2X4U
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![BU of 2x4u by Molmil](/molmil-images/mine/2x4u) | Crystal structure of MHC CLass I HLA-A2.1 bound to HIV-1 Peptide RT468-476 | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, BETA-2-MICROGLOBULIN, GLYCEROL, ... | Authors: | Celie, P.H.N, Toebes, M, Rodenko, B, Ovaa, H, Perrakis, A, Schumacher, T.N.M. | Deposit date: | 2010-02-02 | Release date: | 2010-03-02 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Uv-Induced Ligand Exchange in Mhc Class I Protein Crystals. J.Am.Chem.Soc., 131, 2009
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3L6F
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![BU of 3l6f by Molmil](/molmil-images/mine/3l6f) | |
6GH1
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![BU of 6gh1 by Molmil](/molmil-images/mine/6gh1) | HLA-E*01:03 in complex with Mtb44 | Descriptor: | Beta-2-microglobulin, Enoyl-[acyl-carrier-protein] reductase [NADH], MHC class I antigen, ... | Authors: | Walters, L.C, Gillespie, G.M, McMichael, A.J, Rozbesky, D, Jones, E.Y, Harlos, K. | Deposit date: | 2018-05-04 | Release date: | 2018-08-08 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Pathogen-derived HLA-E bound epitopes reveal broad primary anchor pocket tolerability and conformationally malleable peptide binding. Nat Commun, 9, 2018
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5T70
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![BU of 5t70 by Molmil](/molmil-images/mine/5t70) | KIR3DL1 in complex with HLA-B*57:01 presenting TSNLQEQIGW | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Beta-2-microglobulin, Decapeptide: THR-SER-ASN-LEU-GLN-GLU-GLN-ILE-GLY-TRP, ... | Authors: | Pymm, P, Rossjohn, J, Vivian, J.P. | Deposit date: | 2016-09-02 | Release date: | 2017-03-01 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | MHC-I peptides get out of the groove and enable a novel mechanism of HIV-1 escape. Nat. Struct. Mol. Biol., 24, 2017
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6BIZ
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![BU of 6biz by Molmil](/molmil-images/mine/6biz) | HLA-DRB1 in complex with citrullinated Histone 2B peptide | Descriptor: | 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, HLA class II DR-beta (HLA-DR B), ... | Authors: | Ting, Y.T, Scally, S.W, Rossjohn, J. | Deposit date: | 2017-11-03 | Release date: | 2018-01-17 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | The interplay between citrullination and HLA-DRB1 polymorphism in shaping peptide binding hierarchies in rheumatoid arthritis. J. Biol. Chem., 293, 2018
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6TMO
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![BU of 6tmo by Molmil](/molmil-images/mine/6tmo) | Structure determination of an enhanced affinity TCR, a24b17, in complex with HLA-A*02:01 presenting a MART-1 peptide, EAAGIGILTV | Descriptor: | 1,2-ETHANEDIOL, Alpha chain of engineered high affinity T-cell receptor, Beta chain of high affinity engineered T-cell receptor, ... | Authors: | Rizkallah, P.J, Cole, D.K. | Deposit date: | 2019-12-05 | Release date: | 2020-10-07 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Molecular Rules Underpinning Enhanced Affinity Binding of Human T Cell Receptors Engineered for Immunotherapy. Mol Ther Oncolytics, 18, 2020
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3GBL
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![BU of 3gbl by Molmil](/molmil-images/mine/3gbl) | |
1PQZ
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![BU of 1pqz by Molmil](/molmil-images/mine/1pqz) | |
2XNA
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![BU of 2xna by Molmil](/molmil-images/mine/2xna) | Crystal structure of the complex between human T cell receptor and staphylococcal enterotoxin | Descriptor: | ENTEROTOXIN H, GLYCEROL, SODIUM ION, ... | Authors: | Saline, M, Rodstrom, K.E.J, Fischer, G, Orekhov, V.Y, Karlsson, B.G, Lindkvist-Petersson, K. | Deposit date: | 2010-07-31 | Release date: | 2010-11-24 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | The Structure of Superantigen Complexed with Tcr and Mhc Reveals Novel Insights Into Superantigenic T Cell Activation. Nat.Commun., 1, 2010
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6NIX
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![BU of 6nix by Molmil](/molmil-images/mine/6nix) | Crystal structure of Immune Receptor | Descriptor: | 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, HLA class II histocompatibility antigen, ... | Authors: | Ting, Y.T, Reid, H.H, Rossjohn, J. | Deposit date: | 2019-01-01 | Release date: | 2020-01-22 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Immune Receptor To Be Published
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1HSA
