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7OOH
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BU of 7ooh by Molmil
Plasmodium falciparum Hsp70-x chaperone nucleotide binding domain in complex with NCL-00023818
Descriptor: 4-IODOPYRAZOLE, AMP PHOSPHORAMIDATE, CHLORIDE ION, ...
Authors:Mohamad, N, O'Donoghue, A, Kantsadi, A.L, Vakonakis, I.
Deposit date:2021-05-27
Release date:2021-06-09
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.36 Å)
Cite:Plasmodium falciparum Hsp70-x chaperone nucleotide binding domain in complex with NCL-00023818
To Be Published
7OOG
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BU of 7oog by Molmil
Plasmodium falciparum Hsp70-x chaperone nucleotide binding domain in complex with NCL-00023823
Descriptor: 4-bromanylpyridin-2-amine, AMP PHOSPHORAMIDATE, CHLORIDE ION, ...
Authors:Mohamad, N, O'Donoghue, A, Kantsadi, A.L, Vakonakis, I.
Deposit date:2021-05-27
Release date:2021-06-02
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.42 Å)
Cite:Plasmodium falciparum Hsp70-x chaperone nucleotide binding domain in complex with NCL-00023823
To Be Published
7OOE
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BU of 7ooe by Molmil
Plasmodium falciparum Hsp70-x chaperone nucleotide binding domain in complex with Z321318226
Descriptor: AMP PHOSPHORAMIDATE, CHLORIDE ION, GLYCEROL, ...
Authors:Mohamad, N, O'Donoghue, A, Kantsadi, A.L, Vakonakis, I.
Deposit date:2021-05-27
Release date:2021-06-02
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.369 Å)
Cite:Structures of P. falciparum Hsp70-x nucleotide binding domain with small molecule ligands
To Be Published
7P31
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BU of 7p31 by Molmil
Plasmodium falciparum Hsp70-x chaperone nucleotide binding domain in complex with NCL-00023818
Descriptor: 4-IODOPYRAZOLE, AMP PHOSPHORAMIDATE, CHLORIDE ION, ...
Authors:Mohamad, N, O'Donoghue, A, Kantsadi, A.L, Vakonakis, I.
Deposit date:2021-07-06
Release date:2021-07-14
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.36 Å)
Cite:Plasmodium falciparum Hsp70-x chaperone nucleotide binding domain in complex with small molecule ligands
To Be Published
6DWS
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BU of 6dws by Molmil
Crystal structure of human GRP78 in complex with (2R,3R,4S,5R)-2-(6-amino-8-((2-chlorobenzyl)amino)-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
Descriptor: 8-{[(2-chlorophenyl)methyl]amino}adenosine, Endoplasmic reticulum chaperone BiP, MAGNESIUM ION
Authors:Chen, Y, Antoshchenko, T, Smil, D, Zepeda, C, Huang, Y, Park, H.W.
Deposit date:2018-06-27
Release date:2019-07-03
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of human GRP78 in complex with (2R,3R,4S,5R)-2-(6-amino-8-((2-chlorobenzyl)amino)-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
To Be Published
3GDQ
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BU of 3gdq by Molmil
Crystal structure of the human 70kDa heat shock protein 1-like ATPase domain in complex with ADP and inorganic phosphate
Descriptor: ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, Heat shock 70 kDa protein 1-like, ...
