8OEK
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8OEP
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![BU of 8oep by Molmil](/molmil-images/mine/8oep) | Crystal structure of the PTPN3 PDZ domain bound to the HPV18 E6 oncoprotein C-terminal peptide | Descriptor: | Protein E6, SODIUM ION, Tyrosine-protein phosphatase non-receptor type 3 | Authors: | Genera, M, Colcombet-Cazenave, B, Croitoru, A, Raynal, B, Mechaly, A, Caillet, J, Haouz, A, Wolff, N, Caillet-Saguy, C. | Deposit date: | 2023-03-11 | Release date: | 2023-05-10 | Last modified: | 2024-06-19 | Method: | X-RAY DIFFRACTION (1.87 Å) | Cite: | Interactions of the protein tyrosine phosphatase PTPN3 with viral and cellular partners through its PDZ domain: insights into structural determinants and phosphatase activity. Front Mol Biosci, 10, 2023
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8ODR
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![BU of 8odr by Molmil](/molmil-images/mine/8odr) | Mimetic of UBC9-SUMO1 | Descriptor: | SULFATE ION, SUMO-conjugating enzyme UBC9, Small ubiquitin-related modifier 1 | Authors: | Coste, F, Goffinont, S, Suskiewicz, M.J. | Deposit date: | 2023-03-09 | Release date: | 2023-06-07 | Last modified: | 2024-06-19 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | Structural insights into the regulation of the human E2∼SUMO conjugate through analysis of its stable mimetic. J.Biol.Chem., 299, 2023
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5JXE
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![BU of 5jxe by Molmil](/molmil-images/mine/5jxe) | Human PD-1 ectodomain complexed with Pembrolizumab Fab | Descriptor: | Pembrolizumab Fab heavy chain, Pembrolizumab Fab light chain, Programmed cell death protein 1 | Authors: | Na, Z, Bharath, S.R, Song, H. | Deposit date: | 2016-05-13 | Release date: | 2016-08-10 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Structural basis for blocking PD-1-mediated immune suppression by therapeutic antibody pembrolizumab. Cell Res., 27, 2017
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8OFD
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5JYI
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![BU of 5jyi by Molmil](/molmil-images/mine/5jyi) | Trypsin bound with succinic acid at 1.9A | Descriptor: | CALCIUM ION, Cationic trypsin, SODIUM ION, ... | Authors: | Manohar, R, Kutumbarao, N.H.V, KarthiK, L, Malathy, P, Velmurugan, D, Gunasekaran, K. | Deposit date: | 2016-05-14 | Release date: | 2016-07-06 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.914 Å) | Cite: | Trypsin bound with succinic acid at 1.9A To Be Published
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5JQR
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![BU of 5jqr by Molmil](/molmil-images/mine/5jqr) | The Structure of Ascorbate Peroxidase Compound II formed by reaction with m-CPBA | Descriptor: | Ascorbate peroxidase, POTASSIUM ION, PROTOPORPHYRIN IX CONTAINING FE, ... | Authors: | Kwon, H, Raven, E.L, Moody, P.C.E. | Deposit date: | 2016-05-05 | Release date: | 2016-12-21 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.81 Å) | Cite: | Direct visualization of a Fe(IV)-OH intermediate in a heme enzyme. Nat Commun, 7, 2016
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5JRM
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![BU of 5jrm by Molmil](/molmil-images/mine/5jrm) | Crystal Structure of a Xylanase at 1.56 Angstroem resolution | Descriptor: | Endo-1,4-beta-xylanase, GLYCEROL, SULFATE ION | Authors: | Gomez, S, Payne, A.M, Savko, M, Fox, G.C, Shepard, W.E, Fernandez, F.J, Vega, M.C. | Deposit date: | 2016-05-06 | Release date: | 2017-05-24 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.56 Å) | Cite: | Crystal Structure of a Xylanase at 1.56 Angstroem resolution To Be Published
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5JZB
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![BU of 5jzb by Molmil](/molmil-images/mine/5jzb) | Crystal structure of HsaD bound to 3,5-dichlorobenzene sulphonamide | Descriptor: | 3,5-dichlorobenzene-1-sulfonamide, 4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase, PHOSPHATE ION | Authors: | Ryan, A, Polycarpou, E, Lack, N.A, Evangelopoulos, D, Sieg, C, Halman, A, Bhakta, S, Sinclair, A, Eleftheriadou, O, McHugh, T.D, Keany, S, Lowe, E, Ballet, R, Abihammad, A, Ciulli, A, Sim, E. | Deposit date: | 2016-05-16 | Release date: | 2017-04-05 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.102 Å) | Cite: | Investigation of the mycobacterial enzyme HsaD as a potential novel target for anti-tubercular agents using a fragment-based drug design approach. Br. J. Pharmacol., 174, 2017