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![BU of 1hsa by Molmil](/molmil-images/mine/1hsa) | THE THREE-DIMENSIONAL STRUCTURE OF HLA-B27 AT 2.1 ANGSTROMS RESOLUTION SUGGESTS A GENERAL MECHANISM FOR TIGHT PEPTIDE BINDING TO MHC | Descriptor: | BETA 2-MICROGLOBULIN, CLASS I HISTOCOMPATIBILITY ANTIGEN (HLA-B*2705), MODEL PEPTIDE SEQUENCE - ARAAAAAAA | Authors: | Madden, D.R, Gorga, J.C, Strominger, J.L, Wiley, D.C. | Deposit date: | 1992-08-11 | Release date: | 1992-10-15 | Last modified: | 2024-06-05 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | The three-dimensional structure of HLA-B27 at 2.1 A resolution suggests a general mechanism for tight peptide binding to MHC. Cell(Cambridge,Mass.), 70, 1992
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3DTX
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![BU of 3dtx by Molmil](/molmil-images/mine/3dtx) | Crystal structure of HLA-B*2705 complexed with the double citrullinated vasoactive intestinal peptide type 1 receptor (VIPR) peptide (residues 400-408) | Descriptor: | Beta-2-microglobulin, Double citrullinated vasoactive intestinal polypeptide receptor, MHC class I antigen (Fragment) | Authors: | Beltrami, A, Gabdulkhakov, A, Rossmann, M, Ziegler, A, Uchanska-Ziegler, B, Saenger, W. | Deposit date: | 2008-07-16 | Release date: | 2009-05-05 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Citrullination-and mhc polymorphism-dependent conformational changes of a self peptide To be Published
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1L7T
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![BU of 1l7t by Molmil](/molmil-images/mine/1l7t) | Crystal Structure Analysis of the anti-testosterone Fab fragment | Descriptor: | anti-testosterone (heavy chain), anti-testosterone (light chain) | Authors: | Valjakka, J, Hemminki, A, Niemi, S, Soderlund, H, Takkinen, K, Rouvinen, J. | Deposit date: | 2002-03-17 | Release date: | 2002-10-02 | Last modified: | 2018-04-04 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystal Structure of an in Vitro Affinity- and Specificity-matured Anti-testosterone
Fab in Complex with Testosterone. IMPROVED AFFINITY RESULTS FROM
SMALL STRUCTURAL CHANGES WITHIN THE VARIABLE DOMAINS J.Biol.Chem., 277, 2002
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3GSX
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![BU of 3gsx by Molmil](/molmil-images/mine/3gsx) | Crystal structure of the binary complex between HLA-A2 and HCMV NLV-T8V peptide variant | Descriptor: | Beta-2-microglobulin, HCMV pp65 fragment 495-503, variant T8V (NLVPMVAVV), ... | Authors: | Reiser, J.-B, Saulquin, X, Gras, S, Debeaupuis, E, Echasserieau, K, Kissenpfennig, A, Legoux, F, Chouquet, A, Le Gorrec, M, Machillot, P, Neveu, B, Thielens, N, Malissen, B, Bonneville, M, Housset, D. | Deposit date: | 2009-03-27 | Release date: | 2009-08-04 | Last modified: | 2021-10-13 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural bases for the affinity-driven selection of a public TCR against a dominant human cytomegalovirus epitope. J.Immunol., 183, 2009
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4HS3
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![BU of 4hs3 by Molmil](/molmil-images/mine/4hs3) | Crystal structure of H-2Kb with a disulfide stabilized F pocket in complex with the LCMV derived peptide GP34 | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, Beta-2-microglobulin, Envelope glycoprotein, ... | Authors: | Uchtenhagen, H, Boulanger, B, Hein, Z, Abualrous, E.T, Zacharias, M, Werner, J, Elliott, T, Springer, S, Achour, A. | Deposit date: | 2012-10-29 | Release date: | 2014-05-07 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Peptide-independent stabilization of MHC class I molecules breaches cellular quality control. J.Cell.Sci., 127, 2014
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6MV5
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![BU of 6mv5 by Molmil](/molmil-images/mine/6mv5) | |
3PGF
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![BU of 3pgf by Molmil](/molmil-images/mine/3pgf) | Crystal structure of maltose bound MBP with a conformationally specific synthetic antigen binder (sAB) | Descriptor: | GLYCEROL, IMIDAZOLE, Maltose-binding periplasmic protein, ... | Authors: | Kossiakoff, A.A, Duguid, E.M, Sandstrom, A. | Deposit date: | 2010-11-01 | Release date: | 2011-03-09 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Allosteric control of ligand-binding affinity using engineered conformation-specific effector proteins. Nat.Struct.Mol.Biol., 18, 2011
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5HHQ
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![BU of 5hhq by Molmil](/molmil-images/mine/5hhq) | Crystal Structure of HLA-A*0201 in complex with M1-L3W | Descriptor: | Beta-2-microglobulin, HLA class I histocompatibility antigen, A-2 alpha chain, ... | Authors: | Gras, S, Josephs, T.M, Rossjohn, J. | Deposit date: | 2016-01-11 | Release date: | 2016-03-23 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Molecular basis for universal HLA-A*0201-restricted CD8+ T-cell immunity against influenza viruses. Proc.Natl.Acad.Sci.USA, 113, 2016
