binding to variants of the HSP70-NBD.
To Be Published
5MKS
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BU of 5mks by Molmil
HSP72-NBD bound to compound TCI 8 - Tyr15 in down-conformation
Descriptor: 3-[(2~{R},3~{S},4~{R},5~{R})-5-[6-azanyl-8-[(4-chlorophenyl)methylamino]purin-9-yl]-3,4-bis(oxidanyl)oxolan-2-yl]propyl prop-2-enoate, Heat shock 70 kDa protein 1A
Authors:Pettinger, J, Westwood, I.M, Cronin, N, Le Bihan, Y.-V, Van Montfort, R.L.M.
Deposit date:2016-12-05
Release date:2017-03-01
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:An Irreversible Inhibitor of HSP72 that Unexpectedly Targets Lysine-56.
Angew. Chem. Int. Ed. Engl., 56, 2017
7O6R
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BU of 7o6r by Molmil
Crystal structure of bovine Hsc70(aa1-554)E213A/D214A in complex with 1H-Indazole
Descriptor: 1H-indazole, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, DIMETHYL SULFOXIDE, ...
Authors:Zehe, M, Grimm, C, Sotriffer, C.
Deposit date:2021-04-12
Release date:2022-05-04
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2 Å)
Cite:Combined In-Solution Fragment Screening and Crystallographic Binding-Mode Analysis with a Two-Domain Hsp70 Construct.
Acs Chem.Biol., 2024
7ODI
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BU of 7odi by Molmil
Crystal structure of bovine Hsc70(aa1-554)E213A/D214A in complex with methanesulfonamide
Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, GLYCEROL, Heat shock cognate 71 kDa protein, ...
Authors:Zehe, M, Grimm, C, Sotriffer, C.
Deposit date:2021-04-29
Release date:2022-06-01
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:Combined In-Solution Fragment Screening and Crystallographic Binding-Mode Analysis with a Two-Domain Hsp70 Construct.
Acs Chem.Biol., 2024
7ODD
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BU of 7odd by Molmil
Crystal structure of bovine Hsc70(aa1-554)E213A/D214A in complex with tricine
Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, GLYCEROL, Heat shock cognate 71 kDa protein, ...
Authors:Zehe, M, Grimm, C, Sotriffer, C.
Deposit date:2021-04-29
Release date:2022-06-01
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.984 Å)
Cite:Combined In-Solution Fragment Screening and Crystallographic Binding-Mode Analysis with a Two-Domain Hsp70 Construct.
Acs Chem.Biol., 2024
7ODB
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BU of 7odb by Molmil
Crystal structure of bovine Hsc70(aa1-554)E213A/D214A in complex with triazine-derivative
Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 6-methyl-5-sulfanylidene-2H-1,2,4-triazin-3-one, GLYCEROL, ...
Authors:Zehe, M, Grimm, C, Sotriffer, C.
Deposit date:2021-04-29
Release date:2022-06-01
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.662 Å)
Cite:Combined In-Solution Fragment Screening and Crystallographic Binding-Mode Analysis with a Two-Domain Hsp70 Construct.
Acs Chem.Biol., 2024
5MB9
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BU of 5mb9 by Molmil
Crystal structure of the eukaryotic ribosome associated complex (RAC), a unique Hsp70/Hsp40 pair
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, GLYCEROL, MAGNESIUM ION, ...
Authors:Gumiero, A, Weyer, F.A, Valentin Gese, G, Lapouge, K, Sinning, I.
Deposit date:2016-11-07
Release date:2016-12-28
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structural insights into a unique Hsp70-Hsp40 interaction in the eukaryotic ribosome-associated complex.
Nat. Struct. Mol. Biol., 24, 2017
7OOE
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BU of 7ooe by Molmil
Plasmodium falciparum Hsp70-x chaperone nucleotide binding domain in complex with Z321318226
Descriptor: AMP PHOSPHORAMIDATE, CHLORIDE ION, GLYCEROL, ...
Authors:Mohamad, N, O'Donoghue, A, Kantsadi, A.L, Vakonakis, I.
Deposit date:2021-05-27
Release date:2021-06-02
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.369 Å)
Cite:Structures of P. falciparum Hsp70-x nucleotide binding domain with small molecule ligands
To Be Published
7OOH
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BU of 7ooh by Molmil
Plasmodium falciparum Hsp70-x chaperone nucleotide binding domain in complex with NCL-00023818
Descriptor: 4-IODOPYRAZOLE, AMP PHOSPHORAMIDATE, CHLORIDE ION, ...
Authors:Mohamad, N, O'Donoghue, A, Kantsadi, A.L, Vakonakis, I.
Deposit date:2021-05-27
Release date:2021-06-09
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.36 Å)
Cite:Plasmodium falciparum Hsp70-x chaperone nucleotide binding domain in complex with NCL-00023818
To Be Published

221051

数据于2024-06-12公开中

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