Authors:Wisniewska, M, Moche, M, Arrowsmith, C.H, Berglund, H, Bountra, C, Collins, R, Dahlgren, L.G, Edwards, A.M, Flodin, S, Flores, A, Graslund, S, Hammarstrom, M, Johansson, A, Johansson, I, Karlberg, T, Kotenyova, T, Lehtio, L, Nilsson, M.E, Nordlund, P, Nyman, T, Persson, C, Sagemark, J, Schutz, P, Siponen, M, Thorsell, A.G, Tresaugues, L, Van Den Berg, S, Weigelt, J, Welin, M, Schueler, H, Structural Genomics Consortium (SGC)
Deposit date:2009-02-24
Release date:2009-04-14
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structures of the ATPase domains of four human Hsp70 isoforms: HSPA1L/Hsp70-hom, HSPA2/Hsp70-2, HSPA6/Hsp70B', and HSPA5/BiP/GRP78
Plos One, 5, 2010
7NQZ
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BU of 7nqz by Molmil
Plasmodium falciparum Hsp70-x chaperone nucleotide binding domain in complex with Z1827898537
Descriptor: (3S)-N-benzylpyrrolidin-3-amine, AMP PHOSPHORAMIDATE, CHLORIDE ION, ...
Authors:Mohamad, N, O'Donoghue, A, Kantsadi, A.L, Vakonakis, I.
Deposit date:2021-03-02
Release date:2021-03-10
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.319 Å)
Cite:Structures of P. falciparum Hsp70-x nucleotide binding domain with small molecule ligands
To Be Published
7NQR
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BU of 7nqr by Molmil
Plasmodium falciparum Hsp70-x chaperone nucleotide binding domain in complex with Z287256168
Descriptor: (S)-N-(1-cyclopropylethyl)-6-methylpicolinamide, 1-(2-METHOXY-ETHOXY)-2-{2-[2-(2-METHOXY-ETHOXY]-ETHOXY}-ETHANE, AMP PHOSPHORAMIDATE, ...
Authors:Mohamad, N, O'Donoghue, A, Kantsadi, A.L, Vakonakis, I.
Deposit date:2021-03-02
Release date:2021-03-10
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.22 Å)
Cite:Structures of P. falciparum Hsp70-x nucleotide binding domain with small molecule ligands
To Be Published
7NQU
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BU of 7nqu by Molmil
Plasmodium falciparum Hsp70-x chaperone nucleotide binding domain in complex with Z396380540
Descriptor: AMP PHOSPHORAMIDATE, CHLORIDE ION, GLYCEROL, ...
Authors:Mohamad, N, O'Donoghue, A, Kantsadi, A.L, Vakonakis, I.
Deposit date:2021-03-02
Release date:2021-03-10
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.13 Å)
Cite:Structures of P. falciparum Hsp70-x nucleotide binding domain with small molecule ligands
To Be Published
7NQS
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BU of 7nqs by Molmil
Plasmodium falciparum Hsp70-x chaperone nucleotide binding domain in complex with Z1203107138
Descriptor: 1-ethyl-N-[(4-fluorophenyl)methyl]-1H-pyrazole-4-carboxamide, AMP PHOSPHORAMIDATE, GLYCEROL, ...
Authors:Mohamad, N, O'Donoghue, A, Kantsadi, A.L, Vakonakis, I.
Deposit date:2021-03-02
Release date:2021-03-17
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.56 Å)
Cite:Structures of P. falciparum Hsp70-x nucleotide binding domain with small molecule ligands
To Be Published
6EOF
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BU of 6eof by Molmil
Crystal structure of AMPylated GRP78 in ADP state
Descriptor: 78 kDa glucose-regulated protein, ADENOSINE MONOPHOSPHATE, ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Yan, Y, Preissler, S, Read, R.J, Ron, D.
Deposit date:2017-10-09
Release date:2017-11-01
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.59 Å)
Cite:AMPylation targets the rate-limiting step of BiP's ATPase cycle for its functional inactivation.
Elife, 6, 2017
6CZ1
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BU of 6cz1 by Molmil
Crystal structure of ATPase domain of Human GRP78 bound to Ver155008
Descriptor: 4-[[(2R,3S,4R,5R)-5-[6-amino-8-[(3,4-dichlorophenyl)methylamino]purin-9-yl]-3,4-dihydroxy-oxolan-2-yl]methoxymethyl]benzonitrile, Endoplasmic reticulum chaperone BiP, MAGNESIUM ION
Authors:Antoshchenko, T, Chen, Y, Hughes, S, Park, H.