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1AJ7
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![BU of 1aj7 by Molmil](/molmil-images/mine/1aj7) | IMMUNOGLOBULIN 48G7 GERMLINE FAB ANTIBODY COMPLEXED WITH HAPTEN 5-(PARA-NITROPHENYL PHOSPHONATE)-PENTANOIC ACID. AFFINITY MATURATION OF AN ESTEROLYTIC ANTIBODY | Descriptor: | 5-(PARA-NITROPHENYL PHOSPHONATE)-PENTANOIC ACID, IMMUNOGLOBULIN 48G7 FAB (HEAVY CHAIN), IMMUNOGLOBULIN 48G7 FAB (LIGHT CHAIN) | Authors: | Wedemayer, G.J, Wang, L.H, Patten, P.A, Schultz, P.G, Stevens, R.C. | Deposit date: | 1997-05-15 | Release date: | 1997-11-12 | Last modified: | 2023-08-02 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural insights into the evolution of an antibody combining site. Science, 276, 1997
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1DQM
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![BU of 1dqm by Molmil](/molmil-images/mine/1dqm) | CRYSTAL STRUCTURE OF ANTI-LYSOZYME ANTIBODY | Descriptor: | ANTI-LYSOZYME ANTIBODY HYHEL-63 (HEAVY CHAIN), ANTI-LYSOZYME ANTIBODY HYHEL-63 (LIGHT CHAIN) | Authors: | Li, H, Mariuzza, R.A. | Deposit date: | 2000-01-04 | Release date: | 2000-01-19 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Three-dimensional structures of the free and antigen-bound Fab from monoclonal antilysozyme antibody HyHEL-63(,). Biochemistry, 39, 2000
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3S5L
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![BU of 3s5l by Molmil](/molmil-images/mine/3s5l) | Crystal structure of CD4 mutant bound to HLA-DR1 | Descriptor: | GLYCEROL, HA peptide, HLA class II histocompatibility antigen DR beta chain, ... | Authors: | Li, Y. | Deposit date: | 2011-05-23 | Release date: | 2011-09-21 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Affinity maturation of human CD4 by yeast surface display and crystal structure of a CD4-HLA-DR1 complex. Proc.Natl.Acad.Sci.USA, 108, 2011
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2AEP
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![BU of 2aep by Molmil](/molmil-images/mine/2aep) | An epidemiologically significant epitope of a 1998 influenza virus neuraminidase forms a highly hydrated interface in the NA-antibody complex. | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, FAB heavy chain, ... | Authors: | Venkatramani, L, Bochkareva, E, Lee, J.T, Gulati, U, Laver, W.G, Bochkarev, A, Air, G.M. | Deposit date: | 2005-07-23 | Release date: | 2005-12-20 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | An Epidemiologically Significant Epitope of a 1998 Human Influenza Virus Neuraminidase Forms a Highly Hydrated Interface in the NA-Antibody Complex J.Mol.Biol., 356, 2006
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2ZOK
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![BU of 2zok by Molmil](/molmil-images/mine/2zok) | Crystal structure of H-2Db in complex with JHMV epitope S510 | Descriptor: | 9-meric peptide from Spike glycoprotein, Beta-2-microglobulin, GLYCEROL, ... | Authors: | Theodossis, A, Dunstone, M.A, Rossjohn, J. | Deposit date: | 2008-05-22 | Release date: | 2008-06-10 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural and biological basis of CTL escape in coronavirus-infected mice. J Immunol., 180, 2008
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1OSZ
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![BU of 1osz by Molmil](/molmil-images/mine/1osz) | MHC CLASS I H-2KB HEAVY CHAIN COMPLEXED WITH BETA-2 MICROGLOBULIN AND AN (L4V) MUTANT OF THE VESICULAR STOMATITIS VIRUS NUCLEOPROTEIN | Descriptor: | BETA-2 MICROGLOBULIN, MHC CLASS I H-2KB HEAVY CHAIN, VESICULAR STOMATITIS VIRUS NUCLEOPROTEIN | Authors: | Ghendler, Y, Teng, M.-K, Liu, J.-H, Witte, T, Liu, J, Kim, K.S, Kern, P, Chang, H.-C, Wang, J.-H, Reinherz, E.L. | Deposit date: | 1998-06-18 | Release date: | 1999-01-13 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Differential thymic selection outcomes stimulated by focal structural alteration in peptide/major histocompatibility complex ligands. Proc.Natl.Acad.Sci.USA, 95, 1998
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1MHC
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![BU of 1mhc by Molmil](/molmil-images/mine/1mhc) | MODEL OF MHC CLASS I H2-M3 WITH NONAPEPTIDE FROM RAT ND1 REFINED AT 2.3 ANGSTROMS RESOLUTION | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, MHC CLASS I ANTIGEN H2-M3, NONAPEPTIDE FROM RAT NADH DEHYDROGENASE | Authors: | Wang, C.-R, Fischer Lindahl, K, Deisenhofer, J. | Deposit date: | 1995-08-23 | Release date: | 1996-01-29 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Nonclassical binding of formylated peptide in crystal structure of the MHC class Ib molecule H2-M3 Cell(Cambridge,Mass.), 82, 1995
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