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5JZN
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![BU of 5jzn by Molmil](/molmil-images/mine/5jzn) | Crystal structure of DCLK1-KD in complex with NVP-TAE684 | Descriptor: | 5-CHLORO-N-[2-METHOXY-4-[4-(4-METHYLPIPERAZIN-1-YL)PIPERIDIN-1-YL]PHENYL]-N'-(2-PROPAN-2-YLSULFONYLPHENYL)PYRIMIDINE-2,4-DIAMINE, SULFATE ION, Serine/threonine-protein kinase DCLK1 | Authors: | Patel, O, Lucet, I. | Deposit date: | 2016-05-17 | Release date: | 2016-08-24 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | Biochemical and Structural Insights into Doublecortin-like Kinase Domain 1. Structure, 24, 2016
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5JS5
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![BU of 5js5 by Molmil](/molmil-images/mine/5js5) | Nitric oxide complex of the L16F mutant of cytochrome c prime from Alcaligenes xylosoxidans | Descriptor: | ASCORBIC ACID, Cytochrome c', HEME C, ... | Authors: | Kekilli, D, Strange, R.W, Hough, M.A. | Deposit date: | 2016-05-07 | Release date: | 2017-03-08 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Engineering proximal vs. distal heme-NO coordination via dinitrosyl dynamics: implications for NO sensor design. Chem Sci, 8, 2017
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8JTL
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![BU of 8jtl by Molmil](/molmil-images/mine/8jtl) | Structure of OY phytoplasma SAP05 binding with AtRpn10 | Descriptor: | 26S proteasome non-ATPase regulatory subunit 4 homolog, Sequence-variable mosaic (SVM) signal sequence domain-containing protein | Authors: | Du, Y.X, Zhang, L.Y, Zheng, Q.Y. | Deposit date: | 2023-06-22 | Release date: | 2023-07-12 | Last modified: | 2024-07-17 | Method: | X-RAY DIFFRACTION (1.78 Å) | Cite: | Structure basis for recognition of plant Rpn10 by phytoplasma SAP05 in ubiquitin-independent protein degradation. Iscience, 27, 2024
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8JUK
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5K1L
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8JU8
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![BU of 8ju8 by Molmil](/molmil-images/mine/8ju8) | de novo designed protein | Descriptor: | de novo designed protein | Authors: | Zhang, L. | Deposit date: | 2023-06-25 | Release date: | 2023-07-26 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | de novo designed Rossmann fold protein To Be Published
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8JTK
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![BU of 8jtk by Molmil](/molmil-images/mine/8jtk) | Structure of AYWB phytoplasma SAP05 recognizing AtRpn10 | Descriptor: | 26S proteasome non-ATPase regulatory subunit 4 homolog, Sequence-variable mosaic (SVM) signal sequence domain-containing protein | Authors: | Du, Y.X, Zhang, L.Y, Zheng, Q.Y. | Deposit date: | 2023-06-22 | Release date: | 2023-07-19 | Last modified: | 2024-07-17 | Method: | X-RAY DIFFRACTION (1.57 Å) | Cite: | Structure basis for recognition of plant Rpn10 by phytoplasma SAP05 in ubiquitin-independent protein degradation. Iscience, 27, 2024
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8OI7
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![BU of 8oi7 by Molmil](/molmil-images/mine/8oi7) | Trichomonas vaginalis riboside hydrolase | Descriptor: | CALCIUM ION, DI(HYDROXYETHYL)ETHER, Inosine-uridine preferring nucleoside hydrolase family protein, ... | Authors: | Patrone, M, Stockman, B.J, Degano, M. | Deposit date: | 2023-03-22 | Release date: | 2023-08-02 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | A riboside hydrolase that salvages both nucleobases and nicotinamide in the auxotrophic parasite Trichomonas vaginalis. J.Biol.Chem., 299, 2023
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8OIZ
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![BU of 8oiz by Molmil](/molmil-images/mine/8oiz) | Crystal structure of human CRBN-DDB1 in complex with Pomalidomide | Descriptor: | 1,2-ETHANEDIOL, DNA damage-binding protein 1, Protein cereblon, ... | Authors: | Le Bihan, Y.-V, Cabry, M.P, van Montfort, R.L.M. | Deposit date: | 2023-03-23 | Release date: | 2023-07-19 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | A Degron Blocking Strategy Towards Improved CRL4 CRBN Recruiting PROTAC Selectivity. Chembiochem, 24, 2023
