6TMO
Structure determination of an enhanced affinity TCR, a24b17, in complex with HLA-A*02:01 presenting a MART-1 peptide, EAAGIGILTV
Summary for 6TMO
Entry DOI | 10.2210/pdb6tmo/pdb |
Descriptor | MHC class I antigen, Beta-2-microglobulin, EAAGIGILTV, ... (10 entities in total) |
Functional Keywords | high affinity, t-cell receptor, immune system |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 5 |
Total formula weight | 95917.22 |
Authors | Rizkallah, P.J.,Cole, D.K. (deposition date: 2019-12-05, release date: 2020-10-07, Last modification date: 2024-01-24) |
Primary citation | Crean, R.M.,MacLachlan, B.J.,Madura, F.,Whalley, T.,Rizkallah, P.J.,Holland, C.J.,McMurran, C.,Harper, S.,Godkin, A.,Sewell, A.K.,Pudney, C.R.,van der Kamp, M.W.,Cole, D.K. Molecular Rules Underpinning Enhanced Affinity Binding of Human T Cell Receptors Engineered for Immunotherapy. Mol Ther Oncolytics, 18:443-456, 2020 Cited by PubMed: 32913893DOI: 10.1016/j.omto.2020.07.008 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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