Deposit date:2018-04-07
Release date:2019-04-10
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.68 Å)
Cite:Crystallographic selection of adenosine analogs that fit the mold of the active site of human GRP78 and beyond
To be Published
7Q4R
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BU of 7q4r by Molmil
Crystal structure of human HSP72-NBD in complex with fragment 1
Descriptor: 4-(4-phenyl-1,3-thiazol-2-yl)piperazine-1-carboxamide, Heat shock 70 kDa protein 1A, MAGNESIUM ION, ...
Authors:Le Bihan, Y.V, Westwood, I.M, van Montfort, R.L.M.
Deposit date:2021-11-02
Release date:2022-02-02
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:Discovery and Characterization of a Cryptic Secondary Binding Site in the Molecular Chaperone HSP70.
Molecules, 27, 2022
6DO2
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BU of 6do2 by Molmil
Crystal structure of human GRP78 in complex with 7-deaza-2'-C-methyladenosine
Descriptor: 7-(2-C-methyl-beta-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine, Endoplasmic reticulum chaperone BiP
Authors:Ferrie, R.P, Chen, Y, Antoshchenko, T, Cooney, O.M, Huang, Y, Park, H.W.
Deposit date:2018-06-08
Release date:2019-06-12
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal structure of human GRP78 in complex with 7-deaza-2'-C-methyladenosine
To Be Published
6DFM
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BU of 6dfm by Molmil
Crystal structure of human GRP78 in complex with 8-aminoadenosine
Descriptor: (2R,3R,4S,5R)-2-(6,8-diaminopurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol, Endoplasmic reticulum chaperone BiP
Authors:Ferrie, R.P, Chen, Y, Antoshchenko, T, Cooney, O.M, Huang, Y, Park, H.W.
Deposit date:2018-05-15
Release date:2019-05-15
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.14 Å)
Cite:Crystal structure of human GRP78 in complex with 8-aminoadenosine
To be Published
3GL1
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BU of 3gl1 by Molmil
Crystal structure of ATPase domain of Ssb1 chaperone, a member of the HSP70 family, from Saccharomyces cerevisiae
Descriptor: CHLORIDE ION, GLYCEROL, Heat shock protein SSB1, ...
Authors:Osipiuk, J, Li, H, Bargassa, M, Sahi, C, Craig, E.A, Joachimiak, A, Midwest Center for Structural Genomics (MCSG)
Deposit date:2009-03-11
Release date:2009-03-24
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:Crystal structure of ATPase domain of Ssb1 chaperone, member of the HSP70 family from Saccharomyces cerevisiae.
To be Published
6EOC
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BU of 6eoc by Molmil
Crystal structure of AMPylated GRP78 in apo form (Crystal form 2)
Descriptor: 78 kDa glucose-regulated protein, CITRATE ANION, SULFATE ION
Authors:Yan, Y, Preissler, S, Ron, D, Read, R.J.
Deposit date:2017-10-09
Release date:2017-11-01
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.67 Å)
Cite:AMPylation targets the rate-limiting step of BiP's ATPase cycle for its functional inactivation.
Elife, 6, 2017
7N6M
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BU of 7n6m by Molmil
Crystal structure of the substrate-binding domain of E. coli DnaK in complex with the peptide RQKPLLGLSR
Descriptor: Alkaline phosphatase peptide, Chaperone protein DnaK, SULFATE ION
Authors:Jansen, R.M, Ozden, C, Gierasch, L.M, Garman, S.C.
Deposit date:2021-06-08
Release date:2021-06-23
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:Selective promiscuity in the binding of E. coli Hsp70 to an unfolded protein.
