3LDN
Crystal structure of human GRP78 (70kDa heat shock protein 5 / BIP) ATPase domain in apo form
Summary for 3LDN
Entry DOI | 10.2210/pdb3ldn/pdb |
Related | 3LDL 3LDO 3LDP 3LDQ |
Descriptor | 78 kDa glucose-regulated protein (2 entities in total) |
Functional Keywords | grp78, hsp70, hsc70, chaperone, heat shock, protein folding, atp-binding, adenosine, nucleoside, nucleotide-binding, stress response, small molecule inhibitor, selectivity, endoplasmic reticulum, phosphoprotein |
Biological source | Homo sapiens (human) |
Cellular location | Endoplasmic reticulum lumen: P11021 |
Total number of polymer chains | 2 |
Total formula weight | 84599.70 |
Authors | Dokurno, P.,Surgenor, A.E.,Shaw, T.,Macias, A.T.,Massey, A.J.,Williamson, D.S. (deposition date: 2010-01-13, release date: 2011-01-26, Last modification date: 2023-09-06) |
Primary citation | Macias, A.T.,Williamson, D.S.,Allen, N.,Borgognoni, J.,Clay, A.,Daniels, Z.,Dokurno, P.,Drysdale, M.J.,Francis, G.L.,Graham, C.J.,Howes, R.,Matassova, N.,Murray, J.B.,Parsons, R.,Shaw, T.,Surgenor, A.E.,Terry, L.,Wang, Y.,Wood, M.,Massey, A.J. Adenosine-Derived Inhibitors of 78 kDa Glucose Regulated Protein (Grp78) ATPase: Insights into Isoform Selectivity. J.Med.Chem., 54:4034-4041, 2011 Cited by PubMed: 21526763DOI: 10.1021/jm101625x PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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