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8K4Y
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![BU of 8k4y by Molmil](/molmil-images/mine/8k4y) | Structure of a triple-helix region of human ReCol 3 from Trautec | Descriptor: | SULFATE ION, triple-helix region of human ReCol 3 | Authors: | Chu, Y, Zhai, Y, Fan, X, Li, J, Wang, L, Fu, S, Feng, P, Qian, S. | Deposit date: | 2023-07-20 | Release date: | 2023-08-02 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Structure of a triple-helix region of human ReCol 3 from Trautec. To Be Published
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5JUH
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![BU of 5juh by Molmil](/molmil-images/mine/5juh) | Crystal structure of C-terminal domain (RV) of MpAFP | Descriptor: | Antifreeze protein, CALCIUM ION | Authors: | Guo, S. | Deposit date: | 2016-05-10 | Release date: | 2017-07-19 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.35 Å) | Cite: | Structure of a 1.5-MDa adhesin that binds its Antarctic bacterium to diatoms and ice. Sci Adv, 3, 2017
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8JDE
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![BU of 8jde by Molmil](/molmil-images/mine/8jde) | Crystal structure of mLDHD in complex with D-lactate | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, LACTIC ACID, MANGANESE (II) ION, ... | Authors: | Jin, S, Chen, X, Yang, J, Ding, J. | Deposit date: | 2023-05-13 | Release date: | 2023-10-18 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.729 Å) | Cite: | Lactate dehydrogenase D is a general dehydrogenase for D-2-hydroxyacids and is associated with D-lactic acidosis. Nat Commun, 14, 2023
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8JDZ
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![BU of 8jdz by Molmil](/molmil-images/mine/8jdz) | Crystal structure of mLDHD in complex with 2-keto-3-methylvaleric acid | Descriptor: | (3S)-3-methyl-2-oxopentanoic acid, FLAVIN-ADENINE DINUCLEOTIDE, MANGANESE (II) ION, ... | Authors: | Jin, S, Chen, X, Yang, J, Ding, J. | Deposit date: | 2023-05-15 | Release date: | 2023-10-18 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.56 Å) | Cite: | Lactate dehydrogenase D is a general dehydrogenase for D-2-hydroxyacids and is associated with D-lactic acidosis. Nat Commun, 14, 2023
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8JDP
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![BU of 8jdp by Molmil](/molmil-images/mine/8jdp) | Crystal structure of H405A mLDHD in complex with D-2-hydroxyisovaleric acid | Descriptor: | DEAMINOHYDROXYVALINE, FLAVIN-ADENINE DINUCLEOTIDE, Probable D-lactate dehydrogenase, ... | Authors: | Jin, S, Chen, X, Yang, J, Ding, J. | Deposit date: | 2023-05-15 | Release date: | 2023-10-18 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Lactate dehydrogenase D is a general dehydrogenase for D-2-hydroxyacids and is associated with D-lactic acidosis. Nat Commun, 14, 2023
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8JEA
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![BU of 8jea by Molmil](/molmil-images/mine/8jea) | Crystal structure of CGL1 from Crassostrea gigas, mannotriose-bound form (CGL1/Man(alpha)1-2Man(alpha)1-2Man) | Descriptor: | ACETIC ACID, CACODYLATE ION, MAGNESIUM ION, ... | Authors: | Unno, H, Hatakeyama, T. | Deposit date: | 2023-05-15 | Release date: | 2023-10-25 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (0.97 Å) | Cite: | Mannose oligosaccharide recognition of CGL1, a mannose-specific lectin containing DM9 motifs from Crassostrea gigas, revealed by X-ray crystallographic analysis. J.Biochem., 175, 2023
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5K76
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![BU of 5k76 by Molmil](/molmil-images/mine/5k76) | IRAK4 in complex with Compound 28 | Descriptor: | Interleukin-1 receptor-associated kinase 4, ~{N}-(4-morpholin-4-ylcyclohexyl)-5-(oxan-4-yl)-7~{H}-pyrrolo[2,3-d]pyrimidin-4-amine | Authors: | Ferguson, A.D. | Deposit date: | 2016-05-25 | Release date: | 2017-12-06 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.74 Å) | Cite: | Discovery and Optimization of Pyrrolopyrimidine Inhibitors of Interleukin-1 Receptor Associated Kinase 4 (IRAK4) for the Treatment of Mutant MYD88L265P Diffuse Large B-Cell Lymphoma. J. Med. Chem., 60, 2017
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