Proc.Natl.Acad.Sci.USA, 118, 2021
7N6K
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BU of 7n6k by Molmil
Crystal structure of the substrate-binding domain of E. coli DnaK in complex with the peptide RALALLPLSR
Descriptor: Alkaline phosphatase peptide, Chaperone protein DnaK, SULFATE ION
Authors:Jansen, R.M, Ozden, C, Gierasch, L.M, Garman, S.C.
Deposit date:2021-06-08
Release date:2021-06-23
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Selective promiscuity in the binding of E. coli Hsp70 to an unfolded protein.
Proc.Natl.Acad.Sci.USA, 118, 2021
7N6J
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BU of 7n6j by Molmil
Crystal structure of the substrate-binding domain of E. coli DnaK in complex with the peptide RKQSTIALALLPLLFTPRR
Descriptor: Alkaline phosphatase peptide, Chaperone protein DnaK, SULFATE ION
Authors:Jansen, R.M, Ozden, C, Gierasch, L.M, Garman, S.C.
Deposit date:2021-06-08
Release date:2021-06-23
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2 Å)
Cite:Selective promiscuity in the binding of E. coli Hsp70 to an unfolded protein.
Proc.Natl.Acad.Sci.USA, 118, 2021
7N6L
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BU of 7n6l by Molmil
Crystal structure of the substrate-binding domain of E. coli DnaK in complex with the peptide EANQQKPLLGLFADG
Descriptor: Alkaline phosphatase peptide, Chaperone protein DnaK, GLYCEROL, ...
Authors:Jansen, R.M, Ozden, C, Gierasch, L.M, Garman, S.C.
Deposit date:2021-06-08
Release date:2021-06-23
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Selective promiscuity in the binding of E. coli Hsp70 to an unfolded protein.
Proc.Natl.Acad.Sci.USA, 118, 2021
6DFO
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BU of 6dfo by Molmil
Crystal structure of human GRP78 in complex with 8-bromoadenosine
Descriptor: 8-bromoadenosine, Endoplasmic reticulum chaperone BiP
Authors:Ferrie, R.P, Chen, Y, Antoshchenko, T, Cooney, O.M, Huang, Y, Park, H.W.
Deposit date:2018-05-15
Release date:2019-05-15
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.54 Å)
Cite:Crystal structure of human GRP78 in complex with 8-bromoadenosine
To be Published
7N1R
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BU of 7n1r by Molmil
A novel and unique ATP hydrolysis to AMP by a human Hsp70 BiP
Descriptor: ADENOSINE MONOPHOSPHATE, DI(HYDROXYETHYL)ETHER, Endoplasmic reticulum chaperone BiP, ...
Authors:Yang, J, Musayev, F, Liu, Q.
Deposit date:2021-05-28
Release date:2022-01-12
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:A novel and unique ATP hydrolysis to AMP by a human Hsp70 Binding immunoglobin protein (BiP).
Protein Sci., 31, 2022
6EOE
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BU of 6eoe by Molmil
Crystal structure of AMPylated GRP78 with nucleotide
Descriptor: 78 kDa glucose-regulated protein, ADENOSINE-5'-DIPHOSPHATE, CITRATE ANION, ...
Authors:Yan, Y, Preissler, S, Ron, D, Read, R.J.
Deposit date:2017-10-09
Release date:2017-11-01
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.71 Å)
Cite:AMPylation targets the rate-limiting step of BiP's ATPase cycle for its functional inactivation.
Elife, 6, 2017
6EOB
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BU of 6eob by Molmil
Crystal structure of AMPylated GRP78 in apo form (Crystal form 1)
Descriptor: 78 kDa glucose-regulated protein, PHOSPHATE ION
Authors:Yan, Y, Preissler, S, Ron, D, Read, R.J.
Deposit date:2017-10-09
Release date:2017-11-01
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2 Å)
Cite:AMPylation targets the rate-limiting step of BiP's ATPase cycle for its functional inactivation.
Elife, 6, 2017

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数据于2024-06-19公开中

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